LOCUS       NM_001108668            5353 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus AT-hook transcription factor (Akna), mRNA.
ACCESSION   NM_001108668 XM_001064334 XM_342848
VERSION     NM_001108668.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5353)
  AUTHORS   Camargo Ortega G, Falk S, Johansson PA, Peyre E, Broix L, Sahu SK,
            Hirst W, Schlichthaerle T, De Juan Romero C, Draganova K, Vinopal
            S, Chinnappa K, Gavranovic A, Karakaya T, Steininger T, Merl-Pham
            J, Feederle R, Shao W, Shi SH, Hauck SM, Jungmann R, Bradke F,
            Borrell V, Geerlof A, Reber S, Tiwari VK, Huttner WB,
            Wilsch-Brauninger M, Nguyen L and Gotz M.
  TITLE     The centrosome protein AKNA regulates neurogenesis via microtubule
            organization
  JOURNAL   Nature 567 (7746), 113-117 (2019)
   PUBMED   30787442
REFERENCE   2  (bases 1 to 5353)
  AUTHORS   Liu X, Huang D, Guo P, Wu Q, Dai M, Cheng G, Hao H, Xie S, Yuan Z
            and Wang X.
  TITLE     PKA/CREB and NF-kappaB pathway regulates AKNA transcription: A
            novel insight into T-2 toxin-induced inflammation and GH deficiency
            in GH3 cells
  JOURNAL   Toxicology 392, 81-95 (2017)
   PUBMED   29079362
  REMARK    GeneRIF: T-2 toxin activates the PKA/CREB and NF-kappaB/p65
            pathways, thereby promoting the direct binding of phospho-CREB and
            phospho-p65 to the AKNA promoter, thus inhibiting AKNA expression.
            GH and inflammatory cytokines (TNF-alpha, IL-1beta, and IL-6)
            expression were significantly downregulated after AKNA silencing.
REFERENCE   3  (bases 1 to 5353)
  AUTHORS   Ma W, Ortiz-Quintero B, Rangel R, McKeller MR, Herrera-Rodriguez S,
            Castillo EF, Schluns KS, Hall M, Zhang H, Suh WK, Okada H, Mak TW,
            Zhou Y, Blackburn MR and Martinez-Valdez H.
  TITLE     Coordinate activation of inflammatory gene networks, alveolar
            destruction and neonatal death in AKNA deficient mice
  JOURNAL   Cell Res 21 (11), 1564-1577 (2011)
   PUBMED   21606955
REFERENCE   4  (bases 1 to 5353)
  AUTHORS   Ghosh D, Lippert D, Krokhin O, Cortens JP and Wilkins JA.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   5  (bases 1 to 5353)
  AUTHORS   Siddiqa A, Sims-Mourtada JC, Guzman-Rojas L, Rangel R, Guret C,
            Madrid-Marina V, Sun Y and Martinez-Valdez H.
  TITLE     Regulation of CD40 and CD40 ligand by the AT-hook transcription
            factor AKNA
  JOURNAL   Nature 410 (6826), 383-387 (2001)
   PUBMED   11268217
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473978.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_342848.3, XM_001064334.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMD00132285, SAMD00132300
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..5353
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q24"
     gene            1..5353
                     /gene="Akna"
                     /note="AT-hook transcription factor"
                     /db_xref="GeneID:362530"
                     /db_xref="RGD:1308202"
     exon            1..139
                     /gene="Akna"
                     /inference="alignment:Splign:2.1.0"
     exon            140..499
                     /gene="Akna"
                     /inference="alignment:Splign:2.1.0"
     CDS             250..4458
                     /gene="Akna"
                     /note="AT-hook-containing transcription factor"
                     /codon_start=1
                     /product="microtubule organization protein AKNA"
                     /protein_id="NP_001102138.1"
                     /db_xref="GeneID:362530"
                     /db_xref="RGD:1308202"
                     /translation="MASSGTKAQWAGSNLGQGPRRRRWAWAEEQDADGRGDQGWRNKQ
                     SLPEAITPELLEDFRQAQEHLPPLEWDPDMQGSEESSAEDTEADDVSSPEGSPVPLPW
                     LSRHSQRLGLSDEELDETPGSPEVDLAGESSTELECEDQGDLSPPVAGQEPARGWVAS
                     IKQGSNYRPSEHPEAQPSVEHSRTKSWSNATMGLGQPSDSLGSTWEGDTDVPQPDTLP
                     EALPQSPCHNLLHPDDRNEGDVAPATPTEFRHSLAAPARNPERSAGTWGRETTSLPSS
                     RPEDQSWKRTKASPKPLPSRFTGSVSPLSTRLGAVNKVVSQHKQGATVAGHSSSRVPK
                     YGRGRLNYPLPDFSKVGPRVRFPKDENYRPPKSRGHNRQQGSTRPLIFKSPAEIVRDV
                     LLSSGDTPLAKESSLAHPVTRVPQEFQTPEQATELVHQLQEDYHKLLTKYAEAENTID
                     QLRLGAKVHLYSDPPQPSQSFCSGSMPQGSKVLSFSIPQPRSAEWWPDPAQDSQASEA
                     TGWPFPRTDLSPSSSPSMATPGRPHQSQGIAVDQPSTGQIQALTSQASRLLAKVESFE
                     ELVLAGHLPPQDQIKSLEQLRAAHMALEAEYVQACGEEHLDPQLDASQGSPRTLNLCR
                     ELEAEIYQLGQRLEELQDHIDQTRAEPEPCGTDLQDSTPTIPFQPQPAHLPMPSGPVP
                     PPDVQTYQEPVTTTTSPGNSCMLPMPKEVNLGIRTEGSPRGLLVPLKDRKLQAEQDFH
                     GLLERYLSVKSLPEALRVEDEEDPEEEEEQQDHPDTLKVDGSTAAPGKTEARRASPGQ
                     HPAQAEERHRAAIQEDKEQMVSMKSSNFQPSMARNRYTPVLDTAGVAQGGTKPMPSHQ
                     SSLTSLEESRPSDLLPRKALLRAGGPHTEEPWMVSPETDSGFVGSETSIVSPFTQTPE
                     HQISHISTPGPSAQHLTVSAPGDGTSHPKVKGPVVPRRATEAGIPRSLTQRHHSSLSS
                     LRRGAQSCHLEETPVAKIAVPRSEFKRQKQISKQHLPSGTTSPDSAPAPTAASMPHGS
                     AESTANLLLTRTERDQAIKDLQAEVSRLRLQLEDSLHRPRPDSPACVAPAFNCSTQTQ
                     KKLVDSSPSWGSRYGSKSTERLFGEPSGAEPAEPMGRRQVRSSSVPRDVPRLSSSESE
                     SPAPRLSSEKNRTFEEHPQAAQWGTRPLGSTKRRERVSFWGQYTGQEYHILSPKTNLK
                     DSGTASCPHCQPIRTQDTGNAVSREPLGSSAADTLRCSLCGGVKPSAEADGPSPAPSE
                     KNTPQKPAPSTPSLKRKKRQTDSPVRMLPGLWYLAAAPPAPAPPALAYISAPIMPYPP
                     PTVYYATPAPTSVHTASPQPAQGPRRTRHSVQLGLNDLEELQAALREAARAAENVRST
                     TRQLSHSLSADLRHARSLRGSCLF"
     exon            500..1545
                     /gene="Akna"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..1620
                     /gene="Akna"
                     /inference="alignment:Splign:2.1.0"
     exon            1621..1777
                     /gene="Akna"
                     /inference="alignment:Splign:2.1.0"
     exon            1778..1932
                     /gene="Akna"
                     /inference="alignment:Splign:2.1.0"
     exon            1933..1992
                     /gene="Akna"
                     /inference="alignment:Splign:2.1.0"
     exon            1993..2120
                     /gene="Akna"
                     /inference="alignment:Splign:2.1.0"
     exon            2121..2322
                     /gene="Akna"
                     /inference="alignment:Splign:2.1.0"
     exon            2323..2483
                     /gene="Akna"
                     /inference="alignment:Splign:2.1.0"
     exon            2484..2684
                     /gene="Akna"
                     /inference="alignment:Splign:2.1.0"
     exon            2685..2904
                     /gene="Akna"
                     /inference="alignment:Splign:2.1.0"
     exon            2905..3011
                     /gene="Akna"
                     /inference="alignment:Splign:2.1.0"
     exon            3012..3220
                     /gene="Akna"
                     /inference="alignment:Splign:2.1.0"
     exon            3221..3383
                     /gene="Akna"
                     /inference="alignment:Splign:2.1.0"
     exon            3384..3560
                     /gene="Akna"
                     /inference="alignment:Splign:2.1.0"
     exon            3561..3673
                     /gene="Akna"
                     /inference="alignment:Splign:2.1.0"
     exon            3674..3820
                     /gene="Akna"
                     /inference="alignment:Splign:2.1.0"
     exon            3821..3916
                     /gene="Akna"
                     /inference="alignment:Splign:2.1.0"
     exon            3917..4033
                     /gene="Akna"
                     /inference="alignment:Splign:2.1.0"
     exon            4034..4217
                     /gene="Akna"
                     /inference="alignment:Splign:2.1.0"
     exon            4218..5353
                     /gene="Akna"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcggttctg gctggcagag cagtctggag gcggtccagg gtgctgtgga gactgggggc
       61 tccccaggtt tgaaacaaag accttgtggg cagctcccct gagcccaggc cggcaggatg
      121 gtggtgtagt ccaagtgagg ccacaggcag gatggctggt gctcagagga gccacctgtg
      181 atttggatcc ccagctgcag ctcagtctct tgacgatgaa gtggccgagg tgaagccagg
      241 ccaggtccca tggccagctc agggacaaag gcacaatggg cagggtcaaa cctggggcaa
      301 ggaccccgaa ggcggcgctg ggcttgggcc gaggaacaag atgcagacgg aagaggtgac
      361 cagggctgga gaaacaaaca gtctcttcct gaagccatca ctcctgagct cctagaggac
      421 tttcgccagg cacaggagca cctgccaccc ctggagtggg acccagacat gcagggctcc
      481 gaagagtctt ctgcagaaga cactgaagct gacgatgtga gcagcccaga gggttccccc
      541 gtgcctctgc cctggctctc caggcacagt caacggctgg gcctgtctga tgaggagctg
      601 gatgagaccc ctgggagccc tgaggtggac ttagctggag agagtagtac ggaactggag
      661 tgtgaagacc agggagatct cagccctccg gttgcaggac aggagccagc cagaggctgg
      721 gttgcctcta tcaaacaagg cagtaactac agaccttcag agcatccaga ggcccagcca
      781 tctgttgaac acagccgcac aaagtcttgg agcaatgcga ccatgggcct cggtcaacct
      841 agtgacagcc ttggttctac ctgggaagga gacactgatg tcccccagcc tgacaccttg
      901 cctgaagccc tgccacagag tccatgccac aaccttctcc acccagatga cagaaatgaa
      961 ggtgacgttg ctccggcaac acccacagaa ttccggcact ccttagcagc gccagcccgg
     1021 aatcctgagc gctctgctgg cacatggggc cgagaaacca ccagcctacc cagctctcgg
     1081 cctgaggacc aaagctggaa gagaactaag gcatcaccta agccactgcc ctcccggttt
     1141 actggctctg ttagccccct gagtactcgg cttggggcag taaacaaagt tgtgtcacag
     1201 cacaagcagg gagccaccgt ggctggccac tcttcttcac gggttcctaa gtatggcagg
     1261 gggcgcctga actacccact ccctgacttc tccaaggtgg ggccccgggt gaggtttccc
     1321 aaagatgaga actaccgacc cccaaaatcc agaggccaca ataggcaaca aggctctacc
     1381 agacccctca tcttcaagtc accagctgag atcgtccggg atgtactgtt gagtagcgga
     1441 gacacgcccc tggccaagga atcttctctt gctcaccctg tcaccagggt gccccaggag
     1501 ttccagacac cggagcaagc caccgagcta gttcatcagc tccaggagga ctatcacaag
     1561 ctcctcacca agtatgcaga ggctgagaac accatcgacc aacttcgcct tggggccaag
     1621 gtgcacctgt attcagaccc gccccagccc agtcagagct tctgctctgg gtcaatgcca
     1681 cagggaagca aggtcttatc tttctctatc ccgcaaccca gatcagcaga gtggtggcct
     1741 gaccctgccc aggattcaca ggcctctgag gccacagggt ggccgttccc acgaacagac
     1801 ctgagtccct cctcgtcccc cagcatggcc actccagggc ggcctcatca gagccagggc
     1861 attgctgtag accagccctc cacaggacag atccaggcac tgacctctca ggccagccgg
     1921 ctcctggcca aggtggaatc cttcgaggaa ctggtactgg ccggacacct cccaccccag
     1981 gaccaaatca agagcttgga gcaactgagg gcagcccaca tggccctaga ggcagagtac
     2041 gtgcaggcct gcggagaaga gcacctggac cctcagcttg atgcctccca ggggagtccc
     2101 aggactctca acctctgcag ggagctagaa gcagagatat accagctggg acagcgcctg
     2161 gaagagctgc aggaccatat agaccagacc cgagcagagc cagagccatg cgggacagac
     2221 ctgcaggaca gcaccccaac catacccttc cagccccagc cagctcacct acccatgcct
     2281 tcaggaccag tgcccccgcc agatgtgcaa acctaccagg agcctgtcac caccaccact
     2341 tcccctggaa actcctgcat gctccccatg cccaaggagg taaacctggg catcaggaca
     2401 gagggaagcc caagaggtct cctggtccca ctcaaggaca ggaagcttca ggcagagcag
     2461 gacttccatg gccttctgga gagatacctc agtgtgaagt ccctccctga agccttgagg
     2521 gttgaagacg aggaagaccc ggaggaggag gaagagcagc aggatcaccc tgacaccttg
     2581 aaagttgatg gttcaactgc agctccagga aaaacagaag ccaggagggc atcaccagga
     2641 cagcacccag cacaggctga ggaaagacac agggctgcta tccaggagga taaggagcag
     2701 atggtatcta tgaagtcatc aaacttccag ccatccatgg ccagaaatag atacacgcca
     2761 gtcctggata cagctggagt ggctcaaggg ggcaccaaac ccatgccatc acatcagagc
     2821 agtctgacca gcctggaaga gagcaggccc tcagatctcc tccctcgaaa agccctgctt
     2881 cgggctggtg ggccccacac tgaggagccc tggatggtgt ctccagagac agacagtggc
     2941 ttcgtgggct cagaaaccag cattgtgtca cccttcaccc agaccccaga gcaccagatc
     3001 tcccacatca gcaccccagg cccatcagct caacacctca ctgtctctgc ccctggtgac
     3061 gggacctccc atcccaaggt taagggaccc gtggttccca gaagagccac tgaggctggc
     3121 atacccagaa gcctaaccca gcggcatcac tccagcctga gctctctccg gagaggggca
     3181 cagagctgcc acctagagga gacaccagtg gctaagatag ccgttcccag gtctgagttc
     3241 aagagacaga agcagatttc caaacagcac cttcccagtg gaacaaccag ccccgactct
     3301 gccccagctc ccacagctgc ctccatgccg catgggtcag cagagagcac ggccaacctc
     3361 ctcctcacca ggacagagcg cgaccaggcc atcaaggatc tgcaggcaga ggtgtcacgg
     3421 ctccgcctac aactggaaga cagcctgcac cggccacgcc cagacagccc agcttgtgtg
     3481 gctcctgctt tcaactgctc cacccagacc cagaaaaagc tggtggattc ctcaccctcc
     3541 tggggctccc gctatggcag taaatccaca gagaggctgt ttggggagcc tagtggtgca
     3601 gagccagctg agccaatggg aagaaggcaa gtcaggtcct cctcggtgcc tcgggatgta
     3661 cccagactgt caagttctga atctgaatcg cctgcccctc ggctatcatc tgagaagaac
     3721 agaacatttg aggagcatcc ccaggctgcc cagtggggga cgagaccact gggcagcacg
     3781 aagcggaggg aaagagtctc cttctggggt caatacacag gccaggagta ccacattctg
     3841 tccccaaaga ccaacctgaa ggacagtggc acagcctcct gtccccactg ccagcccatt
     3901 aggacccagg acacaggcaa tgctgtctct agagagccac tgggatcatc tgctgctgac
     3961 accctccgct gttctctgtg tggtggagtc aagccctctg cagaagcaga tggccccagc
     4021 ccagccccct cagagaaaaa caccccccaa aaacctgcac cttccacccc cagcctcaag
     4081 cggaagaaga ggcagacgga ctcgccagtg cgaatgctcc ctggactctg gtacctggct
     4141 gctgcacccc cagccccagc cccaccagcc ttggcctaca tctcggctcc cattatgcct
     4201 tatccaccac ccactgtgta ctatgcaacc ccagcaccta cctcagtcca cacagcttcc
     4261 ccacagcctg ctcagggacc tcggagaacc cggcactctg tgcagctggg tctgaatgac
     4321 ctggaggagc tgcaggctgc cctcagggag gctgcacggg ctgctgagaa cgtccgctcc
     4381 accacccgcc agctgagcca ctccctgtct gcagacctgc gccatgcccg tagcctgaga
     4441 ggctcctgcc tcttctgact ccctgcagtc tccgagaccc agtaggcagg cagccgctgt
     4501 ttcccggtca acagtctcct ggtaccaccg atgcctggaa gatgtcatgc cctcctcccc
     4561 aggagtgcca tctgcctggt tcatgtggcg tgtttaaagt ggaaagacat tggcctggtc
     4621 aggagtggat gaatgtccag ggggtcagct ctgtctaaca ggcaggcata gtagccatag
     4681 ctccctctgt ccagtcagag cctctgagac tctcctcatt gtccgcctcc tgcccatgtg
     4741 cttctgcagc taataatatg gctcttcctg gacagaatgt ccttcactgg ggagctaact
     4801 tgagcttgga cccatctcag aaggccagag aggacaagag aaggttgggg tctctgaaac
     4861 attttggtca ctgcctgtag tagccactcg gaggcaggca ctatcaggaa gaaccagtta
     4921 gggactttgt tcgtagtaac tagtaggcag gggtagtact tggggacctg taaatgtctt
     4981 gtgacagggg cctcagatga cacatgccaa gctcttctgt ggttacagtt tttcccgtga
     5041 gcccacagag tacagcaact catgtagggc caggacatac ccagcagcct cagaccttcc
     5101 cactatatct ttggattttg ttagcatcca ctagaggacc aagctacctg ccaggccctg
     5161 acttgagact gagagaccag gccagcaccc cttcccctgt cccatagcag agtgacctca
     5221 acatttctgg gatgtgtgtg ttatcacaga ttgtttatat atttgaggca tttaaaaatc
     5281 tatttttgtt ataaaagcaa atgaaggaag ataaataatg aacttaagaa ggggaaaaga
     5341 aatccccaaa gcc
//
