LOCUS       NM_001039914            1480 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus akirin 2 (Akirin2), mRNA.
ACCESSION   NM_001039914 XM_216366
VERSION     NM_001039914.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1480)
  AUTHORS   Komiya,Y., Akiyama,H., Sakumoto,R. and Tashiro,F.
  TITLE     FBI1/Akirin2 promotes tumorigenicity and metastasis of Lewis lung
            carcinoma cells
  JOURNAL   Biochem Biophys Res Commun 444 (3), 382-386 (2014)
   PUBMED   24468084
  REMARK    GeneRIF: results suggest that FBI1/Akirin2 plays an important role
            in oncogenesis of LLC1 lung carcinoma cells, and this protein may
            also serve as an oncogene in other cancers
REFERENCE   2  (bases 1 to 1480)
  AUTHORS   Akiyama,H., Iwahana,Y., Suda,M., Yoshimura,A., Kogai,H.,
            Nagashima,A., Ohtsuka,H., Komiya,Y. and Tashiro,F.
  TITLE     The FBI1/Akirin2 target gene, BCAM, acts as a suppressive oncogene
  JOURNAL   PLoS One 8 (11), e78716 (2013)
   PUBMED   24223164
  REMARK    GeneRIF: Data indicate that the 14-3-3beta-FBI1/Akirin2 complex
            bound to the basal cell adhesion molecule (BCAM) promoter and
            repressed transcription.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1480)
  AUTHORS   Armour,S.M., Bennett,E.J., Braun,C.R., Zhang,X.Y., McMahon,S.B.,
            Gygi,S.P., Harper,J.W. and Sinclair,D.A.
  TITLE     A high-confidence interaction map identifies SIRT1 as a mediator of
            acetylation of USP22 and the SAGA coactivator complex
  JOURNAL   Mol Cell Biol 33 (8), 1487-1502 (2013)
   PUBMED   23382074
REFERENCE   4  (bases 1 to 1480)
  AUTHORS   Komiya,Y., Kurabe,N., Katagiri,K., Ogawa,M., Sugiyama,A.,
            Kawasaki,Y. and Tashiro,F.
  TITLE     A novel binding factor of 14-3-3beta functions as a transcriptional
            repressor and promotes anchorage-independent growth,
            tumorigenicity, and metastasis
  JOURNAL   J Biol Chem 283 (27), 18753-18764 (2008)
   PUBMED   18460465
REFERENCE   5  (bases 1 to 1480)
  AUTHORS   Goto,A., Matsushita,K., Gesellchen,V., El Chamy,L.,
            Kuttenkeuler,D., Takeuchi,O., Hoffmann,J.A., Akira,S., Boutros,M.
            and Reichhart,J.M.
  TITLE     Akirins are highly conserved nuclear proteins required for
            NF-kappaB-dependent gene expression in drosophila and mice
  JOURNAL   Nat Immunol 9 (1), 97-104 (2008)
   PUBMED   18066067
  REMARK    Erratum:[Nat Immunol. 2008 Feb;9(2):216]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB234867.1.
            
            On Feb 23, 2013 this sequence version replaced NM_001039914.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB234867.1, FM074314.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1480              AB234867.1         21-1500
FEATURES             Location/Qualifiers
     source          1..1480
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q21"
     gene            1..1480
                     /gene="Akirin2"
                     /gene_synonym="FBI1; RGD1307791"
                     /note="akirin 2"
                     /db_xref="GeneID:297968"
                     /db_xref="RGD:1307791"
     exon            1..427
                     /gene="Akirin2"
                     /gene_synonym="FBI1; RGD1307791"
                     /inference="alignment:Splign:2.1.0"
     CDS             199..804
                     /gene="Akirin2"
                     /gene_synonym="FBI1; RGD1307791"
                     /note="fourteen-three-three beta interacting-protein 1;
                     fourteen-three-three beta interactant 1"
                     /codon_start=1
                     /product="akirin-2"
                     /protein_id="NP_001035003.1"
                     /db_xref="GeneID:297968"
                     /db_xref="RGD:1307791"
                     /translation="MACGATLKRTLDFDPLLSPASPKRRRCAPLSAPASAAASPAAAT
                     AAAAASAAAASPQKYLRMEPSPFGDVSSRLTTEQILYNIKQEYKRMQKRRHLEASFQQ
                     TDPGCSSDSQPHAFLISGPASPGTSSATSSPLKKEQPLFTLRQVGMICERLLKEREEK
                     VREEYEEILNTKLAEQYDAFVKFTHDQIMRRYGEQPASYVS"
     exon            428..571
                     /gene="Akirin2"
                     /gene_synonym="FBI1; RGD1307791"
                     /inference="alignment:Splign:2.1.0"
     exon            572..721
                     /gene="Akirin2"
                     /gene_synonym="FBI1; RGD1307791"
                     /inference="alignment:Splign:2.1.0"
     exon            722..793
                     /gene="Akirin2"
                     /gene_synonym="FBI1; RGD1307791"
                     /inference="alignment:Splign:2.1.0"
     exon            794..1480
                     /gene="Akirin2"
                     /gene_synonym="FBI1; RGD1307791"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcagcccga gcgcacggcg ggggcggccc ggcctctcgg gagcggcccc gagcgggcgg
       61 cgcgaccctc gcgcctcgcc cgcctgccct gtcgcggctc ctctgtcccg ggccccacac
      121 ctaccgggca cctcggaggg cccgtttgcc ccggtccttc ccggccccgc ccgagccggg
      181 cctcggctgc ccgccgccat ggcgtgcgga gccactctga aaaggactct ggatttcgac
      241 ccactgctta gcccggcatc tccgaagcgg aggcggtgcg cgcctttgtc ggcaccggct
      301 tcggctgccg cctcccctgc cgccgctacc gccgccgccg ctgcctctgc cgcggccgct
      361 tcgccgcaga agtatctccg gatggagcct tcccccttcg gcgacgtctc ctcccgtctc
      421 accacagaac aaattctgta caacataaaa caggaatata aacgtatgca gaagaggaga
      481 catttagaag ctagttttca gcagacagac ccaggttgta gttccgattc acagccacat
      541 gcatttctca tcagtggacc agcatcacca gggacttcat ctgcaacatc ctcaccatta
      601 aaaaaagaac agcccttatt tactctaagg caggttggga tgatctgtga acgtttgttg
      661 aaagaacggg aagagaaggt tcgagaagaa tatgaagaaa tactgaacac aaaacttgca
      721 gaacaatacg atgcatttgt gaagtttacg catgatcaga taatgcggcg atatggagaa
      781 cagcctgcta gttatgtttc atgaatcacg ctttttgcat ttgtgggctg ccttgtccct
      841 tgttgagttg ttgcaggagg tcccagctgt gacatacagc aatgccagcg cccatctgtg
      901 aaccaggtta tttcaagctt tcgtcagtgg caaccactct taggcagcag caattggttt
      961 tggaaatttc cgtgatgtca ttaccacccg gatgtggacc tttgctactt gtattaatac
     1021 cagtggcctc gttttgctgt atcattacaa tttggcttct ttatattaat gtttgaaagg
     1081 gattaaagct ggcattttag aacatgccct tcactggtta tgtaaataaa actgtagaat
     1141 gacacgtcag atgaagttag tgtgatttta attgtgcact acaaccaagc tgtaaccagt
     1201 tattaataac ttagaatgta atcccaggac atttaagcag ttagtctaca gtacttcagt
     1261 gagatggagg aagaggagga ggagggcatt tctgtatttc aggacttttc ttggggtttc
     1321 agaatgggtt tatatgattt cctttattat tttttggtag ttttatttat tctatcagtc
     1381 tttttaacaa atgtttattg ctgcacccct cccccagtgt attattgttt tactgccctt
     1441 gtagcactgg agtttagttg gaaaaataaa acatttactt
//
