LOCUS       NM_001108497            1783 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus A-kinase interacting protein 1 (Akip1), mRNA.
ACCESSION   NM_001108497 XM_001073151 XM_341902
VERSION     NM_001108497.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1783)
  AUTHORS   Tian,Z.Q., Jiang,H. and Lu,Z.B.
  TITLE     MiR-320 regulates cardiomyocyte apoptosis induced by
            ischemia-reperfusion injury by targeting AKIP1
  JOURNAL   Cell Mol Biol Lett 23, 41 (2018)
   PUBMED   30181740
  REMARK    GeneRIF: miR-320 plays an important role in regulating
            cardiomyocyte apoptosis induced by ischemia-reperfusion injury by
            targeting AKIP1 and inducing the mitochondrial apoptotic pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1783)
  AUTHORS   Yu,H., Tigchelaar,W., Koonen,D.P., Patel,H.H., de Boer,R.A., van
            Gilst,W.H., Westenbrink,B.D. and Sillje,H.H.
  TITLE     AKIP1 expression modulates mitochondrial function in rat neonatal
            cardiomyocytes
  JOURNAL   PLoS One 8 (11), e80815 (2013)
   PUBMED   24236204
  REMARK    GeneRIF: AKIP1 expression modulates mitochondrial function in rat
            neonatal cardiomyocytes.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1783)
  AUTHORS   Yu,H., Tigchelaar,W., Lu,B., van Gilst,W.H., de Boer,R.A.,
            Westenbrink,B.D. and Sillje,H.H.
  TITLE     AKIP1, a cardiac hypertrophy induced protein that stimulates
            cardiomyocyte growth via the Akt pathway
  JOURNAL   Int J Mol Sci 14 (11), 21378-21393 (2013)
   PUBMED   24169435
  REMARK    GeneRIF: our results show that AKIP1 is induced in hypertrophic
            hearts and can stimulate adaptive cardiomyocyte growth, which
            involves Akt signaling
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1783)
  AUTHORS   Sastri,M., Haushalter,K.J., Panneerselvam,M., Chang,P.,
            Fridolfsson,H., Finley,J.C., Ng,D., Schilling,J.M., Miyanohara,A.,
            Day,M.E., Hakozaki,H., Petrosyan,S., Koller,A., King,C.C.,
            Darshi,M., Blumenthal,D.K., Ali,S.S., Roth,D.M., Patel,H.H. and
            Taylor,S.S.
  TITLE     A kinase interacting protein (AKIP1) is a key regulator of cardiac
            stress
  JOURNAL   Proc Natl Acad Sci U S A 110 (5), E387-E396 (2013)
   PUBMED   23319652
  REMARK    GeneRIF: Data indicate A-kinase interacting protein 1 (AKIP1) as a
            critical molecular regulator and a therapeutic control point for
            stress adaptation in the heart.
REFERENCE   5  (bases 1 to 1783)
  AUTHORS   Yu,K.P., Itokawa,T., Zhu,M.L., Syam,S., Seth,A. and Insogna,K.
  TITLE     Breast cancer-associated gene 3 (BCA3) is a novel Rac1-interacting
            protein
  JOURNAL   J Bone Miner Res 22 (4), 628-637 (2007)
   PUBMED   17227220
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473956.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_341902.3, XM_001073151.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BF407178.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132272, SAMD00132281
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1783
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q33"
     gene            1..1783
                     /gene="Akip1"
                     /gene_synonym="RGD1306959"
                     /note="A-kinase interacting protein 1"
                     /db_xref="GeneID:361624"
                     /db_xref="RGD:1306959"
     exon            1..441
                     /gene="Akip1"
                     /gene_synonym="RGD1306959"
                     /inference="alignment:Splign:2.1.0"
     CDS             223..903
                     /gene="Akip1"
                     /gene_synonym="RGD1306959"
                     /note="proline-rich protein BCA3; A kinase (PRKA)
                     interacting protein 1"
                     /codon_start=1
                     /product="A-kinase-interacting protein 1"
                     /protein_id="NP_001101967.1"
                     /db_xref="GeneID:361624"
                     /db_xref="RGD:1306959"
                     /translation="MEYCLAAAALNAVDRRSLQRSARLGREVLERAKRRAVDWHSPER
                     SRGCVGVLYGQDPYQERWSVPGPQSLLGEREERRPTLSTSFRTMAEFMDYTSSQCGKY
                     YLSTPEEGGATHVYRYHRRKPAEVHVCSDSGHREAQVRARCSPQHLPCLKRNCRGETS
                     VGPGSIYQTSEHSQESSWPIENISKDLYIEVYPGTYSVTVGSGALSKKTHVVAVDSGQ
                     SVDLVFPV"
     exon            442..522
                     /gene="Akip1"
                     /gene_synonym="RGD1306959"
                     /inference="alignment:Splign:2.1.0"
     exon            523..678
                     /gene="Akip1"
                     /gene_synonym="RGD1306959"
                     /inference="alignment:Splign:2.1.0"
     exon            679..759
                     /gene="Akip1"
                     /gene_synonym="RGD1306959"
                     /inference="alignment:Splign:2.1.0"
     exon            760..1783
                     /gene="Akip1"
                     /gene_synonym="RGD1306959"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgcgagcgc tgcgcgcgtg cgcccagaga agcaggcagg gtgaggggct gtacccaggg
       61 tctgagaagc ggaagtgtaa ggggcaaggg tcctgccttc tagtgccccc acacttggag
      121 tgcgcgatga gggcgaaggg ggagttgggg tcgcggggga agctgccgcc cggatccggg
      181 cctgggtgcg gttgacttgt ctgtgtatgt gtccagggag acatggaata ctgcctggcg
      241 gccgcggcgc tgaacgcggt ggaccggcgc tcgctacagc gctctgctcg gctcgggagg
      301 gaagtattgg agcgcgccaa gagaagggct gtggactggc attctccaga gcgatccaga
      361 ggctgcgtgg gggtccttta cggccaggac ccctaccagg aacgatggtc ggtcccgggt
      421 ccccagagcc tcctaggaga gagagaagaa aggcgcccaa cccttagtac ttccttcagg
      481 acaatggcag aattcatgga ctatacttca agtcagtgtg ggaaatacta cttgtctaca
      541 ccggaggaag gaggggcaac ccacgtctac cgttatcaca gaaggaagcc tgcagaagtg
      601 cacgtgtgct cagactcggg gcacagggaa gcgcaagtgc gtgcccgatg ttccccacag
      661 cacctgcctt gtctcaagag aaactgcaga ggagagacat ctgttggtcc aggaagcatc
      721 tatcaaacat cagagcattc tcaagagtca tcttggccta ttgagaacat ctctaaggac
      781 ctctacatag aagtctatcc agggacctat tctgtcactg tgggctcagg tgccttaagc
      841 aagaagacgc atgtggttgc agttgactcg gggcaaagtg tggacttggt gttccccgta
      901 tgatgttgac atcactgcca tcatttcact ctaagaagaa gaataaaacc accctataac
      961 tgtcttaata atgatgcatt aatcctgggt ttaatgctgg ctgtagtggg gcagcctttc
     1021 tgaactggag tctgtctctt tcaagctcat tttaacctga agttttagaa gtcccccatg
     1081 ctgtgtgccc aaaaacagta acgtaatggt gctgtctgaa cagcctttcc aagtacatgt
     1141 taattatggt aatgaaggga gagattagaa ataaaaataa ttcactttat tggtattaaa
     1201 aagaaagaaa gatagactgg tgagatggct cagtggttaa gagcactgac tactcttcca
     1261 gaggtcctga gttcaaatcc cagcaaccac atggtgattc acaaccatct gtaatgggat
     1321 ccaatgccct cttctggtgt gtctgaagac agctacagtg tacttgtata taataagtaa
     1381 atctttaaaa aaaagcagat agacagtgtt tcccatctat agctgtaggc tttataagaa
     1441 gacagtacaa atgagatgcc tttgcccaga gcagtgggca tgcctgtccc tctgtgaata
     1501 ggtgtcctga gcagttcctc agggcattgg ccaggagttc taaggcatgg ccacccattt
     1561 gtgtgcaggc acagcacgtt cttccagatg ccgctttcct gcaggtctcc gcagagcggt
     1621 tgctcttagg tactcttgtg cgccaccact cagcctcctc tgttcctttg tcaactattc
     1681 tttggggtta ctcttttcat gatcctttaa cttcctgtaa gagaaaaaaa ccttaattca
     1741 tatatgctga ctgtaatttt aaagattttt gctttgtgtt tta
//
