LOCUS       NM_053855               3438 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Rattus norvegicus A-kinase anchoring protein 8 (Akap8), mRNA.
ACCESSION   NM_053855 XM_001074708 XM_343176
VERSION     NM_053855.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3438)
  AUTHORS   Asirvatham,A.L., Schworer,C.M., Stahl,R., Heitzman,D. and
            Carey,D.J.
  TITLE     Role of A-kinase anchoring proteins in cyclic-AMP-mediated Schwann
            cell proliferation
  JOURNAL   Cell Signal 83, 109977 (2021)
   PUBMED   33716104
  REMARK    GeneRIF: Role of A-kinase anchoring proteins in cyclic-AMP-mediated
            Schwann cell proliferation.
REFERENCE   2  (bases 1 to 3438)
  AUTHORS   Marstad,A., Landsverk,O.J., Stromme,O., Otterlei,M., Collas,P.,
            Sundan,A. and Brede,G.
  TITLE     A-kinase anchoring protein AKAP95 is a novel regulator of ribosomal
            RNA synthesis
  JOURNAL   FEBS J 283 (4), 757-770 (2016)
   PUBMED   26683827
REFERENCE   3  (bases 1 to 3438)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   4  (bases 1 to 3438)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   5  (bases 1 to 3438)
  AUTHORS   Gao,X., Chaturvedi,D. and Patel,T.B.
  TITLE     Localization and retention of p90 ribosomal S6 kinase 1 in the
            nucleus: implications for its function
  JOURNAL   Mol Biol Cell 23 (3), 503-515 (2012)
   PUBMED   22130794
  REMARK    GeneRIF: new insights into how AKAP95 orchestrates cell cycle
            progression.
REFERENCE   6  (bases 1 to 3438)
  AUTHORS   Jungmann,R.A. and Kiryukhina,O.
  TITLE     Cyclic AMP and AKAP-mediated targeting of protein kinase A
            regulates lactate dehydrogenase subunit A mRNA stability
  JOURNAL   J Biol Chem 280 (26), 25170-25177 (2005)
   PUBMED   15878851
  REMARK    GeneRIF: lactate dehydrogenase subunit A mRNA stability is
            regulated by Cyclic AMP and AKAP-mediated targeting of protein
            kinase A
REFERENCE   7  (bases 1 to 3438)
  AUTHORS   Tasken,K. and Aandahl,E.M.
  TITLE     Localized effects of cAMP mediated by distinct routes of protein
            kinase A
  JOURNAL   Physiol Rev 84 (1), 137-167 (2004)
   PUBMED   14715913
  REMARK    Review article
REFERENCE   8  (bases 1 to 3438)
  AUTHORS   Bomar,J., Moreira,P., Balise,J.J. and Collas,P.
  TITLE     Differential regulation of maternal and paternal chromosome
            condensation in mitotic zygotes
  JOURNAL   J Cell Sci 115 (Pt 14), 2931-2940 (2002)
   PUBMED   12082153
REFERENCE   9  (bases 1 to 3438)
  AUTHORS   Akileswaran,L., Taraska,J.W., Sayer,J.A., Gettemy,J.M. and
            Coghlan,V.M.
  TITLE     A-kinase-anchoring protein AKAP95 is targeted to the nuclear matrix
            and associates with p68 RNA helicase
  JOURNAL   J Biol Chem 276 (20), 17448-17454 (2001)
   PUBMED   11279182
REFERENCE   10 (bases 1 to 3438)
  AUTHORS   Coghlan,V.M., Langeberg,L.K., Fernandez,A., Lamb,N.J. and
            Scott,J.D.
  TITLE     Cloning and characterization of AKAP 95, a nuclear protein that
            associates with the regulatory subunit of type II cAMP-dependent
            protein kinase
  JOURNAL   J Biol Chem 269 (10), 7658-7665 (1994)
   PUBMED   8125992
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC166580.1.
            
            On or before Sep 7, 2008 this sequence version replaced
            XM_343176.3, XM_001074708.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166580.1, U01914.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3438
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q11"
     gene            1..3438
                     /gene="Akap8"
                     /gene_synonym="Akap95"
                     /note="A-kinase anchoring protein 8"
                     /db_xref="GeneID:116633"
                     /db_xref="RGD:620832"
     exon            1..44
                     /gene="Akap8"
                     /gene_synonym="Akap95"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..2089
                     /gene="Akap8"
                     /gene_synonym="Akap95"
                     /note="A kinase (PRKA) anchor protein 8; AKAP 95; A-kinase
                     anchor protein 95 kDa; AKAP-8"
                     /codon_start=1
                     /product="A-kinase anchor protein 8"
                     /protein_id="NP_446307.1"
                     /db_xref="GeneID:116633"
                     /db_xref="RGD:620832"
                     /translation="MEQSYGGYGAWSAGPANTQGTYGSGVASWQGYENYSYYNAQNTS
                     VPTGTPYSYGPASWEATKASDGGLAAGSSAMHVASFAPEPCTDNSDSLIAKINQRLDM
                     LSKEGGRGGISSGGEGMQDRDSSFRFQPYESYDSRPCMPEHTPYRPSYSYDYDFDLGT
                     DRNGSFGGTFNDCRDPTPERGALDGFLRGRGQGRFQDRSNSSTFIRSDPFMPPSASSE
                     PLSTTWSELNYMGGRGLGGPSTNRPPPSLFSQSMAPDYSMMGMQGVGGFGGTMPYGCG
                     RSQTRIRDWPRRRGFERFGPDNMGRKRKPFPLYEEPDAKLARADSEGDLSENDDGAGD
                     LRSGDEEFRGEDDLCDSRKQRGEKEDEDEDVKKRREKQRRRDRMRDRAADRIQFACSV
                     CKFRSFEDEEIQKHLQSKFHKETLRFISTKLPDKTVEFLQEYIINRNKKIEKRRQELL
                     EKESPKPKPDPFKGIGQEHFFKRIEAAHCLACDMLIPAQHQLLQRHLHSVDHNHNRRL
                     AAEQFKKTSLHVAKSVLNNKHIVKMLEKYLKGEDPFVNETADLETEGDENLGEEKETP
                     EEVAAEVLAEVITAAVKAVEGDGEPAAEHSDVLAEVEGPVDTAEAGSDSHTGKLLEEQ
                     TCETASETRNMEDMARGEAAEARNEAAVPAAAAGSPVPVIAIPGILEDELEQTDAEAK
                     DTPTE"
     exon            45..83
                     /gene="Akap8"
                     /gene_synonym="Akap95"
                     /inference="alignment:Splign:2.1.0"
     exon            84..116
                     /gene="Akap8"
                     /gene_synonym="Akap95"
                     /inference="alignment:Splign:2.1.0"
     exon            117..396
                     /gene="Akap8"
                     /gene_synonym="Akap95"
                     /inference="alignment:Splign:2.1.0"
     exon            397..880
                     /gene="Akap8"
                     /gene_synonym="Akap95"
                     /inference="alignment:Splign:2.1.0"
     exon            881..1010
                     /gene="Akap8"
                     /gene_synonym="Akap95"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1057
                     /gene="Akap8"
                     /gene_synonym="Akap95"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1091
                     /gene="Akap8"
                     /gene_synonym="Akap95"
                     /inference="alignment:Splign:2.1.0"
     exon            1092..1179
                     /gene="Akap8"
                     /gene_synonym="Akap95"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..1321
                     /gene="Akap8"
                     /gene_synonym="Akap95"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..1415
                     /gene="Akap8"
                     /gene_synonym="Akap95"
                     /inference="alignment:Splign:2.1.0"
     exon            1416..1546
                     /gene="Akap8"
                     /gene_synonym="Akap95"
                     /inference="alignment:Splign:2.1.0"
     exon            1547..1642
                     /gene="Akap8"
                     /gene_synonym="Akap95"
                     /inference="alignment:Splign:2.1.0"
     exon            1643..3408
                     /gene="Akap8"
                     /gene_synonym="Akap95"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgctggcg ggtcgtgtcg aagacatgga gcaaagctac ggaggttatg gggcatggag
       61 tgctggacct gccaacaccc agggtacata tggaagtggt gtggccagct ggcaaggtta
      121 tgaaaactac agctactaca atgcccagaa caccagtgtc cctacaggaa caccctatag
      181 ttatggccca gcctcgtggg aggccaccaa ggccagtgat ggtggcctgg cagctgggag
      241 ttctgctatg catgtggcct cttttgcccc agagccatgc accgacaact ctgactcgct
      301 cattgccaag atcaatcaac gtttggacat gttgtccaag gaaggaggca ggggtgggat
      361 cagcagcggt ggggagggca tgcaggaccg agacagctcc ttccgcttcc agccatatga
      421 gtcctacgac tccaggccct gtatgcctga gcatactccc taccgcccca gctacagtta
      481 cgattatgac tttgacttgg gaactgaccg caatggtagt tttggcggga cattcaacga
      541 ctgtcgggac ccaaccccag agcgaggcgc ccttgatggt ttcttaaggg gccggggcca
      601 gggccgcttc caggaccgga gcaactcgag caccttcata cgtagtgacc ccttcatgcc
      661 accctcagcc tcctcagagc ccttatccac cacctggagt gagctgaact acatgggtgg
      721 acgtggtcta ggtgggccct ccaccaacag gccgcctcct tccctcttct cccagtccat
      781 ggcccctgac tacagcatga tgggcatgca gggggtgggc ggttttggtg gcaccatgcc
      841 ttatggatgt ggccggtccc agactcggat acgggattgg cccagaagga gggggtttga
      901 acgctttgga ccagacaaca tgggcaggaa gcggaagccg tttccattgt atgaagaacc
      961 tgatgccaag ctggcccgtg ctgacagtga aggagacctc tctgaaaacg atgatggagc
     1021 tggtgactta cggtcaggag atgaagaatt taggggggag gacgacctct gtgactcccg
     1081 gaagcagaga ggagaaaagg aggacgagga tgaggatgtg aagaagagac gggagaagca
     1141 aaggaggaga gatcggatgc gggaccgagc agctgacagg attcagtttg cctgttctgt
     1201 gtgcaaattt cgtagctttg aagatgaaga aatccaaaag catctgcaaa gtaaatttca
     1261 taaagagacc ttgcggttta taagtaccaa actacctgac aagacagtag aatttctcca
     1321 ggagtatatc ataaacagga ataagaaaat tgagaaacgg cgtcaggagt tgttggagaa
     1381 ggaaagccct aaacccaaac cagatccatt caaagggatt ggccaggagc atttcttcaa
     1441 aaggattgaa gccgcacact gcctggcctg tgacatgctg attcctgcac agcaccagct
     1501 cctgcagcgg catctgcact ctgtggacca taaccataat cgaaggttgg ctgctgaaca
     1561 attcaagaaa acaagtctcc atgtggctaa gagtgttctg aacaacaagc atatagtgaa
     1621 gatgttagaa aaatacctca agggcgagga tccttttgtc aatgaaactg ctgatcttga
     1681 gacagaagga gatgagaact taggagagga gaaggagaca ccagaggagg tagctgcgga
     1741 agtcttagca gaggtgatca cagcagcggt gaaggctgta gagggggatg gagaaccagc
     1801 tgcagagcat agtgacgtcc tagctgaagt ggaagggcct gtggacaccg ccgaggctgg
     1861 tagtgactcc cacactggaa agctgctaga agaacagacc tgtgaaacag catctgaaac
     1921 caggaacatg gaagacatgg ccagaggtga ggctgctgag gccagaaatg aagcagctgt
     1981 gccagcagca gccgccggaa gcccagtacc tgtcatagcc atcccaggaa tcctggaaga
     2041 tgagctggaa caaactgatg cagaggccaa agatactccc acagaataat gatcttctct
     2101 tccctgtttc aagggacgtg ttatatcatg tgttctttgt tttataagct gtactggggt
     2161 gtgtgttatt cggtggaaag actgggccat ttccttccca gtgtacctca aggattgatg
     2221 ctatacagta gatggcttcc cacctctgtt agaaatacaa aaagaggtaa accattttcc
     2281 caagtggcct ttgatggcta tctgtgcact gcagctagaa tagtaagagt agatcttcct
     2341 gacacttgtt gagtcctgaa ttggacagaa tgtgaggatt tttgttttgt tttgtgttgt
     2401 gtttttgttt ggtcttcgtt tcactttatt ttgctttttc tcttgggaag caatctgata
     2461 cgaacatagc ttacttgaga aaaaaattat ttaggggaat tcccttattc acctctgcat
     2521 ggttgatgtg ggacatacac agttcaacca tccatgtgtg caagagctga gattgtgccc
     2581 tccaccaata aacagtcttg tttcaataaa catcaggcca tttcctaagg ccttcggcat
     2641 tgaaatagca tcttgcttgg accaagctag ctttagaact caatcctact gtttgagcct
     2701 ctgcagtgct ggggccatga gtgtacggcc atgctcagtg gggctttggt tttgcaatac
     2761 actgtatcct atgttcctct ccagctgtgg cagcattaga cagatgacat ggcagtgact
     2821 tggctgtgtt tgagatggtc cctcaggctt ccactggaag gacccgcacc tgagcctgta
     2881 gatcgaagac actgctaagg ccttggttct cactgttcag tgcttgctaa tcagttggtg
     2941 ttcgtctccc acctctatta gtggatgttt tgttgtttgc tctctttcct tttgttattt
     3001 ccacctaaag gtatttagaa aaccatggaa ttactccatt gatgaaaaac aaatgtggac
     3061 ttcatagttg ggatctgtct gtcaaaagct caaaccgtta agtaaaagtg tttgactaaa
     3121 gcaagtagta gtccgagcaa gggaggctta gcatgtctct aaagcagcat gtgctaaggt
     3181 tttacaggct cagaatgatg ggtctccccc gttttgaagt tacagtgctg tgtccatttg
     3241 tacacagctc acatcttgga aacatgagcc agtgagggac tacggaagag atggtagacc
     3301 atcacagcaa tttcatcagc acgtctgtct gttaaggagc attactgggg atgtgatagg
     3361 gactttggaa tatcattgtc aaaacaagca ataaattgat gccacggaaa aaaaaaaaaa
     3421 aaaaaaaaaa aaaaaaaa
//
