LOCUS       NM_001001801            3015 bp    mRNA    linear   ROD 07-AUG-2024
DEFINITION  Rattus norvegicus A-kinase anchoring protein 7 (Akap7), mRNA.
ACCESSION   NM_001001801 XM_341736
VERSION     NM_001001801.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3015)
  AUTHORS   Carlson,C.R., Aronsen,J.M., Bergan-Dahl,A., Moutty,M.C., Lunde,M.,
            Lunde,P.K., Jarstadmarken,H., Wanichawan,P., Pereira,L.,
            Kolstad,T.R.S., Dalhus,B., Subramanian,H., Hille,S.,
            Christensen,G., Muller,O.J., Nikolaev,V., Bers,D.M., Sjaastad,I.,
            Shen,X., Louch,W.E., Klussmann,E. and Sejersted,O.M.
  TITLE     AKAP18delta Anchors and Regulates CaMKII Activity at
            Phospholamban-SERCA2 and RYR
  JOURNAL   Circ Res 130 (1), 27-44 (2022)
   PUBMED   34814703
  REMARK    GeneRIF: AKAP18delta Anchors and Regulates CaMKII Activity at
            Phospholamban-SERCA2 and RYR.
REFERENCE   2  (bases 1 to 3015)
  AUTHORS   Seyler,C., Scherer,D., Kopple,C., Kulzer,M., Korkmaz,S.,
            Xynogalos,P., Thomas,D., Kaya,Z., Scholz,E., Backs,J., Karle,C.,
            Katus,H.A. and Zitron,E.
  TITLE     Role of plasma membrane-associated AKAPs for the regulation of
            cardiac IK1 current by protein kinase A
  JOURNAL   Naunyn Schmiedebergs Arch Pharmacol 390 (5), 493-503 (2017)
   PUBMED   28331977
  REMARK    GeneRIF: Report coupling of cardiac Kir2.1 and Kir2.2 subunits with
            the plasma membrane-bound AKAPs 15 and 79. Cardiac
            membrane-associated AKAPs are a functionally essential part of the
            regulatory cascade determining IK1 current function.
REFERENCE   3  (bases 1 to 3015)
  AUTHORS   Jones,B.W., Deem,J., Younts,T.J., Weisenhaus,M., Sanford,C.A.,
            Slack,M.C., Chin,J., Nachmanson,D., McKennon,A., Castillo,P.E. and
            McKnight,G.S.
  TITLE     Targeted deletion of AKAP7 in dentate granule cells impairs spatial
            discrimination
  JOURNAL   Elife 5, e20695 (2016)
   PUBMED   27911261
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3015)
  AUTHORS   Rigatti,M., Le,A.V., Gerber,C., Moraru,I.I. and Dodge-Kafka,K.L.
  TITLE     Phosphorylation state-dependent interaction between
            AKAP7delta/gamma and phospholamban increases phospholamban
            phosphorylation
  JOURNAL   Cell Signal 27 (9), 1807-1815 (2015)
   PUBMED   26027516
  REMARK    GeneRIF: results confirm that AKAP7gamma/delta binding to PLB is
            important for phosphorylation of PLB.
REFERENCE   5  (bases 1 to 3015)
  AUTHORS   Burgers,P.P., van der Heyden,M.A., Kok,B., Heck,A.J. and
            Scholten,A.
  TITLE     A systematic evaluation of protein kinase A-A-kinase anchoring
            protein interaction motifs
  JOURNAL   Biochemistry 54 (1), 11-21 (2015)
   PUBMED   25097019
REFERENCE   6  (bases 1 to 3015)
  AUTHORS   Hulme,J.T., Lin,T.W., Westenbroek,R.E., Scheuer,T. and
            Catterall,W.A.
  TITLE     Beta-adrenergic regulation requires direct anchoring of PKA to
            cardiac CaV1.2 channels via a leucine zipper interaction with A
            kinase-anchoring protein 15
  JOURNAL   Proc Natl Acad Sci U S A 100 (22), 13093-13098 (2003)
   PUBMED   14569017
  REMARK    GeneRIF: Beta-adrenergic regulation requires direct anchoring of
            protein kinase A to cardiac CaV1.2 channels via a leucine zipper
            interaction with protein kinase A-anchoring protein 15(AKAP15).
REFERENCE   7  (bases 1 to 3015)
  AUTHORS   Brown,R.L., August,S.L., Williams,C.J. and Moss,S.B.
  TITLE     AKAP7gamma is a nuclear RI-binding AKAP
  JOURNAL   Biochem Biophys Res Commun 306 (2), 394-401 (2003)
   PUBMED   12804576
REFERENCE   8  (bases 1 to 3015)
  AUTHORS   Potet,F., Scott,J.D., Mohammad-Panah,R., Escande,D. and Baro,I.
  TITLE     AKAP proteins anchor cAMP-dependent protein kinase to KvLQT1/IsK
            channel complex
  JOURNAL   Am J Physiol Heart Circ Physiol 280 (5), H2038-H2045 (2001)
   PUBMED   11299204
REFERENCE   9  (bases 1 to 3015)
  AUTHORS   Trotter,K.W., Fraser,I.D., Scott,G.K., Stutts,M.J., Scott,J.D. and
            Milgram,S.L.
  TITLE     Alternative splicing regulates the subcellular localization of
            A-kinase anchoring protein 18 isoforms
  JOURNAL   J Cell Biol 147 (7), 1481-1492 (1999)
   PUBMED   10613906
REFERENCE   10 (bases 1 to 3015)
  AUTHORS   Fraser,I.D., Tavalin,S.J., Lester,L.B., Langeberg,L.K.,
            Westphal,A.M., Dean,R.A., Marrion,N.V. and Scott,J.D.
  TITLE     A novel lipid-anchored A-kinase Anchoring Protein facilitates
            cAMP-responsive membrane events
  JOURNAL   EMBO J 17 (8), 2261-2272 (1998)
   PUBMED   9545239
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Oct 13, 2022 this sequence version replaced NM_001001801.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC098632.1, SRR26643298.314.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation,
                                                expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-136               JAXUCZ010000001.1  21906676-21906811
            137-268             JAXUCZ010000001.1  21915837-21915968
            269-423             JAXUCZ010000001.1  21923005-21923159
            424-560             JAXUCZ010000001.1  21934299-21934435
            561-721             JAXUCZ010000001.1  21937664-21937824
            722-834             JAXUCZ010000001.1  21961745-21961857
            835-982             JAXUCZ010000001.1  21983233-21983380
            983-3015            JAXUCZ010000001.1  22035058-22037090
FEATURES             Location/Qualifiers
     source          1..3015
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1p12"
     gene            1..3015
                     /gene="Akap7"
                     /gene_synonym="AKAP-18; Akap15; Akap18; AKAP18d"
                     /note="A-kinase anchoring protein 7"
                     /db_xref="GeneID:361458"
                     /db_xref="RGD:1303071"
     exon            1..136
                     /gene="Akap7"
                     /gene_synonym="AKAP-18; Akap15; Akap18; AKAP18d"
                     /inference="alignment:Splign:2.1.0"
     CDS             118..1179
                     /gene="Akap7"
                     /gene_synonym="AKAP-18; Akap15; Akap18; AKAP18d"
                     /note="A-kinase anchoring protein 18, isoform delta;
                     A-kinase anchor protein 18; A kinase (PRKA) anchor protein
                     7"
                     /codon_start=1
                     /product="A-kinase anchor protein 7 isoforms delta and
                     gamma"
                     /protein_id="NP_001001801.1"
                     /db_xref="GeneID:361458"
                     /db_xref="RGD:1303071"
                     /translation="MERPAAGEIDANKCDHLSRGEEGTGDLETSPVGSLADLPFAAVD
                     IQDDCGLPDVPQGNVPQGNPKRSKENRGDRNDHVKKRKKAKKDYQPNYFLSIPITNKK
                     ITAGIKVLQNSILRQDNRLTKAMVGDGSFHITLLVMQLLNEDEVNIGTDALLELKPFV
                     EEILEGKHLTLPFHGIGTFQGQVGFVKLADGDHVSALLEIAETAKRTFQEKGILAGES
                     RTFKPHLTFMKLSKAPMLWKKGVRKIEPGLYEQFIDHRFGEEILYQIDLCSMLKKKQS
                     NGYYHCESSIVIGEKDRKEPEDAELVRLSKRLVENAVLKAVQQYLEETQNKKQPGEGN
                     SVKAEEGDRNGDGSDNNRK"
     exon            137..268
                     /gene="Akap7"
                     /gene_synonym="AKAP-18; Akap15; Akap18; AKAP18d"
                     /inference="alignment:Splign:2.1.0"
     exon            269..423
                     /gene="Akap7"
                     /gene_synonym="AKAP-18; Akap15; Akap18; AKAP18d"
                     /inference="alignment:Splign:2.1.0"
     exon            424..560
                     /gene="Akap7"
                     /gene_synonym="AKAP-18; Akap15; Akap18; AKAP18d"
                     /inference="alignment:Splign:2.1.0"
     exon            561..721
                     /gene="Akap7"
                     /gene_synonym="AKAP-18; Akap15; Akap18; AKAP18d"
                     /inference="alignment:Splign:2.1.0"
     exon            722..834
                     /gene="Akap7"
                     /gene_synonym="AKAP-18; Akap15; Akap18; AKAP18d"
                     /inference="alignment:Splign:2.1.0"
     exon            835..982
                     /gene="Akap7"
                     /gene_synonym="AKAP-18; Akap15; Akap18; AKAP18d"
                     /inference="alignment:Splign:2.1.0"
     exon            983..3015
                     /gene="Akap7"
                     /gene_synonym="AKAP-18; Akap15; Akap18; AKAP18d"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgccgggga tgctgcgact cgcagggctc tgcgcctccg taggcctggc cgccgcggcc
       61 cgcgcccccg ctgccccgcg ggccccgggc ccgcgcctct gccttcgcgc cgcgaccatg
      121 gagcgccccg ccgcgggaga aatagatgcc aataagtgtg atcatttatc aagaggagag
      181 gaagggacgg gggacctgga gaccagccct gtaggttctc tggcagacct gccgtttgct
      241 gccgtagaca ttcaagatga ctgtggactc cctgatgtac ctcaaggaaa tgtacctcaa
      301 ggaaacccaa agagaagcaa agaaaataga ggcgacagga atgatcacgt gaagaagagg
      361 aagaaggcca agaaagatta tcaacccaac tatttcctgt ccattccaat caccaacaaa
      421 aagattacag ctggaattaa agtcttgcaa aattcgatac tgagacagga taatcgattg
      481 accaaagcca tggtcggcga cggctccttt cacatcacct tgctagtgat gcagctatta
      541 aacgaagatg aagtaaacat aggtaccgac gcgcttttgg aactgaagcc gttcgttgag
      601 gagatccttg aggggaagca tctgactttg cccttccacg ggattggcac tttccaaggt
      661 caggttggct ttgtgaagct ggcagacgga gatcacgtca gtgccctcct ggagatagca
      721 gagactgcaa aaaggacatt tcaggaaaaa ggcatcctgg ctggagaaag cagaactttt
      781 aagcctcacc tgacctttat gaagctgtcc aaagcaccaa tgctctggaa gaagggagtg
      841 agaaaaatag agcctggatt gtatgagcaa tttatcgacc acagatttgg agaagaaata
      901 ctgtaccaaa tagatctctg ctccatgctg aagaaaaaac agagcaatgg ttattaccac
      961 tgcgagtctt cgatcgtgat cggtgagaag gaccgaaagg agcctgagga tgctgaactg
     1021 gtcaggctca gtaagaggct ggtggagaac gccgtgctca aggctgtcca gcagtaccta
     1081 gaagagacac agaacaaaaa gcagccgggg gaggggaact ccgtcaaagc tgaggaggga
     1141 gatcggaatg gcgatggcag tgataacaac cggaagtgag agctgaaccc ggtccgctgc
     1201 ccctccgcta agtcgcagac tgactcgcaa tgtgctagtg aagtgtcttg ttcaagccct
     1261 ggagatcacc tagtgattga cgcgattgat gagttcggtt ttgctgcgac acaacagaaa
     1321 agaatggggt gctgggacca gcagaaggaa ttactttaca gaagaacaac acgcacaagg
     1381 gggagccggc acttcgggcc gcctgcccga ctcaaagggc agagggagag gactggtcgc
     1441 cgacagaata ctgttctgcc gtttacattg cttcgatcct ttgactactt tatctgaggc
     1501 caaaacttgc acacagctat caagtgctaa gttcactttg tcactgttga aatgaccatg
     1561 agtatagtga gtccacaatg tttcctgttt gtccccccca tgtgctttta ccacacagtg
     1621 atctttattt acagtaaatt gagttttgtg taaattatat atatttttgg caaatgcaat
     1681 cttttctatg aaatgtgggt aatgttgtaa aggtttttga gccttatttt gataaagtca
     1741 attgccatat ttaatgtcct ccgttgatat ttgtacttta aatgtatcat ataattttcc
     1801 cccttaggca agaaaccagt tggaacccaa gacttaatta acgaagcttt gcaccgagaa
     1861 aggatggagc tgaagtccaa agtgaaacag atcaaagaac ttttgttaaa gcctgagacc
     1921 caggccaaga ttagaaagga gctttttgaa ggaagagttt ttaataatgg tgacccaact
     1981 gatttcaaca tgactttgcc atagctctcc gctgctgtta cgcttgctca catgtttatg
     2041 aactctcagc ccgttaaata gctctttggt gagtaaccaa agtgttctta cggtctctac
     2101 aaagcccaca aaccaacatt tggtaaggaa ctaacaactt cttgccaaag aaaacgtatt
     2161 tttgccttat cgtggtcacc atcatcaccg tcatcatcgt catcaccacc ataaaattga
     2221 gttttagaat gttccttttg gtatcttact cattttatat aaaaacttct taattagctg
     2281 ttgtaagatg ttccatgggt ccttgcagat aatattatat atatatatat atatatacac
     2341 acatatatgt acatatatat acatatatat acacatatac tcacacactt ttaaaaatcc
     2401 tttatagaca aaaacagcaa aacaaaataa aaccaacaac agtattctaa gggtcacctg
     2461 cctcctgttg atgtggtcct gttacttcaa aggaagcatt gtccgggcca gtccagtctc
     2521 aaggtccttt tgctgagcgt ttgagtgctt attgaggatc agcacttgaa cagacattag
     2581 taagcgtaat cgttgtagtc acgggttcag aatgttttat actatctata ttctctcttt
     2641 cattgatgaa gtacagtttg cttttttttt taatttttta tttcttcgtg aacagtgttc
     2701 agggttccta tttcctactc tctgaagatg agcccaagcc tgcgttcttc acggtttgag
     2761 tagcttgcac tggttccttt gtaaacgagc attcttgagt gttatttggg tagtcacttt
     2821 aaaattgctg ctactaatag atgatgggga aagaaagtga ttagagatta aatatataat
     2881 catctcacag tccagtttgc tcgtggattt ttggctattt ctttccactg ggtaaatgat
     2941 gcattaattc atgatgtatt cctttatacg tacctacgtt ttcatgcgtc ataataaaag
     3001 tactctttcc tctat
//
