LOCUS       NM_022618               8824 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus A-kinase anchoring protein 6 (Akap6), mRNA.
ACCESSION   NM_022618 XM_346766
VERSION     NM_022618.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 8824)
  AUTHORS   Li,J., Tan,Y., Passariello,C.L., Martinez,E.C., Kritzer,M.D.,
            Li,X., Li,X., Li,Y., Yu,Q., Ohgi,K., Thakur,H., MacArthur,J.W. Jr.,
            Ivey,J.R., Woo,Y.J., Emter,C.A., Dodge-Kafka,K., Rosenfeld,M.G. and
            Kapiloff,M.S.
  TITLE     Signalosome-Regulated Serum Response Factor Phosphorylation
            Determining Myocyte Growth in Width Versus Length as a Therapeutic
            Target for Heart Failure
  JOURNAL   Circulation 142 (22), 2138-2154 (2020)
   PUBMED   32933333
  REMARK    GeneRIF: Signalosome-Regulated Serum Response Factor
            Phosphorylation Determining Myocyte Growth in Width Versus Length
            as a Therapeutic Target for Heart Failure.
REFERENCE   2  (bases 1 to 8824)
  AUTHORS   Li,J., Aponte Paris,S., Thakur,H., Kapiloff,M.S. and
            Dodge-Kafka,K.L.
  TITLE     Muscle A-kinase-anchoring protein-beta-bound calcineurin toggles
            active and repressive transcriptional complexes of myocyte enhancer
            factor 2D
  JOURNAL   J Biol Chem 294 (7), 2543-2554 (2019)
   PUBMED   30523159
  REMARK    GeneRIF: these results highlight the importance of mAKAPbeta
            signalosomes for regulating MEF2D activity in striated muscle,
            affirming mAKAPbeta as a nodal regulator in the myocyte
            intracellular signaling network.
REFERENCE   3  (bases 1 to 8824)
  AUTHORS   Bedioune,I., Lefebvre,F., Lechene,P., Varin,A., Domergue,V.,
            Kapiloff,M.S., Fischmeister,R. and Vandecasteele,G.
  TITLE     PDE4 and mAKAPbeta are nodal organizers of beta2-ARs nuclear PKA
            signalling in cardiac myocytes
  JOURNAL   Cardiovasc Res 114 (11), 1499-1511 (2018)
   PUBMED   29733383
  REMARK    GeneRIF: In cardiac myocytes, PDE4 insulates a mAKAPbeta-targeted
            PKA pool at the nuclear envelope that prevents nuclear PKA
            activation upon beta2-AR stimulation.
REFERENCE   4  (bases 1 to 8824)
  AUTHORS   Earp,M., Tyrer,J.P., Winham,S.J., Lin,H.Y., Chornokur,G.,
            Dennis,J., Aben,K.K.H., Anton-Culver,H., Antonenkova,N.,
            Bandera,E.V., Bean,Y.T., Beckmann,M.W., Bjorge,L., Bogdanova,N.,
            Brinton,L.A., Brooks-Wilson,A., Bruinsma,F., Bunker,C.H.,
            Butzow,R., Campbell,I.G., Carty,K., Chang-Claude,J., Cook,L.S.,
            Cramer,D.W., Cunningham,J.M., Cybulski,C., Dansonka-Mieszkowska,A.,
            Despierre,E., Doherty,J.A., Dork,T., du Bois,A., Durst,M.,
            Easton,D.F., Eccles,D.M., Edwards,R.P., Ekici,A.B., Fasching,P.A.,
            Fridley,B.L., Gentry-Maharaj,A., Giles,G.G., Glasspool,R.,
            Goodman,M.T., Gronwald,J., Harter,P., Hein,A., Heitz,F.,
            Hildebrandt,M.A.T., Hillemanns,P., Hogdall,C.K., Hogdall,E.,
            Hosono,S., Iversen,E.S., Jakubowska,A., Jensen,A., Ji,B.T.,
            Jung,A.Y., Karlan,B.Y., Kellar,M., Kiemeney,L.A., Kiong Lim,B.,
            Kjaer,S.K., Krakstad,C., Kupryjanczyk,J., Lambrechts,D.,
            Lambrechts,S., Le,N.D., Lele,S., Lester,J., Levine,D.A., Li,Z.,
            Liang,D., Lissowska,J., Lu,K., Lubinski,J., Lundvall,L.,
            Massuger,L.F.A.G., Matsuo,K., McGuire,V., McLaughlin,J.R.,
            McNeish,I., Menon,U., Milne,R.L., Modugno,F., Moysich,K.B.,
            Ness,R.B., Nevanlinna,H., Odunsi,K., Olson,S.H., Orlow,I.,
            Orsulic,S., Paul,J., Pejovic,T., Pelttari,L.M., Permuth,J.B.,
            Pike,M.C., Poole,E.M., Rosen,B., Rossing,M.A., Rothstein,J.H.,
            Runnebaum,I.B., Rzepecka,I.K., Schernhammer,E., Schwaab,I.,
            Shu,X.O., Shvetsov,Y.B., Siddiqui,N., Sieh,W., Song,H.,
            Southey,M.C., Spiewankiewicz,B., Sucheston-Campbell,L.,
            Tangen,I.L., Teo,S.H., Terry,K.L., Thompson,P.J., Thomsen,L.,
            Tworoger,S.S., van Altena,A.M., Vergote,I., Vestrheim Thomsen,L.C.,
            Vierkant,R.A., Walsh,C.S., Wang-Gohrke,S., Wentzensen,N.,
            Whittemore,A.S., Wicklund,K.G., Wilkens,L.R., Woo,Y.L., Wu,A.H.,
            Wu,X., Xiang,Y.B., Yang,H., Zheng,W., Ziogas,A., Lee,A.W.,
            Pearce,C.L., Berchuck,A., Schildkraut,J.M., Ramus,S.J.,
            Monteiro,A.N.A., Narod,S.A., Sellers,T.A., Gayther,S.A.,
            Kelemen,L.E., Chenevix-Trench,G., Risch,H.A., Pharoah,P.D.P.,
            Goode,E.L. and Phelan,C.M.
  TITLE     Variants in genes encoding small GTPases and association with
            epithelial ovarian cancer susceptibility
  JOURNAL   PLoS One 13 (7), e0197561 (2018)
   PUBMED   29979793
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8824)
  AUTHORS   Dodge-Kafka,K.L., Gildart,M., Li,J., Thakur,H. and Kapiloff,M.S.
  TITLE     Bidirectional regulation of HDAC5 by mAKAPbeta signalosomes in
            cardiac myocytes
  JOURNAL   J Mol Cell Cardiol 118, 13-25 (2018)
   PUBMED   29522762
  REMARK    GeneRIF: mAKAPbeta signalosomes serve to bidirectionally regulate
            the nuclear-cytoplasmic localization of class IIa HDACs.[
REFERENCE   6  (bases 1 to 8824)
  AUTHORS   Marx,S.O., Reiken,S., Hisamatsu,Y., Jayaraman,T., Burkhoff,D.,
            Rosemblit,N. and Marks,A.R.
  TITLE     PKA phosphorylation dissociates FKBP12.6 from the calcium release
            channel (ryanodine receptor): defective regulation in failing
            hearts
  JOURNAL   Cell 101 (4), 365-376 (2000)
   PUBMED   10830164
REFERENCE   7  (bases 1 to 8824)
  AUTHORS   Kapiloff,M.S., Schillace,R.V., Westphal,A.M. and Scott,J.D.
  TITLE     mAKAP: an A-kinase anchoring protein targeted to the nuclear
            membrane of differentiated myocytes
  JOURNAL   J Cell Sci 112 (Pt 16), 2725-2736 (1999)
   PUBMED   10413680
REFERENCE   8  (bases 1 to 8824)
  AUTHORS   Schillace,R.V. and Scott,J.D.
  TITLE     Association of the type 1 protein phosphatase PP1 with the A-kinase
            anchoring protein AKAP220
  JOURNAL   Curr Biol 9 (6), 321-324 (1999)
   PUBMED   10209101
REFERENCE   9  (bases 1 to 8824)
  AUTHORS   Yang,J., Drazba,J.A., Ferguson,D.G. and Bond,M.
  TITLE     A-kinase anchoring protein 100 (AKAP100) is localized in multiple
            subcellular compartments in the adult rat heart
  JOURNAL   J Cell Biol 142 (2), 511-522 (1998)
   PUBMED   9679148
REFERENCE   10 (bases 1 to 8824)
  AUTHORS   McCartney,S., Little,B.M., Langeberg,L.K. and Scott,J.D.
  TITLE     Cloning and characterization of A-kinase anchor protein 100
            (AKAP100). A protein that targets A-kinase to the sarcoplasmic
            reticulum
  JOURNAL   J Biol Chem 270 (16), 9327-9333 (1995)
   PUBMED   7721854
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Nov 26, 2020 this sequence version replaced NM_022618.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF139518.1, SRR26360176.1562853.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760389, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-93                JAXUCZ010000006.1  75919513-75919605
            94-457              JAXUCZ010000006.1  76024325-76024688
            458-709             JAXUCZ010000006.1  76099557-76099808
            710-2470            JAXUCZ010000006.1  76108313-76110073
            2471-2593           JAXUCZ010000006.1  76135071-76135193
            2594-2690           JAXUCZ010000006.1  76153921-76154017
            2691-2854           JAXUCZ010000006.1  76155101-76155264
            2855-3003           JAXUCZ010000006.1  76220749-76220897
            3004-3124           JAXUCZ010000006.1  76234714-76234834
            3125-3271           JAXUCZ010000006.1  76270991-76271137
            3272-3493           JAXUCZ010000006.1  76274006-76274227
            3494-3709           JAXUCZ010000006.1  76314277-76314492
            3710-7112           JAXUCZ010000006.1  76345464-76348866
            7113-8824           JAXUCZ010000006.1  76353325-76355036
FEATURES             Location/Qualifiers
     source          1..8824
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q23"
     gene            1..8824
                     /gene="Akap6"
                     /gene_synonym="mAkap"
                     /note="A-kinase anchoring protein 6"
                     /db_xref="GeneID:64553"
                     /db_xref="RGD:69412"
     exon            1..93
                     /gene="Akap6"
                     /gene_synonym="mAkap"
                     /inference="alignment:Splign:2.1.0"
     exon            94..457
                     /gene="Akap6"
                     /gene_synonym="mAkap"
                     /inference="alignment:Splign:2.1.0"
     CDS             128..7072
                     /gene="Akap6"
                     /gene_synonym="mAkap"
                     /note="PRKA6; AKAP-6; protein kinase A-anchoring protein
                     6; A kinase (PRKA) anchor protein 6"
                     /codon_start=1
                     /product="A-kinase anchor protein 6"
                     /protein_id="NP_072140.2"
                     /db_xref="GeneID:64553"
                     /db_xref="RGD:69412"
                     /translation="MLTMSVTLSPLRSQGPDPMATDASPMAINMTPTVEQEEGEGEEA
                     VKAIDAEQQYGKPPPLHTAADWKIVLHLPEIETWLRMTSERVRDLTYSVQQDADSKHV
                     DVHLVQLKDICEDISDHVEQIHALLETEFSLKLLSYSVNVIVDIHAVQLLWHQLRVSV
                     LVLRERILQGLQDANGNYTRQTDILQAFSEETTEGRLDSLTEVDDSGQLTIKCSQDYL
                     SLDCGITAFELSDYSPSEDLLGGLGDMTTSQAKTKSFDSWSYSEMEKEFPELIRSVGL
                     LTVATEPVPSSCGEANEDSSQASLSDDHKGEHGEDGAPVPGQQLDSTVGMSSLDGTLA
                     NAAEHPSETAKQDSTSSPQLGTKKTQPGPCEITTPKRSIRDCFNYNEDSPTQPTLPKR
                     GLFLKETQKNERKGSDRKGQVVDLKPELSRSTPSLVDPPDRSKLCLVLQSSYPSSPSA
                     ASQSYECLHKVGLGNLENIVRSHIKEISSSLGRLTDCHKEKLRLKKPHKTLAEVSLCR
                     IPKQGGGSGKRSESTGSSAGPSMVSPGAPKATMRPETDSASTASGGLCHQRNRSGQLP
                     VQSKASSSPPCSHSSESSLGSDSIKSPVPLLSKNKSQKSSPPAPCHATQNGQVVEAWY
                     GSDEYLALPSHLKQTEVLALKLESLTKLLPQKPRGETIQDIDDWELSEMNSDSEIYPT
                     YHIKKKHTRLGTVSPSSSSDIASSLGESIESGPLSDILSDEDLCLPLSSMKKFTDEKS
                     ERPSSSEKNESHSATRSALIQKLMHDIQHQENYEAIWERIEGFVNKLDEFIQWLNEAM
                     ETTENWTPPKAETDSLRLYLETHLSFKLNVDSHCALKEAVEEEGHQLLELVVSHKAGL
                     KDTLRMIASQWKELQRQIKRQHSWILRALDTIKAEILATDVSVEDEEGTGSPKAEVQL
                     CHLETQRDAVEQMSLKLYSEQYTSGSKRKEEFANMSKAHAEGSNGLLDFDSEYQELWD
                     WLIDMESLVMDSHDLMMSEEQQQHLYKRYSVEMSIRHLKKSELLSKVEALKKGGLSLP
                     DDILEKVDSINEKWELLGKTLREKIQDTIAGHSGSGPRDLLSPESGSLVRQLEVRIKE
                     LKRWLRDTELFIFNSCLRQEKEGTSAEKQLQYFKSLCREIKQRRRGVASILRLCQHLL
                     DDRDTCNLNADHQPMQLIIVNLERRWEAIVMQAVQWQTRLQKKMGKESETLNVIDPGL
                     MDLNGMSEDALEWDETDISNKLISVHEESNDLDQDPEPMLPAVKLEETHHKDSGYEEE
                     AGDCGGSPYTSNITAPSSPHIYQVYSLHNVELHEDSHTPFLKSSPKFTGTTQPTVLTK
                     SLSKDSSFSSTKSLPDLLGGSGLVRPYSCHSGDLSQNSGSESGIVSEGDNEMPTNSDM
                     SLFSMVDGSPSNPETEHPDPQMGDAATVLEQKFKDNGESIKLSSVSRASVSPVGCVNG
                     KAGDLNSVTKHTADCLGEELQGKHDVFTFYDYSYLQGSKLKLPMIMKQPQSEKAHVED
                     PLLGGFYFDKKSCKAKHQASESQPDAPPHERILASAPHEMGRSAYKSSDIEKTFTGIQ
                     SARQLSLLSRSSSVESLSPGGDLFGLGIFKNGSDSLQRSTSLESWLTSYKSNEDLFSC
                     HSSGDISVSSGSVGELSKRTLDLLNRLENIQSPSEQKIKRSVSDMTLQSSSQKMPFAG
                     QMSLDVASSINEDSPASLTELSSSDELSLCSEDIVLHKNKIPESNASFRKRLNRSVAD
                     ESDVNVSMIVNVSCTSACTDDEDDSDLLSSSTLTLTEEELCLKDEDDDSSIATDDEIY
                     EESNLMSGLDYIKNELQTWIRPKLSLTREKKRSGVTDEIKVNKDGGGNEKANPSDTLD
                     IEALLNGSIRCLSENNGNGKTPPRTHGSGTKGENKKSTYDVSKDPHVADMENGNIEST
                     PEREREKPQGLPEVSENLASNVKTISESELSEYEAVMDGSEDSSVARKEFCPPNDRHP
                     PQMGPKLQHPENQSGDCKPVQNPCPGLLSEAGVGSRQDSNGLKSLPNDAPSGARKPAG
                     CCLLEQNETEESASISSNASCCNCKPDVFHQKDDEDCSVHDFVKEIIDMASTALKSKS
                     QPESEVAAPTSLTQIKEKVLEHSHRPIHLRKGDFYSYLSLSSHDSDCGEVTNYIDEKS
                     STPLPPDAVDSGLDDKEDMDCFFEACVEDEPVNEEAGLPGALPNESAIEDGAEQKSEQ
                     KTASSPVLSDKTDLVPLSGLSPQKGADDAKEGDDVSHTSQGCAESTEPTTPSGKANAE
                     GRSRMQGVSATPEENAASAKPKIQAFSLNAKQPKGKVAMRYPSPQTLTCKEKLVNFHE
                     DRHSNMHR"
     exon            458..709
                     /gene="Akap6"
                     /gene_synonym="mAkap"
                     /inference="alignment:Splign:2.1.0"
     exon            710..2470
                     /gene="Akap6"
                     /gene_synonym="mAkap"
                     /inference="alignment:Splign:2.1.0"
     exon            2471..2593
                     /gene="Akap6"
                     /gene_synonym="mAkap"
                     /inference="alignment:Splign:2.1.0"
     exon            2594..2690
                     /gene="Akap6"
                     /gene_synonym="mAkap"
                     /inference="alignment:Splign:2.1.0"
     exon            2691..2854
                     /gene="Akap6"
                     /gene_synonym="mAkap"
                     /inference="alignment:Splign:2.1.0"
     exon            2855..3003
                     /gene="Akap6"
                     /gene_synonym="mAkap"
                     /inference="alignment:Splign:2.1.0"
     exon            3004..3124
                     /gene="Akap6"
                     /gene_synonym="mAkap"
                     /inference="alignment:Splign:2.1.0"
     exon            3125..3271
                     /gene="Akap6"
                     /gene_synonym="mAkap"
                     /inference="alignment:Splign:2.1.0"
     exon            3272..3493
                     /gene="Akap6"
                     /gene_synonym="mAkap"
                     /inference="alignment:Splign:2.1.0"
     exon            3494..3709
                     /gene="Akap6"
                     /gene_synonym="mAkap"
                     /inference="alignment:Splign:2.1.0"
     exon            3710..7112
                     /gene="Akap6"
                     /gene_synonym="mAkap"
                     /inference="alignment:Splign:2.1.0"
     exon            7113..8824
                     /gene="Akap6"
                     /gene_synonym="mAkap"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcatcatgca gcaggtcaaa caaggcatct cctagtattg catcctccag atgtgctgta
       61 aacatcaaaa ggagacgctg ggagcaggag atgctgtttt ggaaagaagt aaggcttaga
      121 tttctccatg ttaaccatga gcgtgacact ttccccactg aggtcacagg gcccagatcc
      181 catggcgacg gatgcttcac ccatggccat caacatgaca cccactgtgg agcaggagga
      241 aggagaggga gaggaagccg tgaaggccat agacgctgag cagcagtatg gaaagccacc
      301 tccgctccac acagcagccg actggaagat tgtcctgcac ttacctgaga ttgagacctg
      361 gctccggatg acctcagaga gggtccgtga cctgacctac tcagtccagc aggatgcaga
      421 cagcaagcat gtggatgtgc atctagttca gctgaaggac atttgtgagg atatttctga
      481 ccatgtggag cagatccatg ccctccttga gacggagttc tccctaaagc tgctgtccta
      541 ctcggtcaac gtcatcgtag acatccacgc agtacagctg ctctggcacc agctccgcgt
      601 atccgtgctg gtcctccggg agcgcatcct acaaggtctg caggacgcca atggcaacta
      661 caccaggcag actgacattc tgcaagcgtt ctctgaagaa acaacggagg gccggcttga
      721 ttccctcaca gaagtggacg actcagggca gttaactatc aaatgttcac aggattactt
      781 gtctctggat tgtggcatta ccgcatttga actctccgac tacagtccaa gtgaggatct
      841 gcttggtggc ctgggcgaca tgaccaccag ccaggccaaa actaaatctt ttgactcttg
      901 gagctacagt gagatggaga aagagttccc tgagcttatc cgaagcgttg ggctgcttac
      961 agtggccacc gagcctgtcc cttccagctg tggagaagcc aatgaggatt catctcaagc
     1021 gtccctttca gacgatcaca aaggtgaaca cggggaagac ggtgctcccg tacctggaca
     1081 gcagctggac tcaacggtgg gaatgtcttc cttagacggc acgctggcaa atgctgccga
     1141 acacccttcg gagacagcaa aacaagactc tacttcctcc ccacagcttg gtacgaagaa
     1201 aacccagcct ggtccttgtg aaattacgac tcccaagaga tccatccgcg attgctttaa
     1261 ttataacgag gactccccca cacagcccac attacccaaa agagggcttt ttctaaaaga
     1321 aactcaaaag aatgagcgca aaggcagtga caggaagggg caggtggttg acttaaagcc
     1381 tgaactgagc agaagcaccc cttccctggt ggacccccct gacagatcga agctctgcct
     1441 agtgttgcag tcctcctacc ccagcagccc ttctgctgcc agccagtcct atgaatgttt
     1501 gcacaaggtg gggctcggca atcttgaaaa catagtcaga agtcacatta aagaaatttc
     1561 ttccagtctg ggaaggctta ctgactgcca taaagagaaa ttgcgactga aaaagccaca
     1621 caagaccttg gccgaagtgt ctctgtgcag aatccctaaa cagggaggcg gttcaggaaa
     1681 gcgatctgag agcaccggga gctcagcagg gcccagcatg gtatcacctg gagctcccaa
     1741 agccacgatg agaccagaaa cagattctgc gtctacagcc tcaggtggcc tgtgccacca
     1801 gagaaatcgc agtggacaat tgccagtgca gtcgaaggcc tccagttcac ccccttgcag
     1861 tcacagcagt gaatcttctc ttggctcaga tagcatcaaa tccccggttc ctcttctttc
     1921 aaaaaacaaa agccaaaaaa gctccccacc tgctccatgt cacgccacac agaacggtca
     1981 ggtggtggag gcctggtacg gctctgatga gtacctagcg ctgccctctc acctgaagca
     2041 gacagaggtg ttagctctca agctggagag cctaaccaag ctcctacccc agaaacccag
     2101 aggagagacc atccaggata ttgatgactg ggaactgtct gaaatgaatt cagattccga
     2161 aatctatcca acataccaca tcaagaaaaa acacacgaga ctgggcacag tgtctccaag
     2221 ctcatccagc gacatagcct catctctcgg ggagagcatt gaatccgggc ccctgagtga
     2281 cattctttct gacgaggact tatgtctgcc cctctccagc atgaaaaagt tcactgacga
     2341 gaaatcagag agaccttcat cctccgagaa gaacgagagc cattctgcaa caagatcagc
     2401 tttgattcag aaactaatgc acgatattca gcaccaagag aactatgaag ccatctggga
     2461 aagaattgag gggtttgtga acaagctgga tgaattcatt cagtggctaa acgaagccat
     2521 ggagaccacc gagaactgga ctcctcctaa agccgagacc gacagcctcc ggctgtacct
     2581 ggagacacac ttgagtttta agttgaacgt agacagccac tgtgccctca aggaagccgt
     2641 ggaggaagaa ggacaccaac ttcttgagct cgttgtatct cacaaagcag gactgaagga
     2701 cacgctgagg atgattgcga gtcaatggaa ggagctgcag aggcaaatca aacggcaaca
     2761 cagctggatt ctcagagccc tggacaccat caaagccgag atactggcta ctgatgtgtc
     2821 tgtggaggac gaggagggga cgggaagccc caaggccgag gttcagctct gccacctgga
     2881 aacacagaga gacgccgtgg aacagatgtc cctgaagctg tacagcgagc agtacaccag
     2941 cgggagcaag aggaaggaag agtttgccaa catgtcgaaa gcgcacgcgg agggaagcaa
     3001 tgggcttctg gactttgatt cagaatatca ggagctctgg gattggctga ttgacatgga
     3061 gtccctcgtg atggacagcc acgacctgat gatgtcagag gagcagcagc agcatcttta
     3121 caagaggtac agtgtggaaa tgtccatcag gcatctgaaa aagtcagagc tactcagcaa
     3181 ggttgaagct ttgaagaaag gtggcctttc actaccagac gatatcctgg aaaaagtgga
     3241 ttcaattaat gaaaaatggg agctgcttgg gaaaacccta agagagaaga tacaggacac
     3301 aatagcgggg cacagtgggt cgggcccacg tgacctgcta tctcctgaaa gcggaagcct
     3361 ggtaaggcag ctggaggtca ggatcaaaga gctgaaaagg tggctaagag atacagagct
     3421 tttcatcttc aattcctgtc tgagacaaga gaaggaagga acaagcgccg agaaacagct
     3481 ccaatacttt aagtcgctct gtcgtgagat caagcagcgg cgtcgaggag tggcctccat
     3541 tctgaggttg tgccagcacc ttctggatga ccgggacacg tgcaacctga acgcagatca
     3601 ccagcccatg cagctgatca ttgtaaacct cgagaggcgg tgggaggcca tcgtcatgca
     3661 agctgtccag tggcaaacac ggttacaaaa gaagatgggg aaggaatccg agactttgaa
     3721 tgtgattgat cctggcttga tggacctgaa tggaatgagt gaggatgccc tggaatggga
     3781 tgaaacagac ataagtaaca aactcattag tgtgcatgaa gaatcaaacg accttgatca
     3841 agacccagag cctatgctac ccgcagtgaa gcttgaagag acacaccaca aggactctgg
     3901 ttatgaagag gaggcaggtg actgtggagg gtctccgtat acctcaaata tcactgcacc
     3961 ttccagccca cacatttacc aagtgtacag tcttcacaat gtggagctcc acgaggacag
     4021 ccacactcca tttctgaaaa gcagccctaa gttcacaggc acaacacagc ctactgtttt
     4081 aactaagagc ctcagcaagg actcttcctt ttcatctaca aaatcgttac cagaccttct
     4141 agggggttcc ggtttggtga ggccttactc gtgtcacagt ggagacttga gccagaattc
     4201 aggcagtgag agtggaattg tcagcgaagg agacaacgag atgccgacca actctgacat
     4261 gagcttgttc agtatggtag acgggtcccc aagtaaccct gaaacggagc atccggaccc
     4321 acaaatggga gatgcagcca ctgtgctaga gcaaaagttt aaagacaacg gggaaagcat
     4381 taagctttca agtgtctctc gggcatccgt ctcaccagtg ggttgtgtaa atggaaaagc
     4441 aggggattta aacagtgtta ccaaacacac tgctgattgt ttgggagaag aactacaagg
     4501 aaaacatgac gtgtttacat tttatgatta ctcgtacctc caaggctcaa aactcaaatt
     4561 accaatgata atgaaacagc cacagagtga aaaggcacac gtggaggatc cccttcttgg
     4621 tggtttttat tttgataaaa agtcctgcaa agctaaacat caggcttcag agtcacaacc
     4681 agatgcgcct ccccacgaaa ggattctggc aagcgcgccc cacgagatgg gacgcagcgc
     4741 atacaaaagt agcgacatag agaagacatt cacgggcatt cagagtgcca gacagctctc
     4801 ccttctatct cgtagctcat ctgtagagtc cctttctcca gggggtgatt tgtttggatt
     4861 gggaatcttt aaaaatggca gtgacagcct ccagcggagc acttctttag aaagttggtt
     4921 gacatcctat aagagcaatg aggatctctt tagctgtcac agctctgggg acataagtgt
     4981 gagcagtggc tcagttggtg agctgagtaa gaggacgtta gaccttctga atcgcctgga
     5041 gaatatacag agcccctcgg agcaaaagat caagcggagt gtttctgaca tgactctaca
     5101 aagcagttcc caaaagatgc ccttcgctgg ccagatgtca ctggatgtcg catcctccat
     5161 caatgaagac tctccggcat ctcttacaga actgagtagt agcgatgagc tctctctttg
     5221 ctcggaggac attgtgttac acaaaaacaa gatcccagaa tccaacgcat cattcaggaa
     5281 gcgcctgaat cgctcagtgg ctgatgagag cgacgtcaat gttagcatga ttgtcaatgt
     5341 gtcctgcacc tctgcttgca ctgatgatga agatgacagc gacctcctct ccagctccac
     5401 tctcacctta actgaagaag agctgtgcct caaagatgag gatgacgact ccagtattgc
     5461 aacagatgat gaaatttatg aagagagcaa cctgatgtct gggctggact acataaagaa
     5521 tgaactgcag acttggataa gaccaaaact ttccttgacg agagaaaaga aacggtccgg
     5581 tgtcactgat gaaataaagg tcaataaaga tgggggaggc aatgagaagg ccaatccctc
     5641 ggacaccctg gacatcgagg cccttctcaa tggctccata agatgtcttt ccgaaaacaa
     5701 cgggaatggt aagactccgc ccagaactca tggctcagga accaaaggtg aaaataagaa
     5761 aagtacgtat gacgttagta aggatccgca cgtggctgac atggaaaatg gcaatattga
     5821 aagtacccca gaaagagaaa gggagaagcc acaagggctt ccagaggtgt cagagaacct
     5881 tgcttcaaat gtgaaaacga tttctgaatc tgagctcagc gagtatgaag cagtaatgga
     5941 tggttctgag gattcaagtg ttgccagaaa ggaattttgt cccccaaatg acagacatcc
     6001 tccacagatg ggtcccaaac tccagcatcc cgaaaatcaa agtggcgact gcaagccagt
     6061 ccagaaccct tgcccggggc tactgtcgga agctggcgtt ggaagcaggc aagacagcaa
     6121 tggactaaaa tctttgccta acgatgcacc aagtggggct agaaaacctg ccggttgctg
     6181 cctgctggag cagaatgaga cagaggaaag tgcttctatc agcagcaacg cttcctgttg
     6241 caactgcaag ccagatgttt tccatcaaaa agatgatgaa gattgttcag tacatgactt
     6301 tgttaaggaa atcattgaca tggcatcaac agccctaaaa agtaagtcac agcctgaaag
     6361 tgaggtggcc gcacccacat cactaaccca aattaaggag aaggtgttag agcattcgca
     6421 ccggcccata cacctgagaa agggggactt ttactcctac ttatcacttt cgtcccacga
     6481 cagtgactgt ggggaggtca ccaattacat agatgagaag agcagtactc cattgccacc
     6541 ggacgctgtg gactctggct tagatgacaa ggaagacatg gactgcttct ttgaagcttg
     6601 tgttgaggat gagcctgtca atgaggaagc tggtctcccc ggtgcccttc ccaatgaatc
     6661 agccatcgag gatggagcag agcaaaagtc agaacaaaag acagccagct ctcctgtgct
     6721 cagtgacaag acagacctgg tgcctctttc aggactttcc cctcagaagg gagctgatga
     6781 tgcaaaggaa ggagatgatg tgtctcacac ttcccagggc tgtgcagaga gcacagagcc
     6841 taccaccccc tcaggaaagg ccaatgcaga ggggaggtca agaatgcaag gtgtatcagc
     6901 aacgccagaa gaaaacgctg cttcggccaa accgaaaatt caagctttct ctttgaatgc
     6961 aaaacagcca aaaggcaagg ttgccatgag gtatcccagc ccccaaactc taacctgtaa
     7021 agagaagctc gtaaactttc atgaagatcg acacagtaac atgcataggt agagtgtaat
     7081 gcccccacgc atggaaatca tctcattgaa agatagcctg gctgaagctc agggctagcc
     7141 caatccaccc tgggccggtc ttgggctcca tcctgttatc actgccgcct gtcacattga
     7201 ctttctgaag acgaaccttc cttccgaatg cagtctgtcc acgtgggcct ctcgacctgg
     7261 atgtgtgcat tgcttctctt aggtgatcat cctagttcca caaagctgct tgttctcccg
     7321 tggattcctg tcccaagcta cctctggcaa ccctgtctct ccagcaagac ttcggttttc
     7381 cctccccctc ctccccccct taaagctccg cggctcacca aattgatggt ccatcaaacc
     7441 cactgtctgg aatgataccc ctcccatcag tacttgacca atgttatgtt ttgctctgaa
     7501 aactttcgct gtattagacc aatgtttatt gaaagagatt tacctaaaaa gcccgccctt
     7561 gatttggttg cagtatagag gagacacatt gatccttcta acaaaattaa gtgatgtctg
     7621 aaagcgccat tttaattatt tctttttaaa taatgatcta tgcagcactt caagaaacaa
     7681 ctataacagt gttgtatctt ataaactggt acattctact attaagtttg tttttggttt
     7741 ctatgcttct tgaggtggtg atgagaaaaa tggttttttt tttaaaacgg tgtgccttgc
     7801 tgtattactt atagcattta ttaaaaagct gctttcatgg taagattaca ctggtttgaa
     7861 aggaggaaat agcaaggtta agatgcgtgc ataatttctg tatatatgta taagctagtg
     7921 caaacactga tgtatgacag tataaaatgc tttcatgttt gtgatgtcca gtggtgtgga
     7981 atataagcct taaacccgtt cgattgcatg gtaattaaaa ttggcataat aaaaatagct
     8041 tattggggga aaggaaaatt aatgatctct tctacctgtg tttaccaatt tctttcatgt
     8101 ggttctggga aagaaaaaga aacaaacccc atatattagc ttccaaaata tccatattgc
     8161 acagaaggct taagttgctt agactacaga ctgggcctga agacttcatg attttccaaa
     8221 tttttctgtt tcactataaa catccgaaat agcaaagatt tctttcccct ccatcaacag
     8281 cattttattc tgaatgtttt tatttctact tgttaatggt ttaaagttgt atttggagat
     8341 ctcttacatg ccctaattta ttttaaatat ttgaatgggt ttggtggatg gtatagaaaa
     8401 tttaattatt attttattta aactacagat ttcaggtgta tttattttgt taaatattcc
     8461 atttggtctt ttggtctttt tatgacttga aagtttcagc ttttaattta tatcataact
     8521 cctactaaag tgcctgacac acagtaggta tttcatagag tttcctgaat tagagtattg
     8581 ggtggtttat atatatatat atatatgaga ttcctgcatt aaaactagaa aaagatgtgc
     8641 aaagtgaacc agacacagca tattatcaga tttcaaaaag gaaagagaac atagccacag
     8701 aaatgacaat cattcattca gtagattagc atcttttgcc tgcaagtcac cattctagat
     8761 tcagggagag cagctatgac cgatgcactg cctttggagg cttctgtgtt agagacagag
     8821 tgac
//
