LOCUS       NM_133515               2700 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Rattus norvegicus A-kinase anchoring protein 5 (Akap5), mRNA.
ACCESSION   NM_133515
VERSION     NM_133515.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2700)
  AUTHORS   Zhang,X., Wang,Q., Wang,Z., Zhang,H., Zhu,F., Ma,J., Wang,W.,
            Chen,Z. and Wang,H.
  TITLE     Interaction between A-kinase anchoring protein 5 and protein kinase
            A mediates CaMKII/HDAC signaling to inhibit cardiomyocyte
            hypertrophy after hypoxic reoxygenation
  JOURNAL   Cell Signal 103, 110569 (2023)
   PUBMED   36565899
  REMARK    GeneRIF: Interaction between A-kinase anchoring protein 5 and
            protein kinase A mediates CaMKII/HDAC signaling to inhibit
            cardiomyocyte hypertrophy after hypoxic reoxygenation.
REFERENCE   2  (bases 1 to 2700)
  AUTHORS   Zhu,F., Yuan,C., Zhang,X., Wang,Z., Wang,Q. and Wang,H.
  TITLE     A-kinase anchoring protein 5-ancored calcineurin regulates the
            remodeling of H9c2 cardiomyocytes exposed to hypoxia and
            reoxygenation
  JOURNAL   Biomed Pharmacother 155, 113689 (2022)
   PUBMED   36115111
  REMARK    GeneRIF: A-kinase anchoring protein 5-ancored calcineurin regulates
            the remodeling of H9c2 cardiomyocytes exposed to hypoxia and
            reoxygenation.
REFERENCE   3  (bases 1 to 2700)
  AUTHORS   Asirvatham,A.L., Schworer,C.M., Stahl,R., Heitzman,D. and
            Carey,D.J.
  TITLE     Role of A-kinase anchoring proteins in cyclic-AMP-mediated Schwann
            cell proliferation
  JOURNAL   Cell Signal 83, 109977 (2021)
   PUBMED   33716104
  REMARK    GeneRIF: Role of A-kinase anchoring proteins in cyclic-AMP-mediated
            Schwann cell proliferation.
REFERENCE   4  (bases 1 to 2700)
  AUTHORS   Shepard,R.D., Gouty,S., Kassis,H., Berenji,A., Zhu,W., Cox,B.M. and
            Nugent,F.S.
  TITLE     Targeting histone deacetylation for recovery of maternal
            deprivation-induced changes in BDNF and AKAP150 expression in the
            VTA
  JOURNAL   Exp Neurol 309, 160-168 (2018)
   PUBMED   30102916
  REMARK    GeneRIF: This study suggest that HDAC-mediated targeting of BDNF
            and AKAP-dependent local signaling within VTA could provide novel
            therapeutics for prevention of later-life psychopathology.
REFERENCE   5  (bases 1 to 2700)
  AUTHORS   Rivera-Pagan,A.F., Mendez-Gonzalez,M.P., Rivera-Aponte,D.E.,
            Malpica-Nieves,C.J., Melnik-Martinez,K.V., Zayas-Santiago,A.,
            Maldonado-Martinez,G., Shuba,Y.M., Skatchkov,S.N. and Eaton,M.J.
  TITLE     A-Kinase-Anchoring Protein (AKAP150) is expressed in Astrocytes and
            Upregulated in Response to Ischemia
  JOURNAL   Neuroscience 384, 54-63 (2018)
   PUBMED   29800717
  REMARK    GeneRIF: AKAP150 is localized in astrocytes and is up-regulated
            during ischemia both in vitro and in vivo. Knock-down of AKAP150 by
            RNAi depolarizes the astrocytic membrane potential and
            substantially reduces by 80% the ability of astrocytes to take up
            extracellular potassium during ischemic conditions.
REFERENCE   6  (bases 1 to 2700)
  AUTHORS   Colledge,M., Dean,R.A., Scott,G.K., Langeberg,L.K., Huganir,R.L.
            and Scott,J.D.
  TITLE     Targeting of PKA to glutamate receptors through a MAGUK-AKAP
            complex
  JOURNAL   Neuron 27 (1), 107-119 (2000)
   PUBMED   10939335
REFERENCE   7  (bases 1 to 2700)
  AUTHORS   Fraser,I.D., Cong,M., Kim,J., Rollins,E.N., Daaka,Y.,
            Lefkowitz,R.J. and Scott,J.D.
  TITLE     Assembly of an A kinase-anchoring protein-beta(2)-adrenergic
            receptor complex facilitates receptor phosphorylation and signaling
  JOURNAL   Curr Biol 10 (7), 409-412 (2000)
   PUBMED   10753752
REFERENCE   8  (bases 1 to 2700)
  AUTHORS   Dodge,K.L., Carr,D.W., Yue,C. and Sanborn,B.M.
  TITLE     A role for AKAP (A kinase anchoring protein) scaffolding in the
            loss of a cyclic adenosine 3',5'-monophosphate inhibitory response
            in late pregnant rat myometrium
  JOURNAL   Mol Endocrinol 13 (12), 1977-1987 (1999)
   PUBMED   10598575
REFERENCE   9  (bases 1 to 2700)
  AUTHORS   Jicha,G.A., Weaver,C., Lane,E., Vianna,C., Kress,Y., Rockwood,J.
            and Davies,P.
  TITLE     cAMP-dependent protein kinase phosphorylations on tau in
            Alzheimer's disease
  JOURNAL   J Neurosci 19 (17), 7486-7494 (1999)
   PUBMED   10460255
REFERENCE   10 (bases 1 to 2700)
  AUTHORS   Bregman,D.B., Bhattacharyya,N. and Rubin,C.S.
  TITLE     High affinity binding protein for the regulatory subunit of
            cAMP-dependent protein kinase II-B. Cloning, characterization, and
            expression of cDNAs for rat brain P150
  JOURNAL   J Biol Chem 264 (8), 4648-4656 (1989)
   PUBMED   2538452
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Aug 3, 2012 this sequence version replaced NM_133515.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U67136.1, SRR26643298.36062.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation,
                                                expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-278               JAXUCZ010000006.1  100787169-100787446
            279-2700            JAXUCZ010000006.1  100790148-100792569
FEATURES             Location/Qualifiers
     source          1..2700
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q24"
     gene            1..2700
                     /gene="Akap5"
                     /gene_synonym="AKAP150; Akap79; P150"
                     /note="A-kinase anchoring protein 5"
                     /db_xref="GeneID:171026"
                     /db_xref="RGD:620829"
     exon            1..278
                     /gene="Akap5"
                     /gene_synonym="AKAP150; Akap79; P150"
                     /inference="alignment:Splign:2.1.0"
     exon            279..2700
                     /gene="Akap5"
                     /gene_synonym="AKAP150; Akap79; P150"
                     /inference="alignment:Splign:2.1.0"
     CDS             526..2670
                     /gene="Akap5"
                     /gene_synonym="AKAP150; Akap79; P150"
                     /note="RII-B-binding protein; AKAP-5; AKAP 150; A-kinase
                     anchor protein 150 kDa; cAMP-dependent protein kinase
                     regulatory subunit II high affinity-binding protein; A
                     kinase (PRKA) anchor protein 5"
                     /codon_start=1
                     /product="A-kinase anchor protein 5"
                     /protein_id="NP_598199.2"
                     /db_xref="GeneID:171026"
                     /db_xref="RGD:620829"
                     /translation="METSVSEIQIETKDEKRPEAASPQKERQERKTATLCFKRRKKVN
                     KKKAKAGSKTAEETKKHAPEAGGSGQRQPAGAWASIKRLVTHRKPSESAEKQKPSEAE
                     MQPEDGALPKKKTKSKLKIPCIRFSRGAKRSRPSKLTEDSGYVRVQGEADDLEIKAQI
                     QPDEQATQAKSTQGLQEDVMVRDGKEIQESHISNNVISGEHVIAIELELEKESSALRM
                     RTPGSEKEAKVILVKQSVQVQQASVLENSAADSPQPVTSTAPLSPATTHQLGLEEPSD
                     SIRESAPSGKDDGRRKTAAEEKKSGETALGQAEEASSVSQADKSVLSQAEEATVGHTE
                     EATVIQAQSQAKEGKLSQAEEATVAQAKETVLSQAEEVKLSQIEEPAISQAKKATVGQ
                     AKEAIVSQAEEAIVGHTEKATMGQAEEATVGHIEKTTVGQAEEATVGQAEEATVGQAE
                     EATVGQAEEATVGQAEEATVGQAGEATVSHIEKTTVGQAEEAIVGQAEEATVGQAEEA
                     TVGQAEEATVGQAEEATVDQAEEATVGQAEEATVGQAGEAAVGQAEEAIVAQAEEATV
                     GQAGEATVGQAEKATVGQAEEPIVGQAEETVLRHASDLKVNGVDAEKPRSEESKRMEP
                     IAIIITDTEISEFDVKKSKNVPKQFLISMENEQVGVFANDSDFEGRTSEQYETLLIET
                     ASSLVKNAIELSVEQLVNEMVSEDNQINTLFQ"
ORIGIN      
        1 tccgcgctgg ggagggggcg cgcggctgcg gtccctctgc agagggctgc gcgctccgcg
       61 gtctccgggg ctccccgtgg tttgggtccg tgctcctcga cctcgggagc agggctgtcc
      121 tgagaccgca acgatctggg taactagagg caagaccaga agctctgggt cagaatctga
      181 tgcactgagc ccccggtaac ggcggcagac ccggggtcct ggtcaccaga ttgtgaggga
      241 cacggactac aaggtcgcca gtcctcaggc ggctccaggt tgggctttaa ataatggaga
      301 agtttatcga cgaaagtgct ttcatttaaa gagtaaatta agagacaacg ccgtgaacag
      361 ctgataaaca aggcatttgt gtcctgaaga gccacagaaa caagtgtgat gtgaggggag
      421 agtagacaca taggaggaat cagacctggt gtgatatttt tgtcacaaaa gacttgagga
      481 agagagaagc cacttttcca gagaatgaaa gagtgcagtg tcaaaatgga gaccagcgtt
      541 tctgagattc aaatcgagac taaggatgag aagagaccag aagcagccag tcctcagaaa
      601 gagaggcagg agagaaaaac agccacactg tgcttcaaga gaaggaagaa agtgaacaag
      661 aagaaggcca aagctggttc caagactgct gaggagacaa agaagcatgc cccagaagct
      721 gggggttctg gtcagcggca accagcgggg gcctgggcct ccattaaacg ccttgtgaca
      781 cacaggaaac cgtccgagtc tgcagagaag cagaagccat ctgaggctga aatgcagcct
      841 gaggatggag ctcttcctaa gaagaagaca aaatccaaac ttaagattcc ttgcatacga
      901 ttctcaagag gggcaaagag aagtcgtcct tccaaactca cagaagattc aggctatgtc
      961 cgagtccagg gagaggcaga cgatttggag ataaaagccc agatccagcc cgatgagcag
     1021 gcaacccagg ctaagtccac ccagggccta caggaagatg tgatggtgag agatggtaag
     1081 gagatccaag aatcacacat aagcaacaac gtcatatcgg gagagcatgt gattgccata
     1141 gaactggaat tagaaaagga atcttctgct ctccggatga gaactccagg gagtgaaaag
     1201 gaggctaaag tgattctggt aaagcagagt gttcaggtac agcaagcaag tgtgcttgag
     1261 aattcagcag cagacagccc tcagccagtg acttctactg ctcctctctc accagcaacc
     1321 acacatcaac tcggtctgga agaacccagt gacagcatcc gggaaagtgc accaagtgga
     1381 aaagatgacg gaaggagaaa gactgctgct gaagaaaaga aatcaggaga gactgcgctg
     1441 ggccaggcag aggaggcttc ttcagtcagc caggcagaca aaagtgtact aagccaggca
     1501 gaagaagcta cagtgggcca cacagaggaa gctactgtga tccaggcaca gagtcaggca
     1561 aaggaaggta aactgagcca ggcagaggaa gctacagtgg cccaggcaaa ggaaactgta
     1621 ttgagtcagg cagaggaagt taaactgagc cagatagaag aacctgcaat tagccaggca
     1681 aagaaagcta cagtaggaca agcaaaggaa gctatagtta gccaggcaga ggaagctata
     1741 gttggtcaca cagagaaagc caccatgggt caggcagagg aagctacagt tggccacata
     1801 gagaaaacca cagtgggcca ggcagaggaa gctacagtgg gtcaagcaga ggaagccaca
     1861 gtgggtcaag cagaggaagc cacagtgggt caagcagagg aagctacagt tggacaggca
     1921 gaggaagcta cagttggtca ggcaggggaa gctacagtta gccacataga gaaaaccaca
     1981 gtgggccagg cagaggaagc tatagttggt caggcagagg aagccacagt gggtcaagca
     2041 gaggaagcca cagtgggtca agcagaggaa gctacagttg gccaggcaga ggaagccaca
     2101 gtggatcaag cagaggaagc tacagttggc caggcagagg aagctacagt tggtcaggca
     2161 ggggaagctg cagttggcca ggcagaggaa gctatagttg ctcaggcaga ggaagccaca
     2221 gttggtcagg caggggaagc tacagttggc caagcagaga aagccacagt tggccaagca
     2281 gaggaaccca tagttggcca ggcagaggaa actgtattga ggcatgcatc agatctgaaa
     2341 gtaaatggag ttgatgcaga gaaaccaaga tcagaagaaa gcaaaagaat ggagccaatt
     2401 gctattatca taacagacac tgaaatcagt gaatttgatg ttaagaaatc taaaaatgtc
     2461 cctaagcaat tcctaatttc catggaaaat gagcaagtgg gggtttttgc taatgatagt
     2521 gatttcgagg ggagaacttc agaacagtat gaaacactct taatagaaac agcttcttct
     2581 ctcgtcaaga atgctatcga gttgtctgta gaacagctgg ttaacgaaat ggtttctgag
     2641 gataatcaaa taaatacgct gttccagtga ctccatttcc aggtcacggg aagaaaggaa
//
