LOCUS       NM_024402               2786 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus A-kinase anchoring protein 4 (Akap4), mRNA.
ACCESSION   NM_024402 XM_346866
VERSION     NM_024402.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2786)
  AUTHORS   Liu,W., Wu,H., Wang,L., Yang,X., Liu,C., He,X., Li,W., Wang,J.,
            Chen,Y., Wang,H., Gao,Y., Tang,S., Yang,S., Jin,L., Zhang,F. and
            Cao,Y.
  TITLE     Homozygous loss-of-function mutations in FSIP2 cause male
            infertility with asthenoteratospermia
  JOURNAL   J Genet Genomics 46 (1), 53-56 (2019)
   PUBMED   30745215
REFERENCE   2  (bases 1 to 2786)
  AUTHORS   Martinez,G., Kherraf,Z.E., Zouari,R., Fourati Ben Mustapha,S.,
            Saut,A., Pernet-Gallay,K., Bertrand,A., Bidart,M.,
            Hograindleur,J.P., Amiri-Yekta,A., Kharouf,M., Karaouzene,T.,
            Thierry-Mieg,N., Dacheux-Deschamps,D., Satre,V., Bonhivers,M.,
            Toure,A., Arnoult,C., Ray,P.F. and Coutton,C.
  TITLE     Whole-exome sequencing identifies mutations in FSIP2 as a recurrent
            cause of multiple morphological abnormalities of the sperm flagella
  JOURNAL   Hum Reprod 33 (10), 1973-1984 (2018)
   PUBMED   30137358
REFERENCE   3  (bases 1 to 2786)
  AUTHORS   Sironen,A., Kotaja,N., Mulhern,H., Wyatt,T.A., Sisson,J.H.,
            Pavlik,J.A., Miiluniemi,M., Fleming,M.D. and Lee,L.
  TITLE     Loss of SPEF2 function in mice results in spermatogenesis defects
            and primary ciliary dyskinesia
  JOURNAL   Biol Reprod 85 (4), 690-701 (2011)
   PUBMED   21715716
REFERENCE   4  (bases 1 to 2786)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   5  (bases 1 to 2786)
  AUTHORS   Carnegie,G.K., Means,C.K. and Scott,J.D.
  TITLE     A-kinase anchoring proteins: from protein complexes to physiology
            and disease
  JOURNAL   IUBMB Life 61 (4), 394-406 (2009)
   PUBMED   19319965
  REMARK    Review article
REFERENCE   6  (bases 1 to 2786)
  AUTHORS   Brown,P.R., Miki,K., Harper,D.B. and Eddy,E.M.
  TITLE     A-kinase anchoring protein 4 binding proteins in the fibrous sheath
            of the sperm flagellum
  JOURNAL   Biol Reprod 68 (6), 2241-2248 (2003)
   PUBMED   12606363
REFERENCE   7  (bases 1 to 2786)
  AUTHORS   Miki,K., Willis,W.D., Brown,P.R., Goulding,E.H., Fulcher,K.D. and
            Eddy,E.M.
  TITLE     Targeted disruption of the Akap4 gene causes defects in sperm
            flagellum and motility
  JOURNAL   Dev Biol 248 (2), 331-342 (2002)
   PUBMED   12167408
REFERENCE   8  (bases 1 to 2786)
  AUTHORS   Miki,K. and Eddy,E.M.
  TITLE     Identification of tethering domains for protein kinase A type
            Ialpha regulatory subunits on sperm fibrous sheath protein FSC1
  JOURNAL   J Biol Chem 273 (51), 34384-34390 (1998)
   PUBMED   9852104
REFERENCE   9  (bases 1 to 2786)
  AUTHORS   Turner,R.M., Johnson,L.R., Haig-Ladewig,L., Gerton,G.L. and
            Moss,S.B.
  TITLE     An X-linked gene encodes a major human sperm fibrous sheath
            protein, hAKAP82. Genomic organization, protein kinase A-RII
            binding, and distribution of the precursor in the sperm tail
  JOURNAL   J Biol Chem 273 (48), 32135-32141 (1998)
   PUBMED   9822690
REFERENCE   10 (bases 1 to 2786)
  AUTHORS   Carrera,A., Gerton,G.L. and Moss,S.B.
  TITLE     The major fibrous sheath polypeptide of mouse sperm: structural and
            functional similarities to the A-kinase anchoring proteins
  JOURNAL   Dev Biol 165 (1), 272-284 (1994)
   PUBMED   8088444
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF008114.1.
            
            [WARNING] On Jul 19, 2024 this sequence was replaced by
            NM_024402.2.
            
            On Dec 17, 2003 this sequence version replaced XM_346866.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF008114.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2786
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq12"
     gene            1..2786
                     /gene="Akap4"
                     /note="A-kinase anchoring protein 4"
                     /db_xref="GeneID:79254"
                     /db_xref="RGD:620828"
     exon            1..81
                     /gene="Akap4"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..2598
                     /gene="Akap4"
                     /note="PRKA4; major sperm fibrous sheath protein; protein
                     kinase A-anchoring protein 4; AKAP-4; 75 kDa fibrous
                     sheath protein; A kinase (PRKA) anchor protein 4"
                     /codon_start=1
                     /product="A-kinase anchor protein 4"
                     /protein_id="NP_077378.1"
                     /db_xref="GeneID:79254"
                     /db_xref="RGD:620828"
                     /translation="MIAYCGTTKMSDDIDWLHSRRGVCKVDLYSPEGQQDQDRKVICF
                     VDVSTLNVEDDSKGAAGPRSDGELNLENLEEKEIIVIKDTEKQDQPKTEGSVCLFKQA
                     PSDPISVLNWLLNDLQKYALGFQHALSPSASSCKHKVGDLEGDYHKIPSENCYSVYAD
                     QVNLDYLNKGPQNLRLEMAASKNTNNNQSPSNPATKSPSNQRSVATPDGECSMDDLSY
                     YVNRLSSLVIQMARKEIKDKLEGGNKCLHHSMYTSGEKGKTSPRSAVSKIASEMAHEA
                     VELTSSEMRGNGEEGRDGRKTFLYSELSNKNKCGEKQQMCPKDSKEFADSISKGLMVY
                     ANQVASDMMVSVMKTLKVHSCGKPIPACVVLKRVLLKHTKEIVSDLIDSCMKNLHNIT
                     GVLMTDSDFVSAVKRNLFNHGKQNAADIMEAMLKRLVSALLGEKKETKSQSLAYATLK
                     AGTHDPKCKNQSLEFSAMKAEMKGKDKGKTKGDPCCKSLTSAERVSEHILKESLTMWN
                     NQKQGTQGRVPNKVCPSKDEKREKISPSTDSLAKDLIVSALMLIQYHLTQQAKGKDPC
                     EEECPGSSMGYMSQSAQYEKSGGGQSSKSLSMKHFESRGAPGPSTCAKENQLESQKMD
                     MSNMVLSLIQKLLSESPFSCDELSESENKRCCDSRSKQAAPVAKRPEDQSQDSTEMDF
                     ISGMKQMNRQFIDQLVESVMKLCLIMAKYSNNGAALAELEEQAALASNGPRCGREAVM
                     SQSYLETPGPEVIVNNQCSTSNLQKQLQAVLQWIAASQFNVPMLYFMGDDDGQLEKLP
                     EVSAKAAEKGYSVGDLLQEVMKFAKERQLDEAVGNMARKQLLDWLLANL"
     exon            82..177
                     /gene="Akap4"
                     /inference="alignment:Splign:2.1.0"
     exon            178..225
                     /gene="Akap4"
                     /inference="alignment:Splign:2.1.0"
     exon            226..327
                     /gene="Akap4"
                     /inference="alignment:Splign:2.1.0"
     exon            328..2442
                     /gene="Akap4"
                     /inference="alignment:Splign:2.1.0"
     exon            2443..2786
                     /gene="Akap4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagtcatcg cagcatccaa attctccaaa aaaaatacca tcccaaggtc ccaaatgatt
       61 gcttactgtg gcactacaaa gatgtctgat gacattgact ggttacacag ccgcagaggc
      121 gtgtgcaagg tagatcttta cagcccagaa ggacaacaag atcaggaccg aaaagtgata
      181 tgctttgtgg atgtgtccac cttgaatgtg gaagatgatt ccaagggtgc tgctggtccc
      241 aggtcagacg gcgaattaaa cctggagaat ctggaagaaa aagagattat cgtgatcaag
      301 gacacagaaa aacaagacca gcctaagacg gagggatctg tatgcctttt caaacaagct
      361 ccctctgacc ccataagtgt cctcaactgg ctcctcaatg atctccagaa gtacgccttg
      421 ggtttccaac atgcattaag tccctcagcc tctagctgta aacataaagt aggagaccta
      481 gagggtgatt atcacaaaat tccctcagag aactgctaca gtgtgtatgc tgatcaagta
      541 aacttagatt atttgaacaa aggacctcaa aaccttcgcc tagaaatggc ggcatccaaa
      601 aataccaaca ataaccaaag tccctcaaat cctgcaacta aatctcctag caatcagagg
      661 tcagttgcca ctcctgatgg agaatgttcg atggacgacc tctcctacta tgtcaaccga
      721 ttgtcatctc tagtaatcca aatggcccgt aaggaaatca aggacaaatt ggaaggtgga
      781 aacaaatgcc tccatcattc catgtataca tcaggagaaa aggggaaaac cagcccccgg
      841 agtgctgtca gcaaaattgc ttctgagatg gcccatgaag ctgttgaact gacctcatca
      901 gaaatgcgtg gcaatggaga agaaggcagg gatggccgga aaaccttttt gtatagtgag
      961 ttatctaata agaacaagtg tggagagaag cagcagatgt gcccaaaaga cagcaaagaa
     1021 tttgcagatt ccatcagcaa ggggcttatg gtttatgcaa atcaggtagc atctgacatg
     1081 atggtctctg ttatgaaaac cttgaaagtg cacagctgtg ggaagccaat tccagcttgt
     1141 gtggtcctga agagggtact attaaagcac accaaggaaa ttgtatctga tctgattgac
     1201 tcatgcatga agaacttgca taatataaca ggagtcctga tgacagactc agacttcgtt
     1261 tctgctgtca agaggaatct tttcaatcat ggtaaacaaa atgcagcaga catcatggag
     1321 gccatgctaa agcgtctggt cagtgctctt cttggtgaga agaaggagac taaatctcaa
     1381 agtttggcat atgcaacctt aaaagctgga actcatgacc cgaaatgcaa gaatcagagc
     1441 cttgagttct cagctatgaa agctgaaatg aaaggaaagg acaaaggcaa aactaaagga
     1501 gatccatgct gtaaatcact gacaagtgct gagagagtca gcgaacatat cctcaaagag
     1561 agccttacta tgtggaacaa ccagaagcaa ggaacccaag gcagggtgcc taacaaagta
     1621 tgccctagta aagatgaaaa gagagagaag atcagtcctt ccacagactc actggccaag
     1681 gatctaattg tctctgccct tatgctcatt caataccatc tgacccaaca agcgaagggc
     1741 aaagatccat gtgaagagga gtgccctggt tcctccatgg gctatatgtc gcaaagtgca
     1801 caatatgaaa agagtggagg tggccaaagt tctaaatcac tttcaatgaa gcattttgaa
     1861 tctcgtggag ctcctggacc atctacatgt gcgaaggaaa atcaacttga gtcccagaag
     1921 atggatatgt caaacatggt tctgtccctg attcagaaac ttctgagtga gagccctttc
     1981 agctgtgatg aactatctga aagtgagaat aagcgttgtt gtgattctcg atcaaagcaa
     2041 gcagctcccg tggccaagag acctgaagat caaagccaag acagcacaga aatggacttc
     2101 atcagcggga tgaagcaaat gaaccggcag tttatagacc aactagtaga atcggtgatg
     2161 aaactgtgcc tgatcatggc taagtacagc aacaatggag cagcactagc tgagctagaa
     2221 gagcaagcag ccctagcaag caatggcccc agatgtggcc gtgaggctgt gatgtcacaa
     2281 agttatctgg aaactcctgg ccctgaagtt atcgtcaaca atcagtgctc tacaagcaac
     2341 ttgcagaagc agctgcaggc tgtcctgcaa tggattgcag cgtctcagtt taatgtgccc
     2401 atgctctact tcatgggaga tgatgatgga caactagaga agctccctga agtttcagct
     2461 aaggcagcag agaaaggtta cagtgtagga gatcttcttc aggaggtcat gaagtttgcc
     2521 aaagaacgac aactggatga agccgtgggc aacatggcta gaaagcaact gctggactgg
     2581 cttctcgcta acctgtaagc tgagaattcc tctgactccc tccatccatc ctctccccgg
     2641 cagcaattcc acccagctgg agccaccctc accatcaggc tggtaaactg cacaattgtg
     2701 atcacattta ccaatacatc tgagcagttg aactgtgaaa atacggggtg ccctcctggg
     2761 caacatgaat aaaaaaaatt caaaaa
//
