LOCUS       NM_001005557            2889 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus A-kinase anchoring protein 3 (Akap3), mRNA.
ACCESSION   NM_001005557 XM_232363
VERSION     NM_001005557.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2889)
  AUTHORS   Liu,W., Wu,H., Wang,L., Yang,X., Liu,C., He,X., Li,W., Wang,J.,
            Chen,Y., Wang,H., Gao,Y., Tang,S., Yang,S., Jin,L., Zhang,F. and
            Cao,Y.
  TITLE     Homozygous loss-of-function mutations in FSIP2 cause male
            infertility with asthenoteratospermia
  JOURNAL   J Genet Genomics 46 (1), 53-56 (2019)
   PUBMED   30745215
REFERENCE   2  (bases 1 to 2889)
  AUTHORS   Cui,W., Dai,X., Marcho,C., Han,Z., Zhang,K., Tremblay,K.D. and
            Mager,J.
  TITLE     Towards Functional Annotation of the Preimplantation Transcriptome:
            An RNAi Screen in Mammalian Embryos
  JOURNAL   Sci Rep 6, 37396 (2016)
   PUBMED   27869233
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2889)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   4  (bases 1 to 2889)
  AUTHORS   Carnegie,G.K., Means,C.K. and Scott,J.D.
  TITLE     A-kinase anchoring proteins: from protein complexes to physiology
            and disease
  JOURNAL   IUBMB Life 61 (4), 394-406 (2009)
   PUBMED   19319965
  REMARK    Review article
REFERENCE   5  (bases 1 to 2889)
  AUTHORS   Krisfalusi,M., Miki,K., Magyar,P.L. and O'Brien,D.A.
  TITLE     Multiple glycolytic enzymes are tightly bound to the fibrous sheath
            of mouse spermatozoa
  JOURNAL   Biol Reprod 75 (2), 270-278 (2006)
   PUBMED   16687649
REFERENCE   6  (bases 1 to 2889)
  AUTHORS   Lea,I.A., Widgren,E.E. and O'Rand,M.G.
  TITLE     Association of sperm protein 17 with A-kinase anchoring protein 3
            in flagella
  JOURNAL   Reprod Biol Endocrinol 2, 57 (2004)
   PUBMED   15257753
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2889)
  AUTHORS   Tasken,K. and Aandahl,E.M.
  TITLE     Localized effects of cAMP mediated by distinct routes of protein
            kinase A
  JOURNAL   Physiol Rev 84 (1), 137-167 (2004)
   PUBMED   14715913
  REMARK    Review article
REFERENCE   8  (bases 1 to 2889)
  AUTHORS   Brown,P.R., Miki,K., Harper,D.B. and Eddy,E.M.
  TITLE     A-kinase anchoring protein 4 binding proteins in the fibrous sheath
            of the sperm flagellum
  JOURNAL   Biol Reprod 68 (6), 2241-2248 (2003)
   PUBMED   12606363
REFERENCE   9  (bases 1 to 2889)
  AUTHORS   Carr,D.W., Fujita,A., Stentz,C.L., Liberty,G.A., Olson,G.E. and
            Narumiya,S.
  TITLE     Identification of sperm-specific proteins that interact with
            A-kinase anchoring proteins in a manner similar to the type II
            regulatory subunit of PKA
  JOURNAL   J Biol Chem 276 (20), 17332-17338 (2001)
   PUBMED   11278869
REFERENCE   10 (bases 1 to 2889)
  AUTHORS   Vijayaraghavan,S., Liberty,G.A., Mohan,J., Winfrey,V.P., Olson,G.E.
            and Carr,D.W.
  TITLE     Isolation and molecular characterization of AKAP110, a novel,
            sperm-specific protein kinase A-anchoring protein
  JOURNAL   Mol Endocrinol 13 (5), 705-717 (1999)
   PUBMED   10319321
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC081924.1.
            
            On Oct 8, 2004 this sequence version replaced XM_232363.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081924.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2889
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..2889
                     /gene="Akap3"
                     /note="A-kinase anchoring protein 3"
                     /db_xref="GeneID:312720"
                     /db_xref="RGD:1359735"
     exon            1..91
                     /gene="Akap3"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..2668
                     /gene="Akap3"
                     /note="A kinase (PRKA) anchor protein 3"
                     /codon_start=1
                     /product="A-kinase anchor protein 3"
                     /protein_id="NP_001005557.1"
                     /db_xref="GeneID:312720"
                     /db_xref="RGD:1359735"
                     /translation="MADRVDWLQSQSGVCKVGVYSPGDNQHQDWKMDSSTDPVRVLSW
                     LRKDLEKSTAGFQDSRFKPGESSFGEEVAYPGDQRKGFCVDYYNTTNKGNPGRLHFEM
                     SHKETPPQGLIAHVGNGGSIDEVSFYANRLTNLVIAMARKEINEKIHGTENKCVHQSL
                     YMGDDPTPHKSLSTVASELVNETVSACSKNITGDKAPGSGDRALASSQSPGLRFTSTL
                     KIKESTKEGKCPDNKPGSKKSFFYKEVFESRNAGDAKEGGRSLPGDRKLFRCPDRPDD
                     FSNSISQGIMTYANSVVSDMMVSIMKTLKIQVKDTTIATILLKKVLMKHAKEVVSDLI
                     DSFMKNLHSVTGSLMTDTDFVSAVKRSFFSHGSQKATDIMDAMLGKLYNVMCAKKYPE
                     NIRKARDKSESYSLISMKSRPGDPKLSNLNFAMKSESKLKENLFSACISEKEKTCAET
                     LGEHIIKEGLNMWHKSQQNSPGLERATKQGAVPQEVSFECPDPCEVNPLQQPQPPENF
                     ENFMCESDSWAKDLIVSALLLIQYHLAQGGRMDAQSFLEAAASTNFPTKSSPVVHDEG
                     KVKSPPLKICEQEQTEKKDLMSVIFNFIRNLLSETIFKGSRNCESKAHEQIIKEEEIN
                     LCERPLSPCERPMSPPVPKFCEDEEATGGALSGLTKMVANQLDGCMNGQMVEHLMDSV
                     MKLCLIIAKSCDSPLSELGDEKCGDASRPSSAFPDNLYECLPVKGTGTAEALLQNAYL
                     AIHNELRGLSGQPPEGCEIPKVIVSNHNLADTVQNKQLQAVLQWVAASELNVPILYFA
                     GDDEGIQEKLLQLSATAVEKGRSVGEVLQSVLRYEKERQLDEAVGNVTRLQLLDWLMA
                     NL"
     exon            92..187
                     /gene="Akap3"
                     /inference="alignment:Splign:2.1.0"
     exon            188..2512
                     /gene="Akap3"
                     /inference="alignment:Splign:2.1.0"
     exon            2513..2860
                     /gene="Akap3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttcagctga gtaagaacat cccagcatct tcattgactt taaaagtata ttctggagtc
       61 tcctgtggtt cactattcta gagcttcgga gatggcggat agggttgact ggttacaaag
      121 tcaaagtggc gtttgcaaag ttggtgtcta ttcacctgga gacaaccaac accaagactg
      181 gaaaatggat tcatcaacag atcctgtccg agtgctcagc tggctccgca aagacctgga
      241 gaaaagtaca gcagggttcc aggactcgag gttcaagcct ggagaatcat catttgggga
      301 ggaagtggct tacccaggag accaacgaaa aggtttctgc gttgattatt acaataccac
      361 caacaagggc aatccaggga gattgcattt tgagatgtct cacaaggaga cccctcccca
      421 gggcctcatt gcccatgttg gtaatggggg ttccatagac gaagtttcct tctacgccaa
      481 ccgcctcaca aacctagtga tcgccatggc ccgaaaagag atcaatgaga agattcatgg
      541 tactgaaaac aaatgtgtcc accagtcatt gtatatgggg gatgatccca caccccacaa
      601 aagcttgagt acagtagctt ctgagctcgt gaatgagaca gtcagtgcat gttccaagaa
      661 tattaccggt gacaaagctc ccggctctgg agacagggcc ttggcgtctt cacagagccc
      721 tggtctaaga ttcacaagca ctctgaagat caaggagagc acgaaggaag gcaagtgtcc
      781 tgacaacaag cctggttcta agaagtcctt cttctacaag gaagtgtttg agtctcggaa
      841 tgcaggagat gccaaggagg gtgggaggtc cttacctgga gatagaaaac tgttcaggtg
      901 cccggacagg cctgacgact tttccaactc tatcagtcaa gggatcatga cctatgccaa
      961 cagtgtggtg tctgacatga tggtgtccat catgaagaca ctgaagatcc aggtaaaaga
     1021 cacaaccatc gccactattc tgctgaagaa ggtgttgatg aagcatgcaa aagaggttgt
     1081 ctccgatctc atcgactcct tcatgaagaa cctccacagt gtcacaggga gtctcatgac
     1141 tgacacagac ttcgtctcag ctgtgaagcg aagttttttt tctcatggaa gccaaaaggc
     1201 tacagatatc atggatgcca tgctgggcaa gctatacaat gtgatgtgtg ccaagaaata
     1261 tcctgagaac atcaggaaag ccagggacaa gtccgagagt tactccctta tctccatgaa
     1321 atcacgacct ggtgacccaa agctctcaaa cttgaacttt gcgatgaaat cagaatcaaa
     1381 actgaaagaa aatttgtttt ctgcatgcat atcagagaaa gagaagacat gcgctgaaac
     1441 tctgggtgag cacatcatta aggagggact gaacatgtgg cacaagagtc agcaaaattc
     1501 tcctggcttg gagcgtgcca caaaacaggg cgccgttcca caggaggtct cctttgagtg
     1561 tccggatcct tgtgaggtaa accctcttca gcaacctcag ccaccagaga actttgaaaa
     1621 ttttatgtgt gaatcagact cctgggccaa ggacctgatt gtatctgccc tgcttctgat
     1681 tcagtaccac ctggcacagg gaggaaggat ggatgctcag agcttcctgg aagccgccgc
     1741 cagcaccaat tttcccacca agtcctctcc tgtagttcat gatgagggca aagttaagtc
     1801 tcctcccctt aagatatgtg agcaggaaca aacagaaaag aaagatctga tgagtgtcat
     1861 cttcaatttt atccggaact tactcagtga gaccatattc aagggtagcc gtaattgtga
     1921 gtccaaggct cacgagcaga tcattaagga agaagagatc aacctatgtg aaaggcctct
     1981 gtctccatgt gaaaggccta tgtccccacc tgtcccgaaa ttctgtgagg atgaggaggc
     2041 cactggtggt gccttatctg ggctaaccaa gatggtcgcc aaccagctag atggctgtat
     2101 gaatgggcag atggtggagc atctgatgga ctcggtgatg aagttatgcc tcattatcgc
     2161 caagtcctgt gactcgccct tgtcagagct gggagacgaa aagtgtgggg atgccagccg
     2221 gccgagttct gccttcccag ataacttata tgagtgctta ccagtcaagg gcacggggac
     2281 agccgaagcc ctcctgcaga acgcctatct agccatccac aacgaactga gaggtttgtc
     2341 aggacagcca cccgagggct gtgaaatccc caaggtgatc gtcagcaacc acaatctggc
     2401 tgacactgtc cagaacaagc agctgcaagc tgtccttcag tgggtggctg cctcagagct
     2461 caatgtccct attttgtact tcgctggtga cgatgaagga atccaggaga agctgcttca
     2521 gctctcagcc actgctgtgg agaaaggccg aagcgtcggg gaggttctgc agtcggtgct
     2581 taggtatgag aaggagcgac agctggatga ggcagtggga aatgtcacgc ggctgcagct
     2641 gctggactgg ctgatggcaa acctgtgatt ggggcccacc cggtgttcct gcagtgggcc
     2701 gagtccctgc cctctcagcc cctccctgcc gcacagagcc ctaaagttcc ctccatacca
     2761 cccacactag acacgccatc taatgctact cactggattt tgcagatttt cttgtccatg
     2821 cgagcaagga cataaattaa aagattacag ttaaagggca aaaaaaaaaa aaaaaaaaaa
     2881 aaaaaaaaa
//
