LOCUS       NM_001309260            6892 bp    mRNA    linear   ROD 09-APR-2024
DEFINITION  Rattus norvegicus paralemmin A kinase anchor protein (Pakap),
            transcript variant 1, mRNA.
ACCESSION   NM_001309260 XM_006238184
VERSION     NM_001309260.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6892)
  AUTHORS   Carnegie,G.K., Means,C.K. and Scott,J.D.
  TITLE     A-kinase anchoring proteins: from protein complexes to physiology
            and disease
  JOURNAL   IUBMB Life 61 (4), 394-406 (2009)
   PUBMED   19319965
  REMARK    Review article
REFERENCE   2  (bases 1 to 6892)
  AUTHORS   Kinderman,F.S., Kim,C., von Daake,S., Ma,Y., Pham,B.Q.,
            Spraggon,G., Xuong,N.H., Jennings,P.A. and Taylor,S.S.
  TITLE     A dynamic mechanism for AKAP binding to RII isoforms of
            cAMP-dependent protein kinase
  JOURNAL   Mol Cell 24 (3), 397-408 (2006)
   PUBMED   17081990
REFERENCE   3  (bases 1 to 6892)
  AUTHORS   Tasken,K. and Aandahl,E.M.
  TITLE     Localized effects of cAMP mediated by distinct routes of protein
            kinase A
  JOURNAL   Physiol Rev 84 (1), 137-167 (2004)
   PUBMED   14715913
  REMARK    Review article
REFERENCE   4  (bases 1 to 6892)
  AUTHORS   Dong,F., Feldmesser,M., Casadevall,A. and Rubin,C.S.
  TITLE     Molecular characterization of a cDNA that encodes six isoforms of a
            novel murine A kinase anchor protein
  JOURNAL   J Biol Chem 273 (11), 6533-6541 (1998)
   PUBMED   9497389
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On May 28, 2015 this sequence version replaced XM_006238184.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments and orthologous data.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643296.15284.1,
                                           SRR26643295.21425.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-84                JAXUCZ010000005.1  77399956-77400039
            85-2530             JAXUCZ010000005.1  77412249-77414694
            2531-2709           JAXUCZ010000005.1  77429958-77430136
            2710-2748           JAXUCZ010000005.1  77433134-77433172
            2749-6892           JAXUCZ010000005.1  77439513-77443656
FEATURES             Location/Qualifiers
     source          1..6892
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q24"
     gene            1..6892
                     /gene="Pakap"
                     /gene_synonym="AKAP-2; Akap2; Palm2"
                     /note="paralemmin A kinase anchor protein"
                     /db_xref="GeneID:298024"
                     /db_xref="RGD:1305135"
     exon            1..84
                     /gene="Pakap"
                     /gene_synonym="AKAP-2; Akap2; Palm2"
                     /inference="alignment:Splign:2.1.0"
     exon            85..2530
                     /gene="Pakap"
                     /gene_synonym="AKAP-2; Akap2; Palm2"
                     /inference="alignment:Splign:2.1.0"
     CDS             196..2847
                     /gene="Pakap"
                     /gene_synonym="AKAP-2; Akap2; Palm2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     A-kinase anchor protein 2; A kinase (PRKA) anchor protein
                     2; paralemmin 2; paralemmin-2-like; A-kinase anchoring
                     protein 2"
                     /codon_start=1
                     /product="A-kinase anchor protein 2 isoform 1"
                     /protein_id="NP_001296189.1"
                     /db_xref="GeneID:298024"
                     /db_xref="RGD:1305135"
                     /translation="MEIGVSVAECKSVPGITSTPHSKDHSSPFYSPSHNGLLTDHHES
                     LDNDVAREIQYLDEVLEANCCDSSVDGTYNGISSPEPGAAILVSSLGSPAHSATKVEP
                     IEKASGRQLPPHIELSRSPSDSMAEGERANGHSTDQPQDMLGNSLQAPASPSSSTSSH
                     CSSRDGEFTLTTLKKEAKFELRAFHEDKKPSKLFEEDEHEKEQFCIRKVRPSEEMIEL
                     EKERRELIRSQAVKKNPGIAAKWWNPPQEKTIEEQLDEEHLESHRKYKERKEKRAQQE
                     QLQLQQQQQQQLQQLQQLQQQQQQQLSTSQLCTAPAAHEHLDSIEHTKEDVVTEQIDF
                     SAARKQFQQMENSRQTLAKGQSTPRLFSIKPFYKPLGSINSDKPPTILRPATIGGTVE
                     DSSTQAAKEQKALCVSESQSAGAGTGNAATQGKEGPYSEPSKRGPLSKLWAEDGEFTS
                     ARAVLTVVKDEDHGILDQFSRSVNVSLTQEELDSGLDELSVRSQDTTVLETLSNDFSM
                     DNISDSGASNETPNALQENSLADFSLPQTPQTDNPSEGREGVSKSFSDHGFYSPSSTL
                     GDSPSVDDPLEYQAGLLVQNAIQQAIAEQVDKAEVHTSKEGSEQQEPGAMVEEAGSQA
                     PGSEKPQGMFAPPQVSSPVQEKRDVLPKILPGEDKTLREKGPSQPPTAVQPSGPVNMK
                     ETRPEGGYFSKYSEAAELRSTASLLATQESDVMVGPFKLRSRKQRTLSMIEEEIRAAQ
                     EREEELKRQRQVRQSTPSPRAQNAPSLPSRTTCYKTAPGKIEKVKPPPSPTTEGPSLQ
                     PDLAPEEAAGAQRPKNLMQTLMEDYETHKSKRRERMDDSSYTSKLLSCKVTSEVLEAT
                     RVNRRKSALALRWEAGIYANQEEEDNE"
     exon            2531..2709
                     /gene="Pakap"
                     /gene_synonym="AKAP-2; Akap2; Palm2"
                     /inference="alignment:Splign:2.1.0"
     exon            2710..2748
                     /gene="Pakap"
                     /gene_synonym="AKAP-2; Akap2; Palm2"
                     /inference="alignment:Splign:2.1.0"
     exon            2749..6892
                     /gene="Pakap"
                     /gene_synonym="AKAP-2; Akap2; Palm2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgaacgctgg aatctgtctg gagaaagagg cgattctgac tgcggactcc gaggtgcgcg
       61 cactgggctt tttctctggg caggaaaagc ccccagcttt ctgacgatgc taaccagctg
      121 agaaacaagc aagacaactg tggtgacagt cgcctggagc ctgccgccag ctctctctcc
      181 ccagatcaca aaaacatgga aattggggtg tccgtggcag aatgtaaaag tgtacctgga
      241 atcacctcta ccccccattc caaggaccac tcctcccctt tctattctcc ctcacacaat
      301 ggcctcctca ctgatcacca cgagtcttta gataatgatg tcgccagaga gatccaatac
      361 ctagatgagg tgctggaggc caactgctgc gattcctccg tggatggaac ttacaacggg
      421 atctcttccc cagagcctgg tgcagccata ctggtaagca gccttggctc acctgcccac
      481 tcagccacca aggtagaacc cattgagaaa gcatctggta ggcagctgcc tcctcacatc
      541 gaactcagta gaagcccttc tgacagcatg gctgaaggag aaagagccaa tggacactcc
      601 actgaccagc ctcaagacat gctggggaat agcctgcagg ctcctgccag ccccagttcc
      661 tctaccagct cccactgctc ctcccgagat ggagagttca cactcaccac actgaagaag
      721 gaggccaagt ttgagctgcg tgccttccac gaggacaaga agccctccaa gctctttgag
      781 gaggacgagc acgagaagga gcagttctgc atccggaaag tgaggccctc tgaggagatg
      841 atagagctgg agaaggagcg gagggaactc attcggagtc aggctgtgaa gaagaatcct
      901 ggcatcgcgg ccaagtggtg gaatcctccc caggaaaaaa ctattgagga acagctggat
      961 gaggaacatc tggagtcaca cagaaagtac aaggagcgca aagagaaaag ggcacagcag
     1021 gaacagctac agttacagca acagcagcag cagcagctac aacagttgca acagttgcag
     1081 cagcagcaac agcagcagct gtccacctct cagctctgca cagccccagc tgctcatgaa
     1141 cacctagata gcattgaaca cacaaaggag gatgtcgtca ctgagcagat tgatttctca
     1201 gctgcacgca agcagttcca gcagatggag aattccaggc aaacactggc caagggccag
     1261 agcacaccta ggctgttctc catcaagcct ttctacaaac ctcttggatc catcaactcg
     1321 gacaagccac cgaccatctt gcgaccagct actatcgggg gaactgtgga agacagcagc
     1381 acacaggcag ccaaagagca gaaagctctc tgtgtatctg agagccagtc tgcaggagca
     1441 ggaacaggta atgctgccac tcagggaaag gaagggccat acagtgagcc ttccaaacgc
     1501 gggcccttat ccaaactgtg ggcagaggat ggagagttca caagtgcccg ggccgtcctt
     1561 actgtagtca aagatgaaga tcatgggatt ttggaccagt tttcaagatc ggtcaatgta
     1621 tctttgaccc aggaggagct ggactcaggt ttggatgagt tgtcagtaag gtcccaggac
     1681 accactgtcc tggagacttt gtccaatgac ttcagcatgg acaacataag tgacagtgga
     1741 gcttctaatg agacacccaa tgcccttcag gaaaactctc tggctgattt ctccctgcct
     1801 cagactcccc aaacagacaa cccctcagag ggccgagaag gcgtctccaa gtccttcagt
     1861 gaccatggtt tctattctcc ttcctccaca ctgggagatt ccccatccgt tgatgacccc
     1921 ttggaatatc aggctgggct cctggtgcag aatgccattc aacaagccat agccgagcag
     1981 gtggataagg ctgaggtgca caccagcaaa gagggatcag aacagcagga acctggagca
     2041 atggtagagg aagctggaag ccaggctcct ggctctgaga agccccaggg catgtttgca
     2101 ccacctcagg tgtcctctcc cgttcaagag aaaagggatg tattaccaaa gatcctcccc
     2161 ggggaggaca agacactcag ggaaaaggga ccctcccagc cacccacagc tgtgcagccc
     2221 agcggtccag tcaacatgaa agagaccagg cctgaaggag ggtacttcag caaatactca
     2281 gaggcagccg agctgagaag cacagcctcc cttctggcta ctcaagagtc tgatgtcatg
     2341 gttgggccct tcaaactgag gtcaaggaag cagcggactt tgtccatgat tgaagaagag
     2401 atccgggcag cccaggaaag ggaagaggag ctaaagcggc aaagacaagt gaggcaaagc
     2461 accccaagcc ccagggctca gaacgcccca tcgctgcctt ccagaaccac ctgctacaaa
     2521 actgctccag ggaaaataga gaaagtcaaa cctcctccat cccccacaac tgaaggtccc
     2581 agcttgcagc ctgacttagc ccctgaagag gctgccggag cccagcggcc caagaacctg
     2641 atgcagaccc tcatggaaga ctatgagaca cacaaatcta aaaggcgcga gagaatggat
     2701 gatagtagtt acacctctaa gttactgtct tgcaaggtga cttccgaggt cctggaggcc
     2761 actcgggtta atcgaaggaa gagtgctctg gccttgcgct gggaggcagg gatttatgcc
     2821 aaccaggagg aggaggacaa tgaataaact tccttcagcc caggaaactc cttggccaaa
     2881 gagtttccgc aaagaaacca agaaattatt gaatcagacg cattttaata gactacttat
     2941 taaagtgcat acaaactcaa taaccctcat gtagaccaga agctgcaata cacaatgata
     3001 ataaaacaaa acgaaacaca aaaaagcaaa gcgaagcgaa caggaagttc acccatcaaa
     3061 ctctgagacg gggcagagga gaaagggtgt ctttgtgact caaagaaagc cttggctttg
     3121 gaccattcca caactgatcc aaagggacac agacgggaca agcaagtcca cgtagttgct
     3181 gcaggcagaa ctgaagccag cctcggctgg gcgttacgga ggagcaaaca ggccattcca
     3241 aggcaaccaa caggccccag cctggtgcag cctacagcac acaggctacc cctccaccag
     3301 cttcccaccc ctttctccgt caaggcatca gaagtgttgg gttgactcca ttttctccag
     3361 cagccataaa aacaaatggt gttcctttcc atagttgccc caaaaggagg caacaaggat
     3421 tcgatctctc ttatatgtaa tcatttgaaa ttgggagcac ctaatggtca caatatatat
     3481 aaagtctgta tttttaaggc aatatctctt cacgttgcag acgcaatcta tcctacagca
     3541 ggaggttgag gacggtgggg gagagagcca aaccaaaagg gttattagct ttaggacctt
     3601 gtctgctttt atcgttgact gatcagttta gggaaacaca ctttcacggt tacgtttctt
     3661 catatgaaaa gtatatttag tgagcaatga ctatttttat gatgggatgg gggaacaggg
     3721 acacgggata aaacctgtac acatttgaac ggcttggttc aagatggtag gggtattttt
     3781 agaatggcaa taattgaaaa taaaaggggg cagactctgc cttcaggaag gtagatgacc
     3841 agaaataagg tgtttgtaac tattttctat tttaaagtgg gccttagagg tggctgtggc
     3901 ataggatgag ctgttttgga tctgagaaag gcaaccttaa acgcatggag ataggaagag
     3961 aaaggggcga gagagacaaa gaatgggaaa ggaaggaagg aagggagatt atttttgctg
     4021 aacaaccagt gttttccagg acgacagaga gaaaaatata gcatagaaat ttaagtacac
     4081 atgtggaatc agctacaaat cctaaagatg gtgtgtatgc ctttgtgtgc ttgtataagg
     4141 catgtatgtt ggtgagtaaa tatatgccag cgtggggtgt gtgtgtgtgt gtgtgtgtgt
     4201 gtgtgtgtgt ggtgtgttga ccgtgacaca tgggtgtaca gtatttcctc tgtagctgcc
     4261 tgtcgacttc aggagtgagt gacagttttc tttttttatg aaaaggcaca gggaagacac
     4321 agggctgatg cagtattcct gatgtcaagc tgactgaact atggcatttg catgagtgac
     4381 agtcgtgaag tttccagcag ttttgtattg ataatttgac atttagtaca caccctattt
     4441 attctcatgc tttctgtccg tgcctcgtgt accacagagg acaccggctt cattctttct
     4501 gtcatttcaa gcaatatgat aaggacgttc actaatcggg tgccctgagt ttctgaatga
     4561 gaaaatgttt catttctggc caggaagggg aggtgggagg agggggagaa ggcatggaag
     4621 gggaaggagg aagaaaaaga agaactaacc agccttcatt atttttcctt tatttttaag
     4681 ctatttctta caagcaataa ttaaatcata ccttgctaaa attcattttt gtttttatgt
     4741 tattatgtta taagatctaa tatgttattc taatgagtag cgactccaca atacttatat
     4801 gcacactcca cacactatct tggctttttt gttttgtttt gttttgtttt ctttaaatta
     4861 ggctagtgtg actttaggga aaagcttact cactagtaag tagtgggcac aggtaaaaag
     4921 atggagttgt ctcatggctt atagggatgc ttaaaaacta ccaagggaac gtgtaactcc
     4981 aagacagatt ctgcagtcgc tagccaaaat cgtacgccgg aagtgcgcgc cgtctttaga
     5041 tggttcattc ttttagacat aatgttatta aaaatgctag ccactgagga cagaaagcaa
     5101 aggcagagaa ctgtgctgca aggaatttgc tcttcagtaa gggaggtggg cccagaagca
     5161 aatgttccgg aacagaacgt gacatccatg ccagattaga agtcctgcta ggtagatggg
     5221 cacacgggag aagggccatt tttgtcgaag gacttcccgc cggaggctgt ttacacggtg
     5281 agatgaaggc tccttcctta gggacacaca ggaatcagga ctcgtggggg gcggggagga
     5341 gaggggtagc tgcagtgtcc tgggacctcc gccccactct ggagagcagg gtagtactgt
     5401 gagtgctaca gaaagcaagc tccttcatga tttctggtat gtgctagcga ctgtggaagc
     5461 atcacagacc aactcgccca tttttcacaa agggaaaccg tccccttggc ttccttaaat
     5521 ttcttgtcct gtttagaagg gaaatgtgga ccctcgtgga gggtacactg aggaaagact
     5581 tggcagccag agcccacgca ctccttggag ttccttcggt agcagatgaa gtggtctttt
     5641 gactgcagta gattggatag gaagttcgaa cgctgaggga ttaggcttgt ctgtaggtga
     5701 ggagacacaa gtctcttcct gcttacaggg cttttatcac tggcctctcc atttccaagt
     5761 tttgctggtt tccctgagct gcctctaaag actgccatct gtttccttgc tcccctcgat
     5821 gacagttcta gtgtattttg ttaggataga aaccgcatct ccatcagaga gaggtatttt
     5881 ttgttctgtg ttctttgggg tatttttttt tatttggggt gggtggggtg atttattcgt
     5941 tttctcattc aggaaacatt tgagccattg ctttggacat atcactgtgc taggctctag
     6001 gatcccacgt gggcccctgt caccttccca gtatggagca gatccctgga ggaaaagtct
     6061 tttctgcccc ataagcctga gatgaagagg ctcctggtta cttttgcctc ggatgctcgg
     6121 ctctaccctg caccagtaca caagcttgtt agtctcagct gtaagaaatg tttagcttct
     6181 gtagatgtta aaaaccttcc tgaaggaatt ccacactgca gtgtttatac tcgcacttcc
     6241 ctccagagcc tatgacttga cagccttggc tttctcatct agaaatgagg gatgcagggt
     6301 ctgtcatctg tggcagaggc tgggcggcac ttggatgaca tagtgcatgt cccttcctct
     6361 tacccatgca tgctgcccac cctaggcaat ggcatagaag cagtatatag atcagtgtcc
     6421 acacacacac acacacatac acacacacac acacacacaa acaaggaaca ccaaaacagt
     6481 gttgattgtt gtgtttaaag acatgttttt ttttcacctg aagaatggac ttaaactatg
     6541 tattgaaaaa aaaatagcct aagtgttaga aatggtgaat gtatccagtt tcagttacaa
     6601 aaacgatttc ctgaatttta agcattcagt gagctgccaa ttttgatttt gtgttgctct
     6661 ttatccaaat ggctttttct tttcttcttt cttcttttta taaattggag gaagtggggg
     6721 tggggcgggg agcagcaata ttgtgtttga caaattatac tctgtacctg gctttcctgt
     6781 gttctgttaa ccaccgagat gtttctattc cgttttggtt ttatagtgtc tgtgaggcac
     6841 tcgatgcaac catacagtta ttttctcatt aaaactcagc gtgtgcagtg tt
//
