LOCUS       NM_001106271           12437 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus A-kinase anchoring protein 13 (Akap13), mRNA.
ACCESSION   NM_001106271 XM_001063231 XM_214969
VERSION     NM_001106271.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 12437)
  AUTHORS   Koide,H., Holmbeck,K., Lui,J.C., Guo,X.C., Driggers,P., Chu,T.,
            Tatsuno,I., Quaglieri,C., Kino,T., Baron,J., Young,M.F., Robey,P.G.
            and Segars,J.H.
  TITLE     Mice Deficient in AKAP13 (BRX) Are Osteoporotic and Have Impaired
            Osteogenesis
  JOURNAL   J Bone Miner Res 30 (10), 1887-1895 (2015)
   PUBMED   25892096
REFERENCE   2  (bases 1 to 12437)
  AUTHORS   Abdul Azeez,K.R., Knapp,S., Fernandes,J.M., Klussmann,E. and
            Elkins,J.M.
  TITLE     The crystal structure of the RhoA-AKAP-Lbc DH-PH domain complex
  JOURNAL   Biochem J 464 (2), 231-239 (2014)
   PUBMED   25186459
REFERENCE   3  (bases 1 to 12437)
  AUTHORS   Cavin,S., Maric,D. and Diviani,D.
  TITLE     A-kinase anchoring protein-Lbc promotes pro-fibrotic signaling in
            cardiac fibroblasts
  JOURNAL   Biochim Biophys Acta 1843 (2), 335-345 (2014)
   PUBMED   24269843
  REMARK    GeneRIF: These findings identify AKAP-Lbc as a key Rho-guanine
            nucleotide exchange factor modulating profibrotic responses in
            cardiac fibroblasts.
REFERENCE   4  (bases 1 to 12437)
  AUTHORS   Perez Lopez,I., Cariolato,L., Maric,D., Gillet,L., Abriel,H. and
            Diviani,D.
  TITLE     A-kinase anchoring protein Lbc coordinates a p38 activating
            signaling complex controlling compensatory cardiac hypertrophy
  JOURNAL   Mol Cell Biol 33 (15), 2903-2917 (2013)
   PUBMED   23716597
  REMARK    Erratum:[Mol Cell Biol. 2013 Sep;33(18):3724]
REFERENCE   5  (bases 1 to 12437)
  AUTHORS   del Vescovo,C.D., Cotecchia,S. and Diviani,D.
  TITLE     A-kinase-anchoring protein-Lbc anchors IkappaB kinase beta to
            support interleukin-6-mediated cardiomyocyte hypertrophy
  JOURNAL   Mol Cell Biol 33 (1), 14-27 (2013)
   PUBMED   23090968
  REMARK    GeneRIF: activation of IKKbeta within the AKAP-Lbc complex promotes
            NF-kappaB-dependent production of interleukin-6, which in turn
            enhances fetal gene expression and cardiomyocyte growth.
REFERENCE   6  (bases 1 to 12437)
  AUTHORS   Kino,T., Souvatzoglou,E., Charmandari,E., Ichijo,T., Driggers,P.,
            Mayers,C., Alatsatianos,A., Manoli,I., Westphal,H., Chrousos,G.P.
            and Segars,J.H.
  TITLE     Rho family Guanine nucleotide exchange factor Brx couples
            extracellular signals to the glucocorticoid signaling system
  JOURNAL   J Biol Chem 281 (14), 9118-9126 (2006)
   PUBMED   16469733
REFERENCE   7  (bases 1 to 12437)
  AUTHORS   Tasken,K. and Aandahl,E.M.
  TITLE     Localized effects of cAMP mediated by distinct routes of protein
            kinase A
  JOURNAL   Physiol Rev 84 (1), 137-167 (2004)
   PUBMED   14715913
  REMARK    Review article
REFERENCE   8  (bases 1 to 12437)
  AUTHORS   Diviani,D., Soderling,J. and Scott,J.D.
  TITLE     AKAP-Lbc anchors protein kinase A and nucleates Galpha 12-selective
            Rho-mediated stress fiber formation
  JOURNAL   J Biol Chem 276 (47), 44247-44257 (2001)
   PUBMED   11546812
REFERENCE   9  (bases 1 to 12437)
  AUTHORS   Klussmann,E., Edemir,B., Pepperle,B., Tamma,G., Henn,V.,
            Klauschenz,E., Hundsrucker,C., Maric,K. and Rosenthal,W.
  TITLE     Ht31: the first protein kinase A anchoring protein to integrate
            protein kinase A and Rho signaling
  JOURNAL   FEBS Lett 507 (3), 264-268 (2001)
   PUBMED   11696353
REFERENCE   10 (bases 1 to 12437)
  AUTHORS   Tsuchiya,T., Ochiai,H., Imajoh-Ohmi,S., Ueda,M., Suda,T.,
            Nakamura,M. and Kanegasaki,S.
  TITLE     In vitro reconstitution of an erythropoietin gene transcription
            system using its 5'-flanking sequence and a nuclear extract from
            anemic kidney
  JOURNAL   Biochem Biophys Res Commun 182 (1), 137-143 (1992)
   PUBMED   1731775
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Jun 4, 2021 this sequence version replaced NM_001106271.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA5760383, SAMEA5760386
                              [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on computational evidence
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-105               JAXUCZ010000001.1  138724150-138724254
            106-149             JAXUCZ010000001.1  138799761-138799804
            150-297             JAXUCZ010000001.1  138827559-138827706
            298-594             JAXUCZ010000001.1  138847009-138847305
            595-778             JAXUCZ010000001.1  138862611-138862794
            779-971             JAXUCZ010000001.1  138881162-138881354
            972-4032            JAXUCZ010000001.1  138887186-138890246
            4033-4160           JAXUCZ010000001.1  138893649-138893776
            4161-4236           JAXUCZ010000001.1  138942177-138942252
            4237-4373           JAXUCZ010000001.1  138945201-138945337
            4374-4744           JAXUCZ010000001.1  138953654-138954024
            4745-4798           JAXUCZ010000001.1  138956402-138956455
            4799-4864           JAXUCZ010000001.1  138959445-138959510
            4865-5060           JAXUCZ010000001.1  138961250-138961445
            5061-5169           JAXUCZ010000001.1  138963497-138963605
            5170-5212           JAXUCZ010000001.1  138969782-138969824
            5213-5345           JAXUCZ010000001.1  138971400-138971532
            5346-5466           JAXUCZ010000001.1  138978464-138978584
            5467-5534           JAXUCZ010000001.1  138992110-138992177
            5535-5601           JAXUCZ010000001.1  138994440-138994506
            5602-5737           JAXUCZ010000001.1  138998377-138998512
            5738-5850           JAXUCZ010000001.1  138999801-138999913
            5851-6003           JAXUCZ010000001.1  139000453-139000605
            6004-6254           JAXUCZ010000001.1  139001248-139001498
            6255-6380           JAXUCZ010000001.1  139003226-139003351
            6381-6498           JAXUCZ010000001.1  139003465-139003582
            6499-6747           JAXUCZ010000001.1  139004654-139004902
            6748-6779           JAXUCZ010000001.1  139010327-139010358
            6780-6961           JAXUCZ010000001.1  139010879-139011060
            6962-7044           JAXUCZ010000001.1  139011202-139011284
            7045-7239           JAXUCZ010000001.1  139013913-139014107
            7240-7401           JAXUCZ010000001.1  139017735-139017896
            7402-7472           JAXUCZ010000001.1  139018667-139018737
            7473-7517           JAXUCZ010000001.1  139019202-139019246
            7518-7568           JAXUCZ010000001.1  139022052-139022102
            7569-8018           JAXUCZ010000001.1  139022794-139023243
            8019-8349           JAXUCZ010000001.1  139024232-139024562
            8350-12437          JAXUCZ010000001.1  139025314-139029401
FEATURES             Location/Qualifiers
     source          1..12437
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q31"
     gene            1..12437
                     /gene="Akap13"
                     /gene_synonym="AKAP-13; AKAP-Lbc"
                     /note="A-kinase anchoring protein 13"
                     /db_xref="GeneID:293024"
                     /db_xref="RGD:727893"
     exon            1..105
                     /gene="Akap13"
                     /gene_synonym="AKAP-13; AKAP-Lbc"
                     /inference="alignment:Splign:2.1.0"
     exon            106..149
                     /gene="Akap13"
                     /gene_synonym="AKAP-13; AKAP-Lbc"
                     /inference="alignment:Splign:2.1.0"
     CDS             117..8399
                     /gene="Akap13"
                     /gene_synonym="AKAP-13; AKAP-Lbc"
                     /note="protein kinase A anchoring protein Rt31; A kinase
                     (PRKA) anchor protein 13"
                     /codon_start=1
                     /product="A-kinase anchor protein 13"
                     /protein_id="NP_001099741.2"
                     /db_xref="GeneID:293024"
                     /db_xref="RGD:727893"
                     /translation="MKLSPQQAPLYGDCVVTVLLAEEDKVEDDAIFYLIFSGSTLYHC
                     TSTRKVSSDTLETIAPGHDCCETVKVLLCASKEGLPVFVVAEEDFHFVQDEAYDAAQF
                     LATSAGNQQALNFTRFLDRSGPPSGDVNSLDEKVALAFRHLKLPAEWNVLGTDHTLHD
                     GGPRETLMHFAVRLGLLRLTWFLLQKPGGRGALSIHNKEGATPVSLALERGYHKLHQL
                     LTEENAGEPDSWSSLSYEIPYGDYSVRHHRELDIYTLTSESESHCEPHGDSCTGHISK
                     LMNIQQQLMKTNLKQMDNLMPLMVTTQDSSCVPCVPEPSDHQQLPFEETKSTVCCQGS
                     PGRKDASPCDLSSVVEEENLICSHKKNKDTGRPGEGVEPASAVDSRSASHQDSCLQSI
                     PDCGVKGREGLPSCGNRNEVTGTQYSGVATCQQPLSSESSVPQDVLVTEPDARQHSSG
                     RELPDSSSTDAGAPEKAGELEHSLLTPDATTQNSKPQVGESAKERLENSDISSAEATA
                     VQALREPKQKADVTNHVFAARAAGADAPAEASPAWSPEEIPTGKPGMETQERGCEGGI
                     TSDQSSQVLPAAAAATENKVLDGLELETLPACPCETASSLDLTVSGPRPDGMPKQNSE
                     SSAQHAQSLNSQAPLCSIAGAGTPSAESACPQSTETSSGGSVIEHGSGEASLPESTAA
                     QPEPQGLCTAPCPEDPQADTVTSDTAAHNQKSVGSCHLCALDAKNQEKDLRQDTPSVN
                     TLEDVPHLPSVVPQSEEKLEPDQVSPRGSSFSLASSPESESVTKDDVLSLVSSQKEKG
                     TATPQLHRAPACSDGPDGRDLNDTDKVGDGAASPPTPSAVELQTSMGNTSPVGVGEQE
                     GSSLTATLEVLSDSLLQSVDKAALVSDSLLPEEGGSIVVPESSTALGQGGKDKATKCP
                     SVKEDVHSSEMSREDQRTPPPGQEISRLCEKPMSALCAGEKALQHSNSPDTPSACLQT
                     ETKHNKEVAPQSSPLMKGGAVQNLVPPKTSLSADSEQKTSSTEQSGSSLLPGGASEAL
                     RCSQPSLSVSVESIQFQGKTSACKVSRNAMEDVTVADAFLATAEPTKEDALHHVKDIS
                     DLLNQEKKTTPGLPEALLDKGVTDLQEVITPEIEPLDCKREKLEGTDLSCPTSKSKET
                     PNNEETTQPPARDLPTETGLSAINDNGPQADMKHVTQASVPGEESNVTTVLGMVSTQA
                     ADGPPGADSIEETATRIVEAVIKQIKASNTLRTQVEIQNPPLSSSEIKEIENTGSESA
                     RVFLPGEPLQMENTQKETTGHCSVETEAPEKIILAVHRPEPAPEMPDTKTGGEVDLLS
                     KRSAASEEEAIGNGAATPKMKQAPGTQVINRESWCAIEPCPEAASLLASKQSSECRSF
                     IDVGLGTECATKEGVLQRESGSDSDLFHSPSDEMDSIIFSKPEEEQLLCDTTGSSSST
                     DDTASLDRHSSHGSDVSLPQTSKLNRSRNHQSSNGFFSHGVDPESREGESEPAGSGEM
                     EEEEMDSITEVPANRSFLRNSMRSLSPFRRHSWGPGKNAASDAEMNQRSSMQVLGHVV
                     RRPPIHRRSMSWCPSGVQYSAALNADFNIRSFSLEGLTGGGGVGNKPSSSLEISSANS
                     SELRNPFSGEEQRSSLMSLSEEHLEPDQRQHHRMFDQQTCYRSKQQGFNYCTSAISSP
                     LTKSISLMTISHPGLDNSRPFHSASANLTESITEENCNFLPPSPSKKSFEEKSGTKVS
                     RTFSYIRNKMSSSKKSKKEKDKKTLNGHTFSPIPIVGPINCSQCMKPFTNKDAYTCAS
                     CGAFVHKGCRENLASCAKVKMKQPKGSLQAHDTSSLPTVIMRNKSSQPKERPRSAVLL
                     AEEAIAAPMFTNRRSQQSVSLSKSVSIQNITGVGNDENMSNTWKFLSHSTDSLNKICK
                     VNESTESLTDEGVGTDMNEGQLMGDFESDSKQLEAESWSRTVDSKFLKQQKKDVVKRQ
                     EVIYELMQTELHHIRTLKIMSDVYSRGMMTDLLFEQQMVEKLFPCLDELISIHSQFFQ
                     RILERKKESLVDKSEKNFLIKRIGDVLVSQFSGENAERLKKTYGKFCGQHNQSVNYFK
                     DLYTKDKRFQAFVKKKMSSSVVRRLGIPECILLVTQRITKYPVLFQRILQCTKDNEVE
                     QEDLTQSLSLVKDVIGAVDSKVASYEKKVRLGEIYTKTDSKSIMRMKSGQMFAKEDLR
                     RKKLVRDGSVFLKSATGRLKEKDQKYVFASLDHKSTVISLKKLIVREVAHEEKGLFLI
                     SMGVKDPEMVEVHASSREERNSWIQIIQDTINSLNRDEDEGIPSENEEEKRLLDTKAR
                     ELKEQLQQKDQQILLLLEEKEMIFRDMTECSTPLPEDCSPTHSPRMLFRSNTEEALKG
                     GPLMKSAISEVEILQGLVSGSLGGTLGQPISSPVEQEVMAGPISLPRRAETFGGFDCH
                     QLNASKGGEKEEGDDGQDLRRTESDSGLKKGGNANLVFMLKRNSEQVVQSIVHLHELL
                     TMLQGVVLQQDSYIEDQKLVLTEKVLTRSASRPSSLIEQEKQRSLEKQRQDLANLQKQ
                     QAQHLEEKRRREREWEARELELRDREAKLAEREETVRRRQQDLERDREELQQKKGTYQ
                     CDLERLRAAQKQLEREQEQLKRDAEQLSQRQMEQDLCQVSNKHGRLMRVPSFLPNSDE
                     FSLLSTPSITKSGSLDSELSVSPKRNSISRTQKDKGPFHILSSASQTKVPEGQSQAPS
                     STSTSTRLFGLSKPKEKKEKKKKSKGSRTQPGDGPAPEVPAEGEEIFC"
     exon            150..297
                     /gene="Akap13"
                     /gene_synonym="AKAP-13; AKAP-Lbc"
                     /inference="alignment:Splign:2.1.0"
     exon            298..594
                     /gene="Akap13"
                     /gene_synonym="AKAP-13; AKAP-Lbc"
                     /inference="alignment:Splign:2.1.0"
     exon            595..778
                     /gene="Akap13"
                     /gene_synonym="AKAP-13; AKAP-Lbc"
                     /inference="alignment:Splign:2.1.0"
     exon            779..971
                     /gene="Akap13"
                     /gene_synonym="AKAP-13; AKAP-Lbc"
                     /inference="alignment:Splign:2.1.0"
     exon            972..4032
                     /gene="Akap13"
                     /gene_synonym="AKAP-13; AKAP-Lbc"
                     /inference="alignment:Splign:2.1.0"
     exon            4033..4160
                     /gene="Akap13"
                     /gene_synonym="AKAP-13; AKAP-Lbc"
                     /inference="alignment:Splign:2.1.0"
     exon            4161..4236
                     /gene="Akap13"
                     /gene_synonym="AKAP-13; AKAP-Lbc"
                     /inference="alignment:Splign:2.1.0"
     exon            4237..4373
                     /gene="Akap13"
                     /gene_synonym="AKAP-13; AKAP-Lbc"
                     /inference="alignment:Splign:2.1.0"
     exon            4374..4744
                     /gene="Akap13"
                     /gene_synonym="AKAP-13; AKAP-Lbc"
                     /inference="alignment:Splign:2.1.0"
     exon            4745..4798
                     /gene="Akap13"
                     /gene_synonym="AKAP-13; AKAP-Lbc"
                     /inference="alignment:Splign:2.1.0"
     exon            4799..4864
                     /gene="Akap13"
                     /gene_synonym="AKAP-13; AKAP-Lbc"
                     /inference="alignment:Splign:2.1.0"
     exon            4865..5060
                     /gene="Akap13"
                     /gene_synonym="AKAP-13; AKAP-Lbc"
                     /inference="alignment:Splign:2.1.0"
     exon            5061..5169
                     /gene="Akap13"
                     /gene_synonym="AKAP-13; AKAP-Lbc"
                     /inference="alignment:Splign:2.1.0"
     exon            5170..5212
                     /gene="Akap13"
                     /gene_synonym="AKAP-13; AKAP-Lbc"
                     /inference="alignment:Splign:2.1.0"
     exon            5213..5345
                     /gene="Akap13"
                     /gene_synonym="AKAP-13; AKAP-Lbc"
                     /inference="alignment:Splign:2.1.0"
     exon            5346..5466
                     /gene="Akap13"
                     /gene_synonym="AKAP-13; AKAP-Lbc"
                     /inference="alignment:Splign:2.1.0"
     exon            5467..5534
                     /gene="Akap13"
                     /gene_synonym="AKAP-13; AKAP-Lbc"
                     /inference="alignment:Splign:2.1.0"
     exon            5535..5601
                     /gene="Akap13"
                     /gene_synonym="AKAP-13; AKAP-Lbc"
                     /inference="alignment:Splign:2.1.0"
     exon            5602..5737
                     /gene="Akap13"
                     /gene_synonym="AKAP-13; AKAP-Lbc"
                     /inference="alignment:Splign:2.1.0"
     exon            5738..5850
                     /gene="Akap13"
                     /gene_synonym="AKAP-13; AKAP-Lbc"
                     /inference="alignment:Splign:2.1.0"
     exon            5851..6003
                     /gene="Akap13"
                     /gene_synonym="AKAP-13; AKAP-Lbc"
                     /inference="alignment:Splign:2.1.0"
     exon            6004..6254
                     /gene="Akap13"
                     /gene_synonym="AKAP-13; AKAP-Lbc"
                     /inference="alignment:Splign:2.1.0"
     exon            6255..6380
                     /gene="Akap13"
                     /gene_synonym="AKAP-13; AKAP-Lbc"
                     /inference="alignment:Splign:2.1.0"
     exon            6381..6498
                     /gene="Akap13"
                     /gene_synonym="AKAP-13; AKAP-Lbc"
                     /inference="alignment:Splign:2.1.0"
     exon            6499..6747
                     /gene="Akap13"
                     /gene_synonym="AKAP-13; AKAP-Lbc"
                     /inference="alignment:Splign:2.1.0"
     exon            6748..6779
                     /gene="Akap13"
                     /gene_synonym="AKAP-13; AKAP-Lbc"
                     /inference="alignment:Splign:2.1.0"
     exon            6780..6961
                     /gene="Akap13"
                     /gene_synonym="AKAP-13; AKAP-Lbc"
                     /inference="alignment:Splign:2.1.0"
     exon            6962..7044
                     /gene="Akap13"
                     /gene_synonym="AKAP-13; AKAP-Lbc"
                     /inference="alignment:Splign:2.1.0"
     exon            7045..7239
                     /gene="Akap13"
                     /gene_synonym="AKAP-13; AKAP-Lbc"
                     /inference="alignment:Splign:2.1.0"
     exon            7240..7401
                     /gene="Akap13"
                     /gene_synonym="AKAP-13; AKAP-Lbc"
                     /inference="alignment:Splign:2.1.0"
     exon            7402..7472
                     /gene="Akap13"
                     /gene_synonym="AKAP-13; AKAP-Lbc"
                     /inference="alignment:Splign:2.1.0"
     exon            7473..7517
                     /gene="Akap13"
                     /gene_synonym="AKAP-13; AKAP-Lbc"
                     /inference="alignment:Splign:2.1.0"
     exon            7518..7568
                     /gene="Akap13"
                     /gene_synonym="AKAP-13; AKAP-Lbc"
                     /inference="alignment:Splign:2.1.0"
     exon            7569..8018
                     /gene="Akap13"
                     /gene_synonym="AKAP-13; AKAP-Lbc"
                     /inference="alignment:Splign:2.1.0"
     exon            8019..8349
                     /gene="Akap13"
                     /gene_synonym="AKAP-13; AKAP-Lbc"
                     /inference="alignment:Splign:2.1.0"
     exon            8350..12437
                     /gene="Akap13"
                     /gene_synonym="AKAP-13; AKAP-Lbc"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgtcaccgc cgccgtcgag ggagcggccg cctattgtcc ttctccgccg ccaaggcgcg
       61 gagctgctcc ggctcggccc gcgggggagc ccggggagcc gcacgtgtcc tgggtcatga
      121 aacttagtcc acaacaagct ccattatatg gcgattgtgt tgttacagtc ctgcttgctg
      181 aagaggacaa agttgaagat gatgctattt tttacttgat attttctggc tctaccctct
      241 atcactgcac aagtacccgg aaagtcagtt ctgatacgtt ggagacaatt gctcctggtc
      301 atgactgctg tgagacggtg aaggtgctac tctgtgcttc caaagagggc cttcctgtgt
      361 ttgtagttgc tgaagaagac ttccattttg tccaggatga ggcatatgat gcagctcagt
      421 tcctggcaac cagtgctgga aatcagcagg ctctgaactt cacacggttc cttgatcgat
      481 caggaccccc ttctggagat gtgaactctc tggatgagaa ggtcgcactg gcattcagac
      541 acctgaagct gcctgcagag tggaatgtgt tagggacgga tcacacgttg catgatggtg
      601 gccctcggga aaccctcatg cattttgctg tgcggcttgg attgctgcgg ttgacatggt
      661 tcctgttaca gaagccaggt ggccgtggag ctctcagcat ccacaacaag gaaggggcaa
      721 cgcctgtaag cctggcactg gagcgaggtt atcacaagct tcaccagctc ctgactgagg
      781 aaaatgctgg tgaaccagat tcctggagca gcttatccta tgaaatccct tatggagact
      841 attcagtgag gcaccatcga gaattggaca tctatacatt gacttccgaa tctgaatcac
      901 attgtgaacc gcatggagac agttgtactg gacatatttc taaacttatg aatatccagc
      961 agcagctaat gaaaacaaac ttgaagcaga tggacaatct catgccctta atggtgacaa
     1021 cacaagattc atcttgtgtg ccctgtgtac cagagccttc tgaccaccag cagcttcctt
     1081 ttgaagaaac taagagcact gtgtgctgcc aagggagtcc tgggaggaag gatgcaagtc
     1141 cctgtgactt gtcaagtgtg gttgaggaag aaaatctcat ctgttctcat aagaaaaata
     1201 aagatactgg gagaccaggg gaaggggtgg agccagcgtc tgcggtggac tctaggtctg
     1261 catctcatca agacagctgc cttcagagca tacccgactg tggagtgaag ggtagagaag
     1321 gcctgccatc ctgtggaaac agaaacgaag taactggaac acaatattct ggagttgcca
     1381 cgtgtcagca gcccctgagc agcgagagca gtgtgccgca ggatgtcctg gtcacagaac
     1441 cagatgcgcg ccagcactct tctggaaggg agctaccaga cagttcttca acagatgctg
     1501 gtgccccaga aaaggcagga gaactagaac atagcctact taccccagat gctaccaccc
     1561 agaacagtaa gcctcaagta ggggaaagcg caaaggagag acttgagaat tccgacatta
     1621 gctccgccga ggcgactgct gttcaagctt tacgtgaacc caagcagaaa gctgacgtta
     1681 caaaccatgt ctttgccgcc cgtgctgcgg gtgctgacgc tcctgctgag gcttcacctg
     1741 catggagtcc tgaagaaatc cccactggaa aaccaggaat ggagactcag gagagaggct
     1801 gtgagggggg catcacaagt gaccagagct cccaggtgct tcctgctgct gctgctgcta
     1861 cagaaaacaa ggttttagat ggactagaac ttgaaactct tccagcatgc ccttgtgaga
     1921 cagcatcatc cttggattta accgtgtcag ggccaagacc agatgggatg ccaaaacaaa
     1981 actcagagtc tagtgctcag catgctcaga gcctgaatag ccaggccccg ctctgctcta
     2041 tcgcaggggc cggcacgccc tctgctgagt ctgcgtgtcc gcagagcaca gagacctcta
     2101 gtggcgggtc ggtaatagag catggcagtg gcgaagctag cctgcccgaa agcacagcag
     2161 cgcagccaga accgcaaggt ctttgcaccg ccccctgccc agaagaccca caagctgaca
     2221 cagtcacttc tgacactgca gcacacaacc agaaatctgt ggggtcttgt catctctgtg
     2281 ctttagatgc aaagaaccaa gaaaaagatt tgagacaaga tacaccctca gtgaacacgc
     2341 ttgaggatgt tccacatctg ccttcagttg tcccccaatc tgaggaaaaa ctagagccag
     2401 accaggtatc acctcgaggc agcagtttct ctctggcaag cagtccagag agtgaatcag
     2461 taaccaaaga tgacgtactt tctctcgtct cctcccagaa agaaaaggga acagcaactc
     2521 ctcagctcca tagagctcca gcttgtagtg atggcccaga tggaagagat ctgaatgata
     2581 cggataaggt aggagacggg gctgccagcc cacctacacc ctctgctgta gagcttcaga
     2641 ccagcatggg gaataccagc cctgtaggtg ttggagagca ggaggggtcc agcctaacag
     2701 caacacttga agtgctaagt gactccttgc tacaaagcgt ggataaggct gctttggtct
     2761 ctgactctct tctgcctgaa gaaggtggca gtatagtggt tccagaaagt tccacagctc
     2821 tggggcaagg tggcaaagac aaagcaacga aatgtccttc tgttaaagaa gatgtgcatt
     2881 cttcagaaat gtcaagggag gaccagagaa caccacctcc tgggcaggag atatcaagat
     2941 tatgtgaaaa acctatgtca gccctgtgtg ccggggagaa agcgctgcag cacagtaact
     3001 cgccagacac accctctgcc tgtctgcaaa cagaaactaa acacaacaag gaagtggccc
     3061 cacagagctc cccgctgatg aaaggtgggg ctgtacagaa cctggtgcca ccaaaaacaa
     3121 gtctgtctgc cgattcagag cagaaaacct cgagtacaga gcagagtggc tcatctctgc
     3181 tgccaggtgg tgcgtctgag gcactccgct gtagtcagcc ttcgctcagt gtcagcgtgg
     3241 agagcattca gttccaaggg aaaaccagtg cttgtaaggt aagcagaaat gcaatggagg
     3301 atgttacagt ggctgatgct ttcctagcta ctgctgagcc cacaaaagag gatgcattac
     3361 accacgtcaa agacatttca gacttgttaa accaagagaa gaaaacgact ccaggtttgc
     3421 cagaagcttt actggacaaa ggtgtcactg acttacagga agtcataacc ccagagatag
     3481 aaccacttga ttgcaagaga gagaaactgg agggaacaga ccttagctgt cccacaagta
     3541 aatccaaaga gactccaaac aatgaagaaa caacgcaacc tcctgccagg gacctcccca
     3601 cagagacagg gctctcagct atcaatgaca atggccccca agctgacatg aagcacgtga
     3661 ctcaggcatc ggtcccagga gaggaaagta acgttaccac tgtacttgga atggtctcaa
     3721 cccaagctgc agatgggcct cctggagcag actccataga ggagaccgcc actaggatcg
     3781 tggaggccgt catcaagcag atcaaggcct ccaacacact aaggacacaa gtagaaatcc
     3841 agaatccgcc actgtccagt tcagagatta aggagataga gaacactggt tcagagagtg
     3901 cacgtgtttt cctacccggg gagcccctgc agatggagaa tactcagaaa gaaaccactg
     3961 gacactgtag tgttgagaca gaggcaccag agaaaataat tctagctgtc cacaggcctg
     4021 agccagcacc agaaatgcca gacactaaaa ctggaggtga agtggatctt ctgagtaagc
     4081 gcagtgctgc ttctgaggag gaggctatag gaaatggagc tgccacgccc aagatgaagc
     4141 aagccccagg gacccaggtg atcaaccgag aaagctggtg tgccatagag ccctgccctg
     4201 aagcagcatc tctcttagct tccaaacaga gctcagaatg cagaagcttc atagatgttg
     4261 gactgggcac ggagtgtgcc acaaaagaag gcgtgctcca gagagagtca gggagtgatt
     4321 ctgacctctt tcactcaccc agtgatgaaa tggacagcat catcttctca aagcctgagg
     4381 aagagcagtt gctttgtgat acaacaggat ccagttcttc aacagatgac acagcttccc
     4441 tggatcgaca ttcttctcat ggcagtgatg tgtcccttcc tcagacgtca aagttaaaca
     4501 ggtccagaaa tcatcaaagt tccaatggct ttttcagcca tggggtggac cctgagagtc
     4561 gggaaggtga gagcgagcct gctggctctg gtgaaatgga agaggaggag atggacagca
     4621 tcactgaagt gcctgcaaac cgctcttttc tgaggaactc catgcgctct ctttctcctt
     4681 tccggaggca cagctgggga cctgggaaga atgcagccag tgatgcagaa atgaaccagc
     4741 ggagttcaat gcaagttctt gggcatgttg tcaggagacc tcccattcat aggagaagta
     4801 tgagctggtg tccctctggt gtgcagtact cggctgccct gaatgctgac tttaatatca
     4861 gaagtttcag tctggaaggc ttgacaggag gaggtggtgt tggaaataag ccatcctcat
     4921 ctctagaaat aagctctgca aactccagcg agctcagaaa ccctttcagt ggtgaggagc
     4981 agaggagctc tttgatgtcg ctttcagaag aacacctgga accggaccag agacagcacc
     5041 ataggatgtt tgaccagcag acatgttaca ggtctaaaca acagggattt aactactgta
     5101 catcagctat ttcttctcca ttgacaaaat ccatctcatt aatgacaatc agtcatcctg
     5161 gattagacaa ttcacggccc ttccacagtg ccagtgccaa cctgacagag agtataacag
     5221 aagagaactg taatttcctg cctccaagcc cctcaaaaaa gagttttgaa gaaaagagtg
     5281 ggactaaggt tagtcgcacc ttcagctaca tcaggaataa aatgtccagc agcaagaaga
     5341 gcaaaaagga aaaagataaa aagactctta acgggcacac tttcagcccc attcctattg
     5401 tgggtcccat caactgcagc cagtgcatga agcctttcac caacaaggac gcctacacat
     5461 gtgcaagttg tggtgctttt gtccacaaag gctgcagaga aaatttagcc tcctgtgcaa
     5521 aggtcaaaat gaagcagccg aaggggagcc tccaggcaca cgatacatca tcgctgccca
     5581 cagtcatcat gagaaacaag tcttcacagc ccaaggagcg ccctaggtct gcagtcctct
     5641 tggctgaaga ggccattgct gcaccaatgt ttactaacag aaggtcccag cagagtgtct
     5701 ccctctctaa aagtgtctcc atacaaaaca ttactggagt tggcaacgat gagaacatgt
     5761 caaacacctg gaaatttctg tctcattcaa cagactcact gaataaaatc tgcaaggtca
     5821 atgagtcaac agaatccctt actgatgagg gagtaggtac agacatgaat gaaggacagc
     5881 tgatgggaga ttttgaaagc gactctaaac agctagaagc agagtcatgg agccggacag
     5941 tggacagcaa gttccttaaa cagcagaaga aagatgtggt caagcggcag gaagtgattt
     6001 acgagttgat gcagactgag ttacatcaca tccgcacact gaagatcatg agtgacgtgt
     6061 acagccgggg catgatgaca gatctgctct ttgagcagca gatggtggaa aagctgttcc
     6121 cctgtttgga tgaactgatc agtatccaca gccagttctt tcagagaatc ctggagcgga
     6181 agaaggagtc tctggtggat aaaagtgaaa agaactttct catcaagagg ataggggatg
     6241 tgcttgtcag tcagttctca ggtgagaatg cagagcgttt aaagaagaca tatggcaagt
     6301 tctgtggaca gcacaaccag tctgtcaact acttcaaaga cctgtacacc aaggataagc
     6361 gtttccaagc ctttgtgaag aagaagatga gcagttcagt agtaagaaga ctgggaatcc
     6421 cagagtgcat tttacttgta actcagagga tcaccaagta cccagtttta ttccaaagga
     6481 tactgcaatg taccaaagac aatgaagtgg agcaggaaga cctcacccag tccttgagcc
     6541 tggtgaagga tgtgattgga gccgtggaca gcaaagtagc aagttatgag aagaaagtgc
     6601 gtctcggtga gatttacaca aagacagata gcaagtcgat catgagaatg aagagtgggc
     6661 agatgttcgc caaggaggat ctgagacgga agaagctggt gcgggatgga agtgtgtttc
     6721 tcaagagcgc aacaggaagg ctgaaagaaa aagaccagaa atacgtattt gcatcattgg
     6781 accacaagtc aacagtgatc tccttaaaga aactgattgt aagagaagtt gcccatgagg
     6841 agaaaggcct gttcctcatc agtatggggg tgaaagatcc agagatggtg gaggtccatg
     6901 caagctccag agaggagcgg aatagctgga ttcagatcat tcaggacaca atcaactcct
     6961 tgaacagaga tgaagatgaa gggattccca gtgaaaatga agaagaaaag agattgttgg
     7021 ataccaaagc ccgggagtta aaagaacaac ttcagcagaa ggaccagcag atcctcctct
     7081 tgctggaaga gaaggagatg attttccggg acatgactga gtgcagcact cccttacctg
     7141 aggattgctc cccaacacac agcccgagaa tgctcttccg ctccaacaca gaggaggctc
     7201 tcaaaggagg accgctgatg aaaagtgcaa tcagcgaagt ggaaatcctt caggggttgg
     7261 tgagtggaag ccttggtggc acacttgggc agcccatcag cagccctgtt gagcaggaag
     7321 tcatggctgg gcccatttct ttgccccgga gagcagagac ctttggagga tttgactgtc
     7381 atcagctgaa tgcttccaaa ggaggtgaga aagaagaggg tgatgatggc caagatctta
     7441 ggagaacaga atctgatagt ggcctgaaaa agggtggaaa tgctaacctg gtatttatgc
     7501 ttaaaagaaa cagtgagcag gttgtccaga gcattgtgca cctccacgag ctccttacca
     7561 tgctgcaggg tgttgtgcta caacaagaca gctacattga ggaccagaag ctggtgctga
     7621 cagagaaggt actcacaagg agtgcatccc gccccagctc tctcattgag caggagaagc
     7681 agcggagcct ggagaagcag cgccaggacc tggccaacct gcagaagcag caggcacagc
     7741 acctggagga aaagcgacga cgtgaacgtg agtgggaggc ccgtgagctg gagcttcgag
     7801 accgagaggc caagctggct gagcgggaag agacagtccg tcgtaggcag caggacctgg
     7861 agagggaccg cgaagagctc cagcagaaga agggcactta ccagtgtgat ctagagagac
     7921 tacgggctgc ccagaaacag ctggaacggg agcaggaaca actgaagagg gatgcagagc
     7981 agctcagcca gaggcagatg gagcaggacc tttgccaggt ttcaaataaa catggcagac
     8041 tgatgcgggt cccgtccttc ttgcccaatt cggatgagtt ctccttgctg tctacacctt
     8101 ctataaccaa atcgggctca ctggactcag aactctcagt gtctcctaaa aggaacagca
     8161 tctctcggac acagaaagat aaggggcctt tccatatact gagctcagcc agccaaacaa
     8221 aagtaccaga ggggcagagc caggccccgt ccagcacctc cacttccacc cgactctttg
     8281 gattatctaa gccaaaggaa aagaaggaga agaaaaagaa gagcaaagga agccgcactc
     8341 agcctggtga tggtcctgct ccagaagtac cagcagaggg tgaagagatc ttctgttgac
     8401 ccatttcctc tgccagggca gctgccttcc aaccctgacc tgacagtgga gctgccgggg
     8461 cactcctgct gcccctgtgc acaagtctct tacactggac gcccactgcc cctcagcgtc
     8521 cagtcctcct gagctacccc aggtcctgga caagaaggag cagcacctgt gtggggggtg
     8581 gggacggaca ctcagactcc acttcagctg taacccgtga ctgcccaggg cttgggtggg
     8641 cctggcctca ctcaggtgtt acactgaagg tagtgaccct agaagtatag aagagtttga
     8701 gacatgtcgg gatttcccaa aagctcagag ggtttttcca aatgaggtct gcagctctgc
     8761 cttgtatttg ggggaatcca accagagtca aggagcagat agtgccaact ttgtgtacag
     8821 tgaccgtctt catggacaca tggagcacac agctgtgtac acagttcttc tcaaacatca
     8881 ggagagctta gcccaagggc aagcatctac tgaccaggtg gcaccctgtg gtcctctgag
     8941 actgggtccc ttgaaatggt ccctgtgcac acaccaccca tctctgtatg tattcctcat
     9001 ttcctttcag gaagaacaac aaacacttgt gaaacagcaa gaggcctgat gtgcacggac
     9061 gagcatagtc tgcagtgcct gtatcttctc cacactctag gctgagctct ctgacttcat
     9121 aatcagatca ggaagaaata tactgcctgc cctagatgcc tgtctacatg ctctgggcac
     9181 aaaggaagta gaggggactc ttcaccactg tccccagtat gacattttct agttgttact
     9241 ggacctcgct atgggaaagt gtgtagcctg ttaatgctcc cagccacctg cctgggtctc
     9301 gccctgaggc ttctctggga ttactgacga aaagtaggtt ccagttcagg agttaagtct
     9361 ttctagtggt tttgccaata ccaagaaggg agctggccct gaggcatggc tgtgtgcacg
     9421 cccctcagcc acaggtcctc ctcacatacg gttttcagat gcagtttgct tggttgcgct
     9481 cttcttaccc ttgaagctgt caagtgctgc ttgtctctcc tctcgccctc tgtctccatg
     9541 cgttgatctg tgcatgcttg aggccttcac cagctcgtgt gtgcaggaca gttcattggt
     9601 aatgttccct ccaaggctcg tttactcccc gggagggaca cactaaggtc tgggcttcac
     9661 acgtggcctt cagttcctgg ttttgccctc agaagcgttg tgcagaaaca aacctgtaac
     9721 ttggtgcttg ttgatgacct gcgagctggt cttgcaggga cagatctttc agtttacttg
     9781 gaagagtcct ggtttaaatt ttttagccta aatttgtttt atttattttg tgtttgtgtt
     9841 ttattttatt ctgaaagtga accagtactg gcccagcagt ttaaaccatc ttttcagtac
     9901 agaaaatgaa atgtctccgc aagtgcatga aggtcctgag ggaaactgag gttagatggg
     9961 agctgcgccc ttctgtccca tgcccatttt tttttataag gaacgtttgt tcttttttgg
    10021 agatttttaa agttgcccca ttggctactt ttacctctct ttgacaaggt tggtttggct
    10081 ctttaaagct gggtggggtt ttgtttcgtt ggttgggtgt ttctttttct actaaaacta
    10141 tggtgtatac ttccctcaag caccttaaca gcaagaagtt agtcacttcc ttctccaagt
    10201 ccagctatga cttctccagc tgtcacagta gagcctgctg tgcctcagtg caccacaggg
    10261 tttggctggt tggccttgtc cctgcctctg aacagcctct tcagggggaa tgtgcccttc
    10321 cttccacagc caagcacttc cacttagggg aagagcctga ctcccaccta gatctgacag
    10381 aaaatcaaac caagtcctgc cctcctccct gtgcaggagg ccagtgagcg cctccaggtt
    10441 cactctgacc cacacagtga gccactgtgc aacctaggat ggcctgcccc agttccctct
    10501 acagccaacc agctatgttg tgttttgctt gctttggttg tttttaaaaa ccagttttac
    10561 ttctatccac attccccaaa acaatggtca gtgacagttg ggaggcctta aaaatcaaga
    10621 cagcatccac tgagtgcccc taggctgccc agcttcctcc gggaagagaa ccatttgcca
    10681 agaactgttt cacctgcctg caccacctgg tcccctcaga agtctgtcac gcttggggag
    10741 ttgctgcttg tgctcttgct taggacccca aagactgctg tggctgagtc aacagccttc
    10801 tgtggagtct ctaatatgag aagggtggtt ttctagggac caggttgtgt cctgtcctgt
    10861 tccccattct gagaaatcat gattttatat caagctaaag aaattattgc tttgggggac
    10921 aggtggaaat tgaccccagc cttgtgtaat ccagtgaact ttctgaaaga ttgtatcttc
    10981 tctcaaaaat tataatcatc tcagtagctg tcgtcccatc tgggtgacat gtgcacttta
    11041 aatgacctct catcagctgg cttcatcttt gagacaatca aatctgtaac ggtttcctta
    11101 gagggtggag agggttagga taaagacccg ccagcatgac cccaccatgc tctcatggaa
    11161 gttcctgcag ggggagccct caccatgatt gattggttgt tttttcagaa ggtacgaact
    11221 gagtcttttg agggtcacac cactagcgct gcccttggct agttccgccc accccttgct
    11281 ggttcttccc agcctccctc acagcagtaa gttcaggtgt gttgatccct tcagggtagc
    11341 atgagtacac acaggcttag taaaggacag accttggccc acagaccaga gtttgcccag
    11401 agtcctcctc tccatatgag tttgtaaggt ctcttcctgt ccctgaggct ctgtgacctc
    11461 acccattgtt tttgccaagg ctcttggtat ttcattggac ttaagttgcc tttgacctgt
    11521 acccagaaga cagtcctgaa gtgtgggctt ccttgtctgg acacctgcat gggtgccctt
    11581 aagtgaagca gtgacacaca cacacacaca cacacacaca cacacacagc agtgacacac
    11641 acacacacac acacacacac accccggcca tcgctgcaga gaacaagggc acagtgtgtt
    11701 cagtttcggc tccctgtttt ctttcatgta gcctaacatt cctagttaac tagactttgg
    11761 agtctgctgc ctgctggccg ggtggagaaa tgcaaagtgt tctaatgctg ccataaagtg
    11821 agcagggagg ggtggcagag gccttttcct gcactcacgg gatttaattt gtcaaatgat
    11881 tgacaggtcc tgagttactt ctccatctca actaaggtat aaagtgggtg gcccccacta
    11941 ccgcaagtgt gccctgtgga gaaaccaggc aggtgctgct actgccacag accccagagg
    12001 gcctctgcag gaagcacaga acctatgcct tagaaccctc ccagcctcag ctgccctgcc
    12061 ttggttgcca cctgctggga tgggcctaac ccagcgggtt cgtctcaggt ttgcccctga
    12121 ggcctaggct gtacagaagg tgggcaggat acacctatac ctctgttctt gttgtctcca
    12181 aatgctgtat gaacatttct gtactaagcc tattaagtaa aaagtcgggt tcaacccaag
    12241 cgctgtatag taatttgtaa ttatgtataa agtgaagcag ttctgaactg taaagatttt
    12301 cagtgtgttt tctggaaatt tgccacaaca tactggcttt gtattttatt tatcatcctt
    12361 tgtagttact ggcttccgag tcttgtaaag tccccctcag acctttcaga aataataaat
    12421 gtcctttgaa atcttga
//
