LOCUS       NM_057103               6255 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus A-kinase anchoring protein 12 (Akap12),
            transcript variant 1, mRNA.
ACCESSION   NM_057103
VERSION     NM_057103.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6255)
  AUTHORS   Selvaraju,V., Suresh,S.C., Thirunavukkarasu,M., Mannu,J.,
            Foye,J.L.C., Mathur,P.P., Palesty,J.A., Sanchez,J.A., McFadden,D.W.
            and Maulik,N.
  TITLE     Regulation of A-Kinase-Anchoring Protein 12 by Heat Shock Protein
            A12B to Prevent Ventricular Dysfunction Following Acute Myocardial
            Infarction in Diabetic Rats
  JOURNAL   J Cardiovasc Transl Res 10 (2), 209-220 (2017)
   PUBMED   28281242
  REMARK    GeneRIF: HSPA12B overexpression interacts with AKAP12 and
            downregulate TXNIP in diabetic rats following acute myocardial
            infarction.
REFERENCE   2  (bases 1 to 6255)
  AUTHORS   Wilhelm,T., Lipka,D.B., Witte,T., Wierzbinska,J.A., Fluhr,S.,
            Helf,M., Mucke,O., Claus,R., Konermann,C., Nollke,P.,
            Niemeyer,C.M., Flotho,C. and Plass,C.
  TITLE     Epigenetic silencing of AKAP12 in juvenile myelomonocytic leukemia
  JOURNAL   Epigenetics 11 (2), 110-119 (2016)
   PUBMED   26891149
REFERENCE   3  (bases 1 to 6255)
  AUTHORS   Kritzer,M.D., Li,J., Passariello,C.L., Gayanilo,M., Thakur,H.,
            Dayan,J., Dodge-Kafka,K. and Kapiloff,M.S.
  TITLE     The scaffold protein muscle A-kinase anchoring protein beta
            orchestrates cardiac myocyte hypertrophic signaling required for
            the development of heart failure
  JOURNAL   Circ Heart Fail 7 (4), 663-672 (2014)
   PUBMED   24812305
REFERENCE   4  (bases 1 to 6255)
  AUTHORS   Yan,M., Zhao,J., Zhu,S., Shao,X., Zhang,L., Gao,H. and Yao,D.
  TITLE     Expression of SRC suppressed C kinase substrate in rat neural
            tissues during inflammation
  JOURNAL   Neurochem Res 39 (4), 748-757 (2014)
   PUBMED   24623461
  REMARK    GeneRIF: SSeCKS play an important role in sciatic nerve fibers and
            neurons in spinal cord and dorsal root ganglion during
            inflammation.
REFERENCE   5  (bases 1 to 6255)
  AUTHORS   You,T., Fan,Y., Li,Q., Gao,Y., Yang,Y., Zhao,Z. and Wang,C.
  TITLE     Increased SSeCKS expression in rat hepatic stellate cells upon
            activation in vitro and in vivo
  JOURNAL   Inflammation 36 (6), 1415-1423 (2013)
   PUBMED   23925424
REFERENCE   6  (bases 1 to 6255)
  AUTHORS   Xia,W. and Gelman,I.H.
  TITLE     Mitogen-induced, FAK-dependent tyrosine phosphorylation of the
            SSeCKS scaffolding protein
  JOURNAL   Exp Cell Res 277 (2), 139-151 (2002)
   PUBMED   12083796
  REMARK    GeneRIF: a role in mitogen-induced cytoskeletal reorganization
REFERENCE   7  (bases 1 to 6255)
  AUTHORS   Xiao,H.S., Huang,Q.H., Zhang,F.X., Bao,L., Lu,Y.J., Guo,C.,
            Yang,L., Huang,W.J., Fu,G., Xu,S.H., Cheng,X.P., Yan,Q., Zhu,Z.D.,
            Zhang,X., Chen,Z., Han,Z.G. and Zhang,X.
  TITLE     Identification of gene expression profile of dorsal root ganglion
            in the rat peripheral axotomy model of neuropathic pain
  JOURNAL   Proc Natl Acad Sci U S A 99 (12), 8360-8365 (2002)
   PUBMED   12060780
REFERENCE   8  (bases 1 to 6255)
  AUTHORS   Siegel,S.M., Grove,B.D. and Carr,P.A.
  TITLE     SSeCKS immunolabeling in rat primary sensory neurons
  JOURNAL   Brain Res 926 (1-2), 126-136 (2002)
   PUBMED   11814414
REFERENCE   9  (bases 1 to 6255)
  AUTHORS   Chapline,C., Mousseau,B., Ramsay,K., Duddy,S., Li,Y., Kiley,S.C.
            and Jaken,S.
  TITLE     Identification of a major protein kinase C-binding protein and
            substrate in rat embryo fibroblasts. Decreased expression in
            transformed cells
  JOURNAL   J Biol Chem 271 (11), 6417-6422 (1996)
   PUBMED   8626441
REFERENCE   10 (bases 1 to 6255)
  AUTHORS   Lin,X., Nelson,P.J., Frankfort,B., Tombler,E., Johnson,R. and
            Gelman,I.H.
  TITLE     Isolation and characterization of a novel mitogenic regulatory
            gene, 322, which is transcriptionally suppressed in cells
            transformed by src and ras
  JOURNAL   Mol Cell Biol 15 (5), 2754-2762 (1995)
   PUBMED   7739556
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY695056.1 and BG664488.1.
            
            On Sep 20, 2005 this sequence version replaced NM_057103.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY695056.1, U41453.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6220              AY695056.1         1-6220
            6221-6255           BG664488.1         359-393
FEATURES             Location/Qualifiers
     source          1..6255
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q11"
     gene            1..6255
                     /gene="Akap12"
                     /gene_synonym="AKAP12A; AKAP12B; AKAP12G"
                     /note="A-kinase anchoring protein 12"
                     /db_xref="GeneID:83425"
                     /db_xref="RGD:70988"
     exon            1..306
                     /gene="Akap12"
                     /gene_synonym="AKAP12A; AKAP12B; AKAP12G"
                     /inference="alignment:Splign:2.1.0"
     CDS             157..5220
                     /gene="Akap12"
                     /gene_synonym="AKAP12A; AKAP12B; AKAP12G"
                     /note="isoform alpha is encoded by transcript variant 1; A
                     kinase (PRKA) anchor protein (gravin) 12; SSeCKS, Gravin,
                     AKAP250; A kinase (PRKA) anchor protein 12; AKAP-12"
                     /codon_start=1
                     /product="A-kinase anchor protein 12 isoform alpha"
                     /protein_id="NP_476444.2"
                     /db_xref="GeneID:83425"
                     /db_xref="RGD:70988"
                     /translation="MGAGSSTEQRSPEQPAGSDTPSELVLSGHGPAAEASGAAGDPAD
                     ADPATKLPQKNGQLSTVNGVAEQGDVHVQEENQEGQEEEVVDEDVGQRESEDVREKDR
                     VEEMAANSTAVEDITKDGQEETSEIIEQIPASESNVEEMVQPAESQANDVGFKKVFKF
                     VGFKFTVKKDKNEKSDTVQLLTVKKDEGEGAEASVGAGDHQEPSVETAVGESASKESE
                     LKQSTEKQEGTLKQEQSSTEIPLQAESDQAAEEEAKDEGEEKQEKEPTKSPESPSSPV
                     SSETTSSFKKFFTHGWAGWRKKTSFKKSKEDDLETAEKRKEQEAEKVDEEEKEKTEPA
                     SEEQEPAEDTDQARLSADYEKVELPLEDQVGDLEASSEEKCAPLATEVFDEKMEAHQE
                     VVAEVHVSTVEKTEEEQGGGGEAEGGVVVEGTGESLPPEKLAEPQEVPQEAEPAEELM
                     KSREMCVSGGDHTQLTDLSPEEKTLPKHPEGIVSEVEMLSSQERIKVQGSPLKKLFSS
                     SGLKKLSGKKQKGKRGGGGDEEPGEYQHIHTESPESADEQKGESSASSPEEPEETTCL
                     EKGPLEAPQDGEAEEGTTSDGEKKREGITPWASFKKMVTPKKRVRRPSESDKEEELEK
                     VKSATLSSTDSTVSEMQDEVKTVGEEQKPEEPKRRVDTSVSWEALICVGSSKKRARKA
                     SSSDDEGGPRTLGGDSHRAEEASKDKEAGTDAVPASTQEQDQAQGSSSPEPAGSPSEG
                     EGVSTWESFKRLVTPRKKSKSKLEEKAEDSSVEQLSTEIEPSREESWVSIKKFIPGRR
                     KKRADGKQEQATVEDSGPVEINEDDPDVPAVVPLSEYDAVEREKMEAQGNAELPQLLG
                     AVYVSEELSKTLVHTVSVAVIDGTRAVTSVEERSPSWISASVTEPLEHTAGEAMPPVE
                     EVTEKDIIAEETPVLTQTLPEGKDAHDDMVTSEVDFTSEAVTATETSEALRTEEVTEA
                     SGAEETTDMVSAVSQLTDSPDTTEEATPVQEVEGGVLDTEEEERQTQAILQAVADKVK
                     EESQVPATQTVQRTGSKALEKVEEVEEDSEVLASEKEKDVMPKGPVQEAGAEHLAQGS
                     ETGQATPESLEVPEVTADVDHVATCQVIKLQQLMEQAVAPESSETLTDSETNGSTPLA
                     DSDTADGTQQDETIDSQDSKATAAVRQSQVTEEEAATAQKEEPSTLPNNVPAQEEHGE
                     EPGRDVLEPTQQELAAAAVPVLAKTEVGQEGEVDWLDGEKVKEEQEVFVHSGPNSQKA
                     ADVTYDSEVMGVAGCQEKESTEVQSLSLEEGEMETDVEKEKRETKPEQVSEEGEQETA
                     APEHEGTYGKPVLTLDMPSSERGKALGSLGGSPSLPDQDKAGCIEVQVQSLDTTVTQT
                     AEAVEKVIETVVISETGESPECVGAHLLPAEKSSATGGHWTLQHAEDTVPLGPESQAE
                     SIPIIVTPAPESTLHPDLQGEISASQRERSEEEDKPDAGPDADGKESTAIEKVLKAEP
                     EILELESKSNKIVLNVIQTAVDQFARTETAPETHAYDSQTQVPAMQADSQGAQQMLDK
                     NESCQDETPSAAAQRGLASPDRSGGMGSASEMLAALAVESAGVKVSIEKLPPQPKDQK
                     EHAADGPQLQSLAQAEASASGNLTKESPDTNGPKLTEEGDAPKVEVQEEEMSTKSVKE
                     NKAQAEEDLQEPKGDLAES"
     exon            307..421
                     /gene="Akap12"
                     /gene_synonym="AKAP12A; AKAP12B; AKAP12G"
                     /inference="alignment:Splign:2.1.0"
     exon            422..5228
                     /gene="Akap12"
                     /gene_synonym="AKAP12A; AKAP12B; AKAP12G"
                     /inference="alignment:Splign:2.1.0"
     exon            5229..6229
                     /gene="Akap12"
                     /gene_synonym="AKAP12A; AKAP12B; AKAP12G"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttcattctca gtccgggtac gttctcagca ggatcgcaga gagccggagc tcttcaccct
       61 tagtccctgt ggtcctgggc gcacatcctt gcccttctgc gtctccgcgg tcccaggaag
      121 gcagctagcc ggcgggagta gaagagccac tgagccatgg gcgcaggcag ttccaccgag
      181 cagcggagcc ccgagcagcc ggcggggagc gacacgccga gcgagctggt gctcagtggc
      241 catgggcccg cagctgaagc ctcgggagca gctggagacc ccgccgacgc ggaccccgcc
      301 accaagctcc cacagaagaa tggccagctg tctactgtca acggcgtagc tgaacaagga
      361 gatgtccatg tccaagagga aaaccaggag gggcaggagg aagaagtcgt tgatgaggat
      421 gttggacagc gagagtcaga agatgtgaga gaaaaagacc gagttgaaga aatggcggcc
      481 aactccacag ctgttgaaga tatcacaaag gatgggcagg aggagacatc agaaataatt
      541 gaacagatcc ctgcttcaga aagcaatgtg gaagaaatgg tacagcctgc tgagtcccag
      601 gctaatgatg ttggcttcaa gaaagtattt aaatttgttg gttttaaatt cacggtgaag
      661 aaggataaaa atgaaaagtc agatactgtc caactactca ctgtcaagaa ggatgaaggc
      721 gaaggggcag aagcctctgt cggagctgga gaccaccagg agcccagtgt ggagactgcc
      781 gtcggagagt cagcatccaa agaaagtgag ctgaagcaat ccacagagaa gcaagaaggc
      841 accctgaagc aagaacagag cagcacagaa atcccccttc aagccgaatc tgatcaagcg
      901 gctgaggaag aagccaaaga tgaaggagaa gaaaaacaag agaaagagcc caccaagtcc
      961 ccagaatccc cgagcagccc agtcagcagt gagacaacat cttccttcaa gaagttcttc
     1021 actcacggtt gggccggctg gcgcaagaag accagcttca agaaatcaaa agaggatgat
     1081 ctggaaactg ccgagaagag aaaggagcaa gaggcagaaa aagtagacga ggaagaaaag
     1141 gaaaagacag agccagcctc ggaggagcag gagccggcag aagacacaga ccaggccagg
     1201 ttgtcagcag actacgagaa ggtggagctg cctttggaag accaggttgg tgacctggag
     1261 gcatcgtcag aggagaagtg tgctcctttg gcaacggaag tgtttgatga gaagatggaa
     1321 gcccaccaag aagttgttgc agaggtccac gtgagcaccg tggagaagac agaggaggag
     1381 cagggaggag gaggagaggc tgaagggggc gtggtggtag aaggaacagg agaatccttg
     1441 ccccctgaga aactggctga gccccaggag gtcccccagg aagctgagcc tgctgaggag
     1501 ctgatgaaga gcagagagat gtgtgtctct ggaggagacc acactcaact gacagaccta
     1561 agtcctgaag agaagacgct gcccaaacac ccagaaggca ttgtcagtga ggtggagatg
     1621 ctgtcctctc aggaaagaat caaggtacag ggaagtccct tgaagaaact cttcagtagc
     1681 tcaggcttaa agaagctgtc tgggaagaag cagaagggga aacgaggagg tgggggagac
     1741 gaagagcctg gagaatacca acacattcac accgaatccc cagagagtgc tgatgagcag
     1801 aagggagaga gctctgcgtc gtcccccgag gagcctgagg agaccacgtg tctggagaaa
     1861 gggccgctgg aagcacccca ggatggggaa gctgaggaag gaactacttc cgatggagag
     1921 aagaagaggg aagggatcac tccctgggca tccttcaaaa agatggtgac acccaagaaa
     1981 cgggtccgaa gaccttctga gagtgacaag gaggaagagc tggagaaggt caagagcgcc
     2041 accttgtcct ccactgatag cacagtgtca gaaatgcaag atgaagtcaa aactgttggt
     2101 gaggaacaaa agccagagga accaaagcgt agggtggata cttcagtgtc ttgggaagca
     2161 ctgatttgtg tcggatcatc caagaagaga gcaaggaagg catcctcttc agatgatgaa
     2221 ggagggccaa ggacactggg aggggacagt cacagagcag aggaggccag caaagacaaa
     2281 gaagccggaa cagacgctgt tcctgccagc acccaggagc aggaccaagc gcaaggaagt
     2341 tcctcacccg agccagcggg aagcccttcc gaaggggaag gtgtctccac ttgggagtca
     2401 tttaaaagat tagtcactcc aagaaaaaaa tccaagtcaa aactggaaga gaaagccgaa
     2461 gactctagtg tagagcagtt gtccactgag atcgaaccga gtagagaaga atcttgggtt
     2521 tccattaaga aattcatccc cggacggcgg aagaaaaggg cagatgggaa gcaagaacaa
     2581 gccactgtgg aagactcagg gccagtggag ataaatgagg acgaccctga tgtcccagcc
     2641 gtcgtgcctc tgtctgagta tgatgcagtg gagagggaga agatggaagc ccaggggaat
     2701 gcggagctgc cccagctgct gggggctgtg tacgtgtccg aggagctcag taagactctg
     2761 gtccacactg tgagtgtcgc agtcattgat gggaccaggg cagtcaccag tgtcgaagag
     2821 cggtctcctt cgtggatatc cgcttccgta acagaacctc ttgaacacac agcgggagaa
     2881 gccatgccac ctgttgaaga ggtcactgaa aaagacatca ttgcagaaga aactcctgtg
     2941 ctcacccaga cgttaccaga gggtaaagat gcccatgacg acatggtcac cagtgaagtg
     3001 gatttcacct cagaagctgt gacagccaca gagacctcag aggctctccg tactgaagaa
     3061 gttaccgaag catcgggggc cgaagagacc acagacatgg tgtccgcagt ttcccagctg
     3121 actgactccc cagacaccac agaggaagcc accccagttc aggaggtaga gggtggtgtg
     3181 ctagatacag aagaagagga gcgccagacg caggccatcc tccaagccgt tgcagacaag
     3241 gtgaaagagg agtcccaggt gcctgcaacc cagactgtgc agagaacggg gtcaaaagca
     3301 ctggagaagg ttgaggaggt agaggaggac tccgaagtgc tggcttcgga gaaagagaag
     3361 gacgttatgc cgaaaggacc cgtgcaggaa gctggagctg agcatcttgc acagggctct
     3421 gagactggac aggctactcc agagagcctt gaagttcctg aagtcacagc agatgtagac
     3481 catgtcgcca cgtgccaggt tatcaagctc cagcagctga tggaacaggc cgtggcccct
     3541 gagtcatccg aaaccttgac agacagtgag acaaatggaa gcactccctt agcagattca
     3601 gacactgcag atgggacaca gcaagatgaa accattgaca gccaggacag taaagccact
     3661 gcagctgtca ggcagtcaca ggtcacagaa gaagaggcgg ctactgctca gaaagaggag
     3721 ccttcgacac tacctaataa tgttccagcc caggaagaac atggggaaga accaggaaga
     3781 gatgttcttg aacctacaca gcaagagctt gctgctgcag ccgtgcccgt tctggcaaag
     3841 actgaggtgg gtcaagaggg tgaggttgac tggttggatg gagaaaaagt caaagaagaa
     3901 caggaggtgt ttgtacactc tggacccaac agtcaaaagg ctgctgatgt gacatatgac
     3961 agtgaagtga tgggagtggc cgggtgtcag gaaaaggaga gtactgaagt gcagagtctt
     4021 agcctggagg agggagagat ggaaactgac gttgaaaagg agaaaaggga gacaaagcca
     4081 gagcaagtga gtgaagaagg tgagcaggaa acagccgctc ctgagcatga aggaacctac
     4141 gggaagccag tcctgacact tgacatgccc agctcagaga gggggaaggc actgggaagc
     4201 cttggaggaa gcccttctct cccagaccaa gacaaagcag gttgcataga ggttcaagtt
     4261 caaagcctgg acacaacagt cactcaaaca gcagaagctg tggaaaaggt catagaaacg
     4321 gttgtgattt cagagacagg tgaaagtcca gagtgtgtag gtgcacactt attaccagct
     4381 gagaagtcct ctgcaacggg tggccactgg actcttcagc atgcagagga cacggtaccc
     4441 ctggggcctg agtctcaggc agaatccatc ccaatcatag taactcctgc tcctgaaagc
     4501 accctacatc ctgacctaca aggagaaata agcgcatccc agagagagcg atcagaggaa
     4561 gaggacaagc cagatgctgg tcctgatgct gacggcaagg agagtacagc aatcgaaaaa
     4621 gtcctcaagg ctgaacctga gatcctggaa cttgagagta agagcaacaa gattgtgctg
     4681 aacgtcattc agacagccgt tgaccagttc gcacgtacag aaacagcccc cgaaactcat
     4741 gcttatgatt cacagaccca ggttcctgca atgcaggctg acagccaggg agcccaacag
     4801 atgctggaca aaaatgaaag ttgccaagat gaaacaccca gtgccgcagc ccagagagga
     4861 cttgcaagtc ctgaccgttc tggaggcatg ggctcagcct cggaaatgct tgccgcgctt
     4921 gcagttgaaa gcgccggtgt caaagtaagc attgagaagc tgcctcctca acccaaagat
     4981 caaaaggagc atgctgctga tggccctcag ctccaaagct tagcccaggc agaggccagt
     5041 gcctctggaa acctaaccaa agaatcccca gacaccaacg gaccaaagct aaccgaggag
     5101 ggcgatgccc caaaagttga ggtccaggaa gaagaaatgt ctaccaagtc agtcaaagag
     5161 aacaaggccc aggcagaaga ggacctgcag gagccaaagg gagacctggc agaatcctaa
     5221 gatgttagtt gctcattgta catctgtaag accagaatgt gaaaacaagt cacagaacaa
     5281 gatgctgctg ttgggacctt gagaccaaga tttcagagcc catgagatcc agagagcagg
     5341 gccgtccaat gatttccacc cagtagagca ccccgacaat cctgaggctt catcgggagc
     5401 tagagccagc taacatttcc tcgtttcaag actgcctttg atttgcccct tgatgccgtc
     5461 cgtgtatttc ggatttaagg tcctgcgttc tcaacctgga accaatgtct gccataccta
     5521 gttccacttc tcaaactgga gcatcctcct ttatgtattt atatgtatgt tttatgtagt
     5581 cctcctcctg tacctattgt atattttttt ctaacgttta agcacatgct ttttgtatta
     5641 tgcaatatat aacgggtgtg cagccatagc gacgctttga aaagctccaa gcctcaactg
     5701 taacctgcag caaacagata acattcctgg caagaagaga caagtctttt ttaaagttta
     5761 ctgatgctta gatctgtggg cttctagtcc tctgaaagtg gttgttttcc tatgcacagc
     5821 gagctcagaa ataaaaaccc cattttgaaa catccaggat gtcccaatat taccatgatt
     5881 ttttcccccc tttttgctaa tccagtccag gttggaaaga agtctcctct gtgtcagatt
     5941 aagccctgtc tcttaatgat atggacaaat gagtgtgcct aaggccatga gatgtttcct
     6001 aatgcagaag gaatctgttg tacgtttttt tgattgtact cttctatgct ggaccgaatt
     6061 catatgcaga tcgaagtgag tcctgttctt tacagatggt attttgatag atactggagt
     6121 ttgtctgtgt tatatctgtg ccccttcttt aagaacaatg ttgcattatg ttcctttgga
     6181 taaattgtga tttgacaact gatttaaata aacatatttg cctcacttaa aaaaaaaaaa
     6241 aaaaaaaaaa aaaaa
//
