LOCUS       NM_001394793            9323 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus A-kinase anchoring protein 11 (Akap11), mRNA.
ACCESSION   NM_001394793 XM_017599778
VERSION     NM_001394793.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 9323)
  AUTHORS   Whiting,J.L., Ogier,L., Forbush,K.A., Bucko,P., Gopalan,J.,
            Seternes,O.M., Langeberg,L.K. and Scott,J.D.
  TITLE     AKAP220 manages apical actin networks that coordinate aquaporin-2
            location and renal water reabsorption
  JOURNAL   Proc Natl Acad Sci U S A 113 (30), E4328-E4337 (2016)
   PUBMED   27402760
REFERENCE   2  (bases 1 to 9323)
  AUTHORS   Radeva,M.Y., Kugelmann,D., Spindler,V. and Waschke,J.
  TITLE     PKA compartmentalization via AKAP220 and AKAP12 contributes to
            endothelial barrier regulation
  JOURNAL   PLoS One 9 (9), e106733 (2014)
   PUBMED   25188285
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 9323)
  AUTHORS   Day,M.E., Gaietta,G.M., Sastri,M., Koller,A., Mackey,M.R.,
            Scott,J.D., Perkins,G.A., Ellisman,M.H. and Taylor,S.S.
  TITLE     Isoform-specific targeting of PKA to multivesicular bodies
  JOURNAL   J Cell Biol 193 (2), 347-363 (2011)
   PUBMED   21502359
REFERENCE   4  (bases 1 to 9323)
  AUTHORS   Carnegie,G.K., Means,C.K. and Scott,J.D.
  TITLE     A-kinase anchoring proteins: from protein complexes to physiology
            and disease
  JOURNAL   IUBMB Life 61 (4), 394-406 (2009)
   PUBMED   19319965
  REMARK    Review article
REFERENCE   5  (bases 1 to 9323)
  AUTHORS   Okutsu,R., Rai,T., Kikuchi,A., Ohno,M., Uchida,K., Sasaki,S. and
            Uchida,S.
  TITLE     AKAP220 colocalizes with AQP2 in the inner medullary collecting
            ducts
  JOURNAL   Kidney Int 74 (11), 1429-1433 (2008)
   PUBMED   19008911
REFERENCE   6  (bases 1 to 9323)
  AUTHORS   Garnis,C., Rosin,M.P., Zhang,L. and Lam,W.L.
  TITLE     Alteration of AKAP220, an upstream component of the Rb pathway, in
            oral carcinogenesis
  JOURNAL   Int J Cancer 116 (5), 813-819 (2005)
   PUBMED   15849745
REFERENCE   7  (bases 1 to 9323)
  AUTHORS   Tasken,K. and Aandahl,E.M.
  TITLE     Localized effects of cAMP mediated by distinct routes of protein
            kinase A
  JOURNAL   Physiol Rev 84 (1), 137-167 (2004)
   PUBMED   14715913
  REMARK    Review article
REFERENCE   8  (bases 1 to 9323)
  AUTHORS   Tanji,C., Yamamoto,H., Yorioka,N., Kohno,N., Kikuchi,K. and
            Kikuchi,A.
  TITLE     A-kinase anchoring protein AKAP220 binds to glycogen synthase
            kinase-3beta (GSK-3beta) and mediates protein kinase A-dependent
            inhibition of GSK-3beta
  JOURNAL   J Biol Chem 277 (40), 36955-36961 (2002)
   PUBMED   12147701
REFERENCE   9  (bases 1 to 9323)
  AUTHORS   Schillace,R.V. and Scott,J.D.
  TITLE     Association of the type 1 protein phosphatase PP1 with the A-kinase
            anchoring protein AKAP220
  JOURNAL   Curr Biol 9 (6), 321-324 (1999)
   PUBMED   10209101
REFERENCE   10 (bases 1 to 9323)
  AUTHORS   Lester,L.B., Coghlan,V.M., Nauert,B. and Scott,J.D.
  TITLE     Cloning and characterization of a novel A-kinase anchoring protein.
            AKAP 220, association with testicular peroxisomes
  JOURNAL   J Biol Chem 271 (16), 9460-9465 (1996)
   PUBMED   8621616
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000015.1.
            
            On May 6, 2021 this sequence version replaced XM_017599778.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760386
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-147               JAXUCZ010000015.1  60365189-60365335   c
            148-257             JAXUCZ010000015.1  60350744-60350853   c
            258-374             JAXUCZ010000015.1  60348947-60349063   c
            375-422             JAXUCZ010000015.1  60347025-60347072   c
            423-557             JAXUCZ010000015.1  60345256-60345390   c
            558-822             JAXUCZ010000015.1  60343780-60344044   c
            823-5251            JAXUCZ010000015.1  60338882-60343310   c
            5252-5407           JAXUCZ010000015.1  60336741-60336896   c
            5408-5491           JAXUCZ010000015.1  60331913-60331996   c
            5492-5538           JAXUCZ010000015.1  60331161-60331207   c
            5539-5699           JAXUCZ010000015.1  60327233-60327393   c
            5700-9323           JAXUCZ010000015.1  60320839-60324462   c
FEATURES             Location/Qualifiers
     source          1..9323
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="15"
                     /map="15q11"
     gene            1..9323
                     /gene="Akap11"
                     /gene_synonym="Akap"
                     /note="A-kinase anchoring protein 11"
                     /db_xref="GeneID:498549"
                     /db_xref="RGD:2079"
     exon            1..147
                     /gene="Akap11"
                     /gene_synonym="Akap"
                     /inference="alignment:Splign:2.1.0"
     exon            148..257
                     /gene="Akap11"
                     /gene_synonym="Akap"
                     /inference="alignment:Splign:2.1.0"
     CDS             198..5840
                     /gene="Akap11"
                     /gene_synonym="Akap"
                     /note="AKAP 220; PRKA11; A-kinase anchor protein 220 kDa;
                     protein kinase A-anchoring protein 11; AKAP-11; A-kinase
                     anchoring protein 220, AKAP 220; A kinase (PRKA) anchor
                     protein 11"
                     /codon_start=1
                     /product="A-kinase anchor protein 11"
                     /protein_id="NP_001381722.1"
                     /db_xref="GeneID:498549"
                     /db_xref="RGD:2079"
                     /translation="MAAFQPFRNSHTKTKASVRKSFSEDVFQSVKSLLQSEKELCSVS
                     GGECLNQDEHAQLTEITFLGFNEETDAAHMKDLAAVSLELPDLLNSLHFCSLSENEII
                     CMKDTNKSSDVSSSPLNQSHHSGMLCVMRVSPTLPGLRIDFIFSLLSKYAAGIRHTLD
                     THLHEKLHLETTDEDDDDTNQSVSSIEDDFVTAFEQLEEEENAKLCNDEMNIATLRSR
                     CDAASQTTSGHHLESHDLKVLVSYGSQKSLAKPSPSVNVLGRKEASVKTSVTTSISEP
                     WTQRSLYRSPSASDKGKDTQETFFPPSPVHSSESECSSPSPVIFLDEEGYQKSLKAKL
                     ELPEIPVTKDDIEDSDSEVSEFFDSFDQFDELEQTLETYLFMEDPVIGKSSQKIGHKY
                     EKSCMNPQKFKFERPALPANVRKPTPRKPESPYAHLCGAPDSPRPVVASEDSGLFSPI
                     RTSAFSPPGSCPPAECLCQTDTSENRNHEKYCTYEDYANNLSCEVLGSVLHTQHANTM
                     SDINSIKRGRNNPVTYKHGDSDQKNKCKKSSVITDSVQKFAADLVGKSFGSAFKDLQK
                     GVSSCTNALCHLAVKLTSSIFQMAFNELRRQCAFSLKERAIGSLASLLVSEALSNALK
                     DLQYVKKQMFTNTVARFAADLAEELVFEGIMEVCQFSCPQTPASSQCQSFDFEDKVVK
                     SYAKDLSESVIQEAFIELSQTDVTFTAKAAVNVSMGSVKSVNAENAVPPAQTLTFSSS
                     FSSQAVMMTKPMQEHKKEYTVQQALFCTSGIVTSIPVPLAGSALLPYHVSSTLYQSKS
                     LSSSEHNKANGGSPQEHIAMESSAEEVDCFKNTCLPSELSPCSQNDFKPTNGDIDMQS
                     PSKLMSGSMIISNFSTAMVHTIVNETLESMTSFKATKPVDTNADYLTKTIKGKACSFS
                     LCDQAAPQQNKASSKDMFAEHLSKSIIKHSLDKSKSVLPNIDKKPVSKEHMLVLGEES
                     QLTLGETPKFLDFSDNSPQYCVPECKDSVGFGFSLEALPPCSMMTSQKSDLKGVMKDK
                     VVTRHNLTNTALEPLSFGQESSFRPSQTLSSAVLTCVDSLHVEDKQKIRDRNVIPDTP
                     PSTPLVPSQTSSEWDIKKLTKQLKGELAKEFAPATPPSTPHNSSVGSLSENEQTTIEK
                     EEFMLKLMRSLSEEVESSEGEEHPEMDVKSEHSGKKGQFADALATHIISLATEVAASH
                     LDHEITQEFKVQNSHLTVPSQRSMLPALSHLDESIQTCSFASDMAAGVIAEAEKVANT
                     RSCMLFGHERTICHVEGDRGKAEEKLDVEDIAHPREVETCVLSLPSCMPGLTYKYPSC
                     ESVTDEYAGHVIQVLKQEGGNSELIMDQYASRLAYRSVKSGVREAAKTVKVKCSLKLF
                     PMHTSHVKTNKELLFSSKEHHQEVDKKRQRKKYGSHPCKYQTCDRTQDPCRNELSELY
                     RFSASLASSITRDVKKQLTAPKVDLPKSSTDCCLFEKSECVDNRENVTGPEVSKSCQP
                     LQNHGLCQNTSSLSGYSCGESAHTVEQYARKVVGDTLELSLGPAVFLNSETTTSPDRI
                     TYAEKLSPLINEACRYCDLKESHGCIRNSAQLFSKQGPCASAKPSSHSKLSSIRQKSR
                     IFHLDVPQIHVNLDKRAVLAEKIVAEAIEKAERELSNTSLAADSGIGQDGISFAESLT
                     TEIMTTAMTNAGHAVSSSKEVEDFQSTESLGSQQMNLSVGEDSTGSWSNLSFEDDHQD
                     ESSSFHHLSESNGNSSSWSSLGLEGDLYEDNLSFPTSDSDGPDDRESEQEDGAEGLQP
                     SGKTLLIVNIDVEPGAVDPQLRVILQWLIASEAEVRELYFQDSAKKEFVLLSKQLQER
                     GWKVGDVLQAVLKYYEVVAKASSEDTCTSLFDWLLENA"
     exon            258..374
                     /gene="Akap11"
                     /gene_synonym="Akap"
                     /inference="alignment:Splign:2.1.0"
     exon            375..422
                     /gene="Akap11"
                     /gene_synonym="Akap"
                     /inference="alignment:Splign:2.1.0"
     exon            423..557
                     /gene="Akap11"
                     /gene_synonym="Akap"
                     /inference="alignment:Splign:2.1.0"
     exon            558..822
                     /gene="Akap11"
                     /gene_synonym="Akap"
                     /inference="alignment:Splign:2.1.0"
     exon            823..5251
                     /gene="Akap11"
                     /gene_synonym="Akap"
                     /inference="alignment:Splign:2.1.0"
     exon            5252..5407
                     /gene="Akap11"
                     /gene_synonym="Akap"
                     /inference="alignment:Splign:2.1.0"
     exon            5408..5491
                     /gene="Akap11"
                     /gene_synonym="Akap"
                     /inference="alignment:Splign:2.1.0"
     exon            5492..5538
                     /gene="Akap11"
                     /gene_synonym="Akap"
                     /inference="alignment:Splign:2.1.0"
     exon            5539..5699
                     /gene="Akap11"
                     /gene_synonym="Akap"
                     /inference="alignment:Splign:2.1.0"
     exon            5700..9323
                     /gene="Akap11"
                     /gene_synonym="Akap"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagtgggcgg cgtggggagg cggcggcggt ggcgtcgcgg gctggggcgg gcgagggatc
       61 gccgctgcgc cgcggctcgc gccaccgggc gttgcgggcc gtgacgggag ggtgacatgc
      121 ccgggaactg agaggctgcg ccgccgggtg tgttgtggat tgactccgac agtatcgcac
      181 actgcagtaa cacagttatg gcggctttcc agcctttcag aaatagtcac acgaagacta
      241 aagcatctgt ccgaaaaagt ttcagtgaag atgtgttcca gtccgtaaag tctttattac
      301 agagtgagaa ggagctgtgc agtgtatcag gaggagagtg tttaaaccag gatgagcatg
      361 cccagttaac tgagatcaca tttctgggct ttaatgaaga aacagatgct gctcatatga
      421 aggatctagc tgcagtttca ctagaacttc cagatcttct gaattcgctc catttctgca
      481 gtctaagtga aaatgaaatc atttgtatga aggataccaa taaatcttct gatgtaagca
      541 gtagtcctct aaatcagagt caccattcag gaatgctttg tgtcatgaga gtgtcaccta
      601 cattaccagg actcagaatt gatttcatct ttagtctcct aagtaaatat gctgctggca
      661 taagacacac cctggacaca cacttgcacg agaagctcca ccttgagacc actgatgaag
      721 atgacgatga cacgaaccag tctgtgtctt ccatagagga tgactttgtc actgcttttg
      781 agcagttgga ggaggaagag aatgcaaagc tgtgtaacga cgaaatgaat attgctacac
      841 taaggagccg gtgtgatgct gcctctcaga ctacttcagg tcaccattta gaaagccatg
      901 atcttaaagt gctggttagt tatggatcac agaagtcttt ggctaagccc tcaccttcag
      961 taaatgttct gggacgcaaa gaagcttctg tgaaaacatc agttacaaca tcgatttcag
     1021 agccctggac tcagaggagt ctctacaggt cacccagtgc ctcagataaa ggcaaggaca
     1081 cacaggagac attctttcct ccttctcctg tccactcgtc agagtctgag tgctcaagcc
     1141 caagtcctgt gatttttttg gatgaagagg gatatcaaaa aagtttaaaa gcgaaacttg
     1201 agctgcctga aatccctgtg acaaaagatg atatagagga ttcagactca gaagtgagtg
     1261 agttttttga tagctttgat cagtttgatg aactagagca aactttagag acttacctgt
     1321 tcatggaaga tcctgtcata gggaagtcat cacagaagat agggcacaaa tatgaaaagt
     1381 cttgtatgaa tcctcagaaa ttcaagtttg agcgcccagc tcttccagct aatgttagaa
     1441 agccaacacc tcgcaaacct gagtctccat atgctcacct gtgtggtgct ccagattccc
     1501 ctcgcccagt ggtggcatca gaggacagtg gcttgtttag ccctattcga acctctgctt
     1561 ttagtccccc tggaagctgt cctcctgctg aatgcctttg ccaaacagat actagtgaaa
     1621 ataggaatca tgaaaagtac tgcacttacg aagattatgc aaataatctt tcatgtgaag
     1681 tactaggctc agttcttcat actcaacatg caaacacaat gtcagatatt aatagtatta
     1741 aaaggggaag aaataatcct gtaacttata agcatggaga ctctgatcaa aaaaataaat
     1801 gtaaaaaatc ttcagtgatt accgatagcg ttcagaagtt tgcagcagat cttgtgggaa
     1861 aaagttttgg cagtgcattt aaagacttac agaaaggagt ttcttcatgt accaatgcac
     1921 tgtgccacct ggctgtcaaa ttgacatcat ccatatttca gatggcattt aatgaactaa
     1981 gaaggcagtg tgcattttca ttaaaggagc gagccattgg tagcctggcc agtcttttgg
     2041 tgagcgaagc cttatcaaat gccttgaaag acttacagta tgtgaaaaag cagatgttta
     2101 caaacacagt tgctaggttt gctgcagacc ttgctgaaga gcttgttttt gaaggtatca
     2161 tggaagtgtg tcagttttca tgtcctcaga cacctgcatc ttcacagtgt cagtcatttg
     2221 actttgaaga caaagtcgtg aagtcatatg ccaaagattt gtctgaatct gtaatacaag
     2281 aagcattcat agagctgtca cagacggacg tgaccttcac agcaaaggca gcagttaatg
     2341 tttctatggg tagtgtcaag tccgtgaatg cagaaaatgc agtgccacct gcgcagaccc
     2401 ttacattctc ctcatccttt agcagtcaag cagttatgat gaccaaacca atgcaggagc
     2461 ataagaagga atacacggta cagcaggctt tgttttgtac ctcaggaatt gtcacttcca
     2521 taccagtgcc cttggcaggt agtgcccttc tcccatatca cgtgtcatct actttgtacc
     2581 agtccaagtc tctgtcatcg tctgagcata ataaagcaaa tggcggttct ccccaagagc
     2641 acattgccat ggaaagcagt gcagaggaag tggattgttt taaaaacacc tgtctacctt
     2701 cagaactcag tccttgcagc cagaatgact tcaaaccaac taatggtgat atcgacatgc
     2761 agagtccttc aaaattaatg agtggctcta tgattattag caacttttcc acagcaatgg
     2821 tacatacaat agtaaatgaa accttagagt ccatgacatc cttcaaagcc acaaaacctg
     2881 ttgatacaaa tgcagattat ttaactaaaa caataaaggg aaaagcctgt tctttttccc
     2941 tttgcgacca agcagcacca caacagaaca aagctagcag taaggacatg tttgctgagc
     3001 atttatcaaa gtctattatt aaacattccc tggataaaag caagtcagtc cttccaaata
     3061 tagataaaaa accagttagt aaggaacaca tgcttgttct tggagaagaa tcacagttga
     3121 ccttggggga aactcccaaa ttccttgact tttcagataa ttcacctcag tattgtgttc
     3181 cagaatgtaa agattctgtg ggttttggat tttctttaga ggcactgcca ccttgttcaa
     3241 tgatgacaag tcagaaatct gacttgaagg gagttatgaa ggataaagtg gtaacaagac
     3301 acaatctgac taatactgcg cttgagccct tgtcttttgg acaggaaagc tctttccgtc
     3361 cctcacagac tttatcatct gcagtgctta cctgtgtaga tagtttgcat gtggaagata
     3421 agcagaaaat cagagacaga aatgtgatac ctgatactcc cccatcaaca cctttagtac
     3481 catcccagac tagttctgaa tgggacatca aaaagttaac caaacaactc aaaggggagt
     3541 tagccaaaga atttgctccc gcaacaccac cttcgacacc tcacaactca tccgttggta
     3601 gtttatctga gaatgaacaa actactatag aaaaggaaga gttcatgctg aaactcatgc
     3661 gctctctttc tgaagaagtt gagagcagtg aaggtgagga gcacccagaa atggatgtaa
     3721 agtcagagca ttcagggaaa aaaggtcagt ttgcagacgc attagctaca cacatcattt
     3781 ctcttgcaac tgaagtggca gcctcccact tagatcatga aatcactcaa gaattcaagg
     3841 ttcaaaactc tcacttaact gtgccaagtc aaagaagcat gctgcctgct ctaagtcact
     3901 tagatgaaag catacagacg tgcagttttg caagtgatat ggcagctggt gttattgcag
     3961 aagccgagaa agttgcaaac actagaagtt gtatgctttt cgggcatgag aggaccattt
     4021 gtcatgttga aggtgatcga ggtaaagcag aagagaagct ggatgtggag gatattgcac
     4081 atccaagaga agtagaaacg tgtgttcttt cattaccaag ttgcatgcca ggtctgacat
     4141 acaagtatcc cagctgtgaa agtgtgactg atgaatatgc tgggcacgtt attcaagtgc
     4201 tgaaacagga aggtggcaac agtgagctaa tcatggatca gtatgccagt agattggcct
     4261 accgttctgt caagtcagga gtacgagaag cagctaagac agtaaaagtg aagtgcagtt
     4321 tgaaactctt ccctatgcac acctctcatg tgaaaacaaa caaggaactg ttgttctcaa
     4381 gtaaagagca tcaccaagaa gtagataaaa aaagacaaag aaaaaaatat ggcagccatc
     4441 cttgcaaata ccagacatgt gacaggacac aggatccatg tagaaacgaa ctttctgaac
     4501 tgtacaggtt ttcagcctct cttgctagca gcataacaag agatgtaaag aaacagctga
     4561 cagcacctaa agttgacttg ccaaaatcct caacagactg ttgtcttttt gaaaaatctg
     4621 aatgtgttga caacagagag aatgttactg gaccagaagt ttcaaagtcg tgtcaacctt
     4681 tacaaaacca tggactttgc cagaacacaa gcagtttaag tgggtatagc tgtggagaga
     4741 gtgctcacac tgtagaacag tatgctagga aagtagtggg tgacacttta gagctaagct
     4801 taggacctgc agttttcctt aattcagaga ccacaacatc accagatagg attacttatg
     4861 cagaaaaatt gtcaccactt ataaatgaag cttgcagata ctgtgacctt aaggaatccc
     4921 atggttgtat cagaaattct gctcagctct tttcaaagca gggtccttgt gctagtgcta
     4981 agccaagttc acattcaaaa cttagtagca tccgccagaa atcaagaatt tttcatcttg
     5041 atgttcctca aattcatgtt aatcttgata agagggcggt gcttgcagag aagatagtcg
     5101 ctgaagctat tgaaaaagca gagagagagt tgagcaatac gagtttggca gctgatagtg
     5161 gaattggaca agatggcatt agctttgctg agagccttac cacagaaatc atgaccacag
     5221 ctatgacaaa tgccgggcat gctgttagca gttcaaaaga agtagaagat tttcagtcca
     5281 ctgagtcact tggcagccaa cagatgaatc ttagtgttgg tgaggacagc acgggtagct
     5341 ggtccaactt aagttttgag gatgaccatc aagatgaaag cagcagtttc catcatctca
     5401 gtgaaagtaa tggtaacagc agtagctgga gcagtcttgg tttagaagga gatttgtatg
     5461 aggacaattt atcctttcca acatcagaca gtgatggacc ggatgataga gagagcgaac
     5521 aggaggatgg tgctgagggt ttgcagccga gtggaaagac tctgctgatc gtgaacattg
     5581 acgtggagcc tggggcggtg gaccctcagc tcagggtcat tcttcagtgg ctcattgcct
     5641 cggaggcgga agttagagaa ctttattttc aggactctgc aaagaaggag tttgtcttac
     5701 tttcaaagca gttacaggag agaggatgga aagtgggcga tgtcctgcag gctgtgctga
     5761 aatactacga agtggtggcc aaagcctcaa gcgaggacac gtgcacgtcg ctgtttgatt
     5821 ggcttttaga aaatgcctag cacaccgcag ggcagtgtac tttagtgctt gttttaggaa
     5881 gtaaaaaagt tgatgattta catgtaggat aaaattcaaa tacagaatat taacatttta
     5941 attgaattga gaggaaagta agctttttaa gtgctttctg tcattacact gtatatagtt
     6001 catacttttg taatctttgt caagatattc tctttactta ttcttctgta tatgtgtatg
     6061 tgttatgacc tggagataat attctgtgaa ggacgatcta tcctcacccg aggctggggc
     6121 attcattgtc tgacagcatt tgtttggatt cacatagtgc tgctgctgct gctgctgctg
     6181 ctgctgctgc tgctgctgct gctgctgctg ctgctgctgc aaacagggct gaggcggctg
     6241 gcctggccca cgtgatcact tggttccttt gaaaacaagt ggtgtctaat gataagtcat
     6301 ctgacatgaa gaaagaaaac tgaggctgat attttgttgt ttatttattt ctgataagtt
     6361 tgtattcttt atgtactgtt ctttaaaatc agttttactt cccagttcag ctattggtac
     6421 ttgtagattc cccaatcttt aagctcgtag catactcatt agtgacttag gtttctgtga
     6481 acaccgttat gtgttcccct ggctttccat caagtgatgt tatttgctaa tactgccaat
     6541 tgttatgaga tgagaaggag aagggcgtgt gtgcgtgtgc aagaataaac gctaaccttc
     6601 ccactagttc attcgtttac tttagagttt tcttaaatag aaacccatta ttaacactaa
     6661 ataaaatgtc taaatattgt gcagtaagaa ttttgtcttt ttgatttatt ctacagatgc
     6721 aaatttaggt tgtaaaatac attgaaattt taaaaattaa tgtagaaatg cactcagagg
     6781 agcccaataa tgaatttcag tattggattt tgaagaagaa aaagatcctc ctcacctcac
     6841 caagagtaat ttcttttagc tcggtgattc tcaaccttcc taacgttgca accctttaat
     6901 acagttcctc atgttgtggt aacccctaac cataaaatta tttagttgat acttcataac
     6961 tgtaattttg ctactgttat gacttgtaaa tattggtgtt ttctgatgat ctgatagggg
     7021 tcatttgacc cccaaagagg ttgcaagcca gaggttaaga actgccattt cagcataaaa
     7081 gtacctctct cccaataaaa tgtatctgga taatttcgta aagttccctc tcatgatctt
     7141 ttttggcctc tacattttct actgtgtttt tagagactgc aggttctaat tgagatgagt
     7201 aggctttgtc tcagtgtgct tgagatgtgt gtaggtggga ggttctccct aaccggttct
     7261 ggaatctaag gcgagtcata ctgcctgggc tgttgtgttt tctccattat attttctctc
     7321 ttcccctaag cgctgacttt tctagaacct acagtgaata gatgacataa cacctaccag
     7381 ggtacttcca ttaatctgag ttagtaatta tggtggaaaa gttattttta tagagatgtc
     7441 acatttgctt tgtctccaga aacaacttaa gtattttgaa actacattat aaactctagt
     7501 ttttctcagt tcaacataga gacacagggc ctgccttaag catacatttt ttttttaaaa
     7561 agaagtttct tcaagtattt ttcagagtgg gcaaatgcag gaataatatc catgtgcact
     7621 ctcttacact tatatgagga acaagcacac tgcacatatg taatttgcat gatatgtgtt
     7681 gcttagatta acagtaaaac tgactttaaa tttccttgag atgcaaatga caatgttggt
     7741 cttaaaaaat tgaaagtgcc aggaatgttt ctgtttctgg attagttatt tgaggcaagc
     7801 tctaagttgt gctccgattt cctttgcatt ctggtgaagc cacgctacgc tgtactgccc
     7861 agtgttcttc agtaagtgca acagtgacag aggtggaact cacagtgcgt cggttctgtg
     7921 caggaacaca gaaaacagta ggaagtactg gcagggtgtg tggaagtgta ggcagtttcg
     7981 ttatagaaag catttgcatg tagagccatg ctgcgtgctg gacacaggta aagggggccg
     8041 ctttaaagca cgttgtcttt ggagcaactc tgttgagagt aaaacttaaa atgttgtgat
     8101 acacagtgag ctgactcttg actcaccagt tttaaaggca tccaggatcc acagacagag
     8161 acacctctgt cagaaaagcc agccaagaaa acaaacaaac aacacaaaac ccacagaaga
     8221 aatggcagta gatggatggc tccttatggt aaagctaaca ttgtaacaac cttcagtgaa
     8281 cacatgtagt acctttgttc tttcagaaat gcttcattta cccctaaagg tatttaatgt
     8341 gaattagttc agttcatact actataattc tgcttagcag aggacttata ttgcaggtag
     8401 gaagctacgt gttgagtgca ctgtgcagaa attaaagacg gttgaccatt tgacagagct
     8461 gtggccccca gcggtggcac atgttctctg attgtccgga gcctcggcta cctgccgttc
     8521 cactagtagt gtttctccac agctgctttt agcagcatca agtcagtgta ttgttttgta
     8581 atttttcaaa gaaatcttta cacagagttt aaatatgttg ggtccacaca cgggtaggga
     8641 aaatactctc cgtttaaaac cgtgtctgcc tgtcagcagc acggagaact gtgggagcgt
     8701 ctgtgggagt cggaaggggc ggactcaagt caagtgcgct ttgctcttca gcgcaagccc
     8761 tgtaggcacc ccttgtttac ggtgcgcctg ctctgcacac gcaggcgcgg tgctggtcac
     8821 tcctgcctct ctatttattt attttgacat ctgtacattc ctttcctata gttaagagcc
     8881 gcagttctgc aggctcctat ctcaatctgt tgtacggttt ggatgctatt taaatgccag
     8941 gttctgtgtg gctggatttg ctgccttcag ttacttgtgc tgtgtttcaa gtaatctgca
     9001 ttcttgttca cttaatgaat atttagtaga agtaactttg agtaactgtg gccacttatt
     9061 tgggtttgct catttagcac actaaggtcg tatactgtgc gtagtagtaa tctctctttc
     9121 tgctcttgag taatttaatg ttcatttatc aaactcggaa cttcaaagtg cactaaagtt
     9181 ttgtttagca gtggttcaaa ctgtttcaga aattactttt gtaatcattt gcaattaatt
     9241 gttcttttgt ctttactctt gttcaagcct gtgatctttc ctctcccagc caagaattat
     9301 tcaataaatt taagaaatgt caa
//
