LOCUS       NM_017135                677 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus adenylate kinase 4 (Ak4), mRNA; nuclear gene for
            mitochondrial product.
ACCESSION   NM_017135
VERSION     NM_017135.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 677)
  AUTHORS   Jiang,W., Jia,Q., Ma,H., Han,S., Bi,S., Zhu,K., Chen,L. and
            Liang,G.
  TITLE     MicroRNA-124 conducts neuroprotective effect via inhibiting
            AK4/ATF3 after subarachnoid hemorrhage
  JOURNAL   Exp Brain Res 242 (1), 33-45 (2024)
   PUBMED   37932484
  REMARK    GeneRIF: MicroRNA-124 conducts neuroprotective effect via
            inhibiting AK4/ATF3 after subarachnoid hemorrhage.
REFERENCE   2  (bases 1 to 677)
  AUTHORS   Jan,Y.H., Lai,T.C., Yang,C.J., Lin,Y.F., Huang,M.S. and Hsiao,M.
  TITLE     Adenylate kinase 4 modulates oxidative stress and stabilizes
            HIF-1alpha to drive lung adenocarcinoma metastasis
  JOURNAL   J Hematol Oncol 12 (1), 12 (2019)
   PUBMED   30696468
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 677)
  AUTHORS   Fujisawa,K., Terai,S., Takami,T., Yamamoto,N., Yamasaki,T.,
            Matsumoto,T., Yamaguchi,K., Owada,Y., Nishina,H., Noma,T. and
            Sakaida,I.
  TITLE     Modulation of anti-cancer drug sensitivity through the regulation
            of mitochondrial activity by adenylate kinase 4
  JOURNAL   J Exp Clin Cancer Res 35, 48 (2016)
   PUBMED   26980435
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 677)
  AUTHORS   Lanning,N.J., Looyenga,B.D., Kauffman,A.L., Niemi,N.M.,
            Sudderth,J., DeBerardinis,R.J. and MacKeigan,J.P.
  TITLE     A mitochondrial RNAi screen defines cellular bioenergetic
            determinants and identifies an adenylate kinase as a key regulator
            of ATP levels
  JOURNAL   Cell Rep 7 (3), 907-917 (2014)
   PUBMED   24767988
REFERENCE   5  (bases 1 to 677)
  AUTHORS   Kong,F., Binas,B., Moon,J.H., Kang,S.S. and Kim,H.J.
  TITLE     Differential expression of adenylate kinase 4 in the context of
            disparate stress response strategies of HEK293 and HepG2 cells
  JOURNAL   Arch Biochem Biophys 533 (1-2), 11-17 (2013)
   PUBMED   23474458
REFERENCE   6  (bases 1 to 677)
  AUTHORS   Yamamoto,T., Kikkawa,R., Yamada,H. and Horii,I.
  TITLE     Investigation of proteomic biomarkers in in vivo hepatotoxicity
            study of rat liver: toxicity differentiation in hepatotoxicants
  JOURNAL   J Toxicol Sci 31 (1), 49-60 (2006)
   PUBMED   16538043
REFERENCE   7  (bases 1 to 677)
  AUTHORS   Noma,T.
  TITLE     Dynamics of nucleotide metabolism as a supporter of life phenomena
  JOURNAL   J Med Invest 52 (3-4), 127-136 (2005)
   PUBMED   16167529
  REMARK    Review article
REFERENCE   8  (bases 1 to 677)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   9  (bases 1 to 677)
  AUTHORS   Noma,T., Fujisawa,K., Yamashiro,Y., Shinohara,M., Nakazawa,A.,
            Gondo,T., Ishihara,T. and Yoshinobu,K.
  TITLE     Structure and expression of human mitochondrial adenylate kinase
            targeted to the mitochondrial matrix
  JOURNAL   Biochem J 358 (Pt 1), 225-232 (2001)
   PUBMED   11485571
REFERENCE   10 (bases 1 to 677)
  AUTHORS   Yoneda,T., Sato,M., Maeda,M. and Takagi,H.
  TITLE     Identification of a novel adenylate kinase system in the brain:
            cloning of the fourth adenylate kinase
  JOURNAL   Brain Res Mol Brain Res 62 (2), 187-195 (1998)
   PUBMED   9813319
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from D87809.1.
            
            [WARNING] On Apr 23, 2024 this sequence was replaced by
            NM_017135.4.
            
            On Jun 10, 2007 this sequence version replaced NM_017135.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D87809.1, BC087024.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..677
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q33"
     gene            1..677
                     /gene="Ak4"
                     /gene_synonym="AK 4; Ak3l1; Ak3l2"
                     /note="adenylate kinase 4"
                     /db_xref="GeneID:29223"
                     /db_xref="RGD:2078"
     exon            1..146
                     /gene="Ak4"
                     /gene_synonym="AK 4; Ak3l1; Ak3l2"
                     /inference="alignment:Splign:2.1.0"
     CDS             2..673
                     /gene="Ak4"
                     /gene_synonym="AK 4; Ak3l1; Ak3l2"
                     /EC_number="2.7.4.10"
                     /EC_number="2.7.4.6"
                     /note="adenylate kinase isoenzyme 4, mitochondrial;
                     ATP-AMP transphosphorylase; adenylate kinase 3-like 2;
                     adenylate kinase 3 alpha-like 1; adenylate kinase 3-like
                     1; GTP:AMP phosphotransferase AK4, mitochondrial"
                     /codon_start=1
                     /product="adenylate kinase 4, mitochondrial"
                     /protein_id="NP_058831.1"
                     /db_xref="GeneID:29223"
                     /db_xref="RGD:2078"
                     /translation="MASKLLRAVILGPPGSGKGTVCERIAQNFGLQHLSSGHLLRENL
                     KTNTEVGDVAKQYLEKGLLVPDHVITRLMMSELETRSAQHWLLDGFPRTLVQAEALDR
                     ICDVDLVISLNIPFETLKDRLSRRWIHPSSGRVYNLDFNPPQVLGVDDITGEPLVQQE
                     DDKPEALAARLRRYKDAAKPVIELYKSRGVLHQFSGTETNRIWPYVYTLFSNKITPIQ
                     SKEAY"
     exon            147..266
                     /gene="Ak4"
                     /gene_synonym="AK 4; Ak3l1; Ak3l2"
                     /inference="alignment:Splign:2.1.0"
     exon            267..439
                     /gene="Ak4"
                     /gene_synonym="AK 4; Ak3l1; Ak3l2"
                     /inference="alignment:Splign:2.1.0"
     exon            440..558
                     /gene="Ak4"
                     /gene_synonym="AK 4; Ak3l1; Ak3l2"
                     /inference="alignment:Splign:2.1.0"
     exon            559..677
                     /gene="Ak4"
                     /gene_synonym="AK 4; Ak3l1; Ak3l2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 catggcttcc aaactcctgc gcgcagtcat cctggggccg cctggctctg gcaagggcac
       61 ggtatgcgaa aggatcgccc agaactttgg cctccagcat ctctccagcg gccacttgtt
      121 gcgggagaac ctaaagacca acacggaagt tggtgacgtg gcaaaacagt acctagaaaa
      181 aggtcttttg gttccggacc atgtgatcac gcgcctaatg atgtcagaac tggagacccg
      241 gagtgcccag cactggctat tagatggatt cccaaggaca ttagtgcagg cagaagctct
      301 ggacagaatc tgtgatgtgg acctagtaat cagtttgaat attcctttcg agacacttaa
      361 agatcgtctg agccgacggt ggattcaccc ttccagcggg agggtctata acctagactt
      421 caacccacct caagtgctgg gggttgatga catcaccggc gagcctcttg tccaacagga
      481 agatgataaa cctgaagcac ttgctgcccg gctaagacgg tacaaggacg cagcaaaacc
      541 agtcatcgaa ctgtacaaga gccgtggagt gctccaccag ttttctggga cggagactaa
      601 cagaatctgg ccttatgttt acacgctctt ctccaacaag atcacaccca ttcaatccaa
      661 agaagcctac tgagcct
//
