LOCUS       NM_013218               3025 bp    mRNA    linear   ROD 17-FEB-2024
DEFINITION  Rattus norvegicus adenylate kinase 3 (Ak3), mRNA; nuclear gene for
            mitochondrial product.
ACCESSION   NM_013218 XM_346582
VERSION     NM_013218.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3025)
  AUTHORS   Admoni-Elisha,L., Nakdimon,I., Shteinfer,A., Prezma,T., Arif,T.,
            Arbel,N., Melkov,A., Zelichov,O., Levi,I. and Shoshan-Barmatz,V.
  TITLE     Novel Biomarker Proteins in Chronic Lymphocytic Leukemia: Impact on
            Diagnosis, Prognosis and Treatment
  JOURNAL   PLoS One 11 (4), e0148500 (2016)
   PUBMED   27078856
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3025)
  AUTHORS   Melle,C., Ernst,G., Scheibner,O., Kaufmann,R., Schimmel,B.,
            Bleul,A., Settmacher,U., Hommann,M., Claussen,U. and von
            Eggeling,F.
  TITLE     Identification of specific protein markers in microdissected
            hepatocellular carcinoma
  JOURNAL   J Proteome Res 6 (1), 306-315 (2007)
   PUBMED   17203974
REFERENCE   3  (bases 1 to 3025)
  AUTHORS   Noma,T.
  TITLE     Dynamics of nucleotide metabolism as a supporter of life phenomena
  JOURNAL   J Med Invest 52 (3-4), 127-136 (2005)
   PUBMED   16167529
  REMARK    Review article
REFERENCE   4  (bases 1 to 3025)
  AUTHORS   de Lange,P., Ragni,M., Silvestri,E., Moreno,M., Schiavo,L.,
            Lombardi,A., Farina,P., Feola,A., Goglia,F. and Lanni,A.
  TITLE     Combined cDNA array/RT-PCR analysis of gene expression profile in
            rat gastrocnemius muscle: relation to its adaptive function in
            energy metabolism during fasting
  JOURNAL   FASEB J 18 (2), 350-352 (2004)
   PUBMED   14656997
REFERENCE   5  (bases 1 to 3025)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   6  (bases 1 to 3025)
  AUTHORS   Tanabe,T., Yamada,M., Noma,T., Kajii,T. and Nakazawa,A.
  TITLE     Tissue-specific and developmentally regulated expression of the
            genes encoding adenylate kinase isozymes
  JOURNAL   J Biochem 113 (2), 200-207 (1993)
   PUBMED   8468325
REFERENCE   7  (bases 1 to 3025)
  AUTHORS   Tomasselli,A.G. and Noda,L.H.
  TITLE     Mitochondrial GTP-AMP phosphotransferase. 2. Kinetic and
            equilibrium dialysis studies
  JOURNAL   Eur J Biochem 93 (2), 263-267 (1979)
   PUBMED   218813
REFERENCE   8  (bases 1 to 3025)
  AUTHORS   Sapico,V., Litwack,G. and Criss,W.E.
  TITLE     Purification of rat liver adenylate kinase isozyme II and
            comparison with isozyme 3
  JOURNAL   Biochim Biophys Acta 258 (2), 436-445 (1972)
   PUBMED   5010295
REFERENCE   9  (bases 1 to 3025)
  AUTHORS   Filler,R. and Criss,W.E.
  TITLE     Development of adenylate kinase isoenzymes in rat liver
  JOURNAL   Biochem J 122 (4), 553-555 (1971)
   PUBMED   5123889
REFERENCE   10 (bases 1 to 3025)
  AUTHORS   Criss,W.E., Sapico,V. and Litwack,G.
  TITLE     Rat liver adenosine triphosphate: adenosine monophosphate
            phosphotransferase activity. I. Purification and physical and
            kinetic characterization of adenylate kinase 3
  JOURNAL   J Biol Chem 245 (23), 6346-6351 (1970)
   PUBMED   5484813
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000047.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by NM_013218.4.
            
            On Feb 10, 2021 this sequence version replaced NM_013218.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC064656.1, FQ221271.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00155321, SAMEA5756307
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-283               JACYVU010000047.1  13785158-13785440   c
            284-403             JACYVU010000047.1  13775106-13775225   c
            404-576             JACYVU010000047.1  13764860-13765032   c
            577-695             JACYVU010000047.1  13763929-13764047   c
            696-3025            JACYVU010000047.1  13758265-13760594   c
FEATURES             Location/Qualifiers
     source          1..3025
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q52"
     gene            1..3025
                     /gene="Ak3"
                     /note="adenylate kinase 3"
                     /db_xref="GeneID:26956"
                     /db_xref="RGD:619885"
     exon            1..283
                     /gene="Ak3"
                     /inference="alignment:Splign:2.1.0"
     CDS             133..816
                     /gene="Ak3"
                     /EC_number="2.7.4.10"
                     /note="GTP:AMP phosphotransferase, mitochondrial; AK 3;
                     adenylate kinase 3 alpha-like 1"
                     /codon_start=1
                     /product="GTP:AMP phosphotransferase AK3, mitochondrial"
                     /protein_id="NP_037350.2"
                     /db_xref="GeneID:26956"
                     /db_xref="RGD:619885"
                     /translation="MGASGRLLRAVIMGAPGSGKGTVSSRITKHFELKHLSSGDLLRQ
                     NMLQGTEIGVLAKTFIDQGKLIPDDVMTRLALHELKNLTQCSWLLDGFPRTLPQAEAL
                     DRVYQIDTVINLNVPFEVIKLRLTARWIHPASGRVYNIEFNPPKTVGIDDLTGEPLIQ
                     REDDKPETVIKRLKAYEAQTEPVLQYYQKKGVLETFSGTETNKIWPHVYSFLQMKVPE
                     TIQKASVTP"
     exon            284..403
                     /gene="Ak3"
                     /inference="alignment:Splign:2.1.0"
     exon            404..576
                     /gene="Ak3"
                     /inference="alignment:Splign:2.1.0"
     exon            577..695
                     /gene="Ak3"
                     /inference="alignment:Splign:2.1.0"
     exon            696..3025
                     /gene="Ak3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acttccggga gagccgggcg ccctggccac cgcccgcttg cagttgccag cgggccaggg
       61 cctcagagcc tttgagcgcc caggccaggc cgcagttcag cgtctgcgca gcttcggcca
      121 ccgcttgcca ccatgggggc atcggggcgg ctgctgcgcg ccgtgatcat gggggccccg
      181 ggctccggta agggcaccgt gtcgtcacgc atcaccaaac acttcgagct gaagcacctc
      241 tccagcgggg acctgctccg ccagaacatg ctgcagggca cagaaatcgg tgtgttggcc
      301 aagactttca ttgaccaagg aaagctcatc ccggatgatg tcatgactcg gctggccctc
      361 catgagctga aaaaccttac ccagtgtagc tggctgttgg acggatttcc aaggacactt
      421 ccacaggcag aagccctgga tagagtttat cagatagaca cagtgataaa tctcaacgtg
      481 ccctttgagg tcattaaact acgccttact gctcgctgga ttcatcctgc cagtggccga
      541 gtttacaaca ttgaattcaa ccctcccaag actgtgggca tcgatgacct aacgggagaa
      601 cctctgattc agcgtgagga cgacaaacca gagacggtga tcaagagatt gaaggcgtat
      661 gaagcccaga cagagccggt cctgcagtat taccagaaaa aaggggtgtt ggaaacattc
      721 tccggaacag aaaccaacaa gatctggccc cacgtatact ccttcctgca aatgaaagtt
      781 ccagaaacca tccaaaaagc ctctgttact ccctgaggaa ggcacttggc gggatgaagc
      841 agggcctcct ccactcctcc cctcgcctct gtatttcgaa gctcttttcc taagacttct
      901 ctgaaaatta tgatttagtc ctaatggctc tgcctaatga gtcagaaact aaggctgacc
      961 gtgtgtttat ctagttgtct tccatggatg tgcaattcaa aacgtcagac atgttgaaac
     1021 aaacaaactc agagcacaat taagagagca actggtgggg ttggggattt agctcagtgg
     1081 tagagcgctt gcctaggaag tacaaggccc tgggttcggt ccccagctcc gaaaaaaaaa
     1141 agaaccaaaa aaaaaaaaga accaaaaaaa aaaaaaaaaa aaaaaaaaaa aaagagagag
     1201 agcaactggt aatcatctaa cctttgttca gttagtcaga gtggttgatc acattttcat
     1261 gtttttctgg aaaagttcaa aaaaaaatta catgtcactc gaggcagcta aatatctcat
     1321 tggaggcttt tgcataaggc agtgcccact gcgatcgaga aagatgcttt ctagcccggg
     1381 gatgtggtat tgggagatgc tgtctataga gtccagaaag aaagctacaa gcgttacaga
     1441 tgccgctagc cgcacactca ctgctgcctt acagcaagag ccagggcaca ggggccaggc
     1501 tgtgcaccct ctacttaccc agtcttctat gaaaacgcag ccactggcac ttaggaacac
     1561 atgacttgga tctggatcgt cctctttttc aaacatgtgt ggactgaggt atgtggttgt
     1621 gttcactgac ctaggttcta ggaggagcac tggcaactga caatggaatg aagtcctaag
     1681 ttttcacatg ccactcagat ggaggaccat gttttaggac atacctctca gtttcccact
     1741 ctgatccaaa tggactgcct gccttgatga gcaagacagt aaacagaaaa ctaaagggta
     1801 agacacaata cccatggcag tttgccactg cggaagtaga tggggcatgg ggacagcccc
     1861 ttgacagaaa gaccaatcga caggtgtagt aacagaagga ttttgcacag tgggttcaaa
     1921 agcactgtaa aggaactccc ttacggacat tttatacctg ggttgaagtt ctaaattcaa
     1981 gatcctcttg tcttggcctc tctcaagtgc tgggatcact gtgtgctaca gcttcccacc
     2041 ctaccttaaa gggaaacaac tcctcaggtg ccatccaagc agcctcctca tctacctaca
     2101 gtgctggcat ccaatccagc ctgtgcactg ggcaaacatc ctactctgtc cttgctctcc
     2161 agcccttttt gttgatgctg ttggtggtga tgactcagtt ttgttttgac acagtttggt
     2221 tttagttctc ctgaactatg tagacaggct ggcgtcaaac tcagagatca cctgtctctg
     2281 cttcccaagt actgaggtgt aaggtgtgtg caccagcatg acacccagcc caagtcctta
     2341 gtttttgaag cgggtcttac tatgtagccc aggctggctt gagactatta tagtccaaac
     2401 tggcctcaca ttcatcattc atggtcctct tgttttagtt tcctgagtgc ttaaattaca
     2461 ggtgtgtacc actaaatcaa ctctgagaac ctattttaaa atgtcagtca ctttagtttc
     2521 cttagtggga caaggacctg tccttacata ttgtggcctg aagggacaaa atatgagaag
     2581 tttaataaaa ggacaattcc actgtttatt ttccttggtg ctaaattaaa gaatcaagcc
     2641 cttgttcgag cctttgaaat tttggcctac tttatttcag acactcaaaa tacaaatgcc
     2701 aacaaatggt tctgatatat ttgagagtgg gaaggaatct ctgatgttta aatttcactg
     2761 ttgatctttc aaaatggact aggcttagga ttacaatgaa ccttttgtcc tttgtcagtg
     2821 tttctctact gccttatctg gattgttgat aaccactttc taaacgctgc tgtcaagtac
     2881 ctaaacctgg aactatccgc aggtggcagc agcactgtgg ctgttgccct ttgcccccgg
     2941 cccttcacag ggccctaaac ccccttcctg tctgctgcca caatgtctca ctggtttctt
     3001 tctaataaat ggtcttcaaa catta
//
