LOCUS       NM_001033967            1711 bp    mRNA    linear   ROD 19-SEP-2024
DEFINITION  Rattus norvegicus adenylate kinase 2 (Ak2), transcript variant 2,
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_001033967
VERSION     NM_001033967.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1711)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1711)
  AUTHORS   Peng,X., Wang,L., Chen,G. and Wang,X.
  TITLE     Dynamic expression of adenylate kinase 2 in the hippocampus of
            pilocarpine model rats
  JOURNAL   J Mol Neurosci 47 (1), 150-157 (2012)
   PUBMED   22246993
  REMARK    GeneRIF: AK2 participates in the pathophysiological process of
            temporal lobe epilepsy.
REFERENCE   3  (bases 1 to 1711)
  AUTHORS   Severino,V., Locker,J., Ledda-Columbano,G.M., Columbano,A.,
            Parente,A. and Chambery,A.
  TITLE     Proteomic characterization of early changes induced by
            triiodothyronine in rat liver
  JOURNAL   J Proteome Res 10 (7), 3212-3224 (2011)
   PUBMED   21563808
REFERENCE   4  (bases 1 to 1711)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   5  (bases 1 to 1711)
  AUTHORS   Yamamoto,T., Yoshimura,Y., Yamada,A., Gouda,S., Yamashita,K.,
            Yamazaki,N., Kataoka,M., Nagata,T., Terada,H. and Shinohara,Y.
  TITLE     Distinct behaviors of adenylate kinase and cytochrome c observed
            following induction of mitochondrial permeability transition by
            Ca(2+) in the absence of respiratory substrate
  JOURNAL   J Bioenerg Biomembr 40 (6), 619-623 (2008)
   PUBMED   19139979
REFERENCE   6  (bases 1 to 1711)
  AUTHORS   Nobumoto,M., Yamada,M., Song,S., Inouye,S. and Nakazawa,A.
  TITLE     Mechanism of mitochondrial import of adenylate kinase isozymes
  JOURNAL   J Biochem 123 (1), 128-135 (1998)
   PUBMED   9504419
REFERENCE   7  (bases 1 to 1711)
  AUTHORS   Tanabe,T., Yamada,M., Noma,T., Kajii,T. and Nakazawa,A.
  TITLE     Tissue-specific and developmentally regulated expression of the
            genes encoding adenylate kinase isozymes
  JOURNAL   J Biochem 113 (2), 200-207 (1993)
   PUBMED   8468325
REFERENCE   8  (bases 1 to 1711)
  AUTHORS   Hamada,M., Sumida,M., Okuda,H., Watanabe,T., Nojima,M. and
            Kuby,S.A.
  TITLE     Adenosine triphosphate-adenosine-5'-monophosphate
            phosphotransferase from normal human liver mitochondria. Isolation,
            chemical properties, and immunochemical comparison with Duchenne
            dystrophic serum aberrant adenylate kinase
  JOURNAL   J Biol Chem 257 (21), 13120-13128 (1982)
   PUBMED   6182143
REFERENCE   9  (bases 1 to 1711)
  AUTHORS   Sapico,V., Litwack,G. and Criss,W.E.
  TITLE     Purification of rat liver adenylate kinase isozyme II and
            comparison with isozyme 3
  JOURNAL   Biochim Biophys Acta 258 (2), 436-445 (1972)
   PUBMED   5010295
REFERENCE   10 (bases 1 to 1711)
  AUTHORS   Filler,R. and Criss,W.E.
  TITLE     Development of adenylate kinase isoenzymes in rat liver
  JOURNAL   Biochem J 122 (4), 553-555 (1971)
   PUBMED   5123889
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CO570724.1 and BC061727.1.
            
            On Jun 6, 2012 this sequence version replaced NM_001033967.1.
            
            Transcript Variant: This variant (2) differs in the 3' coding
            region and 3' UTR compared to variant 1. The resulting protein
            (isoform b) is shorter and has a distinct C-terminus compared to
            isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061727.1, EV778359.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-46                CO570724.1         1-46
            47-958              BC061727.1         1-912
            959-1711            BC061727.1         914-1666
FEATURES             Location/Qualifiers
     source          1..1711
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1711
                     /gene="Ak2"
                     /note="adenylate kinase 2"
                     /db_xref="GeneID:24184"
                     /db_xref="RGD:2077"
     exon            1..156
                     /gene="Ak2"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..762
                     /gene="Ak2"
                     /EC_number="2.7.4.3"
                     /note="isoform b is encoded by transcript variant 2;
                     ATP:AMP phosphotransferase; ATP-AMP transphosphorylase 2;
                     adenylate monophosphate kinase; adenylate kinase 2,
                     mitochondrial; AK 2"
                     /codon_start=1
                     /product="adenylate kinase 2, mitochondrial isoform b"
                     /protein_id="NP_001029139.1"
                     /db_xref="GeneID:24184"
                     /db_xref="RGD:2077"
                     /translation="MAPNALAPEPEHPKGIRAVLLGPPGAGKGTQAPKLAENFCVCHL
                     ATGDMLRAMVASGSELGKKLKATMDAGKLVSDEMVVELIEKNLETPSCKNGFLLDGFP
                     RTVKQAEMLDDLMDKRKEKLDSVIEFSIQDSLLIRRITGRLIHPKSGRSYHEEFNPPK
                     EAMKDDITGEPLIRRSDDNEKALKTRLEAYHTQTTPLVEYYRKRGIHCAIDASQTPDV
                     VFASILAAFSKATS"
     exon            157..282
                     /gene="Ak2"
                     /inference="alignment:Splign:2.1.0"
     exon            283..393
                     /gene="Ak2"
                     /inference="alignment:Splign:2.1.0"
     exon            394..488
                     /gene="Ak2"
                     /inference="alignment:Splign:2.1.0"
     exon            489..561
                     /gene="Ak2"
                     /inference="alignment:Splign:2.1.0"
     exon            562..757
                     /gene="Ak2"
                     /inference="alignment:Splign:2.1.0"
     exon            758..1685
                     /gene="Ak2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tggcctggaa acgctagacc tgtgaggtgt gcgggtggct ggtggagtga agctttggta
       61 gacatggctc ccaacgcgtt ggctcctgaa ccggagcatc cgaagggcat ccgggccgtg
      121 ttgctggggc ctcccggggc tggcaagggg acccaggcac ccaaattggc tgagaatttc
      181 tgtgtctgtc acttggccac tggggacatg ctgagagcga tggtagcttc aggctcggag
      241 ctggggaaaa agctgaaggc gacaatggat gccggaaaac tggtgagtga tgaaatggtc
      301 gtggagctca ttgagaagaa tttggagact ccttcctgca aaaatggctt tcttctagat
      361 ggcttccctc ggactgtgaa gcaggctgaa atgcttgatg acctcatgga taagaggaaa
      421 gagaagctcg attcagtcat cgagttcagc atccaggact ccctgctgat ccggagaatc
      481 acgggaaggc tgattcaccc caagagtggc cggtcctacc atgaggagtt caaccctcca
      541 aaggaggcca tgaaagatga tatcactggg gagcccctga tccgcaggtc agatgacaac
      601 gagaaagcct tgaagacccg cctggaggcc taccacactc agaccactcc gcttgtggaa
      661 tactacagga aacggggcat tcactgcgcc attgatgcgt cccagacccc tgacgtggtg
      721 tttgcaagca tcctggcagc cttctccaaa gccacatcct agtagcagaa ggccaggcgc
      781 gaccgcacca ctgctcatct ccccgccgtg tgatccccgc tcttaggtgc tgggcagaag
      841 agaaaagggt ggacatggga aggaaggatg atggatggtg agggaggtgg ggaggggctc
      901 aaaaggaaca tttggaacag tggcagtgtt ataattagta agtttgtttt ttttttttac
      961 acataggtga gaatttttca agtataagca agggaaaaga ttaatttttt taaaaaactg
     1021 tgattggggg gcattggtgc aaataaggag acatggtgtt ctttttaagc aatcagcctc
     1081 tcgtttcctc tggaccataa agctaatgct ctctaagaga cctcagcatc tacataagaa
     1141 cttcatggat ctccaggcca aggacacagc agtcagactg ggcctgtgtc ctgtgcagag
     1201 gagggactgt tgaccagcgg tggcccccat tccataagga ctcccctgcg tatatggaag
     1261 agatgggggg tgagccaatg ggtgctggtc gtggggcgca gggggagacg gatcccacac
     1321 ttgtgactta agagttgcct gctctggtga cagagctgtc agccacccag ctcacgagag
     1381 tcttacagcc ttgccttcat catccatggg accctttaaa taactgaacg aggcctagga
     1441 atgtagctca gcgtgtgtgc ctggcactgg aaagccctgg gttcggtcct ctacagtgaa
     1501 ggggttaggg aacaagctaa catgtcttaa gctaagtcat ccaaagattg tccttctcac
     1561 cctcaaatcc tgggactggg attgcccgac aacactgtga tatatttttc aatgaggtgc
     1621 ctttcataac tgaccaaatg ctgccatttt tgacccctga gtcaataaaa tatgttgaaa
     1681 atttgaaaaa aaaaaaaaaa aaaaaaaaaa a
//
