LOCUS       NM_024349               1983 bp    mRNA    linear   ROD 13-OCT-2024
DEFINITION  Rattus norvegicus adenylate kinase 1 (Ak1), mRNA.
ACCESSION   NM_024349 XM_001053025
VERSION     NM_024349.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1983)
  AUTHORS   Rodriguez,C., Sanchez,A., Saenz-Medina,J., Munoz,M., Hernandez,M.,
            Lopez,M., Rivera,L., Contreras,C. and Prieto,D.
  TITLE     Activation of AMP kinase ameliorates kidney vascular dysfunction,
            oxidative stress and inflammation in rodent models of obesity
  JOURNAL   Br J Pharmacol 178 (20), 4085-4103 (2021)
   PUBMED   34192805
  REMARK    GeneRIF: Activation of AMP kinase ameliorates kidney vascular
            dysfunction, oxidative stress and inflammation in rodent models of
            obesity.
REFERENCE   2  (bases 1 to 1983)
  AUTHORS   Gemelli,T., de Andrade,R.B., Rojas,D.B., Bonorino,N.F.,
            Mazzola,P.N., Tortorelli,L.S., Funchal,C., Filho,C.S. and
            Wannmacher,C.M.
  TITLE     Effects of beta-alanine administration on selected parameters of
            oxidative stress and phosphoryltransfer network in cerebral cortex
            and cerebellum of rats
  JOURNAL   Mol Cell Biochem 380 (1-2), 161-170 (2013)
   PUBMED   23620342
  REMARK    GeneRIF: Data indicate that the beta-alanine administration was
            able to inhibit the enzyme pyruvate kinase, cytosolic creatine
            kinase, and adenylate kinase activities in cerebral cortex, and
            increase in cerebellum.
REFERENCE   3  (bases 1 to 1983)
  AUTHORS   Amiri,M., Conserva,F., Panayiotou,C., Karlsson,A. and Solaroli,N.
  TITLE     The human adenylate kinase 9 is a nucleoside mono- and diphosphate
            kinase
  JOURNAL   Int J Biochem Cell Biol 45 (5), 925-931 (2013)
   PUBMED   23416111
REFERENCE   4  (bases 1 to 1983)
  AUTHORS   Lin,J.F., Wu,S., Huang,S.S., Lu,B.Y., Lin,S.M. and Tsai,S.K.
  TITLE     Resveratrol protects left ventricle by increasing adenylate kinase
            and isocitrate dehydrogenase activities in rats with myocardial
            infarction
  JOURNAL   Chin J Physiol 54 (6), 406-412 (2011)
   PUBMED   22229508
REFERENCE   5  (bases 1 to 1983)
  AUTHORS   Ouyang,J., Parakhia,R.A. and Ochs,R.S.
  TITLE     Metformin activates AMP kinase through inhibition of AMP deaminase
  JOURNAL   J Biol Chem 286 (1), 1-11 (2011)
   PUBMED   21059655
REFERENCE   6  (bases 1 to 1983)
  AUTHORS   Matsuura,S., Igarashi,M., Tanizawa,Y., Yamada,M., Kishi,F.,
            Kajii,T., Fujii,H., Miwa,S., Sakurai,M. and Nakazawa,A.
  TITLE     Human adenylate kinase deficiency associated with hemolytic anemia.
            A single base substitution affecting solubility and catalytic
            activity of the cytosolic adenylate kinase
  JOURNAL   J Biol Chem 264 (17), 10148-10155 (1989)
   PUBMED   2542324
REFERENCE   7  (bases 1 to 1983)
  AUTHORS   Stallings,R.L. and Siciliano,M.J.
  TITLE     Confirmational, provisional, and/or regional assignment of 15
            enzyme loci onto Chinese hamster autosomes 1, 2, and 7
  JOURNAL   Somatic Cell Genet 7 (6), 683-698 (1981)
   PUBMED   7323947
REFERENCE   8  (bases 1 to 1983)
  AUTHORS   Schafer,R., Doehmer,J., Rademacher,I. and Willecke,K.
  TITLE     Assignment of the gene for cytoplasmic glutamate-oxaloacetate
            transaminase to mouse chromosome 19 using chinese hamster x mouse
            somatic cell hybrids
  JOURNAL   Somatic Cell Genet 6 (6), 709-717 (1980)
   PUBMED   7444718
REFERENCE   9  (bases 1 to 1983)
  AUTHORS   Tsuboi,K.K.
  TITLE     AMP (dAMP) kinase from human erythrocytes
  JOURNAL   Methods Enzymol 51, 467-473 (1978)
   PUBMED   211388
REFERENCE   10 (bases 1 to 1983)
  AUTHORS   Francke,U., Lalley,P.A., Moss,W., Ivy,J. and Minna,J.D.
  TITLE     Gene mapping in Mus musculus by interspecific cell hybridization:
            assignment of the genes for tripeptidase-1 to chromosome 10,
            dipeptidase-2 to chromosome 18, acid phosphatase-1 to chromosome
            12, and adenylate kinase-1 to chromosome 2
  JOURNAL   Cytogenet Cell Genet 19 (2-3), 57-84 (1977)
   PUBMED   198184
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Feb 10, 2021 this sequence version replaced NM_024349.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643294.12784.1,
                                           SRR26643290.11125.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                JAXUCZ010000003.1  36313533-36313577
            46-81               JAXUCZ010000003.1  36314923-36314958
            82-245              JAXUCZ010000003.1  36315612-36315775
            246-362             JAXUCZ010000003.1  36316586-36316702
            363-554             JAXUCZ010000003.1  36319002-36319193
            555-1983            JAXUCZ010000003.1  36319329-36320757
FEATURES             Location/Qualifiers
     source          1..1983
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p11"
     gene            1..1983
                     /gene="Ak1"
                     /gene_synonym="Ak 1"
                     /note="adenylate kinase 1"
                     /db_xref="GeneID:24183"
                     /db_xref="RGD:2076"
     exon            1..45
                     /gene="Ak1"
                     /gene_synonym="Ak 1"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..623
                     /gene="Ak1"
                     /gene_synonym="Ak 1"
                     /EC_number="2.7.4.3"
                     /EC_number="2.7.4.6"
                     /EC_number="2.7.4.4"
                     /note="myokinase; ATP:AMP phosphotransferase; ATP-AMP
                     transphosphorylase 1; adenylate monophosphate kinase;
                     adenylate kinase isoenzyme 1-like"
                     /codon_start=1
                     /product="adenylate kinase isoenzyme 1"
                     /protein_id="NP_077325.2"
                     /db_xref="GeneID:24183"
                     /db_xref="RGD:2076"
                     /translation="MEDKLKKAKIIFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLR
                     AEVSSGSSRGKMLSSIMEKGELVPLETVLDMLRDAMLAKVDSSNGFLIDGYPREVKQG
                     EEFERKIAQPTLLLYVDAGPETMTQRLLKRGETSGRVDDNEETIKKRLETYYKATEPV
                     ISFYDKRGIVRKVNAEGSVDTVFSQVCTYLDSLK"
     exon            46..81
                     /gene="Ak1"
                     /gene_synonym="Ak 1"
                     /inference="alignment:Splign:2.1.0"
     exon            82..245
                     /gene="Ak1"
                     /gene_synonym="Ak 1"
                     /inference="alignment:Splign:2.1.0"
     exon            246..362
                     /gene="Ak1"
                     /gene_synonym="Ak 1"
                     /inference="alignment:Splign:2.1.0"
     exon            363..554
                     /gene="Ak1"
                     /gene_synonym="Ak 1"
                     /inference="alignment:Splign:2.1.0"
     exon            555..1983
                     /gene="Ak1"
                     /gene_synonym="Ak 1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttgcagagc gctgacctag ctcccagacc tcagcaggat ggaagacaag ctgaagaagg
       61 ccaagatcat cttcgtggtg ggcgggcctg gctcaggaaa aggtacccag tgtgagaaga
      121 ttgtgcagaa atatggctac acccacctct ctactgggga cctgcttcgg gcagaagtca
      181 gctctggatc gtcgaggggc aagatgctgt catctatcat ggagaaggga gagctggtgc
      241 cactggagac ggtgctggac atgcttcggg atgctatgtt agccaaagtg gactcttcca
      301 acggcttctt gattgacggc tacccgaggg aggtgaaaca gggagaagag tttgaacgga
      361 agatcgcaca gcccacactg ctactgtatg tggacgcagg ccccgagacc atgacccaac
      421 gactcctaaa gcgaggggag accagtggcc gtgtggacga taacgaggag accatcaaga
      481 agaggctgga gacgtattac aaagccacag aacctgtcat ctccttctat gacaaacgcg
      541 gcattgtgcg caaggtcaat gctgaaggct cagtggacac tgtcttctcc caggtctgca
      601 cctatcttga ctccctgaag taactggatc cctcggccag ttcccagccc accccgccct
      661 tgccccctga ccccaggcag cctggctcga gcccagcacc tccaccctgc cgggctgtgc
      721 acagacacag gaagctatta tcctgtccca tggacatttg agcactaaag aaattgccaa
      781 ggacgcttag ggttgttccc tcttcttgct tccaaccgag gtgattcatg ctgccacagc
      841 cggaggctcc agcgctgccg gcccattttt tcctgtgcct cagcccagct gtcttgtctc
      901 cctctggctc tgctgggatc ctaggccctt ccttagccag cccatgtcaa gcctaggggc
      961 ccctgggttg ataggctgct ccttggggtc tggtgttccc cctctatttc tcatggcctt
     1021 gtcgtacggc tttggcccta agccatcatc tctctggagt gagctccttt cctttttttt
     1081 cttttttctt ttctttcttt ttcttttctt tttttctttt cttttcttct ttttttttct
     1141 cttttgacag cattttgtgt gacttaagct ggcctcaaac ctgttctgta actgaggaca
     1201 accttgatcc tcctgcctcc acttgtcttc ctatgtgctg agattacagg tgtgtgtacc
     1261 tccaccactc ctggtttatg gggtgctggg gatcaagccc atggccctgt gtacattaag
     1321 ccagcaccct acaaattgag ctacatcccc aggctgaaca ggttttctat gcctgactgg
     1381 ggcctgggct gcaatgggca aagggtcatg ggctcaccag ctggggccac atggccaatg
     1441 ggtggcaagg agctgtgcta tgggcatgcc gctgggtggg cagcttcggt cagggatggt
     1501 cttcctgagg aaggactcga aggttcccct ggcatggccc ttgccaggcc ttgccaccct
     1561 ttggctggtt ctaagacttg ttctttcatg ctgtgtccca accctcaccc aaggcattag
     1621 gacaagaaca tacagattaa ggagtgcgag ttgccatgga cgtggatgtg ggatcaagga
     1681 cgattctggg acccagagga ttcccagaag agctggcagc tctctccagt tctttactct
     1741 ttgatctcat tacacaggaa ggctctgttg atactcacct gtccttggac cctgtcccca
     1801 tccctagtga cttcccctgt gagcccagag agcctgtaag ccagcagcca tggctgtccg
     1861 ggggacacct gcccctgggg gtgatggtgc tcactccttt ctgtttactg ccactggggc
     1921 cacctttcct tctgcattgc ctatttaagc tgtcctttaa aataaacaaa tgtatttcag
     1981 tta
//
