LOCUS       NM_021590               1579 bp    mRNA    linear   ROD 25-NOV-2024
DEFINITION  Rattus norvegicus aryl hydrocarbon receptor-interacting
            protein-like 1 (Aipl1), mRNA.
ACCESSION   NM_021590 XM_017597499
VERSION     NM_021590.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1579)
  AUTHORS   Singh,R.K., Kolandaivelu,S. and Ramamurthy,V.
  TITLE     Early alteration of retinal neurons in Aipl1-/- animals
  JOURNAL   Invest Ophthalmol Vis Sci 55 (5), 3081-3092 (2014)
   PUBMED   24736053
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1579)
  AUTHORS   Ramamurthy,V., Niemi,G.A., Reh,T.A. and Hurley,J.B.
  TITLE     Leber congenital amaurosis linked to AIPL1: a mouse model reveals
            destabilization of cGMP phosphodiesterase
  JOURNAL   Proc Natl Acad Sci U S A 101 (38), 13897-13902 (2004)
   PUBMED   15365178
REFERENCE   3  (bases 1 to 1579)
  AUTHORS   Liu,X., Bulgakov,O.V., Wen,X.H., Woodruff,M.L., Pawlyk,B., Yang,J.,
            Fain,G.L., Sandberg,M.A., Makino,C.L. and Li,T.
  TITLE     AIPL1, the protein that is defective in Leber congenital amaurosis,
            is essential for the biosynthesis of retinal rod cGMP
            phosphodiesterase
  JOURNAL   Proc Natl Acad Sci U S A 101 (38), 13903-13908 (2004)
   PUBMED   15365173
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 2005 Jan 11;102(2):515]
REFERENCE   4  (bases 1 to 1579)
  AUTHORS   Ramamurthy,V., Roberts,M., van den Akker,F., Niemi,G., Reh,T.A. and
            Hurley,J.B.
  TITLE     AIPL1, a protein implicated in Leber's congenital amaurosis,
            interacts with and aids in processing of farnesylated proteins
  JOURNAL   Proc Natl Acad Sci U S A 100 (22), 12630-12635 (2003)
   PUBMED   14555765
REFERENCE   5  (bases 1 to 1579)
  AUTHORS   Akey,D.T., Zhu,X., Dyer,M., Li,A., Sorensen,A., Blackshaw,S.,
            Fukuda-Kamitani,T., Daiger,S.P., Craft,C.M., Kamitani,T. and
            Sohocki,M.M.
  TITLE     The inherited blindness associated protein AIPL1 interacts with the
            cell cycle regulator protein NUB1
  JOURNAL   Hum Mol Genet 11 (22), 2723-2733 (2002)
   PUBMED   12374762
  REMARK    Erratum:[Hum Mol Genet. 2003 Feb 15;12(4):451]
REFERENCE   6  (bases 1 to 1579)
  AUTHORS   Sohocki,M.M., Perrault,I., Leroy,B.P., Payne,A.M., Dharmaraj,S.,
            Bhattacharya,S.S., Kaplan,J., Maumenee,I.H., Koenekoop,R.,
            Meire,F.M., Birch,D.G., Heckenlively,J.R. and Daiger,S.P.
  TITLE     Prevalence of AIPL1 mutations in inherited retinal degenerative
            disease
  JOURNAL   Mol Genet Metab 70 (2), 142-150 (2000)
   PUBMED   10873396
REFERENCE   7  (bases 1 to 1579)
  AUTHORS   Sohocki,M.M., Bowne,S.J., Sullivan,L.S., Blackshaw,S., Cepko,C.L.,
            Payne,A.M., Bhattacharya,S.S., Khaliq,S., Qasim Mehdi,S.,
            Birch,D.G., Harrison,W.R., Elder,F.F., Heckenlively,J.R. and
            Daiger,S.P.
  TITLE     Mutations in a new photoreceptor-pineal gene on 17p cause Leber
            congenital amaurosis
  JOURNAL   Nat Genet 24 (1), 79-83 (2000)
   PUBMED   10615133
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On or before Apr 7, 2017 this sequence version replaced
            XM_017597499.1, NM_021590.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF180340.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-126               JAXUCZ010000010.1  57163330-57163455   c
            127-306             JAXUCZ010000010.1  57162584-57162763   c
            307-495             JAXUCZ010000010.1  57157005-57157193   c
            496-672             JAXUCZ010000010.1  57155989-57156165   c
            673-814             JAXUCZ010000010.1  57155774-57155915   c
            815-1579            JAXUCZ010000010.1  57154226-57154990   c
FEATURES             Location/Qualifiers
     source          1..1579
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q24"
     gene            1..1579
                     /gene="Aipl1"
                     /note="aryl hydrocarbon receptor-interacting protein-like
                     1"
                     /db_xref="GeneID:59110"
                     /db_xref="RGD:70906"
     exon            1..126
                     /gene="Aipl1"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..1017
                     /gene="Aipl1"
                     /codon_start=1
                     /product="aryl-hydrocarbon-interacting protein-like 1"
                     /protein_id="NP_067601.1"
                     /db_xref="GeneID:59110"
                     /db_xref="RGD:70906"
                     /translation="MDVSLLLNVEGVKKTILHGGTGELPNFITGSRVTFHFRTMKCDE
                     ERTVIDDSKQVGQPMNIIIGNMFKLEVWETLLTSMRLGEVAEFWCDTIHTGVYPMLSR
                     SLRQVAEGKDPTSWHVHTCGLANMFAYHTLGYEDLDELQKEPQPLIFLIELLQVEAPN
                     EYQRETWNLNNEERMQAVPLLHGEGNRLYKLGRYDQAATKYQEAIVCLRNLQTKEKPW
                     EVEWLKLEKMINTLILNYCQCLLKKEEYYEVLEHTSDILRHHPGIVKAYYMRARAHAE
                     VWNAEEAKADLEKVLELEPSMRKAVLRELRLLESRLADKQEEERQRCRSMLG"
     exon            127..306
                     /gene="Aipl1"
                     /inference="alignment:Splign:2.1.0"
     exon            307..495
                     /gene="Aipl1"
                     /inference="alignment:Splign:2.1.0"
     exon            496..672
                     /gene="Aipl1"
                     /inference="alignment:Splign:2.1.0"
     exon            673..814
                     /gene="Aipl1"
                     /inference="alignment:Splign:2.1.0"
     exon            815..1579
                     /gene="Aipl1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtctgagcag acctctcccc tacctgcagc atggacgtct ctctactcct caatgtggag
       61 ggtgtcaaga agaccattct gcatgggggg acaggagagc tccccaactt catcactggc
      121 tccagagtga cctttcattt ccgaacaatg aagtgtgatg aagaacgcac ggtgatcgat
      181 gacagcaagc aggtgggaca gcccatgaac atcatcattg gcaacatgtt caagctggag
      241 gtgtgggaga cgctgctgac ctccatgcgg ctgggtgagg tggctgagtt ctggtgcgac
      301 accatccaca ccggggtcta ccctatgctg tcccgcagcc tgcggcaggt ggctgaaggc
      361 aaggacccca caagctggca cgtgcacacg tgcgggttgg ccaacatgtt tgcgtaccac
      421 actctgggct acgaggatct ggatgagctg cagaaggagc cacagcctct catcttcctc
      481 attgagctgc tccaggtgga ggccccaaat gagtaccaga gggagacgtg gaacttgaat
      541 aatgaagaga ggatgcaggc cgtgcctctt cttcatggag aaggtaacag gctctacaag
      601 ctgggtcgct acgatcaggc tgccaccaag taccaggagg ccattgtgtg cctgaggaac
      661 cttcagacca aggagaagcc gtgggaggtt gagtggctga agctggagaa gatgatcaac
      721 acactgatcc tcaactactg ccaatgcctg ctgaagaagg aggagtacta tgaggtgttg
      781 gagcatacta gcgacattct acgacaccac ccagggatcg tgaaggccta ctatatgcgc
      841 gcacgggctc acgcggaggt atggaacgct gaggaggcca aagcggacct ggagaaagtg
      901 ctggagttgg agccatccat gcgcaaggcg gtgctcaggg aactgagatt gctggagagc
      961 cgcctggcgg acaagcagga ggaggagcgg cagcgctgcc ggagcatgct gggctaggct
     1021 gggctggatt ccactgcgtt agactgggct aggttgggtg agagctgctg gttgaagccc
     1081 tggaccaagg gctggggcta tggactgagg ccctttaccc acactgctcc acttgctgca
     1141 ggggtcccca ggagaggtgt ccttggctac taggagtcag ccatagactt ctctgagttc
     1201 ccacagcctg tgggccacct gtgcagcaag catagactgg cgtccctggt tcaactaacc
     1261 aggattttga tgtcacttct tagcatatat tcttattaaa tcacataaga ctaatgtcta
     1321 agggctgggg atatagctca gtgggagaga gcttgtttag caaacctgga gccctggggt
     1381 tgatctctga cataaataaa tagatgtaca cacaaataaa tgcattttgt gagatcgaag
     1441 tcataggttc ccatggaaaa tcaaagcccc ctcatccccc gcaacccaaa attaacaaag
     1501 ggcacaggac agttaccctt ccttagctca ggcataacaa ccaaactcat tttaaattaa
     1561 aatatttttt agagattta
//
