LOCUS       NM_172327               1340 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Rattus norvegicus aryl-hydrocarbon receptor-interacting protein
            (Aip), mRNA.
ACCESSION   NM_172327 XM_006230699
VERSION     NM_172327.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1340)
  AUTHORS   Garcia-Rendueles,A.R., Chenlo,M., Oroz-Gonjar,F., Solomou,A.,
            Mistry,A., Barry,S., Gaston-Massuet,C., Garcia-Lavandeira,M.,
            Perez-Romero,S., Suarez-Farina,M., Pradilla-Dieste,A., Dieguez,C.,
            Mehlen,P., Korbonits,M. and Alvarez,C.V.
  TITLE     RET signalling provides tumorigenic mechanism and tissue
            specificity for AIP-related somatotrophinomas
  JOURNAL   Oncogene 40 (45), 6354-6368 (2021)
   PUBMED   34588620
  REMARK    GeneRIF: RET signalling provides tumorigenic mechanism and tissue
            specificity for AIP-related somatotrophinomas.
            Erratum:[Oncogene. 2023 Dec;42(49):3655-3656. doi:
            10.1038/s41388-023-02862-9.. PMID: 37932482]
REFERENCE   2  (bases 1 to 1340)
  AUTHORS   Fukuda,T., Tanaka,T., Hamaguchi,Y., Kawanami,T., Nomiyama,T. and
            Yanase,T.
  TITLE     Augmented Growth Hormone Secretion and Stat3 Phosphorylation in an
            Aryl Hydrocarbon Receptor Interacting Protein (AIP)-Disrupted
            Somatotroph Cell Line
  JOURNAL   PLoS One 11 (10), e0164131 (2016)
   PUBMED   27706259
  REMARK    GeneRIF: Results demonstrated that Aip inactivation promoted
            somatotroph tumorigenesis and overproduction of growth hormone
            probably through increased Stat3 activation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1340)
  AUTHORS   Formosa,R., Xuereb-Anastasi,A. and Vassallo,J.
  TITLE     Aip regulates cAMP signalling and GH secretion in GH3 cells
  JOURNAL   Endocr Relat Cancer 20 (4), 495-505 (2013)
   PUBMED   23702468
  REMARK    GeneRIF: Aip regulates cAMP signalling and growth hormone secretion
            in GH3 cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1340)
  AUTHORS   de Oliveira,S.K., Hoffmeister,M., Gambaryan,S., Muller-Esterl,W.,
            Guimaraes,J.A. and Smolenski,A.P.
  TITLE     Phosphodiesterase 2A forms a complex with the co-chaperone XAP2 and
            regulates nuclear translocation of the aryl hydrocarbon receptor
  JOURNAL   J Biol Chem 282 (18), 13656-13663 (2007)
   PUBMED   17329248
REFERENCE   5  (bases 1 to 1340)
  AUTHORS   Pollenz,R.S. and Dougherty,E.J.
  TITLE     Redefining the role of the endogenous XAP2 and C-terminal
            hsp70-interacting protein on the endogenous Ah receptors expressed
            in mouse and rat cell lines
  JOURNAL   J Biol Chem 280 (39), 33346-33356 (2005)
   PUBMED   16085934
  REMARK    GeneRIF: The role of Xap2 and C-terminal hsp-70 interacting protein
            on the endogenous Ah receptors expressed in rat cell lines was
            determined.
REFERENCE   6  (bases 1 to 1340)
  AUTHORS   Marschang,P., Brich,J., Weeber,E.J., Sweatt,J.D., Shelton,J.M.,
            Richardson,J.A., Hammer,R.E. and Herz,J.
  TITLE     Normal development and fertility of knockout mice lacking the tumor
            suppressor gene LRP1b suggest functional compensation by LRP1
  JOURNAL   Mol Cell Biol 24 (9), 3782-3793 (2004)
   PUBMED   15082773
REFERENCE   7  (bases 1 to 1340)
  AUTHORS   Yano,M., Terada,K. and Mori,M.
  TITLE     AIP is a mitochondrial import mediator that binds to both import
            receptor Tom20 and preproteins
  JOURNAL   J Cell Biol 163 (1), 45-56 (2003)
   PUBMED   14557246
REFERENCE   8  (bases 1 to 1340)
  AUTHORS   Bolger,G.B., Peden,A.H., Steele,M.R., MacKenzie,C., McEwan,D.G.,
            Wallace,D.A., Huston,E., Baillie,G.S. and Houslay,M.D.
  TITLE     Attenuation of the activity of the cAMP-specific phosphodiesterase
            PDE4A5 by interaction with the immunophilin XAP2
  JOURNAL   J Biol Chem 278 (35), 33351-33363 (2003)
   PUBMED   12810716
  REMARK    GeneRIF: results suggest that XAP2 functionally interacts with
            PDE4A5 in cells
REFERENCE   9  (bases 1 to 1340)
  AUTHORS   Ma,Q. and Whitlock,J.P. Jr.
  TITLE     A novel cytoplasmic protein that interacts with the Ah receptor,
            contains tetratricopeptide repeat motifs, and augments the
            transcriptional response to 2,3,7,8-tetrachlorodibenzo-p-dioxin
  JOURNAL   J Biol Chem 272 (14), 8878-8884 (1997)
   PUBMED   9083006
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On or before Mar 2, 2021 this sequence version replaced
            XM_006230699.4, NM_172327.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643292.4876.1,
                                           SRR26643286.3642.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760386,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-128               JAXUCZ010000001.1  210848507-210848634 c
            129-338             JAXUCZ010000001.1  210844185-210844394 c
            339-518             JAXUCZ010000001.1  210840844-210841023 c
            519-707             JAXUCZ010000001.1  210838989-210839177 c
            708-884             JAXUCZ010000001.1  210838327-210838503 c
            885-1026            JAXUCZ010000001.1  210838085-210838226 c
            1027-1340           JAXUCZ010000001.1  210837473-210837786 c
FEATURES             Location/Qualifiers
     source          1..1340
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..1340
                     /gene="Aip"
                     /gene_synonym="XAP2"
                     /note="aryl-hydrocarbon receptor-interacting protein"
                     /db_xref="GeneID:282827"
                     /db_xref="RGD:628619"
     exon            1..128
                     /gene="Aip"
                     /gene_synonym="XAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            129..338
                     /gene="Aip"
                     /gene_synonym="XAP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             240..1232
                     /gene="Aip"
                     /gene_synonym="XAP2"
                     /EC_number="5.2.1.8"
                     /note="HBV-X associated protein; immunophilin XAP2"
                     /codon_start=1
                     /product="AH receptor-interacting protein"
                     /protein_id="NP_758830.2"
                     /db_xref="GeneID:282827"
                     /db_xref="RGD:628619"
                     /translation="MADLIARLREDGIQKRVIQEGRGELPEFQDGTKATFHFRTLHSD
                     PEGSVIDDSRARGKPMELIIGKKFKLPVWETIVRTMREGETAQFLCDVKHTVLYPLVA
                     KSLRNIAEGKDPLEGQRHCCGIAQMHEHSSLGHADLDALQQNPQPLIFHIEMLKVESP
                     GTYQQDPWAMTDEEKAKAVPLIHQEGNRLYREGQVKEAAAKYYDAIACLKNLQMKEQP
                     GSPDWIQLDLQITPLLLNYCQCKLVAQEYYEVLDHCSSILNKYDDNVKAYFKRGKAHA
                     AVWNAQEAQADFAKVLELDPALAPVVSRELRALEARIRQKDEEDKARFRGIFSH"
     exon            339..518
                     /gene="Aip"
                     /gene_synonym="XAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            519..707
                     /gene="Aip"
                     /gene_synonym="XAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            708..884
                     /gene="Aip"
                     /gene_synonym="XAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            885..1026
                     /gene="Aip"
                     /gene_synonym="XAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1340
                     /gene="Aip"
                     /gene_synonym="XAP2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgcagaatgc cgagttgatt cgggaatcac gtcagagtct cgcgggtagc gggactcgcg
       61 gcgccaccca gaggctacct tggtgagcga cagcccgggc tgtgacggaa ctatctaggc
      121 ttgctctttc aaaatggcgc ttgctcagaa gctgcccagg ctctaggagt tgccgaaaca
      181 ggtccggaag ctaccgagcg agtccggaag ttgccgaaag ggagcagcgg ggaaggagga
      241 tggcggatct catcgcaaga cttcgagagg acgggatcca aaagcgtgtg atacaggagg
      301 gccgaggaga gttgccggaa tttcaggatg gcactaaggc caccttccac ttccggacgc
      361 tgcatagtga cccggagggc tccgtcatag atgacagccg agcacgcggc aagcccatgg
      421 agctcatcat cggcaagaag ttcaagctgc ctgtgtggga gaccatcgtg cgtaccatgc
      481 gtgaggggga gacggcccag ttcctctgcg atgtcaagca cacagtcctg tatcctctgg
      541 tggccaagag cctccgcaac atcgctgagg gcaaggaccc cttggagggc cagcggcatt
      601 gctgtggaat tgctcaaatg catgagcata gctccctggg tcatgcggac ctggacgccc
      661 tgcagcagaa ccctcaaccc ctcatcttcc acatcgagat gctgaaggtg gagagccctg
      721 gcacctacca gcaggaccca tgggcaatga cagatgagga gaaagcaaag gcagtaccac
      781 tcatccacca agagggcaac cgcttatacc gtgaggggca ggtgaaggag gctgctgcca
      841 agtactacga tgccattgcc tgcctcaaga acctgcagat gaaggagcag cctggatcac
      901 ccgactggat ccagttggac ttgcagatca caccactgct actcaactat tgccagtgca
      961 agctggtggc tcaggagtac tatgaggtgc tggatcactg ctcctccatc ctcaacaagt
     1021 atgatgacaa tgtcaaggct tacttcaagc ggggtaaggc ccatgctgct gtgtggaatg
     1081 cccaggaggc ccaggctgac tttgccaagg tgttggagct cgaccctgcc ctggcgcctg
     1141 tggtaagcag agagctgcgg gccctggagg cacggatccg gcagaaggat gaggaggaca
     1201 aagcccgctt ccggggcatc ttttcccact aacaggacct cagttctgcc ctgccctgcc
     1261 aagcccactg ctgccaccac ctgtcaatcc cccactgcca ccttgtgctt ctgtgtatat
     1321 aaaggcctta tttatctctc
//
