LOCUS       NM_053757               1081 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus aminoacyl tRNA synthetase complex-interacting
            multifunctional protein 1 (Aimp1), mRNA.
ACCESSION   NM_053757 XM_342344
VERSION     NM_053757.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1081)
  AUTHORS   Liu LB, Xie H, Xue YX, Liu YH, Li Z and Wang P.
  TITLE     Endothelial-monocyte-activating polypeptide II induces rat C6
            glioma cell apoptosis via the mitochondrial pathway
  JOURNAL   Biochem Biophys Res Commun 457 (4), 595-601 (2015)
   PUBMED   25600803
  REMARK    GeneRIF: EMAP2 decreases cell viability of rat C6 glioma cells.
            EMAP2 induces rat C6 glioma cells apoptosis via the mitochondrial
            pathway.
REFERENCE   2  (bases 1 to 1081)
  AUTHORS   Forster F, Paster W, Supper V, Schatzlmaier P, Sunzenauer S, Ostler
            N, Saliba A, Eckerstorfer P, Britzen-Laurent N, Schutz G, Schmid
            JA, Zlabinger GJ, Naschberger E, Sturzl M and Stockinger H.
  TITLE     Guanylate binding protein 1-mediated interaction of T cell antigen
            receptor signaling with the cytoskeleton
  JOURNAL   J Immunol 192 (2), 771-781 (2014)
   PUBMED   24337748
REFERENCE   3  (bases 1 to 1081)
  AUTHORS   Li Z, Liu YH, Xue YX, Liu LB and Wang P.
  TITLE     Signal mechanisms underlying low-dose endothelial
            monocyte-activating polypeptide-II-induced opening of the
            blood-tumor barrier
  JOURNAL   J Mol Neurosci 48 (1), 291-301 (2012)
   PUBMED   22531886
  REMARK    GeneRIF: EMAP-II induces blood tumor barrier opening via the
            RhoA/Rho kinase/PKC-alpha/beta signaling pathways, however,
            PKC-zeta is involved in this process by other mechanisms.
REFERENCE   4  (bases 1 to 1081)
  AUTHORS   Li Z, Liu YH, Xue YX, Liu LB and Xie H.
  TITLE     Mechanisms for endothelial monocyte-activating
            polypeptide-II-induced opening of the blood-tumor barrier
  JOURNAL   J Mol Neurosci 47 (2), 408-417 (2012)
   PUBMED   21969114
  REMARK    GeneRIF: EMAP-II increases permeability through alpha-ATP synthase
            on the surface of brain microvascular endothelial cells.
REFERENCE   5  (bases 1 to 1081)
  AUTHORS   Chen Y, Legan SK, Mahan A, Thornton J, Xu H and Schwarz MA.
  TITLE     Endothelial-monocyte activating polypeptide II disrupts alveolar
            epithelial type II to type I cell transdifferentiation
  JOURNAL   Respir Res 13 (1), 1 (2012)
   PUBMED   22214516
  REMARK    GeneRIF: The findings demonstrate that small inducible cytokine
            subfamily E member 1 interferes with alveolar cell
            transdifferentiation resulting in a proliferating non-myofibroblast
            cell.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1081)
  AUTHORS   Brabeck C, Michetti F, Geloso MC, Corvino V, Goezalan F, Meyermann
            R and Schluesener HJ.
  TITLE     Expression of EMAP-II by activated monocytes/microglial cells in
            different regions of the rat hippocampus after trimethyltin-induced
            brain damage
  JOURNAL   Exp Neurol 177 (1), 341-346 (2002)
   PUBMED   12429238
  REMARK    GeneRIF: Upregulation of EMAP-II by activated monocytes/microglial
            cells may serve as a sensitive marker of neurotoxic lesions in the
            brain.
REFERENCE   7  (bases 1 to 1081)
  AUTHORS   Kim JY, Kang YS, Lee JW, Kim HJ, Ahn YH, Park H, Ko YG and Kim S.
  TITLE     p38 is essential for the assembly and stability of macromolecular
            tRNA synthetase complex: implications for its physiological
            significance
  JOURNAL   Proc Natl Acad Sci U S A 99 (12), 7912-7916 (2002)
   PUBMED   12060739
REFERENCE   8  (bases 1 to 1081)
  AUTHORS   Chang SY, Park SG, Kim S and Kang CY.
  TITLE     Interaction of the C-terminal domain of p43 and the alpha subunit
            of ATP synthase. Its functional implication in endothelial cell
            proliferation
  JOURNAL   J Biol Chem 277 (10), 8388-8394 (2002)
   PUBMED   11741979
REFERENCE   9  (bases 1 to 1081)
  AUTHORS   Shalak V, Kaminska M, Mitnacht-Kraus R, Vandenabeele P, Clauss M
            and Mirande M.
  TITLE     The EMAPII cytokine is released from the mammalian multisynthetase
            complex after cleavage of its p43/proEMAPII component
  JOURNAL   J Biol Chem 276 (26), 23769-23776 (2001)
   PUBMED   11306575
REFERENCE   10 (bases 1 to 1081)
  AUTHORS   Ko YG, Kang YS, Kim EK, Park SG and Kim S.
  TITLE     Nucleolar localization of human methionyl-tRNA synthetase and its
            role in ribosomal RNA synthesis
  JOURNAL   J Cell Biol 149 (3), 567-574 (2000)
   PUBMED   10791971
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC098675.1.
            
            On Sep 19, 2005 this sequence version replaced XM_342344.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC098675.1, SRR8487226.70502.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMN06621351
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1081
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q43"
     gene            1..1081
                     /gene="Aimp1"
                     /gene_synonym="Emap2; Scye1"
                     /note="aminoacyl tRNA synthetase complex-interacting
                     multifunctional protein 1"
                     /db_xref="GeneID:114632"
                     /db_xref="RGD:620466"
     exon            1..47
                     /gene="Aimp1"
                     /gene_synonym="Emap2; Scye1"
                     /inference="alignment:Splign:2.1.0"
     CDS             46..993
                     /gene="Aimp1"
                     /gene_synonym="Emap2; Scye1"
                     /note="endothelial monocyte activating polypeptide 2;
                     small inducible cytokine subfamily E, member 1"
                     /codon_start=1
                     /product="aminoacyl tRNA synthase complex-interacting
                     multifunctional protein 1"
                     /protein_id="NP_446209.1"
                     /db_xref="GeneID:114632"
                     /db_xref="RGD:620466"
                     /translation="MIFCRFWGKMATNDAVLKRLEQKGAEADQIIEYLKQQVALLKEK
                     AILQATLREEKKLQVENAKLKKEIEELKQELIQAEIHNGVKQVPVPSSSSLETHCSVS
                     ESVTRSASVTTTTMTGGGGEEKKVKEKTEKKGEKKEKKQQSAAASADSKPVDVSRLDL
                     RIGCIVTAKKHPDADSLYVEEVDVGEAAPRTVVSGLVNHVPLEQMQNRMVVLLCNLKP
                     AKMRGVLSQAMVMCASSPEKVEILAPPNGSVPGDRITFDAFPGEPDKELNPKKKIWEQ
                     IQPDLHTNDECVATYKGAPFEVKGKGVCRAQTMANSGIK"
     exon            48..181
                     /gene="Aimp1"
                     /gene_synonym="Emap2; Scye1"
                     /inference="alignment:Splign:2.1.0"
     exon            182..295
                     /gene="Aimp1"
                     /gene_synonym="Emap2; Scye1"
                     /inference="alignment:Splign:2.1.0"
     exon            296..445
                     /gene="Aimp1"
                     /gene_synonym="Emap2; Scye1"
                     /inference="alignment:Splign:2.1.0"
     exon            446..657
                     /gene="Aimp1"
                     /gene_synonym="Emap2; Scye1"
                     /inference="alignment:Splign:2.1.0"
     exon            658..826
                     /gene="Aimp1"
                     /gene_synonym="Emap2; Scye1"
                     /inference="alignment:Splign:2.1.0"
     exon            827..1053
                     /gene="Aimp1"
                     /gene_synonym="Emap2; Scye1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tacacactcg gctgaggctg ctctcgagct gcggttcacc acttcatgat tttctgccga
       61 ttctggggaa agatggccac caatgatgct gttctgaagc ggctggagca gaaaggcgca
      121 gaggcggatc agatcattga gtatctcaag cagcaggttg ctcttctcaa ggagaaagca
      181 attttgcagg caactttgag agaagaaaag aaacttcaag ttgaaaatgc taaactgaaa
      241 aaagaaatag aagaactaaa gcaagagttg attcaggcag aaattcataa tggagtgaag
      301 caggtgcctg tcccatcgag ttcttcactg gagactcatt gttccgtttc tgaaagtgtg
      361 actcggtctg catcagtaac aaccaccacc atgaccggag ggggagggga agaaaagaag
      421 gtaaaagaga agacggaaaa gaaaggagag aaaaaggaga agaagcagca gtcagcggca
      481 gcaagtgctg attcgaagcc tgtcgacgta tcacgcctgg atcttcgaat tggatgtatt
      541 gtcactgcca aaaaacaccc ggatgcagat tcgttgtatg tggaggaagt cgatgtggga
      601 gaagcagctc cacggacggt cgtcagcggg ctggtgaatc atgtccctct agaacagatg
      661 caaaaccgga tggtggtttt gctttgtaat ctgaagcctg caaaaatgcg gggagtgctg
      721 tcccaagcaa tggtgatgtg cgccagttca ccagagaaag tggagatttt ggcccctccc
      781 aacgggtctg ttcctggaga cagaattact tttgatgctt tccctggaga gcctgacaag
      841 gagctgaacc ctaagaagaa gatctgggag cagatccagc ctgacctgca caccaatgat
      901 gagtgtgtag ccacatacaa aggagctccc tttgaggtga aggggaaggg agtttgcagg
      961 gcccaaacca tggccaacag cggaattaaa taagtgctct gtaactgaaa gacaccactg
     1021 aaaccttaat aacaataaag aggagtgagt ttaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1081 a
//
