LOCUS       NM_001013977            2314 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Rattus norvegicus AIF family member 3 (Aifm3), mRNA.
ACCESSION   NM_001013977 XM_001058959 XM_001066198 XM_001066255 XM_001066308
            XM_008768876
VERSION     NM_001013977.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2314)
  AUTHORS   Zhang,D., Fan,Z., Han,Y., Bai,X., Liu,W., Lu,S., Wang,M., Xu,L.,
            Luo,J., Li,J. and Wang,H.
  TITLE     Apoptosis-inducing factor is involved in gentamicin-induced
            vestibular hair cell death
  JOURNAL   ORL J Otorhinolaryngol Relat Spec 74 (1), 1-5 (2012)
   PUBMED   22085972
  REMARK    GeneRIF: AIF participates in GM-induced apoptosis of vestibular
            hair cells.
REFERENCE   2  (bases 1 to 2314)
  AUTHORS   Blancas,S. and Moran,J.
  TITLE     Role for apoptosis-inducing factor in the physiological death of
            cerebellar neurons
  JOURNAL   Neurochem Int 58 (8), 934-942 (2011)
   PUBMED   21447364
  REMARK    GeneRIF: Apoptosis-inducing factor is involved in apoptotic-like
            death of cerebellar granule neurons and could be an alternative
            mechanism of neuronal death during cerebellar development.
REFERENCE   3  (bases 1 to 2314)
  AUTHORS   Xie,Q., Lin,T., Zhang,Y., Zheng,J. and Bonanno,J.A.
  TITLE     Molecular cloning and characterization of a human AIF-like gene
            with ability to induce apoptosis
  JOURNAL   J Biol Chem 280 (20), 19673-19681 (2005)
   PUBMED   15764604
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB769270.1 and JAXUCZ010000011.1.
            
            On or before Sep 25, 2014 this sequence version replaced
            XM_008768876.1, NM_001013977.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760386
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-402               CB769270.1         1-402
            403-417             JAXUCZ010000011.1  97016594-97016608   c
            418-527             JAXUCZ010000011.1  97016272-97016381   c
            528-637             JAXUCZ010000011.1  97015967-97016076   c
            638-682             JAXUCZ010000011.1  97015831-97015875   c
            683-776             JAXUCZ010000011.1  97015521-97015614   c
            777-889             JAXUCZ010000011.1  97015326-97015438   c
            890-976             JAXUCZ010000011.1  97014833-97014919   c
            977-1068            JAXUCZ010000011.1  97014391-97014482   c
            1069-1199           JAXUCZ010000011.1  97014172-97014302   c
            1200-1315           JAXUCZ010000011.1  97013956-97014071   c
            1316-1387           JAXUCZ010000011.1  97013783-97013854   c
            1388-1451           JAXUCZ010000011.1  97013616-97013679   c
            1452-1528           JAXUCZ010000011.1  97013019-97013095   c
            1529-1646           JAXUCZ010000011.1  97012800-97012917   c
            1647-1745           JAXUCZ010000011.1  97011537-97011635   c
            1746-1821           JAXUCZ010000011.1  97010803-97010878   c
            1822-1926           JAXUCZ010000011.1  97010237-97010341   c
            1927-1947           JAXUCZ010000011.1  97009670-97009690   c
            1948-2314           JAXUCZ010000011.1  97009100-97009466   c
FEATURES             Location/Qualifiers
     source          1..2314
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q23"
     gene            1..2314
                     /gene="Aifm3"
                     /gene_synonym="RGD1306028"
                     /note="AIF family member 3"
                     /db_xref="GeneID:303786"
                     /db_xref="RGD:1306028"
     exon            1..22
                     /gene="Aifm3"
                     /gene_synonym="RGD1306028"
                     /inference="alignment:Splign:2.1.0"
     exon            23..203
                     /gene="Aifm3"
                     /gene_synonym="RGD1306028"
                     /inference="alignment:Splign:2.1.0"
     CDS             173..1987
                     /gene="Aifm3"
                     /gene_synonym="RGD1306028"
                     /note="apoptosis-inducing factor, mitochondrion-associated
                     3; apoptosis inducing factor, mitochondria associated 3"
                     /codon_start=1
                     /product="apoptosis-inducing factor 3"
                     /protein_id="NP_001013999.2"
                     /db_xref="GeneID:303786"
                     /db_xref="RGD:1306028"
                     /translation="MGGCFSKPKPVELKIEVVLPEKERGKEELSASGKGSPRGYQGNG
                     TARHFHAEERLPTPQPYPSPQDCVEATVCHVKDLENGQMREVELGWGKVLLVKDNGEF
                     HALGHKCPHYGAPLVKGVLSRGRVRCPWHGACFNIGTGDLEDFPGLDSLHKFQVKIEK
                     EKVTVRASKQALQLQRRTKVMAKCISPSAGHSSTNVLIVGAGAAGLVCAETLRQEGFS
                     DRIVLCTLDRHLPYDRAKLSKSLDAQPEQLALRPKEFFRAYGIEMLTEAQVVTVDVRN
                     KKVVFKDGFKLEYSKLLLAPGSSPKTLTCKGKDIENVFTIRTPEDANRVLRLARGRNA
                     VVVGAGFLGMEVAAYLTEKAHSVSVVELEETPFRRFLGERVGRALMKMFENNRVKFYM
                     QTEVSELRAQEGKLQEVVLKSSKVLRADVCVVGIGAVPATGFLRQSGIGLDSRGFIPV
                     NKMMQTNIPGVFAAGDAVTFPLAWRNNRKVNIPHWQMAHAQGRVAAQNMLAQEAEINT
                     VPYLWTAMFGKSLRYAGYGEGFDDVIIQGDLEELKFVAFYTKGDEVIAVASMNYDPIV
                     SKVAEVLASGRAIRKREVELFMLHSKTGDMSWLTGKGS"
     exon            204..417
                     /gene="Aifm3"
                     /gene_synonym="RGD1306028"
                     /inference="alignment:Splign:2.1.0"
     exon            418..527
                     /gene="Aifm3"
                     /gene_synonym="RGD1306028"
                     /inference="alignment:Splign:2.1.0"
     exon            528..637
                     /gene="Aifm3"
                     /gene_synonym="RGD1306028"
                     /inference="alignment:Splign:2.1.0"
     exon            638..682
                     /gene="Aifm3"
                     /gene_synonym="RGD1306028"
                     /inference="alignment:Splign:2.1.0"
     exon            683..776
                     /gene="Aifm3"
                     /gene_synonym="RGD1306028"
                     /inference="alignment:Splign:2.1.0"
     exon            777..889
                     /gene="Aifm3"
                     /gene_synonym="RGD1306028"
                     /inference="alignment:Splign:2.1.0"
     exon            890..976
                     /gene="Aifm3"
                     /gene_synonym="RGD1306028"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1068
                     /gene="Aifm3"
                     /gene_synonym="RGD1306028"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..1199
                     /gene="Aifm3"
                     /gene_synonym="RGD1306028"
                     /inference="alignment:Splign:2.1.0"
     exon            1200..1315
                     /gene="Aifm3"
                     /gene_synonym="RGD1306028"
                     /inference="alignment:Splign:2.1.0"
     exon            1316..1387
                     /gene="Aifm3"
                     /gene_synonym="RGD1306028"
                     /inference="alignment:Splign:2.1.0"
     exon            1388..1451
                     /gene="Aifm3"
                     /gene_synonym="RGD1306028"
                     /inference="alignment:Splign:2.1.0"
     exon            1452..1528
                     /gene="Aifm3"
                     /gene_synonym="RGD1306028"
                     /inference="alignment:Splign:2.1.0"
     exon            1529..1646
                     /gene="Aifm3"
                     /gene_synonym="RGD1306028"
                     /inference="alignment:Splign:2.1.0"
     exon            1647..1745
                     /gene="Aifm3"
                     /gene_synonym="RGD1306028"
                     /inference="alignment:Splign:2.1.0"
     exon            1746..1821
                     /gene="Aifm3"
                     /gene_synonym="RGD1306028"
                     /inference="alignment:Splign:2.1.0"
     exon            1822..1926
                     /gene="Aifm3"
                     /gene_synonym="RGD1306028"
                     /inference="alignment:Splign:2.1.0"
     exon            1927..1947
                     /gene="Aifm3"
                     /gene_synonym="RGD1306028"
                     /inference="alignment:Splign:2.1.0"
     exon            1948..2314
                     /gene="Aifm3"
                     /gene_synonym="RGD1306028"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagtgactc tcacggaagg aggttctaaa gctgtctagc tggcatggca gctccagcgt
       61 ctctgagcgc cacagggggt ccagtcctac agggctcatc ctagacctcg gacagctgga
      121 cagcctgcca tccgtgctcc caccagccgg gctagatcca ggccattcaa ccatgggcgg
      181 ctgcttctcc aagcccaagc cagtggagct caagatcgaa gtggtgctgc cagagaaaga
      241 gcggggcaag gaagagctgt cagccagcgg aaagggcagc ccccggggtt accagggcaa
      301 tggcacagca cgtcacttcc atgctgaaga gcgtctgccc actccacagc cctaccccag
      361 ccctcaggac tgtgtggagg ctaccgtctg ccatgtcaag gacctggaga atggccagat
      421 gcgggaagtg gagttgggct ggggaaaggt gttgctggtg aaggataatg gggaattcca
      481 cgccctgggc cataagtgtc ctcactacgg agcacccctg gtgaaaggtg tgctgtcccg
      541 gggacgtgtg cgctgcccct ggcatggtgc ctgcttcaat attggaactg gggacctaga
      601 ggacttccca ggcctggaca gtctgcataa gttccaggtg aagattgaga aggagaaggt
      661 gaccgttcgg gcaagcaagc aggccctgca gctgcagcgg aggacaaagg tgatggccaa
      721 gtgcatctct ccaagtgctg gccacagcag caccaatgtg ctcatagtgg gcgcaggtgc
      781 tgctggccta gtgtgcgcag agacactgag gcaggagggc ttctcagacc gcattgtcct
      841 ttgcacactg gatcgacatc tgccttatga tcgggccaag ctcagcaagt ccctggatgc
      901 acaacctgaa cagctggccc tgagacccaa ggaattcttc cgggcctatg gcatcgagat
      961 gctcactgaa gctcaggtgg tcacagtgga cgtgagaaat aagaaggttg tgttcaagga
     1021 cggcttcaag ctagagtaca gcaagctgct gctggcacca ggaagtagcc ctaagaccct
     1081 gacctgcaaa gggaaagaca tagagaatgt gttcaccatc cgcacgcctg aggatgccaa
     1141 ccgcgtgctg cggctggccc ggggccgaaa tgctgttgtt gtgggagcag gctttctggg
     1201 gatggaggtc gctgcttatc tgactgaaaa agcccactca gtatctgtgg tagagctgga
     1261 ggagacgccc ttccgcaggt tcctggggga gcgtgttggt cgtgccctta tgaagatgtt
     1321 tgaaaacaac cgggtgaagt tctatatgca gacagaggtg tcagagctgc gggctcaaga
     1381 gggcaagctg caggaggtgg tgctgaagag cagcaaagtt ctgcgggcag acgtctgcgt
     1441 ggtaggcatc ggtgcggtgc ctgccacagg cttcctgagg cagagtggca ttggtctgga
     1501 ttcccgaggt ttcatcccag tcaacaagat gatgcagacc aacatcccag gagtgtttgc
     1561 tgcaggtgat gctgtcacct ttcctcttgc ctggaggaac aatcggaaag tgaacatccc
     1621 acactggcag atggctcatg cccagggtcg ggtagcagct cagaacatgc tggcacagga
     1681 ggcagagatc aacacggtac cttatctgtg gactgccatg ttcggcaaga gcctgcgcta
     1741 tgctggctac ggagaaggct tcgatgatgt catcattcag ggggatctgg aggagctgaa
     1801 gtttgtggct ttttatacca aaggtgacga agtgattgct gtggccagca tgaactacga
     1861 ccccatcgta tccaaggtgg ccgaggtgct ggcctcaggt cgagccatcc ggaagcggga
     1921 ggtggagttg tttatgctgc acagcaagac cggtgacatg tcttggctca cagggaaagg
     1981 atcctgagct ctctctctct ctcatgtggt ggacttaggc aggcctctgg gacaccaagg
     2041 tcagagacta agtcccgggg caagtgccaa tctccaatat cccaggatcc cccaaggtgg
     2101 aatctgagtc ttccaaggct tgccttcaac tgtctgcctc acctccagag aggctactac
     2161 tgcctccaga agatgatccg ttccgaaggc ctcagctgtc actgacagct ggttttagag
     2221 gcaggacagg ctctgtctct gcttcctctg ttaggactgt tttcccagca agccccttca
     2281 acattacctt aaaattaaaa cacatatatc agca
//
