LOCUS       NM_001139483            3422 bp    mRNA    linear   ROD 11-SEP-2024
DEFINITION  Rattus norvegicus AIF family member 2 (Aifm2), mRNA.
ACCESSION   NM_001139483 NM_001108534 XM_001056179 XM_342137
VERSION     NM_001139483.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3422)
  AUTHORS   Bersuker,K., Hendricks,J.M., Li,Z., Magtanong,L., Ford,B.,
            Tang,P.H., Roberts,M.A., Tong,B., Maimone,T.J., Zoncu,R.,
            Bassik,M.C., Nomura,D.K., Dixon,S.J. and Olzmann,J.A.
  TITLE     The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit
            ferroptosis
  JOURNAL   Nature 575 (7784), 688-692 (2019)
   PUBMED   31634900
REFERENCE   2  (bases 1 to 3422)
  AUTHORS   Doll,S., Freitas,F.P., Shah,R., Aldrovandi,M., da Silva,M.C.,
            Ingold,I., Goya Grocin,A., Xavier da Silva,T.N., Panzilius,E.,
            Scheel,C.H., Mourao,A., Buday,K., Sato,M., Wanninger,J.,
            Vignane,T., Mohana,V., Rehberg,M., Flatley,A., Schepers,A.,
            Kurz,A., White,D., Sauer,M., Sattler,M., Tate,E.W., Schmitz,W.,
            Schulze,A., O'Donnell,V., Proneth,B., Popowicz,G.M., Pratt,D.A.,
            Angeli,J.P.F. and Conrad,M.
  TITLE     FSP1 is a glutathione-independent ferroptosis suppressor
  JOURNAL   Nature 575 (7784), 693-698 (2019)
   PUBMED   31634899
REFERENCE   3  (bases 1 to 3422)
  AUTHORS   Miriyala,S., Thippakorn,C., Chaiswing,L., Xu,Y., Noel,T.,
            Tovmasyan,A., Batinic-Haberle,I., Vander Kooi,C.W., Chi,W.,
            Latif,A.A., Panchatcharam,M., Prachayasittikul,V.,
            Butterfield,D.A., Vore,M., Moscow,J. and St Clair,D.K.
  TITLE     Novel role of 4-hydroxy-2-nonenal in AIFm2-mediated mitochondrial
            stress signaling
  JOURNAL   Free Radic Biol Med 91, 68-80 (2016)
   PUBMED   26689472
REFERENCE   4  (bases 1 to 3422)
  AUTHORS   Bohm,D., Keller,K., Pieter,J., Boehm,N., Wolters,D., Siggelkow,W.,
            Lebrecht,A., Schmidt,M., Kolbl,H., Pfeiffer,N. and Grus,F.H.
  TITLE     Comparison of tear protein levels in breast cancer patients and
            healthy controls using a de novo proteomic approach
  JOURNAL   Oncol Rep 28 (2), 429-438 (2012)
   PUBMED   22664934
REFERENCE   5  (bases 1 to 3422)
  AUTHORS   Mei,J., Webb,S., Zhang,B. and Shu,H.B.
  TITLE     The p53-inducible apoptotic protein AMID is not required for normal
            development and tumor suppression
  JOURNAL   Oncogene 25 (6), 849-856 (2006)
   PUBMED   16186796
  REMARK    GeneRIF: Functional characterization of the mouse Amid ortholog and
            comparison to the human protein.
REFERENCE   6  (bases 1 to 3422)
  AUTHORS   Marshall,K.R., Gong,M., Wodke,L., Lamb,J.H., Jones,D.J.,
            Farmer,P.B., Scrutton,N.S. and Munro,A.W.
  TITLE     The human apoptosis-inducing protein AMID is an oxidoreductase with
            a modified flavin cofactor and DNA binding activity
  JOURNAL   J Biol Chem 280 (35), 30735-30740 (2005)
   PUBMED   15958387
REFERENCE   7  (bases 1 to 3422)
  AUTHORS   Shultz,M.A., Zhang,L., Gu,Y.Z., Baker,G.L., Fannuchi,M.V.,
            Padua,A.M., Gurske,W.A., Morin,D., Penn,S.G., Jovanovich,S.B.,
            Plopper,C.G. and Buckpitt,A.R.
  TITLE     Gene expression analysis in response to lung toxicants: I.
            Sequencing and microarray development
  JOURNAL   Am J Respir Cell Mol Biol 30 (3), 296-310 (2004)
   PUBMED   12947022
REFERENCE   8  (bases 1 to 3422)
  AUTHORS   Fujimoto,Y., Itabe,H., Sakai,J., Makita,M., Noda,J., Mori,M.,
            Higashi,Y., Kojima,S. and Takano,T.
  TITLE     Identification of major proteins in the lipid droplet-enriched
            fraction isolated from the human hepatocyte cell line HuH7
  JOURNAL   Biochim Biophys Acta 1644 (1), 47-59 (2004)
   PUBMED   14741744
REFERENCE   9  (bases 1 to 3422)
  AUTHORS   Ohiro,Y., Garkavtsev,I., Kobayashi,S., Sreekumar,K.R., Nantz,R.,
            Higashikubo,B.T., Duffy,S.L., Higashikubo,R., Usheva,A., Gius,D.,
            Kley,N. and Horikoshi,N.
  TITLE     A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue
            of the apoptosis-inducing factor (AIF)
  JOURNAL   FEBS Lett 524 (1-3), 163-171 (2002)
   PUBMED   12135761
REFERENCE   10 (bases 1 to 3422)
  AUTHORS   Wu,M., Xu,L.G., Li,X., Zhai,Z. and Shu,H.B.
  TITLE     AMID, an apoptosis-inducing factor-homologous
            mitochondrion-associated protein, induces caspase-independent
            apoptosis
  JOURNAL   J Biol Chem 277 (28), 25617-25623 (2002)
   PUBMED   11980907
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000020.1.
            
            On Dec 16, 2008 this sequence version replaced NM_001108534.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360186.2527500.1,
                                           SRR26360194.912962.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-202               JAXUCZ010000020.1  30207829-30208030
            203-318             JAXUCZ010000020.1  30208339-30208454
            319-438             JAXUCZ010000020.1  30209565-30209684
            439-531             JAXUCZ010000020.1  30210078-30210170
            532-640             JAXUCZ010000020.1  30214110-30214218
            641-793             JAXUCZ010000020.1  30216060-30216212
            794-994             JAXUCZ010000020.1  30217175-30217375
            995-3422            JAXUCZ010000020.1  30218536-30220963
FEATURES             Location/Qualifiers
     source          1..3422
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20q11"
     gene            1..3422
                     /gene="Aifm2"
                     /gene_synonym="Amid; Prg3"
                     /note="AIF family member 2"
                     /db_xref="GeneID:361843"
                     /db_xref="RGD:1304964"
     exon            1..202
                     /gene="Aifm2"
                     /gene_synonym="Amid; Prg3"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..1146
                     /gene="Aifm2"
                     /gene_synonym="Amid; Prg3"
                     /note="apoptosis-inducing factor (AIF)-like
                     mitochondrion-associated inducer of death;
                     apoptosis-inducing factor 2; apoptosis-inducing factor,
                     mitochondrion-associated 2; apoptosis inducing factor,
                     mitochondria associated 2"
                     /codon_start=1
                     /product="ferroptosis suppressor protein 1"
                     /protein_id="NP_001132955.1"
                     /db_xref="GeneID:361843"
                     /db_xref="RGD:1304964"
                     /translation="MGSQVSVDTGAVHVVIVGGGFGGIAAASQLQALNVPFMLVDMKD
                     SFHHNVAALRASVESGFAKKTFISYSVTFKDNFRQGKVIGIDLKNRMVLLEGGEALPF
                     SHLILATGSTGPFPGKFNEVSCQQAAIQAYEDMVKQIQRSQFIVVVGGGSAGVEMAAE
                     IKTEYPEKEVTLIHSRVPLADKELLPCVRQEVKEILLRKGVQLLLSERVSNLEELPRN
                     EYREYIKVETDKGTEVATNMVIVCNGIKINSSAYRSAFESRLASNGALKVNEFLQVEG
                     YSNIYAIGDCADIKEPKMAYHAGLHANIAVANIVNSMKQRPLKAYKPGALTFLLSMGR
                     NDGVGQISGFYVGRLMVRLAKSRDLLISTSWKTMRQSPP"
     exon            203..318
                     /gene="Aifm2"
                     /gene_synonym="Amid; Prg3"
                     /inference="alignment:Splign:2.1.0"
     exon            319..438
                     /gene="Aifm2"
                     /gene_synonym="Amid; Prg3"
                     /inference="alignment:Splign:2.1.0"
     exon            439..531
                     /gene="Aifm2"
                     /gene_synonym="Amid; Prg3"
                     /inference="alignment:Splign:2.1.0"
     exon            532..640
                     /gene="Aifm2"
                     /gene_synonym="Amid; Prg3"
                     /inference="alignment:Splign:2.1.0"
     exon            641..793
                     /gene="Aifm2"
                     /gene_synonym="Amid; Prg3"
                     /inference="alignment:Splign:2.1.0"
     exon            794..994
                     /gene="Aifm2"
                     /gene_synonym="Amid; Prg3"
                     /inference="alignment:Splign:2.1.0"
     exon            995..3422
                     /gene="Aifm2"
                     /gene_synonym="Amid; Prg3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagcccagca gtgccaagtt caagatgggc tcccaggtct cggtggacac aggagctgtg
       61 cacgtggtga tcgtgggcgg gggctttgga gggatagcgg ccgccagtca gctgcaggct
      121 ctgaatgtcc ccttcatgct ggtggacatg aaggactcct tccaccacaa tgtggcagcc
      181 ctccgggcct ccgtggagag cgggttcgcc aaaaagacat tcatttctta ctcggtgacc
      241 ttcaaggaca acttccgcca gggcaaagtg attggcatag acttgaagaa ccggatggtg
      301 ctgctagagg gtggtgaggc cttgcccttc tcacatctta ttctggccac aggcagtact
      361 gggccctttc ctggcaaatt taacgaggtg tcctgccaac aggcagccat ccaggcctat
      421 gaggacatgg tgaagcagat ccagcgctcg cagttcatcg tggtggtggg aggcggctct
      481 gcaggagttg agatggccgc agagattaaa accgagtacc ctgagaagga ggtcactctt
      541 atccactcca gagtacccct ggcggacaag gagctcctgc cttgtgtgcg acaggaagtg
      601 aaggagatcc tcctccgaaa gggtgtgcag ctgctgctga gtgagcgggt gagcaacctg
      661 gaggaactgc ctcgcaatga gtatcgggag tacatcaagg tggaaacgga caagggcaca
      721 gaggtggcca ccaacatggt gattgtgtgc aatgggatca agattaacag ctctgcctac
      781 cgcagtgcgt ttgagagtag gctggccagc aacggggctc tgaaagtgaa cgagttcctc
      841 caggtggaag gttacagcaa catttacgcc attggcgact gtgctgacat caaggagccc
      901 aagatggcct atcacgctgg cctgcatgcc aacattgctg tggccaacat tgtcaactcc
      961 atgaagcaga ggcccctcaa agcctacaag ccaggtgcgc tgacattcct cctgtccatg
     1021 ggcagaaacg atggcgtggg ccagatcagt ggcttctatg taggccgcct catggtgcgg
     1081 ctggccaaga gcagggacct tctcatctcc acaagctgga aaaccatgcg gcaatctcca
     1141 ccatgacagg gaggctgcat gggagtcgag gtaccactcg gaggggtgac agactgcttg
     1201 acaaaggaca cccttctgac aggtgccaat ggcagagctc tttgtctgga tcatggtgtc
     1261 agccatgtgc tggctggaaa tacaatttgg gtaaaaccgg aaatgagaga cagagagtaa
     1321 aggggggagg cattaaaaaa agaaaaacta acctagaaga ttccttccag gtttggaagg
     1381 tctgcctgca gctgtgctag ctaacgggtc tcggggaggc agagggaggc tgagggagcc
     1441 tcccatatca taggcttcca tctaaggatg cacatgagtc tgtgtgtgca catgagtctg
     1501 tgtgtgcacg agtctgtgtg cacatgagtc tgtgtgtgca catgagtctg tgtgtgcaca
     1561 tgagtctgtg tacacgagtc tgtgtgcaca tgaatctgtg tgtgtacaca tgagtctgtg
     1621 tgtgcacatg agtctgtgtg cacatgaatc tgtgtgtgca catgaaagca ttgggctttg
     1681 ggagtactgt tgagagctct tgttggacag ggctgggcaa ttctagcacg gacctcatct
     1741 gtagtatagt caagagagcc catagcatga gaccaagggt gctggggtgg ggagcttgta
     1801 tatctcacag tatgcaggga ttaactgggg ccccgttttt atcttcctct ctatggttag
     1861 tacctgcact ttgctctccc tccgtcttct ttccttccct ctgaacaaca ctcacacagc
     1921 gcgcgagtgc aacatctctc tccaccccca cagtgtctac ctatattatt cagtttccct
     1981 caaactcctg agctcgtcat gctcctgcct cagtctttcc tggtgccttg ggaccctctt
     2041 taacctttgt gagtctttgt gtccatgttc ggcttgactg tgtgtcacag gtacattcat
     2101 gaagagtcag acaaaatccc tctctagctc acccatctgt tgctgaaatc tctttgggaa
     2161 gtgagggaga tataagccac atctgtccct tctcctaagg tcccaatgac aaactgaggc
     2221 agggttctgt cagactttac tccagggaac cagtgagtgt attgggcttc cttacatatt
     2281 gttggcttct cccatgacag gccaagctgg gaagctttaa gcagcaggga tgagagcctc
     2341 acagatccga ggcagtacag agagcacctc tctccctagc ctttcccagc ctatatgccc
     2401 aagccttgag gccagatgca gtgccattaa agtggacttg tgtgtaagtg gtaggggcct
     2461 gctagataca cagatgaagg tctcctgacc ctccccacga caccatcatc agatacaaat
     2521 agtcaacaag gccagctggg acaatcctct taaaggggag agcggctgaa ctccccagga
     2581 tggtggtcgc ttggctccga ggacagtcat gcaaacagca tcctaacagg gtgaggttta
     2641 taagtctgga gaggctaagg ctgaaccctg gttggcttta ggaatcccag gatagagacc
     2701 tgtggctggg ggagagcatt ggctgcttga tctccagaga ccagaggggc aactgagtcc
     2761 tcgagtgatt tccaggttac cagcaggctt ctgtgggggg tggggagcta tgctgctcat
     2821 tttcggccag ctcctgtcac ttgggtcctc attggtcacc atgtgtgcta tagattgcta
     2881 aggtgtatga attatatgaa ggacttccct atccaagtag ggaatagcca cttgtgcatg
     2941 gcctaagttg aatgtcttag cagaagagac tgaaagtcca ctccagtagc ttcagacatg
     3001 actctcccca ccctgcttct ttctgcttgc ttttggcctt ggcctctggt tatgggtggc
     3061 aagagtcctt gagatagcag cctccgtggg atttccagtc catccccatt tggactgtga
     3121 ccaaggtctg ttccacactg gagttgagac ttgactctct ctcccagaga ctgaccactc
     3181 accggcagct ctgcccctgg ctctgctgtc gtgggtgcca cccagcaagc tcaccctttg
     3241 ttggggcagg atcaactgtc tgcaggaagc tggccatgtc agagcttcac agagcgtggc
     3301 aggactctcc agtgacaggc tttgtgtgat ttctttacaa tactctggat gaatctatct
     3361 gcagggaacg caggtttcca agaggagggg aatatcacaa taaagggcta tgttataaga
     3421 aa
//
