LOCUS       NM_031356               2218 bp    mRNA    linear   ROD 03-SEP-2024
DEFINITION  Rattus norvegicus apoptosis inducing factor, mitochondria
            associated 1 (Aifm1), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_031356
VERSION     NM_031356.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2218)
  AUTHORS   Li,C., Wang,Z., Ren,M., Ren,S., Wu,G. and Wang,L.
  TITLE     Synaptic vesicle protein 2A mitigates parthanatos via
            apoptosis-inducing factor in a rat model of pharmacoresistant
            epilepsy
  JOURNAL   CNS Neurosci Ther 30 (5), e14778 (2024)
   PUBMED   38801174
  REMARK    GeneRIF: Synaptic vesicle protein 2A mitigates parthanatos via
            apoptosis-inducing factor in a rat model of pharmacoresistant
            epilepsy.
REFERENCE   2  (bases 1 to 2218)
  AUTHORS   Yang,D., Rong,R., Yang,R., You,M., Wang,M., Li,H. and Ji,D.
  TITLE     CaMK II -induced Drp1 phosphorylation contributes to blue
            light-induced AIF-mediated necroptosis in retinal R28 cells
  JOURNAL   Biochem Biophys Res Commun 559, 113-120 (2021)
   PUBMED   33940381
  REMARK    GeneRIF: CaMK II -induced Drp1 phosphorylation contributes to blue
            light-induced AIF-mediated necroptosis in retinal R28 cells.
REFERENCE   3  (bases 1 to 2218)
  AUTHORS   Ghanbarinejad,V., Jamshidzadeh,A., Khalvati,B., Farshad,O., Li,H.,
            Shi,X., Chen,Y., Ommati,M.M. and Heidari,R.
  TITLE     Apoptosis-inducing factor plays a role in the pathogenesis of
            hepatic and renal injury during cholestasis
  JOURNAL   Naunyn Schmiedebergs Arch Pharmacol 394 (6), 1191-1203 (2021)
   PUBMED   33527194
  REMARK    GeneRIF: Apoptosis-inducing factor plays a role in the pathogenesis
            of hepatic and renal injury during cholestasis.
REFERENCE   4  (bases 1 to 2218)
  AUTHORS   Kostic,S., Hauke,T., Ghahramani,N., Filipovic,N. and Vukojevic,K.
  TITLE     Expression pattern of apoptosis-inducing factor in the kidneys of
            streptozotocin-induced diabetic rats
  JOURNAL   Acta Histochem 122 (8), 151655 (2020)
   PUBMED   33171392
  REMARK    GeneRIF: Expression pattern of apoptosis-inducing factor in the
            kidneys of streptozotocin-induced diabetic rats.
REFERENCE   5  (bases 1 to 2218)
  AUTHORS   Li,W.H., Yang,Y.L., Cheng,X., Liu,M., Zhang,S.S., Wang,Y.H. and
            Du,G.H.
  TITLE     Baicalein attenuates caspase-independent cells death via inhibiting
            PARP-1 activation and AIF nuclear translocation in cerebral
            ischemia/reperfusion rats
  JOURNAL   Apoptosis 25 (5-6), 354-369 (2020)
   PUBMED   32338336
  REMARK    GeneRIF: Baicalein attenuates caspase-independent cells death via
            inhibiting PARP-1 activation and AIF nuclear translocation in
            cerebral ischemia/reperfusion rats.
REFERENCE   6  (bases 1 to 2218)
  AUTHORS   Zhu,C., Qiu,L., Wang,X., Hallin,U., Cande,C., Kroemer,G.,
            Hagberg,H. and Blomgren,K.
  TITLE     Involvement of apoptosis-inducing factor in neuronal death after
            hypoxia-ischemia in the neonatal rat brain
  JOURNAL   J Neurochem 86 (2), 306-317 (2003)
   PUBMED   12871572
  REMARK    GeneRIF: AIF-mediated cell death may be an important mechanism of
            hypoxia-ischemia induced neuronal loss in the immature brain
REFERENCE   7  (bases 1 to 2218)
  AUTHORS   Fonfria,E., Dare,E., Benelli,M., Sunol,C. and Ceccatelli,S.
  TITLE     Translocation of apoptosis-inducing factor in cerebellar granule
            cells exposed to neurotoxic agents inducing oxidative stress
  JOURNAL   Eur J Neurosci 16 (10), 2013-2016 (2002)
   PUBMED   12453066
  REMARK    GeneRIF: AIF translocation from mitochondria to the nucleus could
            be a key event leading to chromatin condensation and DNA
            degradation in cerebellar granule cells exposed to MeHg and H2O2.
REFERENCE   8  (bases 1 to 2218)
  AUTHORS   Zhang,X., Chen,J., Graham,S.H., Du,L., Kochanek,P.M., Draviam,R.,
            Guo,F., Nathaniel,P.D., Szabo,C., Watkins,S.C. and Clark,R.S.
  TITLE     Intranuclear localization of apoptosis-inducing factor (AIF) and
            large scale DNA fragmentation after traumatic brain injury in rats
            and in neuronal cultures exposed to peroxynitrite
  JOURNAL   J Neurochem 82 (1), 181-191 (2002)
   PUBMED   12091479
REFERENCE   9  (bases 1 to 2218)
  AUTHORS   Braun,J.S., Sublett,J.E., Freyer,D., Mitchell,T.J., Cleveland,J.L.,
            Tuomanen,E.I. and Weber,J.R.
  TITLE     Pneumococcal pneumolysin and H(2)O(2) mediate brain cell apoptosis
            during meningitis
  JOURNAL   J Clin Invest 109 (1), 19-27 (2002)
   PUBMED   11781347
REFERENCE   10 (bases 1 to 2218)
  AUTHORS   Hisatomi,T., Sakamoto,T., Murata,T., Yamanaka,I., Oshima,Y.,
            Hata,Y., Ishibashi,T., Inomata,H., Susin,S.A. and Kroemer,G.
  TITLE     Relocalization of apoptosis-inducing factor in photoreceptor
            apoptosis induced by retinal detachment in vivo
  JOURNAL   Am J Pathol 158 (4), 1271-1278 (2001)
   PUBMED   11290545
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            On Dec 3, 2020 this sequence version replaced NM_031356.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC072697.1, AB041723.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760386,
                                           SAMEA5760494 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-306               JAXUCZ010000021.1  132566932-132567237 c
            307-449             JAXUCZ010000021.1  132557626-132557768 c
            450-549             JAXUCZ010000021.1  132551940-132552039 c
            550-674             JAXUCZ010000021.1  132550032-132550156 c
            675-805             JAXUCZ010000021.1  132549776-132549906 c
            806-896             JAXUCZ010000021.1  132547326-132547416 c
            897-981             JAXUCZ010000021.1  132539626-132539710 c
            982-1058            JAXUCZ010000021.1  132538955-132539031 c
            1059-1167           JAXUCZ010000021.1  132538066-132538174 c
            1168-1275           JAXUCZ010000021.1  132536712-132536819 c
            1276-1364           JAXUCZ010000021.1  132536291-132536379 c
            1365-1505           JAXUCZ010000021.1  132535589-132535729 c
            1506-1648           JAXUCZ010000021.1  132533566-132533708 c
            1649-1773           JAXUCZ010000021.1  132530912-132531036 c
            1774-1970           JAXUCZ010000021.1  132528700-132528896 c
            1971-2218           JAXUCZ010000021.1  132528107-132528354 c
FEATURES             Location/Qualifiers
     source          1..2218
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq36"
     gene            1..2218
                     /gene="Aifm1"
                     /gene_synonym="Aif; Pdcd8"
                     /note="apoptosis inducing factor, mitochondria associated
                     1"
                     /db_xref="GeneID:83533"
                     /db_xref="RGD:620817"
     exon            1..306
                     /gene="Aifm1"
                     /gene_synonym="Aif; Pdcd8"
                     /inference="alignment:Splign:2.1.0"
     CDS             204..2042
                     /gene="Aifm1"
                     /gene_synonym="Aif; Pdcd8"
                     /note="apoptosis-inducing factor 1, mitochondrial;
                     programmed cell death protein 8; apoptosis-inducing factor
                     1, mitochondrial-like; programmed cell death 8
                     (apoptosis-inducing factor); apoptosis-inducing factor,
                     mitochondrion-associated 1"
                     /codon_start=1
                     /product="apoptosis-inducing factor 1, mitochondrial
                     precursor"
                     /protein_id="NP_112646.1"
                     /db_xref="GeneID:83533"
                     /db_xref="RGD:620817"
                     /translation="MFRCGGLAGAFKQKLVPLVRSVCVQRPKQRNRLPGNLFQQWRVP
                     LELQMARQMASSGPSGGKMDNSVLVLIVGLSTIGAGAYAYKTIKEDQKRYNERIMGLG
                     LSPEEKQRRAIASAAEGGSVPPIRVPSHVPFLLIGGGTAAFAAARSIRARDPGARVLI
                     VSEDPELPYMRPPLSKELWFSDDPNVTKTLQFRQWNGKERSIYFQPPSFYVSAQDLPH
                     IENGGVAVLTGKKVVHLDVRGNMVKLNDGSQITFEKCLIATGGTPRSLSAIDRAGAEV
                     KSRTTLFRKIGDFRALEKISREVKSITVIGGGFLGSELACALGRKSQASGIEVIQLFP
                     EKGNMGKILPEYLSNWTMEKVKREGVKVMPNAIVQSVGVSGGKLLIKLKDGRKVETDH
                     IVTAVGLEPNVELAKTGGLEIDSDFGGFRVNAELQARSNIWVAGDAACFYDIKLGRRR
                     VEHHDHAVVSGRLAGENMTGAAKPYWHQSMFWSDLGPDVGYEAIGLVDSSLPTVGVFA
                     KATAQDNPKSATEQSGTGIRSESETESEASEITIPPSDPAVPQVPVEGEDYGKGVIFY
                     LRDKVVVGIVLWNVFNRMPIARKIIKDGEQHEDLNEVAKLFNIHED"
     exon            307..449
                     /gene="Aifm1"
                     /gene_synonym="Aif; Pdcd8"
                     /inference="alignment:Splign:2.1.0"
     exon            450..549
                     /gene="Aifm1"
                     /gene_synonym="Aif; Pdcd8"
                     /inference="alignment:Splign:2.1.0"
     exon            550..674
                     /gene="Aifm1"
                     /gene_synonym="Aif; Pdcd8"
                     /inference="alignment:Splign:2.1.0"
     exon            675..805
                     /gene="Aifm1"
                     /gene_synonym="Aif; Pdcd8"
                     /inference="alignment:Splign:2.1.0"
     exon            806..896
                     /gene="Aifm1"
                     /gene_synonym="Aif; Pdcd8"
                     /inference="alignment:Splign:2.1.0"
     exon            897..981
                     /gene="Aifm1"
                     /gene_synonym="Aif; Pdcd8"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1058
                     /gene="Aifm1"
                     /gene_synonym="Aif; Pdcd8"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1167
                     /gene="Aifm1"
                     /gene_synonym="Aif; Pdcd8"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1275
                     /gene="Aifm1"
                     /gene_synonym="Aif; Pdcd8"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..1364
                     /gene="Aifm1"
                     /gene_synonym="Aif; Pdcd8"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..1505
                     /gene="Aifm1"
                     /gene_synonym="Aif; Pdcd8"
                     /inference="alignment:Splign:2.1.0"
     exon            1506..1648
                     /gene="Aifm1"
                     /gene_synonym="Aif; Pdcd8"
                     /inference="alignment:Splign:2.1.0"
     exon            1649..1773
                     /gene="Aifm1"
                     /gene_synonym="Aif; Pdcd8"
                     /inference="alignment:Splign:2.1.0"
     exon            1774..1970
                     /gene="Aifm1"
                     /gene_synonym="Aif; Pdcd8"
                     /inference="alignment:Splign:2.1.0"
     exon            1971..2218
                     /gene="Aifm1"
                     /gene_synonym="Aif; Pdcd8"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tagggttcca gcctcagtac cttttccccg gctctagcgg gccggtttct ctatccaatg
       61 tccactcggg gctgggagga ggagcctgcg taatgtgcgt gtgacgggag ggggagcgga
      121 cccgagcccg tggtgtttga ccccttcggc ggtgtgtgaa aagaaaagga aggagccgga
      181 gcttcctagg agcggtcgcc gaaatgttcc ggtgtggagg cctggcgggt gctttcaagc
      241 agaaactggt gcccttggtg cggtcggtgt gcgtccagag gccgaaacag aggaaccggc
      301 ttccaggcaa cttgttccag caatggcgtg ttcctctaga actccagatg gcaagacaaa
      361 tggctagctc tggtccatca gggggcaaaa tggataattc tgtgttagtc cttattgtgg
      421 gcttatcaac aataggagct ggtgcatatg cctacaagac tattaaagaa gaccaaaaaa
      481 gatataatga aagaataatg ggattaggac tgtcaccaga agagaaacag agaagagcca
      541 ttgcctctgc tgcagaagga ggctcagttc ctccaatcag ggtaccaagt cacgtccctt
      601 tcctgctgat tggtggaggt actgctgcct ttgcagcagc tagatccatc cgggctcggg
      661 atcctggggc cagggtcctc atcgtatctg aagaccctga actaccatac atgcgacctc
      721 ctctttcaaa agaattgtgg ttttcagatg acccaaatgt cacaaagaca ctgcagttca
      781 gacagtggaa tggaaaagag agaagcatct atttccagcc accttctttc tatgtctctg
      841 ctcaggacct gcctcatatt gagaatggtg gtgtggctgt cctcaccggg aagaaggtag
      901 tccacctgga tgtaagaggc aacatggtga aacttaatga tggctctcag attacctttg
      961 aaaagtgctt gattgcaacg ggaggcactc caagaagtct gtctgctatc gatagggctg
     1021 gagcagaggt gaagagtaga acaacacttt tcagaaagat tggagatttt agagccttgg
     1081 agaagatctc ccgggaagtc aagtcaatta cagttattgg tggaggcttc cttgggagcg
     1141 aactggcctg tgctcttggc agaaagtctc aagcctcagg catagaagtg attcagctct
     1201 tccctgagaa aggaaatatg gggaagatcc ttcctgaata cctcagcaac tggaccatgg
     1261 aaaaagtcaa acgagaggga gtgaaagtga tgcccaatgc aattgtacaa tcagttggag
     1321 tcagcggtgg caagttactc attaagctaa aggacggaag gaaggtagaa actgaccaca
     1381 tagtaacagc tgtgggccta gaacccaatg tcgagttggc caagactggt gggctggaaa
     1441 tagattccga ttttggtggc ttccgggtaa atgcagagct ccaagcacgt tctaacatct
     1501 gggtggcagg agatgctgca tgcttctatg atataaagtt gggtcgaagg agagtagaac
     1561 atcatgatca cgctgttgtg agtggaagac tggctggaga aaatatgact ggagctgcta
     1621 agccatactg gcatcagtca atgttctgga gtgatttggg tcctgatgtt ggctatgaag
     1681 ctattggtct ggtggatagt agtttgccca cagttggtgt ttttgcaaaa gcaactgcac
     1741 aagacaaccc aaaatctgcc acagagcagt caggaactgg tatccgttcg gagagtgaga
     1801 cagagtctga agcttctgaa atcacaatcc ctcccagtga ccctgcagtc ccacaggtcc
     1861 ctgttgaagg ggaggactac ggcaaaggtg tcatcttcta cctcagggac aaagttgtgg
     1921 tggggattgt gctatggaac gtctttaacc gaatgccgat tgcaaggaag atcattaaag
     1981 acggtgagca acatgaagac ctcaatgaag tagccaaact cttcaacatt catgaagatt
     2041 gaatccctat catggaatac acaagcactt ttccatccct gacagggaat gggtggataa
     2101 aagaacattt tttattcagc atactttttc tttatgtagg agcaggaatc gaacaagcct
     2161 ctgtgaatat tttcatctgt ataaatgcac atcacaaatt aaaatctgat tcttttca
//
