LOCUS       NM_017196                686 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus allograft inflammatory factor 1 (Aif1), mRNA.
ACCESSION   NM_017196 NM_022283 XM_346597
VERSION     NM_017196.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 686)
  AUTHORS   Wu,Q., Qin,B., Wu,X., Zhang,M., Gan,Z., Lan,Y., Ma,C. and Fu,W.
  TITLE     Allograft inflammatory factor-1 enhances inflammation and oxidative
            stress via the NF-kappaB pathway of bladder urothelium in diabetic
            rat model
  JOURNAL   Cytokine 173, 156438 (2024)
   PUBMED   37976702
  REMARK    GeneRIF: Allograft inflammatory factor-1 enhances inflammation and
            oxidative stress via the NF-kappaB pathway of bladder urothelium in
            diabetic rat model.
REFERENCE   2  (bases 1 to 686)
  AUTHORS   Gheorghe,R.O., Grosu,A.V., Magercu,M., Ghenghea,M.S., Zbarcea,C.E.,
            Tanase,A., Negres,S., Filippi,A., Chiritoiu,G., Gherghiceanu,M.,
            Dinescu,S., Gaina,G., Sapunar,D. and Ristoiu,V.
  TITLE     Switching Rat Resident Macrophages from M1 to M2 Phenotype by Iba1
            Silencing Has Analgesic Effects in SNL-Induced Neuropathic Pain
  JOURNAL   Int J Mol Sci 24 (21), 15831 (2023)
   PUBMED   37958812
  REMARK    GeneRIF: Switching Rat Resident Macrophages from M1 to M2 Phenotype
            by Iba1 Silencing Has Analgesic Effects in SNL-Induced Neuropathic
            Pain.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 686)
  AUTHORS   Jeong,S., Yoon,K.S., Lee,J.M., Jo,E.S., Kim,D. and Choi,S.O.
  TITLE     Neurotoxic and cardiotoxic effects of
            N-methyl-1-(naphthalen-2-yl)propan-2-amine (methamnetamine) and
            1-phenyl-2-pyrrolidinylpentane (prolintane)
  JOURNAL   Drug Chem Toxicol 46 (3), 430-440 (2023)
   PUBMED   35296205
  REMARK    GeneRIF: Neurotoxic and cardiotoxic effects of
            N-methyl-1-(naphthalen-2-yl)propan-2-amine (methamnetamine) and
            1-phenyl-2-pyrrolidinylpentane (prolintane).
REFERENCE   4  (bases 1 to 686)
  AUTHORS   Gok,E. and Deveci,E.
  TITLE     Histopathological evaluation of IBA-1, GFAP activity in the brain
            cortex of rats administered cadmium chloride
  JOURNAL   Arch Ital Biol 160 (1-2), 20-27 (2022)
   PUBMED   35913387
  REMARK    GeneRIF: Histopathological evaluation of IBA-1, GFAP activity in
            the brain cortex of rats administered cadmium chloride.
REFERENCE   5  (bases 1 to 686)
  AUTHORS   Hung,T.W., Wu,K.J., Wang,Y.S., Bae,E.K., Song,Y., Yoon,J. and
            Yu,S.J.
  TITLE     Human Milk Oligosaccharide 2'-Fucosyllactose Induces
            Neuroprotection from Intracerebral Hemorrhage Stroke
  JOURNAL   Int J Mol Sci 22 (18), 9881 (2021)
   PUBMED   34576050
  REMARK    GeneRIF: Human Milk Oligosaccharide 2'-Fucosyllactose Induces
            Neuroprotection from Intracerebral Hemorrhage Stroke.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 686)
  AUTHORS   Chen,Z.W., Ahren,B., Ostenson,C.G., Cintra,A., Bergman,T.,
            Moller,C., Fuxe,K., Mutt,V., Jornvall,H. and Efendic,S.
  TITLE     Identification, isolation, and characterization of daintain
            (allograft inflammatory factor 1), a macrophage polypeptide with
            effects on insulin secretion and abundantly present in the pancreas
            of prediabetic BB rats
  JOURNAL   Proc Natl Acad Sci U S A 94 (25), 13879-13884 (1997)
   PUBMED   9391121
REFERENCE   7  (bases 1 to 686)
  AUTHORS   Imai,Y., Ibata,I., Ito,D., Ohsawa,K. and Kohsaka,S.
  TITLE     A novel gene iba1 in the major histocompatibility complex class III
            region encoding an EF hand protein expressed in a monocytic lineage
  JOURNAL   Biochem Biophys Res Commun 224 (3), 855-862 (1996)
   PUBMED   8713135
REFERENCE   8  (bases 1 to 686)
  AUTHORS   Autieri,M.V., Prystowsky,M.B. and Ohlstein,E.H.
  TITLE     Isolation and characterization of BART-1: A novel balloon
            angioplasty responsive transcript in rat carotid arteries
  JOURNAL   DNA Cell Biol 15 (4), 297-304 (1996)
   PUBMED   8639266
REFERENCE   9  (bases 1 to 686)
  AUTHORS   Autieri,M.V., Feuerstein,G.Z., Yue,T.L., Ohlstein,E.H. and
            Douglas,S.A.
  TITLE     Use of differential display to identify differentially expressed
            mRNAs induced by rat carotid artery balloon angioplasty
  JOURNAL   Lab Invest 72 (6), 656-661 (1995)
   PUBMED   7783423
REFERENCE   10 (bases 1 to 686)
  AUTHORS   Utans,U., Arceci,R.J., Yamashita,Y. and Russell,M.E.
  TITLE     Cloning and characterization of allograft inflammatory factor-1: a
            novel macrophage factor identified in rat cardiac allografts with
            chronic rejection
  JOURNAL   J Clin Invest 95 (6), 2954-2962 (1995)
   PUBMED   7769138
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX883046.1, FM053942.1 and BC081822.1.
            
            On Oct 1, 2009 this sequence version replaced NM_017196.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB000818.1, FQ231499.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                BX883046.1         23514-23526         c
            14-577              FM053942.1         1-564
            578-686             BC081822.1         1425-1533
FEATURES             Location/Qualifiers
     source          1..686
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..686
                     /gene="Aif1"
                     /gene_synonym="BART-1; Bart1; iba1; mrf-1"
                     /note="allograft inflammatory factor 1"
                     /db_xref="GeneID:29427"
                     /db_xref="RGD:61924"
     exon            1..123
                     /gene="Aif1"
                     /gene_synonym="BART-1; Bart1; iba1; mrf-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             99..542
                     /gene="Aif1"
                     /gene_synonym="BART-1; Bart1; iba1; mrf-1"
                     /note="protein BART-1; balloon angioplasty responsive
                     transcript; ionized calcium binding adapter molecule 1;
                     AIF-1; microglia response factor; balloon
                     angioplasty-responsive transcript 1"
                     /codon_start=1
                     /product="allograft inflammatory factor 1"
                     /protein_id="NP_058892.1"
                     /db_xref="GeneID:29427"
                     /db_xref="RGD:61924"
                     /translation="MSQSKDLQGGKAFGLLKAQQEERLDGINKHFLDDPKYSSDEDLQ
                     SKLEAFKTKYMEFDLNGNGDIDIMSLKRMLEKLGVPKTHLELKKLIREVSSGSEETFS
                     YSDFLRMMLGKRSAILRMILMYEEKNKEHQKPTGPPAKKAISELP"
     exon            124..185
                     /gene="Aif1"
                     /gene_synonym="BART-1; Bart1; iba1; mrf-1"
                     /inference="alignment:Splign:2.1.0"
     exon            186..252
                     /gene="Aif1"
                     /gene_synonym="BART-1; Bart1; iba1; mrf-1"
                     /inference="alignment:Splign:2.1.0"
     exon            253..294
                     /gene="Aif1"
                     /gene_synonym="BART-1; Bart1; iba1; mrf-1"
                     /inference="alignment:Splign:2.1.0"
     exon            295..457
                     /gene="Aif1"
                     /gene_synonym="BART-1; Bart1; iba1; mrf-1"
                     /inference="alignment:Splign:2.1.0"
     exon            458..657
                     /gene="Aif1"
                     /gene_synonym="BART-1; Bart1; iba1; mrf-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccagaaggga ctggggagct ggtggagaga ggagccagcc aacacactgc agcctcatcg
       61 tcatctcccc acctaaggcc accagcgtct gaggagctat gagccagagc aaggatttgc
      121 agggaggaaa agcttttgga ctgctgaaag cccaacagga agagaggttg gatgggatca
      181 acaagcactt cctcgatgat cccaagtaca gcagtgatga ggatctgcag tccaaactgg
      241 aggccttcaa gacgaagtac atggagtttg atctgaatgg caatggagat atcgatatta
      301 tgtccttgaa gcgaatgctg gagaaacttg gggttcccaa gacccatcta gagctgaaga
      361 aattaattag agaggtgtcc agtggctccg aggagacgtt cagttactct gactttctca
      421 gaatgatgct gggcaagaga tctgccatct tgagaatgat tctgatgtat gaggagaaaa
      481 acaaagaaca ccagaagcca actggtcccc cagccaagaa agctatttct gagttgccct
      541 aattggaggt ggatataaca cggtgggacc gaggaccttc taatgacagc agcatgggaa
      601 aagaagaagc agttgtgagc cagagtcaaa ctaaataaat aatgctccct agtgcaaaaa
      661 aaaaaaaaaa aaaaaaaaaa aaaaaa
//
