LOCUS       NM_001100779            1271 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus activation-induced cytidine deaminase (Aicda),
            mRNA.
ACCESSION   NM_001100779 XM_001060382 XM_575660
VERSION     NM_001100779.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1271)
  AUTHORS   Silva-Barrios,S. and Stager,S.
  TITLE     Hypergammaglobulinemia sustains the development of regulatory
            responses during chronic Leishmania donovani infection in mice
  JOURNAL   Eur J Immunol 49 (7), 1082-1091 (2019)
   PUBMED   31001826
REFERENCE   2  (bases 1 to 1271)
  AUTHORS   Nicholson,L.K., Pratap,H., Bowers,E., Gunzburger,E., Bandi,S.R.,
            Gardner,E.M., Palmer,B.E., Wright,T., Kittelson,J. and Janoff,E.N.
  TITLE     Effective B cell activation in vitro during viremic HIV-1 infection
            with surrogate T cell stimulation
  JOURNAL   Immunobiology 223 (12), 839-849 (2018)
   PUBMED   30219203
REFERENCE   3  (bases 1 to 1271)
  AUTHORS   Pandya,K.D., Palomo-Caturla,I., Walker,J.A., K Sandilya,V.,
            Zhong,Z. and Alugupalli,K.R.
  TITLE     An Unmutated IgM Response to the Vi Polysaccharide of Salmonella
            Typhi Contributes to Protective Immunity in a Murine Model of
            Typhoid
  JOURNAL   J Immunol 200 (12), 4078-4084 (2018)
   PUBMED   29743315
REFERENCE   4  (bases 1 to 1271)
  AUTHORS   Nilaratanakul,V., Chen,J., Tran,O., Baxter,V.K., Troisi,E.M.,
            Yeh,J.X. and Griffin,D.E.
  TITLE     Germ Line IgM Is Sufficient, but Not Required, for
            Antibody-Mediated Alphavirus Clearance from the Central Nervous
            System
  JOURNAL   J Virol 92 (7), e02081-17 (2018)
   PUBMED   29321331
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1271)
  AUTHORS   Matsushita,M., Iwasaki,T., Nonaka,D., Kuwamoto,S., Nagata,K.,
            Kato,M., Kitamura,Y. and Hayashi,K.
  TITLE     Higher Expression of Activation-induced Cytidine Deaminase Is
            Significantly Associated with Merkel Cell Polyomavirus-negative
            Merkel Cell Carcinomas
  JOURNAL   Yonago Acta Med 60 (3), 145-153 (2017)
   PUBMED   28959124
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1271)
  AUTHORS   Suzuki,K., Meek,B., Doi,Y., Muramatsu,M., Chiba,T., Honjo,T. and
            Fagarasan,S.
  TITLE     Aberrant expansion of segmented filamentous bacteria in
            IgA-deficient gut
  JOURNAL   Proc Natl Acad Sci U S A 101 (7), 1981-1986 (2004)
   PUBMED   14766966
REFERENCE   7  (bases 1 to 1271)
  AUTHORS   Chaudhuri,J., Tian,M., Khuong,C., Chua,K., Pinaud,E. and Alt,F.W.
  TITLE     Transcription-targeted DNA deamination by the AID antibody
            diversification enzyme
  JOURNAL   Nature 422 (6933), 726-730 (2003)
   PUBMED   12692563
REFERENCE   8  (bases 1 to 1271)
  AUTHORS   Minegishi,Y., Lavoie,A., Cunningham-Rundles,C., Bedard,P.M.,
            Hebert,J., Cote,L., Dan,K., Sedlak,D., Buckley,R.H., Fischer,A.,
            Durandy,A. and Conley,M.E.
  TITLE     Mutations in activation-induced cytidine deaminase in patients with
            hyper IgM syndrome
  JOURNAL   Clin Immunol 97 (3), 203-210 (2000)
   PUBMED   11112359
REFERENCE   9  (bases 1 to 1271)
  AUTHORS   Revy,P., Muto,T., Levy,Y., Geissmann,F., Plebani,A., Sanal,O.,
            Catalan,N., Forveille,M., Dufourcq-Labelouse,R., Gennery,A.,
            Tezcan,I., Ersoy,F., Kayserili,H., Ugazio,A.G., Brousse,N.,
            Muramatsu,M., Notarangelo,L.D., Kinoshita,K., Honjo,T., Fischer,A.
            and Durandy,A.
  TITLE     Activation-induced cytidine deaminase (AID) deficiency causes the
            autosomal recessive form of the Hyper-IgM syndrome (HIGM2)
  JOURNAL   Cell 102 (5), 565-575 (2000)
   PUBMED   11007475
REFERENCE   10 (bases 1 to 1271)
  AUTHORS   Muramatsu,M., Sankaranand,V.S., Anant,S., Sugai,M., Kinoshita,K.,
            Davidson,N.O. and Honjo,T.
  TITLE     Specific expression of activation-induced cytidine deaminase (AID),
            a novel member of the RNA-editing deaminase family in germinal
            center B cells
  JOURNAL   J Biol Chem 274 (26), 18470-18476 (1999)
   PUBMED   10373455
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Nov 9, 2017 this sequence version replaced NM_001100779.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760389
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-101               JAXUCZ010000004.1  157446120-157446220
            102-249             JAXUCZ010000004.1  157452178-157452325
            250-520             JAXUCZ010000004.1  157453816-157454086
            521-636             JAXUCZ010000004.1  157454779-157454894
            637-1271            JAXUCZ010000004.1  157455324-157455958
FEATURES             Location/Qualifiers
     source          1..1271
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q42"
     gene            1..1271
                     /gene="Aicda"
                     /gene_synonym="aid"
                     /note="activation-induced cytidine deaminase"
                     /db_xref="GeneID:399679"
                     /db_xref="RGD:1303222"
     exon            1..101
                     /gene="Aicda"
                     /gene_synonym="aid"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..690
                     /gene="Aicda"
                     /gene_synonym="aid"
                     /EC_number="3.5.4.38"
                     /codon_start=1
                     /product="single-stranded DNA cytosine deaminase"
                     /protein_id="NP_001094249.1"
                     /db_xref="GeneID:399679"
                     /db_xref="RGD:1303222"
                     /translation="MDSLLMKQKKFLYHFKNVRWAKGRHETYLCYVVKRRDSATSFSL
                     DFGHLRNKSGCHVELLFLRYISDWDLDPGRCYRVTWFTSWSPCYDCARHVAEFLRWNP
                     NLSLRIFTARLYFCEDRKAEPEGLRRLHRAGVQIGIMTFKDYFYCWNTFVENHERTFK
                     AWEGLHENSVRLTRQLRRILLPLYEVDDLRDAFRILGL"
     exon            102..249
                     /gene="Aicda"
                     /gene_synonym="aid"
                     /inference="alignment:Splign:2.1.0"
     exon            250..520
                     /gene="Aicda"
                     /gene_synonym="aid"
                     /inference="alignment:Splign:2.1.0"
     exon            521..636
                     /gene="Aicda"
                     /gene_synonym="aid"
                     /inference="alignment:Splign:2.1.0"
     exon            637..1271
                     /gene="Aicda"
                     /gene_synonym="aid"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcacacaac ggcactgaag cagccttgct tgaagcaagc tccctttgac ctaagacttt
       61 gagggaaaca agaaagtcac gctggagacc gaaatggaca gcctcttgat gaagcaaaag
      121 aagtttcttt accacttcaa aaatgtccgc tgggctaagg gtcggcacga gacctacctg
      181 tgctatgtgg tgaagaggag agatagtgcc acctccttct cactggactt tggccacctt
      241 cgcaacaagt cgggctgcca cgtggaattg ttgttcctac gctacatctc ggactgggac
      301 ctggaccccg gccggtgtta ccgtgtcacc tggttcactt cctggagccc ctgctacgac
      361 tgtgcgcggc acgtggctga gtttctgaga tggaacccta acctcagcct gaggattttc
      421 accgcgcgcc tctacttctg cgaagaccgc aaggctgagc ctgaggggct gcggaggctg
      481 caccgcgccg gagtccagat cgggatcatg accttcaaag actattttta ctgctggaat
      541 acatttgtag aaaatcatga aagaactttc aaagcctggg aagggctgca tgaaaactcc
      601 gtcaggctaa ccagacagct tcggcgcatc cttttgccct tgtatgaagt cgatgacttg
      661 agagatgcgt ttcgtatttt gggactttga tagcaacctc ctggaacgtc acgtgtagtg
      721 aaatttctct gctgaagaga ctggatgaaa aaacaatcct tcaactaccc gtttttcttc
      781 ctaagtactc acttataagt gtagagggga aattatatga cttttaaaaa tacttgagct
      841 gcataggccc tccagagcga tggtgcaaac tgtgctttgt gtacaacatc gccatctact
      901 ggggaacagc agaactgcta gactttggat cacatatgat gctctctcgg acttttcaac
      961 aggatggaaa cggaaggaaa ttgcttagaa aaacatatgg agacgatctc acagtttgtt
     1021 acacctaccc tatgttcttt tattcatttg aattctcagg ggtatcagtg acggattttt
     1081 ctactctttt cttctggggc tcactttcag gggttctctt ctgacgaggc cacggggctg
     1141 tcctatagtc gcggtctgag ccatcacaag tcattctctc aaaagcatta atatgcaggc
     1201 atgtgctata tattgctata tattttcatt gtccgtcctg ttttttatat tcgtacgtga
     1261 gagggtttgg g
//
