LOCUS       NM_012898               1490 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Rattus norvegicus alpha-2-HS-glycoprotein (Ahsg), mRNA.
ACCESSION   NM_012898
VERSION     NM_012898.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1490)
  AUTHORS   Kukla,M., Menzyk,T., Dembinski,M., Winiarski,M., Garlicki,A.,
            Bociaga-Jasik,M., Skonieczna,M., Hudy,D., Maziarz,B.,
            Kusnierz-Cabala,B., Kapusta,M., Skladany,L., Grgurevic,I.,
            Mikolasevic,I., Filipec-Kanizaj,T., Wojcik-Bugajska,M.,
            Grodzicki,T., Rogula,T. and Stygar,D.
  TITLE     Fetuin-A Deficiency but Not Pentraxin 3, FGF-21, or Irisin,
            Predisposes to More Serious COVID-19 Course
  JOURNAL   Biomolecules 11 (10), 1422 (2021)
   PUBMED   34680053
  REMARK    GeneRIF: Fetuin-A Deficiency but Not Pentraxin 3, FGF-21, or
            Irisin, Predisposes to More Serious COVID-19 Course.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1490)
  AUTHORS   Barallobre-Barreiro,J., Gupta,S.K., Zoccarato,A.,
            Kitazume-Taneike,R., Fava,M., Yin,X., Werner,T., Hirt,M.N.,
            Zampetaki,A., Viviano,A., Chong,M., Bern,M., Kourliouros,A.,
            Domenech,N., Willeit,P., Shah,A.M., Jahangiri,M., Schaefer,L.,
            Fischer,J.W., Iozzo,R.V., Viner,R., Thum,T., Heineke,J.,
            Kichler,A., Otsu,K. and Mayr,M.
  TITLE     Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin
            Activity in Human Atrial Fibrillation
  JOURNAL   Circulation 134 (11), 817-832 (2016)
   PUBMED   27559042
REFERENCE   3  (bases 1 to 1490)
  AUTHORS   Barallobre-Barreiro,J., Oklu,R., Lynch,M., Fava,M., Baig,F.,
            Yin,X., Barwari,T., Potier,D.N., Albadawi,H., Jahangiri,M.,
            Porter,K.E., Watkins,M.T., Misra,S., Stoughton,J. and Mayr,M.
  TITLE     Extracellular matrix remodelling in response to venous
            hypertension: proteomics of human varicose veins
  JOURNAL   Cardiovasc Res 110 (3), 419-430 (2016)
   PUBMED   27068509
REFERENCE   4  (bases 1 to 1490)
  AUTHORS   Naito,C., Hashimoto,M., Watanabe,K., Shirai,R., Takahashi,Y.,
            Kojima,M., Watanabe,R., Sato,K., Iso,Y., Matsuyama,T.A., Suzuki,H.,
            Ishibashi-Ueda,H. and Watanabe,T.
  TITLE     Facilitatory effects of fetuin-A on atherosclerosis
  JOURNAL   Atherosclerosis 246, 344-351 (2016)
   PUBMED   26828753
  REMARK    GeneRIF: Fetuin-A exerts the stimulatory effects on inflammatory
            responses in HUVECs, macrophage foam cell formation, and
            proliferation and collagen production in HASMCs, leading to the
            development of atherosclerosis.
            Erratum:[Atherosclerosis. 2016 Oct;253:346. doi:
            10.1016/j.atherosclerosis.2016.05.009.. PMID: 27184817]
REFERENCE   5  (bases 1 to 1490)
  AUTHORS   Shen,X., Yang,L., Yan,S., Zheng,H., Liang,L., Cai,X. and Liao,M.
  TITLE     Fetuin A promotes lipotoxicity in beta cells through the TLR4
            signaling pathway and the role of pioglitazone in anti-lipotoxicity
  JOURNAL   Mol Cell Endocrinol 412, 1-11 (2015)
   PUBMED   25986658
  REMARK    GeneRIF: The protective effects of pioglitazone on lipotoxicity in
            beta cells may involve the inhibition of the activation of the
            Fetuin A and TLR4 signaling pathway.
REFERENCE   6  (bases 1 to 1490)
  AUTHORS   Rauth,G., Poschke,O., Fink,E., Eulitz,M., Tippmer,S., Kellerer,M.,
            Haring,H.U., Nawratil,P., Haasemann,M., Jahnen-Dechent,W. et al.
  TITLE     The nucleotide and partial amino acid sequences of rat fetuin.
            Identity with the natural tyrosine kinase inhibitor of the rat
            insulin receptor
  JOURNAL   Eur J Biochem 204 (2), 523-529 (1992)
   PUBMED   1371750
REFERENCE   7  (bases 1 to 1490)
  AUTHORS   Brown,W.M., Christie,D.L., Dziegielewska,K.M., Saunders,N.R. and
            Yang,F.
  TITLE     The rat protein encoded by clone pp63 is a fetuin/alpha 2-HS
            glycoprotein-like molecule, but is it the tyrosine kinase inhibitor
            pp63?
  JOURNAL   Cell 68 (1), 7-8 (1992)
   PUBMED   1370655
REFERENCE   8  (bases 1 to 1490)
  AUTHORS   Colombo,B.M., Falquerho,L., Manenti,G., Dragani,T.A. and Le Cam,A.
  TITLE     Expression of the pp63 gene encoding the insulin receptor tyrosine
            kinase inhibitor in proliferating liver and in liver tumors
  JOURNAL   Biochem Biophys Res Commun 180 (2), 967-971 (1991)
   PUBMED   1659407
REFERENCE   9  (bases 1 to 1490)
  AUTHORS   Haasemann,M., Nawratil,P. and Muller-Esterl,W.
  TITLE     Rat tyrosine kinase inhibitor shows sequence similarity to human
            alpha 2-HS glycoprotein and bovine fetuin
  JOURNAL   Biochem J 274 (Pt 3) (Pt 3), 899-902 (1991)
   PUBMED   1707273
REFERENCE   10 (bases 1 to 1490)
  AUTHORS   Falquerho,L., Patey,G., Paquereau,L., Rossi,V., Lahuna,O.,
            Szpirer,J., Szpirer,C., Levan,G. and Le Cam,A.
  TITLE     Primary structure of the rat gene encoding an inhibitor of the
            insulin receptor tyrosine kinase
  JOURNAL   Gene 98 (2), 209-216 (1991)
   PUBMED   1849862
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Feb 13, 2023 this sequence version replaced NM_012898.5.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ210159.1, FQ209720.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-285               JAXUCZ010000011.1  91632299-91632583   c
            286-396             JAXUCZ010000011.1  91630392-91630502   c
            397-481             JAXUCZ010000011.1  91629977-91630061   c
            482-645             JAXUCZ010000011.1  91629504-91629667   c
            646-747             JAXUCZ010000011.1  91628150-91628251   c
            748-831             JAXUCZ010000011.1  91627190-91627273   c
            832-1490            JAXUCZ010000011.1  91625975-91626633   c
FEATURES             Location/Qualifiers
     source          1..1490
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q23"
     gene            1..1490
                     /gene="Ahsg"
                     /gene_synonym="Aa2-066; BSP; pp63"
                     /note="alpha-2-HS-glycoprotein"
                     /db_xref="GeneID:25373"
                     /db_xref="RGD:2075"
     exon            1..285
                     /gene="Ahsg"
                     /gene_synonym="Aa2-066; BSP; pp63"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..1131
                     /gene="Ahsg"
                     /gene_synonym="Aa2-066; BSP; pp63"
                     /note="fetuin-A; glycoprotein PP63; 59 kDa bone sialic
                     acid-containing protein; alpha 2 HS-glycoprotein alpha 2
                     (fetuin); phosphorylated N-glycoprotein pp63"
                     /codon_start=1
                     /product="alpha-2-HS-glycoprotein precursor"
                     /protein_id="NP_037030.2"
                     /db_xref="GeneID:25373"
                     /db_xref="RGD:2075"
                     /translation="MKSLVLLLCFAQLWSCQSAPQGAGLGFRELACDDPETEHVALIA
                     VDYLNKHLLQGFRQILNQIDKVKVWSRRPFGEVYELEIDTLETTCHALDPTPLANCSV
                     RQQAEHAVEGDCDFHILKQDGQFRVLHAQCHSTPDSAEDVRKFCPRCPILIRFNDTNV
                     VHTVKTALAAFNAQNNGTYFKLVEISRAQNVPFPVSTLVEFVIAATDCTGQEVTDPAK
                     CNLLAEKQYGFCKATLIHRLGGEEVSVACKLFQTQPQPANANPAGPAPTVGQAAPVAP
                     PAGPPESVVVGPVAVPLGLPDHRTHHDLRHAFSPVASVESASGEVLHSPKVGQPGDAG
                     AAGPVAPLCPGRVRYFKI"
     exon            286..396
                     /gene="Ahsg"
                     /gene_synonym="Aa2-066; BSP; pp63"
                     /inference="alignment:Splign:2.1.0"
     exon            397..481
                     /gene="Ahsg"
                     /gene_synonym="Aa2-066; BSP; pp63"
                     /inference="alignment:Splign:2.1.0"
     exon            482..645
                     /gene="Ahsg"
                     /gene_synonym="Aa2-066; BSP; pp63"
                     /inference="alignment:Splign:2.1.0"
     exon            646..747
                     /gene="Ahsg"
                     /gene_synonym="Aa2-066; BSP; pp63"
                     /inference="alignment:Splign:2.1.0"
     exon            748..831
                     /gene="Ahsg"
                     /gene_synonym="Aa2-066; BSP; pp63"
                     /inference="alignment:Splign:2.1.0"
     exon            832..1490
                     /gene="Ahsg"
                     /gene_synonym="Aa2-066; BSP; pp63"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctagctctcc aagctgatta tctgggctgc ccctgacatt tgtccatctc ccagggcctc
       61 tctggagcag ccatgaagtc cctggtcctg ctcctttgtt ttgctcagct ctggagctgc
      121 caatcagctc cacaaggtgc agggctgggt tttcgagaat tggcttgtga tgacccggaa
      181 acagagcatg tagctttgat agccgtggac tacctcaata aacatcttct tcagggattc
      241 aggcagatct tgaatcagat tgacaaagtc aaggtgtggt ctcggcggcc cttcggagag
      301 gtgtatgagt tggaaattga cacgctggag acaacctgcc acgctctgga cccaaccccc
      361 ttagcaaatt gttctgtgag gcaacaggcc gagcatgcgg tggagggaga ctgtgacttc
      421 cacatcctga aacaagatgg ccagttcagg gtgctacacg cccagtgtca ttccacacca
      481 gactctgcag aggacgttcg gaagttttgc ccacgatgcc caatcctgat ccggttcaat
      541 gacaccaacg tggtccacac tgtcaaaact gccctggctg ccttcaatgc acagaataat
      601 ggaacctatt ttaaactggt ggagatttcc cgagctcaaa atgtgccttt cccggtgtct
      661 actctcgtgg agtttgtgat agctgcgact gactgtactg gtcaggaggt cacagatcca
      721 gccaaatgca acctgctggc agaaaagcaa tatggcttct gcaaggcgac tctcatccac
      781 agacttggtg gggaagaggt ttcagtggcc tgcaagttat tccagacaca gccccagcca
      841 gccaatgcca accctgcagg tcctgcaccc acagtgggcc aagctgcgcc tgtagcccca
      901 ccagctggcc cacctgaatc cgtggtggta ggacccgtgg cagttcctct aggacttcca
      961 gaccaccgaa cccaccatga cctacggcat gccttctctc ctgtggcttc tgtggagtcg
     1021 gcctcaggag aagttcttca ctcacctaag gtgggccagc ctggtgacgc tggtgctgct
     1081 ggcccagtgg cccccctgtg cccagggaga gtcagatact tcaagatcta ggcttgactc
     1141 agggaagtaa ggttttggca ggcaggacat agccaccact gaagtagagg gcttgtccac
     1201 tgaccaagca agtaccacat catagcttga attccaggtc tcttcattcc ccagagaaaa
     1261 ggggcagaga ggtgatggtt aaatttgttg aaagccagca gcagcaacac tagcacttgt
     1321 ggggtgacag actactgtca tttgtttctt tgccttctca ctgacctcat acaaagcagt
     1381 tgcaagcgcg actgtgaaag gtgctctcac caaacttcaa tctacccata aataaaagta
     1441 cccgaaggag ctttcttaaa caagaaggtt ctgagccgag tgtggttgtg
//
