LOCUS       NM_001115034            1391 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus activator of Hsp90 ATPase activity 1 (Ahsa1),
            mRNA.
ACCESSION   NM_001115034 XM_001062110 XM_001062172
VERSION     NM_001115034.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1391)
  AUTHORS   Woodford MR, Sager RA, Marris E, Dunn DM, Blanden AR, Murphy RL,
            Rensing N, Shapiro O, Panaretou B, Prodromou C, Loh SN, Gutmann DH,
            Bourboulia D, Bratslavsky G, Wong M and Mollapour M.
  TITLE     Tumor suppressor Tsc1 is a new Hsp90 co-chaperone that facilitates
            folding of kinase and non-kinase clients
  JOURNAL   EMBO J 36 (24), 3650-3665 (2017)
   PUBMED   29127155
REFERENCE   2  (bases 1 to 1391)
  AUTHORS   Woodford MR, Dunn DM, Blanden AR, Capriotti D, Loiselle D,
            Prodromou C, Panaretou B, Hughes PF, Smith A, Ackerman W, Haystead
            TA, Loh SN, Bourboulia D, Schmidt LS, Marston Linehan W,
            Bratslavsky G and Mollapour M.
  TITLE     The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and
            enhance drug binding
  JOURNAL   Nat Commun 7, 12037 (2016)
   PUBMED   27353360
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1391)
  AUTHORS   Guo Z, Neilson LJ, Zhong H, Murray PS, Zanivan S and Zaidel-Bar R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1391)
  AUTHORS   Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta
            R, Wang NS and Knepper MA.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   5  (bases 1 to 1391)
  AUTHORS   Panaretou B, Siligardi G, Meyer P, Maloney A, Sullivan JK, Singh S,
            Millson SH, Clarke PA, Naaby-Hansen S, Stein R, Cramer R, Mollapour
            M, Workman P, Piper PW, Pearl LH and Prodromou C.
  TITLE     Activation of the ATPase activity of hsp90 by the stress-regulated
            cochaperone aha1
  JOURNAL   Mol Cell 10 (6), 1307-1318 (2002)
   PUBMED   12504007
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473982.1.
            
            On or before Mar 2, 2008 this sequence version replaced
            XM_001062172.1, XM_001062110.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ228977.1, FQ233084.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1391
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q31"
     gene            1..1391
                     /gene="Ahsa1"
                     /note="activator of Hsp90 ATPase activity 1"
                     /db_xref="GeneID:681996"
                     /db_xref="RGD:1589285"
     exon            1..219
                     /gene="Ahsa1"
                     /inference="alignment:Splign:2.1.0"
     CDS             140..1156
                     /gene="Ahsa1"
                     /note="AHA1, activator of heat shock 90kDa protein ATPase
                     homolog 1"
                     /codon_start=1
                     /product="activator of 90 kDa heat shock protein ATPase
                     homolog 1"
                     /protein_id="NP_001108506.1"
                     /db_xref="GeneID:681996"
                     /db_xref="RGD:1589285"
                     /translation="MAKWGEGDPRWIVEERADATNVNNWHWTERDASNWSTEKLKTLF
                     LAVRVENEEGKCEVTEVNKLDGEASINNRKGKLIFFYEWTIKLNWTGTSKSGVQYKGH
                     VEIPNLSDENSVDEVEISVSLAKDEPDTSLVALMKEDGVKLLREAVGIYISTLKTEFT
                     QGMILPTVNGESVDPVGQPALKTEVCKAKCAPSKSQAKPVGVKIPTCKITLKETFLTS
                     PEELYRVFTTQELVQAFTHAPAALEADRGGKFHMVDGNVTGEFTDLVPEKHIAMKWRF
                     KSWPEGHFATITLTFIDKNGETELCMEGRGIPAPEEERTRQGWQRYYFEGIKQTFGYG
                     ARLF"
     exon            220..410
                     /gene="Ahsa1"
                     /inference="alignment:Splign:2.1.0"
     exon            411..493
                     /gene="Ahsa1"
                     /inference="alignment:Splign:2.1.0"
     exon            494..611
                     /gene="Ahsa1"
                     /inference="alignment:Splign:2.1.0"
     exon            612..700
                     /gene="Ahsa1"
                     /inference="alignment:Splign:2.1.0"
     exon            701..829
                     /gene="Ahsa1"
                     /inference="alignment:Splign:2.1.0"
     exon            830..931
                     /gene="Ahsa1"
                     /inference="alignment:Splign:2.1.0"
     exon            932..983
                     /gene="Ahsa1"
                     /inference="alignment:Splign:2.1.0"
     exon            984..1391
                     /gene="Ahsa1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggtggaggg aaaagcaagc caggaggtgc tgtgctgctt ctagtagttt ccaggcgctg
       61 ccaggcggct gggaccgagc ggtcctcagg ctgtggctgc gtctgcttgg gagctggtag
      121 cggtgcgata agtgaactga tggccaagtg gggtgaggga gacccacgct ggatcgtgga
      181 ggagcgggcg gacgccacca acgtcaacaa ctggcactgg acagagaggg atgcttcaaa
      241 ttggtccaca gagaaactga aaactctgtt cctggccgtc cgagtagaaa atgaggaggg
      301 caagtgtgag gtgaccgaag tgaacaagct tgatggagag gcgtccatta acaaccggaa
      361 aggcaaactt atcttctttt atgagtggac catcaaactg aactggacag gtacctctaa
      421 gtcaggagtg cagtacaaag gacacgtgga aatccccaat ttgtctgatg aaaatagcgt
      481 ggacgaagtg gagattagtg tgagccttgc caaagatgag cctgacacaa gtctcgtggc
      541 cttaatgaag gaagacgggg tgaaacttct cagagaagca gtgggaattt acatcagcac
      601 cctcaagaca gagtttactc agggcatgat cttgcccaca gtgaatggag aatcagtaga
      661 cccagtgggc caaccagcac taaaaacgga agtgtgcaag gctaagtgtg ctccttcaaa
      721 aagccaggcc aaacctgttg gtgtcaaaat acccacttgt aagatcaccc tcaaagaaac
      781 cttcctgacc tctccagagg agctctacag agtgttcacc acgcaggagc tggtccaggc
      841 ctttacccat gctcctgcgg ccttggaagc agacagagga gggaagtttc acatggtcga
      901 tggtaacgtc actggggagt ttactgactt ggttcctgag aaacatattg ctatgaagtg
      961 gaggtttaag tcatggccag aggggcactt cgcgaccatc accttgacct tcattgataa
     1021 gaatggagag acagagctgt gcatggaggg ccgcggcatc cctgctcccg aggaagagcg
     1081 gacacggcaa ggctggcagc ggtactactt tgagggcatc aaacagacct ttggctatgg
     1141 tgcacgctta ttttagggcc agcagcaggg gttctggctg tgttgaaact ttagtccagc
     1201 cctcttgcca tgggcttgtg actcacagga ttgcaccatc ccaactgcta acttggggct
     1261 ggggccctcc ctttcacata taccttgggt ttgtgcatgt tttctgctgg gtgggatcta
     1321 agggtgattt ctcttttacg tgtacatatg ctaagtaaac agaattttaa aggcatgcat
     1381 ttcttataat c
//
