LOCUS       NM_001024285            4694 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus aryl-hydrocarbon receptor repressor (Ahrr), mRNA.
ACCESSION   NM_001024285 XM_574291
VERSION     NM_001024285.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4694)
  AUTHORS   Hsu,C.N., Lin,I.C., Yu,H.R., Huang,L.T., Tiao,M.M. and Tain,Y.L.
  TITLE     Maternal Tryptophan Supplementation Protects Adult Rat Offspring
            against Hypertension Programmed by Maternal Chronic Kidney Disease:
            Implication of Tryptophan-Metabolizing Microbiome and Aryl
            Hydrocarbon Receptor
  JOURNAL   Int J Mol Sci 21 (12), 4552 (2020)
   PUBMED   32604820
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4694)
  AUTHORS   Hsu,C.N., Lin,Y.J. and Tain,Y.L.
  TITLE     Maternal Exposure to Bisphenol A Combined with High-Fat
            Diet-Induced Programmed Hypertension in Adult Male Rat Offspring:
            Effects of Resveratrol
  JOURNAL   Int J Mol Sci 20 (18), 4382 (2019)
   PUBMED   31489946
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4694)
  AUTHORS   Hsu,C.N., Lin,Y.J., Lu,P.C. and Tain,Y.L.
  TITLE     Maternal Resveratrol Therapy Protects Male Rat Offspring against
            Programmed Hypertension Induced by TCDD and Dexamethasone
            Exposures: Is It Relevant to Aryl Hydrocarbon Receptor?
  JOURNAL   Int J Mol Sci 19 (8), 2459 (2018)
   PUBMED   30127255
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4694)
  AUTHORS   Nakayama,K., Saito,S., Watanabe,K., Miyashita,H., Nishijima,F.,
            Kamo,Y., Tada,K., Ishizuka,S., Niwa,T., Iwamoto,S. and Shimizu,H.
  TITLE     Influence of AHRR Pro189Ala polymorphism on kidney functions
  JOURNAL   Biosci Biotechnol Biochem 81 (6), 1120-1124 (2017)
   PUBMED   28485216
  REMARK    GeneRIF: The expression of AHRR was upregulated in the kidneys of
            rats with chronic kidney disease.
REFERENCE   5  (bases 1 to 4694)
  AUTHORS   Oshima,M., Mimura,J., Sekine,H., Okawa,H. and Fujii-Kuriyama,Y.
  TITLE     SUMO modification regulates the transcriptional repressor function
            of aryl hydrocarbon receptor repressor
  JOURNAL   J Biol Chem 284 (17), 11017-11026 (2009)
   PUBMED   19251700
REFERENCE   6  (bases 1 to 4694)
  AUTHORS   Nishihashi,H., Kanno,Y., Tomuro,K., Nakahama,T. and Inouye,Y.
  TITLE     Primary structure and organ-specific expression of the rat aryl
            hydrocarbon receptor repressor gene
  JOURNAL   Biol Pharm Bull 29 (4), 640-647 (2006)
   PUBMED   16595894
  REMARK    GeneRIF: the constitutive expression of AhRR mRNA was prominent in
            males when compared with females in parallel with the sexual
            difference in AhR
REFERENCE   7  (bases 1 to 4694)
  AUTHORS   Korkalainen,M., Tuomisto,J. and Pohjanvirta,R.
  TITLE     Primary structure and inducibility by
            2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) of aryl hydrocarbon
            receptor repressor in a TCDD-sensitive and a TCDD-resistant rat
            strain
  JOURNAL   Biochem Biophys Res Commun 315 (1), 123-131 (2004)
   PUBMED   15013435
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB174900.2.
            
            On May 27, 2005 this sequence version replaced XM_574291.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB174900.2, AY367561.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN09345238, SAMN09345329
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4694
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1p11"
     gene            1..4694
                     /gene="Ahrr"
                     /note="aryl-hydrocarbon receptor repressor"
                     /db_xref="GeneID:498999"
                     /db_xref="RGD:1559857"
     exon            1..71
                     /gene="Ahrr"
                     /inference="alignment:Splign:2.1.0"
     exon            72..144
                     /gene="Ahrr"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..2185
                     /gene="Ahrr"
                     /note="ahR repressor"
                     /codon_start=1
                     /product="aryl hydrocarbon receptor repressor"
                     /protein_id="NP_001019456.1"
                     /db_xref="GeneID:498999"
                     /db_xref="RGD:1559857"
                     /translation="MMIPSGECTYAGRKRRKPIQKRRLTMGTEKSNPSKRHRDRLNTE
                     LDHLASLLPFSPDIISKLDKLSVLRLSVSYLRVKSFFQALQETCVWSAPALSPEDHSS
                     RGFPVQEGRLLLESLNGFALVVSAEGMIFYASATIVDYLGFHQTDVMHQNIYDYIHVD
                     DRQDFCRQLHWAMDPPQVVFGQSPHADTDNTVLGKLLRAQEGGKGLPSEYSAFLTRCF
                     ICRVRCLLDSTSGFLTMQFQGKLKFLFGQKKKTPSGTALPPRLSLFCIVAPVLPSVTE
                     MKMKSAFLKAKHRADIVVTMDSRAKAVTSLCESELHPKLNYLAGRSNGENVISLFRGQ
                     TDRSHWTRALARSSCLCLRGGPDLLDPKGTSGDREEDDQKHILRRSPGARGQREMHKY
                     SYGLETPVHLRHLDWSTEQRSQEGTTKLTRQPSKSEPSTCLVPHGSCVPYPGSQGMFS
                     ASNMASFRESLDHPTGTYCSQMNRPLPDIHQGQVDPSTCHIPQGSLGSRIPLSGMQCF
                     TARGFSTEDAKLPSLPVNIGTPCNPVLSLEVPIKMENESGSQDIVEASTTSCVWLGTG
                     DMTRRHLVGFPARMHLKTEPDYRQQVCTPHRGHGILGTNPHSRDTVGSCREHAPLYSA
                     HCTCLSPEPPHHLFMCSHSESQHPSLDQDCRAPIVKREPLDSPSWAAPGHVTVPRMFP
                     KNASITVIPSKGSDGIFLP"
     exon            145..326
                     /gene="Ahrr"
                     /inference="alignment:Splign:2.1.0"
     exon            327..424
                     /gene="Ahrr"
                     /inference="alignment:Splign:2.1.0"
     exon            425..514
                     /gene="Ahrr"
                     /inference="alignment:Splign:2.1.0"
     exon            515..644
                     /gene="Ahrr"
                     /inference="alignment:Splign:2.1.0"
     exon            645..778
                     /gene="Ahrr"
                     /inference="alignment:Splign:2.1.0"
     exon            779..975
                     /gene="Ahrr"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1037
                     /gene="Ahrr"
                     /inference="alignment:Splign:2.1.0"
     exon            1038..1176
                     /gene="Ahrr"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..4694
                     /gene="Ahrr"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agctgacagc ttctggcctc cgcggctctc tcagcgggcg cgcccgatct tctgcgcccc
       61 gcctgcccca ggagcaaaga tgatgattcc gtcaggagag tgcacgtatg ccggtaggaa
      121 gaggaggaaa cccattcaga agcggaggct taccatggga actgagaaat caaatccttc
      181 caaacggcac cgggaccgcc tcaatacaga gctggaccac ctggccagcc tgctgccatt
      241 ttcacccgac atcatctcca agctggacaa actttcagtc cttcgcctca gcgtgagtta
      301 cctcagggtg aagagcttct tccaagcctt gcaggagaca tgtgtatggt cagctccagc
      361 tctgtcacct gaagatcact catccagagg cttccctgtg caggaagggc ggctgctgct
      421 ggagtctctc aatggctttg ctctggtggt gagtgcggaa gggatgatct tctacgcgtc
      481 ggcaacaatt gtggactacc tgggcttcca ccagacagat gtaatgcatc aaaatattta
      541 tgactatatc catgtggatg accggcagga cttctgcaga cagctacact gggccatgga
      601 ccctcctcag gtggtgttcg ggcagtcccc acatgctgac acagacaata ccgtcctagg
      661 gaagttgctc agggcccaag aagggggcaa gggcttgccc tcagagtact cggccttctt
      721 gacacgctgc ttcatttgtc gtgtccgctg cctgctggac agcacctctg gcttcctgac
      781 tatgcagttc caaggaaaac taaaattcct gtttggacag aagaagaaga caccatcagg
      841 aacagccttg cctcctcggc tctccttgtt ttgcattgtg gcgccagtgc tgccttctgt
      901 gactgagatg aaaatgaaaa gtgcattctt gaaggcaaag cacagggcag acattgtggt
      961 cacgatggac tcaagggcaa aagctgttac aagtctgtgt gaatcagaac tgcatcccaa
     1021 actcaattac ttagcaggaa ggagcaatgg agaaaatgtc atttcactgt tcaggggaca
     1081 aacagatagg agccattgga cccgggctct agccaggtct tcatgtctgt gcctcagggg
     1141 tggtcctgac ctgctggacc ccaaggggac ttcaggggac agagaagagg acgatcagaa
     1201 gcacatacta aggagatccc ctggtgcccg ggggcagagg gagatgcaca agtacagcta
     1261 tggcttggag acaccagtac acttgaggca cctggactgg agcacagagc agcgaagtca
     1321 ggagggcact accaagctaa ctcggcagcc cagtaagagt gagccatcca catgcctggt
     1381 gccccatggt tcctgtgtgc cctaccctgg aagtcaaggc atgttcagtg ccagcaacat
     1441 ggcttctttc agggagtccc tagaccatcc cactggtacc tactgcagtc agatgaacag
     1501 acccttgcca gatatccacc agggccaggt ggatccttcc acctgtcata tcccccaggg
     1561 aagtctgggc tctaggatcc ctctgtctgg aatgcagtgc ttcaccgcca ggggattttc
     1621 tacagaggat gcaaaattgc ccagcttgcc agtgaacata ggcaccccgt gcaatccagt
     1681 attgtcactg gaagtgccaa tcaagatgga gaacgaatct gggtcccagg atatagttga
     1741 agccagcaca actagctgtg tgtggctggg aaccggcgac atgaccagaa gacatctggt
     1801 tggtttccct gccaggatgc atctgaaaac agagcctgac tataggcagc aggtctgtac
     1861 cccacaccgt gggcatggta tactggggac taatccccac agcagagaca ctgtggggtc
     1921 ctgtagggag catgctcctc tttactctgc acactgcacc tgcctgagtc cagagcctcc
     1981 tcatcacctc ttcatgtgta gccacagtga aagtcagcat ccctccttgg accaagactg
     2041 cagagctcct attgttaagc gtgagcctct ggactcacca tcatgggctg ctcctggtca
     2101 tgtgactgtg cccaggatgt tccctaagaa tgcctctata actgtgatcc catccaaagg
     2161 atctgatggg attttcctac cctagagttg ctgctctgct ggaaattcag tccttggata
     2221 atggaacatg gtcagatatt cttatagtga tactctttac agaactcagt gagtgaggct
     2281 gagatttcct gtgtgtagcc tagcaacaga gcattctgaa tcacatagga cttcagagaa
     2341 ttctcgtgca taaacctcaa tctgctcaag tggacagcat ttcactttga gaagctaaaa
     2401 tgtttaagga agtagctaac agtattctat gctgggcaga gctcgactga tggtcaaagt
     2461 gatgtgttcc tggtgtccaa gcttgctata cctcctgcct gtgtgcagca ggaattctga
     2521 ggctattagt cagaaactga ggccatactt tgtacgatga tagtcaggga aatatcctat
     2581 accatggaga tttttgtggg tcactgagca tggtttatgt acctgcatcc ctgagtacat
     2641 catatagaga ggttacagta tctaggccag gaaccagagg agcacagcac acagaaaaga
     2701 gtgaagccat actgatgaag agacattgcc caggcaaccg ttcctagccc agggagactt
     2761 agggatgaaa aggcagccag tgtttgttgg aattgtaaag acaatgcact ctgattgtag
     2821 gaaatgtggg tatcatgtat aaacagaaag gaagagtcat caggaaccac ggcaaaatga
     2881 ctgtggctgg gggtgcagta gagaatgctc caagggaggg cttagaccag aaatcctgtg
     2941 ccatcagcac aggatcaact gaacaggaaa aggctctgct tgtctgtttg gttcaaagtc
     3001 ttcctcaggg aattatgaca tccatctctg atgctacttc ctctgaggtc ttaggaatag
     3061 caggagcttg ctggaaaggc ctatggctaa ttctactagg tagtctcttc agcatagatt
     3121 ttctttccct tagccatgac tccaggatac cattgctcgg ccactggctt agtgaaagaa
     3181 gatgtctgga gatgcctatc accttattgg aatcaggttg ggtgggccgg actaggtctt
     3241 ctgcccagtt tttgagctgt ctggctttca agaagactca ccatgggaca aaaatacaac
     3301 tgaagatctg ctagaactga gaatactcac tgtgagagcc cagggccttg tgctctctct
     3361 gtcccttggc ccacagagga ctttcaaagg gcaagatagg ggctgtgctg tcacagatgt
     3421 aaggcatgca catacctcca gtccagcttc cccgttacct aaagcctgaa gccagcatgg
     3481 tgtcccagct cttcctccta tgcccagcca cctgtatccc tcctctcctc aaactgcccc
     3541 agtcccagct tatacatttc tgctaagcat agcataccct atgggtatta atgactaaca
     3601 acaggtagaa ttcgcatttt cctcaacact tcctgttcta aggacatgct caaccactca
     3661 agtgtctgcc attgtatttc tctgtgaaag tacttagcta tgttcccatg ctaagcaaca
     3721 ctcattgtcc tatacacttc ccctacaagg agcagagaac acagcagact gttacattgc
     3781 aatgtataca acatttacag agtgtcctgg agccagtgaa agaaagctag ggaaagggtc
     3841 cttgaaggtg gaattcagag acataattag acatggtggc atgcatttca gcacttaaga
     3901 gactgaagca gacgatgaac cattcaagcc tatatcagac cttgtctcaa acaaaataaa
     3961 acaaagtgca ttactacaca tttatcaatt ttagccagat ctccatcctc tttgtatgta
     4021 atcaaagaag ggctatgccc ctagtgaagc ccatatgttg tctgctcagg tactctgaac
     4081 gtttcagatg gacctcatct gcactcctgc ggggatgact gaccatatgt ggcagctcaa
     4141 ctgggacctg ggtttccctg caggtcaggc tttgtggacc tgagttctgc acttggatgt
     4201 catttcagca gatcttgtat ttgagggggc accacatcac acggcgagct tgggtacctg
     4261 gtgccagttc tgtctaagga cgctcaaacc tcccagacct gcactttggc tcattcatca
     4321 cgagcctcca gtcagcttgc acaggaagga accgaggtcg tccctactct agcatctcac
     4381 catatgcact gactccaggc tcacgctttt tgtgatagct agcttttacc tatatggcta
     4441 aaaattatcc aagattaaat acaatgagag atgggctggg gaggaataaa tacatagtgc
     4501 cctatagttt cagttcctgc tggggaaagt cctcaagatc tggacccagt gaactttaag
     4561 catacactgc agcccagctg tccgtgctct cttcctggtg ctctgtttga acagagaata
     4621 caactgcatt tctcatgcgg tggtttgtac tgcattggca aaacctgtgt aaaataaacc
     4681 tcatgtttcc atgc
//
