LOCUS       NM_013149               5144 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Rattus norvegicus aryl hydrocarbon receptor (Ahr), transcript
            variant 1, mRNA.
ACCESSION   NM_013149 XM_346769
VERSION     NM_013149.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5144)
  AUTHORS   Andersen,M.E., Barutcu,A.R., Black,M.B. and Harrill,J.A.
  TITLE     Transcriptomic analysis of AHR wildtype and Knock-out rat livers
            supports TCDD's role in AHR/ARNT-mediated circadian disruption and
            hepatotoxicity
  JOURNAL   Toxicol Appl Pharmacol 487, 116956 (2024)
   PUBMED   38735589
  REMARK    GeneRIF: Transcriptomic analysis of AHR wildtype and Knock-out rat
            livers supports TCDD's role in AHR/ARNT-mediated circadian
            disruption and hepatotoxicity.
REFERENCE   2  (bases 1 to 5144)
  AUTHORS   Chausse,A.M., Roche,S.M., Moroldo,M., Hennequet-Antier,C.,
            Holbert,S., Kempf,F., Barilleau,E., Trotereau,J. and Velge,P.
  TITLE     Epithelial cell invasion by salmonella typhimurium induces
            modulation of genes controlled by aryl hydrocarbon receptor
            signaling and involved in extracellular matrix biogenesis
  JOURNAL   Virulence 14 (1), 2158663 (2023)
   PUBMED   36600181
  REMARK    GeneRIF: Epithelial cell invasion by salmonella typhimurium induces
            modulation of genes controlled by aryl hydrocarbon receptor
            signaling and involved in extracellular matrix biogenesis.
REFERENCE   3  (bases 1 to 5144)
  AUTHORS   Xu,J., Sun,X., Qin,F., Wang,X., Chen,Q. and Yan,R.
  TITLE     Protective effects of salvianolic acid B on intestinal
            ischemia/reperfusion injury in rats by regulating the
            AhR/IL-22/STAT6 axis
  JOURNAL   J Recept Signal Transduct Res 43 (3), 73-82 (2023)
   PUBMED   37387514
REFERENCE   4  (bases 1 to 5144)
  AUTHORS   Kouno,T., Zeng,S., Wang,Y., Duan,Y., Lang,S., Gao,B., Hartmann,P.,
            Cabre,N., Llorente,C., Galbert,C., Emond,P., Sokol,H., James,M.,
            Chao,C.C., Gao,J.R., Perreault,M., Hava,D.L. and Schnabl,B.
  TITLE     Engineered bacteria producing aryl-hydrocarbon receptor agonists
            protect against ethanol-induced liver disease in mice
  JOURNAL   Alcohol Clin Exp Res (Hoboken) 47 (5), 856-867 (2023)
   PUBMED   36871955
REFERENCE   5  (bases 1 to 5144)
  AUTHORS   Nori,P., Haghshenas,R., Aftabi,Y. and Akbari,H.
  TITLE     Comparison of moderate-intensity continuous training and
            high-intensity interval training effects on the Ido1-KYN-Ahr axis
            in the heart tissue of rats with occlusion of the left anterior
            descending artery
  JOURNAL   Sci Rep 13 (1), 3721 (2023)
   PUBMED   36879035
  REMARK    GeneRIF: Comparison of moderate-intensity continuous training and
            high-intensity interval training effects on the Ido1-KYN-Ahr axis
            in the heart tissue of rats with occlusion of the left anterior
            descending artery.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5144)
  AUTHORS   Fernandez-Salguero,P., Pineau,T., Hilbert,D.M., McPhail,T.,
            Lee,S.S., Kimura,S., Nebert,D.W., Rudikoff,S., Ward,J.M. and
            Gonzalez,F.J.
  TITLE     Immune system impairment and hepatic fibrosis in mice lacking the
            dioxin-binding Ah receptor
  JOURNAL   Science 268 (5211), 722-726 (1995)
   PUBMED   7732381
REFERENCE   7  (bases 1 to 5144)
  AUTHORS   Elferink,C.J. and Whitlock,J.P. Jr.
  TITLE     Dioxin-dependent, DNA sequence-specific binding of a multiprotein
            complex containing the Ah receptor
  JOURNAL   Receptor 4 (3), 157-173 (1994)
   PUBMED   7812217
REFERENCE   8  (bases 1 to 5144)
  AUTHORS   Puga,A., Nebert,D.W. and Carrier,F.
  TITLE     Dioxin induces expression of c-fos and c-jun proto-oncogenes and a
            large increase in transcription factor AP-1
  JOURNAL   DNA Cell Biol 11 (4), 269-281 (1992)
   PUBMED   1605850
REFERENCE   9  (bases 1 to 5144)
  AUTHORS   Ema,M., Sogawa,K., Watanabe,N., Chujoh,Y., Matsushita,N., Gotoh,O.,
            Funae,Y. and Fujii-Kuriyama,Y.
  TITLE     cDNA cloning and structure of mouse putative Ah receptor
  JOURNAL   Biochem Biophys Res Commun 184 (1), 246-253 (1992)
   PUBMED   1314586
REFERENCE   10 (bases 1 to 5144)
  AUTHORS   Okino,S.T., Pendurthi,U.R. and Tukey,R.H.
  TITLE     Phorbol esters inhibit the dioxin receptor-mediated transcriptional
            activation of the mouse Cyp1a-1 and Cyp1a-2 genes by
            2,3,7,8-tetrachlorodibenzo-p-dioxin
  JOURNAL   J Biol Chem 267 (10), 6991-6998 (1992)
   PUBMED   1313028
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Apr 28, 2015 this sequence version replaced NM_013149.2.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AM902286.1, AJ821851.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-90                JAXUCZ010000006.1  57998812-57998901   c
            91-278              JAXUCZ010000006.1  57990688-57990875   c
            279-382             JAXUCZ010000006.1  57978575-57978678   c
            383-472             JAXUCZ010000006.1  57976306-57976395   c
            473-596             JAXUCZ010000006.1  57974458-57974581   c
            597-727             JAXUCZ010000006.1  57973396-57973526   c
            728-930             JAXUCZ010000006.1  57971855-57972057   c
            931-1040            JAXUCZ010000006.1  57971176-57971285   c
            1041-1182           JAXUCZ010000006.1  57970067-57970208   c
            1183-2452           JAXUCZ010000006.1  57967569-57968838   c
            2453-5144           JAXUCZ010000006.1  57961423-57964114   c
FEATURES             Location/Qualifiers
     source          1..5144
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q16"
     gene            1..5144
                     /gene="Ahr"
                     /note="aryl hydrocarbon receptor"
                     /db_xref="GeneID:25690"
                     /db_xref="RGD:2074"
     exon            1..90
                     /gene="Ahr"
                     /inference="alignment:Splign:2.1.0"
     CDS             29..2590
                     /gene="Ahr"
                     /note="isoform 1 is encoded by transcript variant 1; ah
                     receptor"
                     /codon_start=1
                     /product="aryl hydrocarbon receptor isoform 1"
                     /protein_id="NP_037281.3"
                     /db_xref="GeneID:25690"
                     /db_xref="RGD:2074"
                     /translation="MSSGANITYASRKRRKPVQKTVKPVPAEGIKSNPSKRHRDRLNT
                     ELDRLASLLPFPQDVISKLDKLSVLRLSVSYLRAKSFFDVALKSTPADRSRGQDQCRA
                     QVRDWQDLQEGEFLLQALNGFVLVVTADALVFYASSTIQDYLGFQQSDVIHQSVYELI
                     HTEDRAEFQRQLHWALNPSQCTDSAQGVDETHGLPQPAVYYTPDQLPPENTAFMERCF
                     RCRLRCLLDNSSGFLAMNFQGRLKYLHGQNKKGKDGALLPPQLALFAIATPLQPPSIL
                     EIRTKNFIFRTKHKLDFTPIGCDAKGQLILGYTEVELCNKGSGYQFIHAADMLHCAES
                     HIRMIKTGESGMTVFRLLAKHSRWRWVQSNARLIYRNGRPDYIIATQRPLTDEEGREH
                     LQKRSMTLPFMFATGKAVLYEISSPFSPIMDPLPIRTKSNTSRKDWAPQSTPSKDSFH
                     PNSLMSALIQQDESIYLCPPSSPAPLDSHFLMDSMSECGSWQGSFAAASNEALLKHEE
                     IRHTQDVNLTLSGGPSELFPDNKNNDLYSIMRNLGIDFEDIRSMQNEEFFRTDSSGEV
                     DFKDIDITDEILTYVQDSLNNSTLLNSACQQQPVSQHLSCMLQERLQLEQQQQLQQQH
                     PTQTLEPQRQLCQVEVPQHELGQKTKHMQVNGMFASWNPAPPVSFSCPQQERKHYSLF
                     SGLQGTAQEFPYKSEVDSMPYTQNFAPCNQSLLPEHSKGTQLDFPGRDFERSLHPNAS
                     NLEDFVSCLQVPENQRHGINSQSAMVSPQAYYAGAMSMYQCQAGPQHTPVDQMQYSPE
                     IPGSQAFLSKFQSPSILNEAYSADLSSIGHLQTAAHLPRLAEAQPLPDITPSGFL"
     exon            91..278
                     /gene="Ahr"
                     /inference="alignment:Splign:2.1.0"
     exon            279..382
                     /gene="Ahr"
                     /inference="alignment:Splign:2.1.0"
     exon            383..472
                     /gene="Ahr"
                     /inference="alignment:Splign:2.1.0"
     exon            473..596
                     /gene="Ahr"
                     /inference="alignment:Splign:2.1.0"
     exon            597..727
                     /gene="Ahr"
                     /inference="alignment:Splign:2.1.0"
     exon            728..930
                     /gene="Ahr"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1040
                     /gene="Ahr"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1182
                     /gene="Ahr"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..2452
                     /gene="Ahr"
                     /inference="alignment:Splign:2.1.0"
     exon            2453..5144
                     /gene="Ahr"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caggtggagc gggcagggcg cgggcaccat gagcagcggc gccaacatca cctatgccag
       61 ccgcaagcgg cgcaagccgg tgcagaaaac agtaaagccc gtccctgctg aaggaattaa
      121 gtcgaaccct tctaaacgac acagagaccg gctgaacaca gagttagacc gcctggctag
      181 cctgctgccc ttcccacaag atgttattag taagctggac aaactctccg ttctaaggct
      241 cagcgtcagc tacctgaggg ccaagagctt ctttgatgtt gcattaaaat ccaccccggc
      301 tgacagaagt agaggccagg accagtgtag agcacaagtc agagactggc aggacttgca
      361 agaaggagag ttcttgttac aggcgctgaa tggctttgtt ctggttgtca cggcagatgc
      421 cttggtcttc tatgcgtctt ccactatcca agattacctg ggctttcagc aatctgatgt
      481 catacatcag agcgtgtatg agcttatcca tacagaagac cgagctgagt tccagcgcca
      541 gcttcactgg gctctaaacc cctcacagtg cacagactct gcacaaggag tagacgagac
      601 tcatggcctc ccacagccag cggtctacta cacgccagac cagcttcctc cagagaatac
      661 cgctttcatg gagaggtgct tcagatgccg gctgaggtgc ctgctggata attcatctgg
      721 tttcctggca atgaatttcc aagggaggtt aaagtatctt catggacaga acaagaaagg
      781 gaaagacgga gcgctactcc ctccacagtt ggctttgttt gcaatagcta ctccacttca
      841 gccaccgtcc atcctggaaa ttcgaaccaa aaacttcatc ttcaggacca aacacaaact
      901 ggacttcaca cctattggct gtgatgccaa agggcagctt attctgggct acacagaagt
      961 agagctgtgc aacaaaggat cgggatatca gtttatccac gccgctgaca tgcttcactg
     1021 cgcagaatcc cacatccgca tgattaagac tggagaaagt ggcatgacag ttttccggct
     1081 tcttgcaaaa cacagtcgat ggaggtgggt ccagtccaat gcacgcttga tttacagaaa
     1141 tggaagacca gattacatca tcgcaactca gagaccgcta acggatgaag aaggacgcga
     1201 acatttacag aagagaagta tgacactgcc attcatgttt gccactggaa aggctgtact
     1261 gtacgagatc tccagccctt tctctcccat aatggatccc ttgccaatac gcaccaaaag
     1321 caacactagt aggaaagact gggctcccca gtcaaccccg agtaaggatt ctttccaccc
     1381 caattccctt atgagtgcct tgatccaaca ggacgagtcc atctatctct gtcctccttc
     1441 gagccccgca ccattagaca gccattttct catggactcc atgagtgagt gcggcagttg
     1501 gcaaggcagc tttgcagccg caagcaatga agctctgctg aaacacgagg aaatcagaca
     1561 cactcaggac gtgaacctta cactctctgg aggcccctcg gagctcttcc cagataataa
     1621 aaataatgac ttgtatagca tcatgagaaa cctagggatc gatttcgaag acatcagaag
     1681 catgcagaat gaggagttct tccgaaccga ctcctccggt gaggttgact tcaaagacat
     1741 cgacataaca gacgaaatcc tgacgtacgt gcaggattct ctgaacaatt caactctgct
     1801 gaattcagct tgccagcaac agcctgtgag ccagcaccta agctgcatgc tgcaggagcg
     1861 cctgcagctg gagcaacaac agcagcttca gcagcagcac cccactcaga cactggagcc
     1921 ccagcgccag ttgtgtcagg tggaggtccc ccagcacgag ctgggtcaga aaacgaagca
     1981 catgcaagtc aatggcatgt tcgccagttg gaaccctgcc cctcccgtgt ctttcagctg
     2041 tcctcagcag gaacgaaagc actatagcct cttctccggc ttacagggga ctgcacagga
     2101 gtttccctac aagtcagagg tggacagtat gccttacaca cagaactttg ctccctgcaa
     2161 ccagtcactg ctaccagaac attccaaggg tacacagttg gacttccctg gaagggattt
     2221 tgaacgatcc ctgcacccta acgcttctaa tttagaagac tttgtcagtt gtttacaagt
     2281 tcctgaaaac caaagacacg ggataaactc acagtcagcc atggtcagtc ctcaggcgta
     2341 ctacgctggg gccatgtcca tgtaccagtg ccaggcaggg cctcagcaca cccctgtgga
     2401 ccagatgcag tacagccctg agattccagg ctcccaggcg ttcctaagca agtttcagag
     2461 tccgagcatt ttaaatgaag cctactcggc agacttgagc agcattggcc accttcagac
     2521 tgctgctcac ctccctcgcc tggcagaagc ccagcctctt cctgatatca cacccagcgg
     2581 attcctgtag ctcgaggcca ggatgaattt cagttcattc aggaacagga caccagaact
     2641 gtgagggttg gacttcagta cgctttctcc aaaacagatc tcaatgctgg tgtttggtga
     2701 aggagtttaa gaccatattg ctagttacct ataaggtggg atgctctgag gggcacaggg
     2761 agcggccacg tgcattcaca gagctccagc acctcggagt gcacagtgct tactgtggag
     2821 aactcttgga ttctctgctc agtaacttca gctggaaaaa cagtgaagta ctctgagctt
     2881 tgaacttgtg gattcttgtt agtataccaa atacggagtt acaggattaa tcggtttcct
     2941 atttttaacc tctgtttttg tcccagatgt taaaataaat ggtttggtgc ttttctcaaa
     3001 agaaaatgtt ttccttctgc actgttaata taaaagtgcc tcacgttttt gtttttgttt
     3061 ttttttctat ctacctgtaa cacagggtgt gtattttata tgaaatattt ttatctcttt
     3121 tgaattaata ttctttctac acacagaaag tttctcaaat cccaactttc ttttttttta
     3181 atgaatccag gcatgttttt actgcactac tcatcccctt tcttcagata aagggcaaag
     3241 gataaatgaa agttaactat ttattgtgta atatacttgc ttctgaacgt tagatgttcc
     3301 tctgtgcctt atgttgaaaa atttgaaaat aacatattgc caaaattatt taattactgc
     3361 gtactattaa gagagtagca attgaatttt aacagtgttt tctgagaaat gagccctgct
     3421 ggctttccct gagacctcca agatgaaatc agaaaggtca ccatagaaaa tgctaaagat
     3481 ggctgtgccc attagcctgc agtgaaggga ggtggcgctt gttaagctag ttagctaaat
     3541 taagcagagc actcatttca ttgtctgaat tctctttaaa aaactgtctt gggtctgtaa
     3601 tccttttcgt tatattgact ttataaattc cacttctact agtggaaact attagttttt
     3661 ctcatatttg aggagttaag attgaagatg ccgtgtttgg tgcaaggtat tttaatgact
     3721 gaaatgaatg gtgcattgtg taaaggtaac gaacaaaata atctataaaa tgttttcagg
     3781 tttcacttaa gaatagttct tacctcatat gcatatgttt tttcagtgta tcttgttaag
     3841 aaatcaaata atgaattgag gcttttgagc tggcattaag ataaagataa gtacaattca
     3901 cttccctcca tacagtaagt tgtttgtgtg atagaacctt tgctaccaag atggctaatc
     3961 tgtcactccg ccgaatgtag ttctcaaatt gcttaaagaa aaaaaaaatg ccagtgtctg
     4021 tcattgtctt tgtcatcgct gagattaatg tatgaagggc atggacctgg atctgttttt
     4081 catatattgt ataaaaacct gatgaaatcc caaactgaga tgtatgaaaa tatagcattg
     4141 gttctcaacc tgtgagtcat gactcccttt ggagagagaa tggccctttc acaggggtta
     4201 cctaagtcca ttggagagca cagatgttta tatcacagtt tataacagta gtaaaattac
     4261 agttttgaag taacaatgaa aataatttta tggttgaaag agtcacagaa ttaggaaggt
     4321 tgagagccac tgaaatgcag gcctttttat ttttttagaa aattattgta tgtaaacatg
     4381 ccatcaggta aaaaaaaagt ctcttacttc tatgcatttt aagtcaaaat tttgaaactt
     4441 taggattaag cattgaaaaa caactgtcta aaacatttca caatttgctt tcagcatgag
     4501 atatcaccag tggtctgaac taatatcctg tttttctatg taaactttac attaaaagtt
     4561 gccagaaacc attttgtcag tctcttctgc atgttaccaa atgttcagtt aaaaaaaaaa
     4621 acaaaacaaa aaactttgga cactgtgagt atgatggcat ttaatcacac acttatcaaa
     4681 ctgaaagttt taaaaagcaa tattgtgtgt tcttatctat ataaaaatag ctaaaatgcc
     4741 taagaataat aaaatcacat tgaactgcat attcatttgt ctgtattgcc aaatgccaaa
     4801 tggaaagaat ggttaaagca ctgctagact gtgggattaa tttctggatg aaactctaag
     4861 actctgtatg tctgattgaa gttcttttct gggtgtgtgt tacagcacct gaacacttaa
     4921 ccaatatgcc attgtatcaa ccactcaatc cttactatgc acaagctagt ttgttccagc
     4981 atcaatagaa cttaggttta catagcttct tgctgtcctt caaactgtta ttgcttacat
     5041 atgcagtgca tagatttatg ttcgagtatg atttataatg tccttaaata tcaaaggaaa
     5101 tgtaaacagt gatatacgat aataaactaa ccaccaagta tgaa
//
