LOCUS       NP_001385600            5643 aa            linear   ROD 29-MAR-2024
DEFINITION  neuroblast differentiation-associated protein AHNAK isoform 1
            [Rattus norvegicus].
ACCESSION   NP_001385600 XP_038947664
VERSION     NP_001385600.1
DBSOURCE    REFSEQ: accession NM_001398671.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 5643)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 5643)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   3  (residues 1 to 5643)
  AUTHORS   de Morree,A., Droog,M., Grand Moursel,L., Bisschop,I.J.,
            Impagliazzo,A., Frants,R.R., Klooster,R. and van der Maarel,S.M.
  TITLE     Self-regulated alternative splicing at the AHNAK locus
  JOURNAL   FASEB J 26 (1), 93-103 (2012)
   PUBMED   21940993
REFERENCE   4  (residues 1 to 5643)
  AUTHORS   Zacharias,U., Purfurst,B., Schowel,V., Morano,I., Spuler,S. and
            Haase,H.
  TITLE     Ahnak1 abnormally localizes in muscular dystrophies and contributes
            to muscle vesicle release
  JOURNAL   J Muscle Res Cell Motil 32 (4-5), 271-280 (2011)
   PUBMED   22057634
REFERENCE   5  (residues 1 to 5643)
  AUTHORS   Pankonien,I., Alvarez,J.L., Doller,A., Kohncke,C., Rotte,D.,
            Regitz-Zagrosek,V., Morano,I. and Haase,H.
  TITLE     Ahnak1 is a tuneable modulator of cardiac Ca(v)1.2 calcium channel
            activity
  JOURNAL   J Muscle Res Cell Motil 32 (4-5), 281-290 (2011)
   PUBMED   22038483
REFERENCE   6  (residues 1 to 5643)
  AUTHORS   Haase,H., Pagel,I., Khalina,Y., Zacharzowsky,U., Person,V.,
            Lutsch,G., Petzhold,D., Kott,M., Schaper,J. and Morano,I.
  TITLE     The carboxyl-terminal ahnak domain induces actin bundling and
            stabilizes muscle contraction
  JOURNAL   FASEB J 18 (7), 839-841 (2004)
   PUBMED   15001564
  REMARK    GeneRIF: The carboxyl-terminal ahnak domain exerts a stabilizing
            effect on muscle contractility via its interaction with actin of
            thin filaments.
REFERENCE   7  (residues 1 to 5643)
  AUTHORS   Alvarez,J., Hamplova,J., Hohaus,A., Morano,I., Haase,H. and
            Vassort,G.
  TITLE     Calcium current in rat cardiomyocytes is modulated by the
            carboxyl-terminal ahnak domain
  JOURNAL   J Biol Chem 279 (13), 12456-12461 (2004)
   PUBMED   14722071
  REMARK    GeneRIF: AHNAK has a role in modulating calcium current in rat
            cardiomyocyte
REFERENCE   8  (residues 1 to 5643)
  AUTHORS   Benaud,C., Gentil,B.J., Assard,N., Court,M., Garin,J., Delphin,C.
            and Baudier,J.
  TITLE     AHNAK interaction with the annexin 2/S100A10 complex regulates cell
            membrane cytoarchitecture
  JOURNAL   J Cell Biol 164 (1), 133-144 (2004)
   PUBMED   14699089
REFERENCE   9  (residues 1 to 5643)
  AUTHORS   Borgonovo,B., Cocucci,E., Racchetti,G., Podini,P., Bachi,A. and
            Meldolesi,J.
  TITLE     Regulated exocytosis: a novel, widely expressed system
  JOURNAL   Nat Cell Biol 4 (12), 955-962 (2002)
   PUBMED   12447386
  REMARK    GeneRIF: a marker of an extensive form of calcium-induced
            exocytosis
REFERENCE   10 (residues 1 to 5643)
  AUTHORS   Skoldberg,F., Ronnblom,L., Thornemo,M., Lindahl,A., Bird,P.I.,
            Rorsman,F., Kampe,O. and Landgren,E.
  TITLE     Identification of AHNAK as a novel autoantigen in systemic lupus
            erythematosus
  JOURNAL   Biochem Biophys Res Commun 291 (4), 951-958 (2002)
   PUBMED   11866458
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Dec 21, 2021 this sequence version replaced XP_038947664.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR21887622.2983070.1,
                                           SRR26360186.2338126.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..5643
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     Protein         1..5643
                     /product="neuroblast differentiation-associated protein
                     AHNAK isoform 1"
                     /note="desmoyokin; neuroblast differentiation-associated
                     protein AHNAK"
                     /calculated_mol_wt=601995
     Region          23..>57
                     /region_name="PDZ_canonical"
                     /note="canonical PDZ domain; cl49608"
                     /db_xref="CDD:483948"
     Region          <366..690
                     /region_name="AsmA"
                     /note="Uncharacterized conserved protein AsmA involved in
                     outer membrane biogenesis [Cell wall/membrane/envelope
                     biogenesis]; COG2982"
                     /db_xref="CDD:442221"
     Region          1777..>1995
                     /region_name="AsmA"
                     /note="Uncharacterized conserved protein AsmA involved in
                     outer membrane biogenesis [Cell wall/membrane/envelope
                     biogenesis]; COG2982"
                     /db_xref="CDD:442221"
     Region          <2612..2940
                     /region_name="TamB"
                     /note="Autotransporter translocation and assembly protein
                     TamB [Intracellular trafficking, secretion, and vesicular
                     transport]; COG2911"
                     /db_xref="CDD:442155"
     Region          3922..4342
                     /region_name="AsmA"
                     /note="Uncharacterized conserved protein AsmA involved in
                     outer membrane biogenesis [Cell wall/membrane/envelope
                     biogenesis]; COG2982"
                     /db_xref="CDD:442221"
     Region          4373..4723
                     /region_name="AsmA"
                     /note="Uncharacterized conserved protein AsmA involved in
                     outer membrane biogenesis [Cell wall/membrane/envelope
                     biogenesis]; COG2982"
                     /db_xref="CDD:442221"
     Region          4888..>5418
                     /region_name="TamB"
                     /note="Autotransporter translocation and assembly protein
                     TamB [Intracellular trafficking, secretion, and vesicular
                     transport]; COG2911"
                     /db_xref="CDD:442155"
     CDS             1..5643
                     /gene="Ahnak"
                     /gene_synonym="AHNAK 1; RGD1308572; UV118"
                     /coded_by="NM_001398671.1:253..17184"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="GeneID:191572"
                     /db_xref="RGD:619779"
ORIGIN      
        1 mekeeettre lllpnwqgsg shgltiaqrd dgvfvqevmq nspaartgvv kegdqivgat
       61 iyfdnlqsge vtqllntmgh htvglklhrk gdrspepgqt wahevfssrs sevvlsgdde
      121 dyqriyttki kprlrsedgv egdlgetqsr titvtrrvta ytvdvtgreg vkdidisspe
      181 fmikiprhev teisntdvet qpgktvirlp sgsgaasptt gsavdiraga isasgpeleg
      241 ashskfqvtv pgtkvgsldv nvkakgldlg gkggiqvpgv dvssslgggs vegqgpslqs
      301 gdigkvkipt mkmpkfgvsa glegqipegg lnvsapefsv ghkgdkpgla iggniqaphl
      361 evstssvnie glegklkgpq itgpslkgdl glkgtklqgn igmddacask iegsitgpcv
      421 eigtpdvdvh glggklnvpk fsasgskgeg vgidvalptg kvtlpgvsgd vnlpeiatgg
      481 legkmkgakv ktpemivqkp kismqdvdls lgscklkgnm kvsapevkgg vkgpqvavkg
      541 fgvdtetpnl egtltgpkls spsgkigtcr ismadvdlnv aapkgkggid vtlpkvegkv
      601 kgpevdvkgp ktdisapgve vhgpewnlkm pkfsipgvkg egadvnvpla kgdislsgpk
      661 vnveapdvnv eglggklkgp dinlpegsvk tpkismpdvd lhikgpkvkg eydvttpkle
      721 gelkgpkvdt dipqvdvhgp nlkipkmkmp kfsvpgfkae gpevdvnlpk vdidisgtkv
      781 evsapdvsie gpegklkghk fkmpemnira pkismpdvdl hlkgpnvkge ydvtvpraeg
      841 eikvpdvelk sakvdidvpn vdaqgpelhm kmptikmpkf gmpgfkaesp evemnlpkad
      901 idvsgpkvdv kvpdvntegl egklkgpklk mpemnikapk ismpdvdlhm kgpkvkgeyd
      961 vtmpklegdl kgpkvdvsap dvdvhgpdwn mkmpkikmpk ftmpslkgeg peldvsmpka
     1021 dvdisvpkld isapdlnleg pegklkgpkf kmpemhfkap kmslpdvdld lkgpkmkgnv
     1081 dmsapkiege mkvpdvdikg pnvdvqspdw slkmpkmkmp kfsmptlkge gpdvdvslpk
     1141 atidvsgpkl dietsdvsfe gpegklkgpk fkmpdmhfka pkismpdvdl nmkgpkvkgd
     1201 mdvavpeieg kmkvpdvdik gpkvdvdapd vdvqgpdwhl kmpkvkmpkf smpgfkaegp
     1261 evdvslskad ldvsgpkvdi dvpdvniegp daklkgpkfk mpemnikapk ismpdfdlnl
     1321 kgpkvkgdmd vslpkvegei kvpevdikgp kvdidvpdvd vqgpdwhlkm pkmkmpkfsm
     1381 pgfkaegpev dvslpkadld vsgpkvdidv pdvniegpeg klkgpkfkmp emhfkapkis
     1441 mpnidlnlkg pkvkgdmdva vpeiegemkv pdvdikgpkv dinapdvdvq gpdwhlkmpk
     1501 ikmpkfsmpg fkaegpevdv slpkadldvs gpkvdidvpd vniegpdakl kgpkfkmpem
     1561 nikpqkismp dvslnlkgpk akaeydvsvp kvggeikapa vdlkgpkvea pdvevhgpdw
     1621 hlkmpkvkmp kfsmpgfkae gpevdvnlqk anidvsgpkm didvpdvnie gpegklkgpk
     1681 fkmpsmsiqt hkismpdvgl nlkgpklksg vdvslpkveg dlkgpevdvd vgdvdiecpe
     1741 gklkgpkfkm pdmhfkapki smpdvdlhlk gpkvkgdmdv avpeiegemk vpdvdikgpk
     1801 vdinapdvdv qgpdwhlkmp kvkmpkfsmp gfkaegpevd vslpkadldv sgpkvdievp
     1861 dvniegpegk lkgskfkmpk lnikaakism pdvdlnlkgp klkgeidasv pemeadlrgp
     1921 qidvkgpsvd vevpdvdlec peaklkgpkf kmpdmhfkap kismpdvdlh lkgpkvkgdm
     1981 dvtvpklege lkgpsvdvdv pdvdlecpea klkgpkfkmp dmhfkapkis mpdvdlhlkg
     2041 pkvkgdmdvt vpklegelkg psvdvdvpdv dlecpeaklk gpkfkmpdmh fkapkismpd
     2101 vdfnlkgpki kgdidvsvpk legelkgpel dvkspkldan ipevavegpe gkwkspkfkm
     2161 pdmhfkapki smpdidlhlk spkikgdvdv dvpklegdlk gpnvdmsgpd veiegpegkl
     2221 rgpkfkmpdm nikapkismp didlhlkgpk vkgdvdaslp kvegdlkgpe vdikgpkvdi
     2281 dvpdvdvqgp dwhlkmpkvk mpkfsmpgfk aegpevdvsl pkadldvsgp kvdidvpdvn
     2341 iegpdaklkg pkfkmpemni kapkismpdl hlkgpkikgd vdvslpkveg eikvpevdik
     2401 gpkvdvdvpd vdvqgpdwhl kmpkmkmpkf smpgfkaegp evdvslpkad ldvsgqkvdi
     2461 dvpdvniegp daklkgpkfk mpemnikapk ismpdfdlnl kgpkvkgdvd vslpkvegei
     2521 kvpevdikgp kvdidvpdvd vqgpdwhlkm pkmkmpkfsm pgfkaegpev dvslpkadld
     2581 vsgpkvdidv pdvniegpda klkgpkfkmp emniktpkis mpdlnlnlkg pnvkgdvdvs
     2641 ipnvegdlqg psldikspkl dvnapdidih gpegklkgpk lkmpdmhvnm pkismpdidl
     2701 nlkgskvkgd vdisgpkleg diktpkvdvk gpeldisask vnidakgkks rfklpkfnfs
     2761 gskvqtpevd vklkkpdvdv tapkvdinap evevqgkvkg pkfkmpflsi sspkvsmpdv
     2821 elnlkgpkvk geldatvpnl egdfkspkvd ikapdvqlna pdvdvhgqew nlkmhkmkmp
     2881 kfsvsgvkae gpdvavdlpk gdiniegpsm niegpelnve cpegslkgpk fkmpemnika
     2941 pkismpnidl nlkgpkvkgd vdvslpkveg dlkgpevdik gpkmdidvpd vdvqgpdwhl
     3001 kmpkvkmpkf smpgfkaegp evdvslskad ldvsgpkvdi dvpdvniegp daklkgpkfk
     3061 mpemnikapk ismpdidlhl kgpkikgdvd vslpkvegdl egphvdikgp kvdinapdvd
     3121 vqgpdwhlkm pkmkmpkfsm pgfkaegpev dvslpkadld vsgpkvdidv pdvniegpda
     3181 klkgpkfkmp emnikapkis mpnidlnlkg pkvkgdvdms lpkvegeikv pevdikgpkv
     3241 dinapdvdvq gpdwhlkmpk vkmpkfsmpg fkaegpevdv slpkadldvs gpkvdidvpd
     3301 vniegpdakl kgpkfkmpem nikapkismp nidlnlkgpk vkgdvdmslp kvegeikvpe
     3361 vdikgpkvdi dvpdvdvqgp dwhlkmpkvk mpkfsmpgfk aegpevdvsl pkadldvsgp
     3421 kvdidvpdvn iegpdaklkg pkfkmpemni kapkismpdl hlkgpkikgd vdvslpkveg
     3481 eikvpevdik gpkvdinapd vdvqgpdwhl kmpkmkmpkf smpgfkaegp evdvslpkad
     3541 ldvsgpkvdi dvpdvniegp daklkgpkfk mpemnikapk ismpnidlnl kgpkvkgdvd
     3601 mslpkvegei kvpevdikgp kvdidvpdvd vqgpdwhlkm pkvkmpkfsm pgfkaegpev
     3661 dvslpkadld vsgpkvdidv pdvniegpda klkgpkfkmp emnikapkis mpdlhlkgpk
     3721 ikgdvdvslp kvegeikvpe vdikgpkvdi napdvdvqgp dwhlkmpkmk mpkfsmpgfk
     3781 aegpevdvsl pkadldvsgp kvdidvpdvn iegpdaklkg pkfkmpemni kapkismpni
     3841 dlnlkgpkvk gdvdmslpkv egeikvpevd ikgpkvdina pdvdvqgpdw hlkmpkvkmp
     3901 kfsmpgfkae gpevdvslpk adldvsgpkv didvpdvnie gpdaklkgpk fkmpemnika
     3961 pkismpdlhl kgpkikgdvd vslpkvegei kvpevdikgp kvdidvpdvd vqgpdwhlkm
     4021 pkmkmpkfsm pgfkaegpev dvslpkadld vtgpkvdidv pdvnvggpdv kvkgpkfkmp
     4081 emnikapkis mpdfdlhlkg pkvkgdvdas lpkmegpgvd idspdvnieg pegklkgpkf
     4141 kmpdmhikap kismpdfdln lkgskvkgdv dlslpkvegd lkgpeidiec pegklkgpkf
     4201 kmpdvhfktp qismsdidln mkgpkvkgdm disvpklegd lkgtkvdvkg pkmdidtpdi
     4261 dihgpegklk gpkfkmpdlh lkapkismpd vdlnlkgpkv kgdvdislpk vegdlkgpev
     4321 dikgpkvdin apdvdvqgpd whlkmpkvkm pkfsmpgfka egpevdvslp kadldvsgpk
     4381 vdidvpdvni egpdaklkgp kfkmpemnik apkismpdid lnlkgpkvkg dvdmslpkve
     4441 geikvpevdi kgpkmdidvp dvniegpdak lkgpkfkmpe mnikapkism pdlhlkgpkv
     4501 kgdvdvslpk vegeikvpev dikgpkvdvd vpdvdvqgpd whlkmpkvkm pkfsmpgfka
     4561 egpevdvslp kadldvsgpk vdidvpdvnv dgpdmkvkgp kfkmpeinik apkismpdvd
     4621 lelkgpkvkg afdgsvpkie gtlkgpeidm kgpgldfegp daklsgpnlk mpslevpvpk
     4681 isgpdanvhl ktpnvgisgp klgggevdlr gpkvdletps ldvhmespdi niegpdvkvp
     4741 kfkkpkfgfg akspkadikt ptvdvtvpea elsvetpein iggkgkkskf kmpkihmsgp
     4801 kvktkkqgfd lnvpggeida slkvpdvdvs vagpdaalka evkspkvkkt mfgkmyfpdv
     4861 efdikspkfk aeaalpspkl egeikvpdvd isspgvnvea pdihvkapkf kvpgveaagp
     4921 kiegnlkgpk vqanldtpdi niqgpeakik tpsfsvsapq vsipdvnvkl kgpnikgdvp
     4981 svglegpdvd lqgpegkikf pkfslpkisa pgvkmgggst eihaqmpsle aglstsdikf
     5041 egpgvslkgp gvdlpsvdls lpkvsgpdld lnlkgpslkg dvaasspsmk lhapgldmkg
     5101 vagkvqigad gvkvsgtdat aalsvgapdv tlkgsslqgd lavsgdikcp kvsvgtpevs
     5161 vealeggvkl pqmklpqfgi stpgsdldin ikgpqvcgel qgsgtdvnlk gpqisapgmd
     5221 fnlegpkvrg slgatgelkg psiggglpgi siqgpegnlq mpgikasgcd vkvssgqisg
     5281 peikgdlkgs giglhgavpd lsvkgpsfnm aspesdfgvs lkgpkvkggv dvsggvsvpd
     5341 inlgeghmnv kgfggewkgp qvsssvnldt tklvgnlhfs gpkiegdvkg gqiglqgpgl
     5401 svsgpqghle sgsgkvtfpk mkipkftfsg reltgrevgv dvnfpnvean vqagagegel
     5461 eesavklkks kikmpkftfs kpkgkggvtg speasvsgsk gdlksskasl gslegeaeae
     5521 tsspkgkfsl fkskkprnrs nsfsderefs apstptgtle faggegkgkh gklkfgtfgg
     5581 lgskskghye vtgsddeagk lqgsgvslas kksrlsssss ndsgtklgiq lpeveisvst
     5641 kke
//
