LOCUS       NM_001108561            3435 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus adenosylhomocysteinase-like 1 (Ahcyl1), mRNA.
ACCESSION   NM_001108561 XM_001068488 XM_342312
VERSION     NM_001108561.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3435)
  AUTHORS   Harvey,K.E., LaVigne,E.K., Dar,M.S., Salyer,A.E., Pratt,E.P.S.,
            Sample,P.A., Aryal,U.K., Gowher,H. and Hockerman,G.H.
  TITLE     RyR2/IRBIT regulates insulin gene transcript, insulin content, and
            secretion in the insulinoma cell line INS-1
  JOURNAL   Sci Rep 12 (1), 7713 (2022)
   PUBMED   35562179
  REMARK    GeneRIF: RyR2/IRBIT regulates insulin gene transcript, insulin
            content, and secretion in the insulinoma cell line INS-1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3435)
  AUTHORS   Borth,H., Weber,N., Meyer,D., Wartenberg,A., Arlt,E., Zierler,S.,
            Breit,A., Wennemuth,G., Gudermann,T. and Boekhoff,I.
  TITLE     The IP3 R Binding Protein Released With Inositol
            1,4,5-Trisphosphate Is Expressed in Rodent Reproductive Tissue and
            Spermatozoa
  JOURNAL   J Cell Physiol 231 (5), 1114-1129 (2016)
   PUBMED   26439876
  REMARK    GeneRIF: The present study documents that IRBIT is expressed in
            Leydig and Sertoli cells.
REFERENCE   3  (bases 1 to 3435)
  AUTHORS   Ando,H., Hirose,M., Gainche,L., Kawaai,K., Bonneau,B., Ijuin,T.,
            Itoh,T., Takenawa,T. and Mikoshiba,K.
  TITLE     IRBIT Interacts with the Catalytic Core of Phosphatidylinositol
            Phosphate Kinase Type Ialpha and IIalpha through Conserved
            Catalytic Aspartate Residues
  JOURNAL   PLoS One 10 (10), e0141569 (2015)
   PUBMED   26509711
  REMARK    GeneRIF: IRBIT forms signaling complexes with PIPKIalpha and
            NBCe1-B, whose activity is regulated by PI(4,5)P2.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3435)
  AUTHORS   Park,S., Shcheynikov,N., Hong,J.H., Zheng,C., Suh,S.H., Kawaai,K.,
            Ando,H., Mizutani,A., Abe,T., Kiyonari,H., Seki,G., Yule,D.,
            Mikoshiba,K. and Muallem,S.
  TITLE     Irbit mediates synergy between ca(2+) and cAMP signaling pathways
            during epithelial transport in mice
  JOURNAL   Gastroenterology 145 (1), 232-241 (2013)
   PUBMED   23542070
REFERENCE   5  (bases 1 to 3435)
  AUTHORS   He,P., Klein,J. and Yun,C.C.
  TITLE     Activation of Na+/H+ exchanger NHE3 by angiotensin II is mediated
            by inositol 1,4,5-triphosphate (IP3) receptor-binding protein
            released with IP3 (IRBIT) and Ca2+/calmodulin-dependent protein
            kinase II
  JOURNAL   J Biol Chem 285 (36), 27869-27878 (2010)
   PUBMED   20584908
  REMARK    GeneRIF: IRBIT is critically involved in mediating activation of
            NHE3 by ANG II via a Ca(2+)/calmodulin-dependent protein kinases
            II-dependent pathway.
REFERENCE   6  (bases 1 to 3435)
  AUTHORS   Ando,H., Mizutani,A. and Mikoshiba,K.
  TITLE     An IRBIT homologue lacks binding activity to inositol
            1,4,5-trisphosphate receptor due to the unique N-terminal appendage
  JOURNAL   J Neurochem 109 (2), 539-550 (2009)
   PUBMED   19220705
REFERENCE   7  (bases 1 to 3435)
  AUTHORS   Yang,D., Shcheynikov,N., Zeng,W., Ohana,E., So,I., Ando,H.,
            Mizutani,A., Mikoshiba,K. and Muallem,S.
  TITLE     IRBIT coordinates epithelial fluid and HCO3- secretion by
            stimulating the transporters pNBC1 and CFTR in the murine
            pancreatic duct
  JOURNAL   J Clin Invest 119 (1), 193-202 (2009)
   PUBMED   19033647
REFERENCE   8  (bases 1 to 3435)
  AUTHORS   He,P., Zhang,H. and Yun,C.C.
  TITLE     IRBIT, inositol 1,4,5-triphosphate (IP3) receptor-binding protein
            released with IP3, binds Na+/H+ exchanger NHE3 and activates NHE3
            activity in response to calcium
  JOURNAL   J Biol Chem 283 (48), 33544-33553 (2008)
   PUBMED   18829453
REFERENCE   9  (bases 1 to 3435)
  AUTHORS   Shirakabe,K., Priori,G., Yamada,H., Ando,H., Horita,S., Fujita,T.,
            Fujimoto,I., Mizutani,A., Seki,G. and Mikoshiba,K.
  TITLE     IRBIT, an inositol 1,4,5-trisphosphate receptor-binding protein,
            specifically binds to and activates pancreas-type Na+/HCO3-
            cotransporter 1 (pNBC1)
  JOURNAL   Proc Natl Acad Sci U S A 103 (25), 9542-9547 (2006)
   PUBMED   16769890
REFERENCE   10 (bases 1 to 3435)
  AUTHORS   Ando,H., Mizutani,A., Matsu-ura,T. and Mikoshiba,K.
  TITLE     IRBIT, a novel inositol 1,4,5-trisphosphate (IP3) receptor-binding
            protein, is released from the IP3 receptor upon IP3 binding to the
            receptor
  JOURNAL   J Biol Chem 278 (12), 10602-10612 (2003)
   PUBMED   12525476
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473952.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_342312.3, XM_001068488.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
FEATURES             Location/Qualifiers
     source          1..3435
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..3435
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /note="adenosylhomocysteinase-like 1"
                     /db_xref="GeneID:362013"
                     /db_xref="RGD:1309768"
     exon            1..114
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /inference="alignment:Splign:2.1.0"
     exon            115..226
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /inference="alignment:Splign:2.1.0"
     CDS             136..1563
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /EC_number="3.13.2.1"
                     /note="S-adenosylhomocysteine hydrolase-like 1; putative
                     adenosylhomocysteinase 2; adoHcyase 2;
                     S-adenosyl-L-homocysteine hydrolase 2; IP3R-binding
                     protein released with inositol 1,4,5-trisphosphate"
                     /codon_start=1
                     /product="S-adenosylhomocysteine hydrolase-like protein 1"
                     /protein_id="NP_001102031.1"
                     /db_xref="GeneID:362013"
                     /db_xref="RGD:1309768"
                     /translation="MQEFTKFPTKTGRRSLSRSISQSSTDSYSSAASYTDSSDDEVSP
                     REKQQTNSKGSSNFCVKNIKQAEFGRREIEIAEQDMSALISLRKRAQGEKPLAGAKIV
                     GCTHITAQTAVLIETLCALGAQCRWSACNIYSTQNEVAAALAEAGVAVFAWKGESEDD
                     FWWCIDRCVNMDGWQANMILDDGGDLTHWVYKKYPNVFKKIRGIVEESVTGVHRLYQL
                     SKAGKLCVPAMNVNDSVTKQKFDNLYCCRESILDGLKRTTDVMFGGKQVVVCGYGEVG
                     KGCCAALKALGAIVYITEIDPICALQACMDGFRVVKLNEVIRQVDVVITCTGNKNVVT
                     REHLDRMKNSCIVCNMGHSNTEIDVTSLRTPELTWERVRSQVDHVIWPDGKRVVLLAE
                     GRLLNLSCSTVPTFVLSITATTQALALIELYNAPEGRYKQDVYLLPKKMDTNGRITMT
                     SPHEPRNSNRVFFKITFIFFLLLSF"
     exon            227..370
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /inference="alignment:Splign:2.1.0"
     exon            371..471
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /inference="alignment:Splign:2.1.0"
     exon            472..574
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /inference="alignment:Splign:2.1.0"
     exon            575..669
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /inference="alignment:Splign:2.1.0"
     exon            670..776
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /inference="alignment:Splign:2.1.0"
     exon            777..893
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /inference="alignment:Splign:2.1.0"
     exon            894..957
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1046
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1117
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1212
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..1311
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /inference="alignment:Splign:2.1.0"
     exon            1312..1380
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..1459
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /inference="alignment:Splign:2.1.0"
     exon            1460..3435
                     /gene="Ahcyl1"
                     /gene_synonym="IRBIT"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttcgcgacag acttttcctg gatggaggag ggccttgaag acgagattgg gagggggtga
       61 acgactcatc tgacctgtcc aggggatgag ggtgtgcagg aaatttcccc tcagcaaatc
      121 cagtttgcgg atgacatgca agagttcacc aaattcccta ctaagactgg ccggagatcc
      181 ttgtctcgct ccatctcaca gtcctccaca gacagctaca gttcagctgc atcctataca
      241 gatagctctg atgatgaggt ttccccccga gagaagcagc aaaccaactc aaagggcagc
      301 agcaatttct gtgtgaagaa catcaagcag gcagagtttg gacgccggga gattgagatt
      361 gcagagcaag acatgtctgc tctgatttca ctcaggaaac gtgctcaggg agagaagcct
      421 ttggctggtg ctaaaatagt gggctgtaca cacatcacag cccagacagc ggtattgatt
      481 gagacacttt gtgccctggg ggctcagtgc cgctggtctg cctgcaacat ctattcaact
      541 cagaatgagg tagctgcagc actggctgag gctggagttg cagtgtttgc ttggaagggc
      601 gagtcagaag atgatttctg gtggtgcatt gaccgctgtg tcaacatgga tgggtggcag
      661 gctaacatga tcctggatga tgggggagac ttaacccact gggtttataa gaagtatcca
      721 aacgtgttta agaagatccg aggcattgtg gaagagagcg tgactggtgt tcacaggctg
      781 tatcagctct ccaaagctgg gaagctctgt gttccagcca tgaatgtcaa tgattctgtt
      841 accaaacaga agtttgataa cttgtactgc tgccgagaat ccattttgga tggcctgaag
      901 aggaccacag atgtgatgtt tggtgggaaa caggtggtgg tgtgtggcta tggtgaggta
      961 ggaaagggct gctgtgctgc tctcaaggcc cttggagcaa ttgtctacat cacagaaatt
     1021 gaccccatct gtgctctgca ggcctgcatg gatgggttcc gggtggtgaa gctgaatgaa
     1081 gtcatccggc aggtggacgt tgtaataact tgcacaggaa ataagaatgt agtgacccgg
     1141 gagcacttgg accgaatgaa aaatagttgc attgtatgta atatgggcca ttccaacaca
     1201 gaaattgatg tgaccagcct ccgcactcca gagctaacat gggagcgcgt acgttctcag
     1261 gtggaccatg tcatctggcc tgatggcaag cgggtcgtcc ttctagcaga gggtcgttta
     1321 ctcaatttga gctgctccac agttcctacc tttgtccttt ccatcacggc tacaacacag
     1381 gctttggcac tgatagaact ttataatgca ccagaaggac gctacaaaca ggatgtgtac
     1441 ttgcttccta agaaaatgga tactaatgga cgtattacaa tgaccagtcc acacgaacca
     1501 cgcaactcta atagagtatt ttttaagata acttttattt tcttcttatt actttccttt
     1561 tgattttttt ttctataatt tcattttttt tctcatctca tcatttgagt tttgcagacc
     1621 acacaggaac ttgctccatg gctgtttagg tgaaactgag gtcaaaggtt tctcaccttt
     1681 agtcactaaa aggggttaat tctgcagccc agaaagtcaa ttctttaacc atttctgggg
     1741 actttgatcg catttagtta ccatattaac agaaaatgct aaggcatctt ctgtgtggaa
     1801 caatctacag tgtctaaatt gccttaaaag agactgttct agctgctgga actagtgctc
     1861 tttacttctt cagaggagcc aggatggctc cagccaggta ggttagacgt aggtggtgca
     1921 tgtcaacttc ccgtagacag acgctctaag ccgtttcctg tctaagatgg cgtgtctgca
     1981 gagatgtgtg ctgttaaact ccgtaggctc actcggattt gtagttcagc ccttccacca
     2041 gtctctctca ttgttctagt tttaactaaa ctgcattcta tcaagttgaa ttttgtccct
     2101 tagcatttat ttgttttgtt tcttttaatt aaggaaaaat tttagtgtta atcctgagga
     2161 acagctcagg tggttagtta ccaatatctc ttttgaacct ttgaagcaaa gtgtcaagag
     2221 ttgaggctag aaaaatgcta gcctcagact ctgatgtttc cagctcatag tttatagtgt
     2281 cagtgaactg gagccataag caaaacttct cagctctgcc tcacgcagct tatgctgacg
     2341 gccgatttct tgagccatta ctcagtataa aacactgagc cctgtcctta gggtttatcc
     2401 tttcagagca aacctgtggg cagctgtgct tctgcaacct aaactgtttg aagggaagtt
     2461 tgcatagatg gaagaaagaa tgacaaattg ggccaaggtg aaacaaatat aactgtataa
     2521 tctgttcaga gctggagacc ttgtctgctg ttagttttat agacatggtg ccacttttga
     2581 ttgacacttg ccacaaaaat agaaaataaa aattgtaaac tgagatctta aagacttggt
     2641 ggagaaagta catcctgatt catgctctaa gagaattcca agagaccctc taaaatcaga
     2701 gagacttatt cccaggccac gcacccgctt gccagcatct ctgcatggtc aaacgagctt
     2761 caagctcaag ctttaggtat ataattatcc gggattttaa gtcctcagcg tgttctagct
     2821 tgtgatcctt caaagatggg ttatgtgtta atgatagata ctggaaatgt ttacttctct
     2881 ctttcactga tcagagaaac aggcattaaa aacagaaata caagaaagga aagcttttac
     2941 cctgcacctt ccttgcaggg aacaattatc ttgccaaaac ttttttccct ttcatctccc
     3001 atttctctgt acccagcccc ttcctgctcc tttccaatgt gatcatgctt tcttctctat
     3061 agatactaac atttgaagac ccctttccta aggcacttaa ccatccaatc agaacaccac
     3121 actcagtagg gccttatctt ggctaacagc agtgtattca tctggtcagc tctactggag
     3181 ggaaggggcc aagttcctgc tgccctctaa tctgccctct ggtcctatct attactgtgt
     3241 ccataggaat aataggtaag ggctagtctc tgtcaagcca tgtaacaaag gacactggaa
     3301 aatgtctggc atcagaggga acatttggag accaacttgg gaggaaaata ttcattttgt
     3361 attgaatgat ttttaatgaa tgcaatatta atccttgcag atgagcaata atcattaaag
     3421 tcaattaaaa gtgat
//
