LOCUS       NM_017201               2029 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus adenosylhomocysteinase (Ahcy), mRNA.
ACCESSION   NM_017201
VERSION     NM_017201.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2029)
  AUTHORS   Lu,S.C. and Mato,J.M.
  TITLE     S-adenosylmethionine in liver health, injury, and cancer
  JOURNAL   Physiol Rev 92 (4), 1515-1542 (2012)
   PUBMED   23073625
  REMARK    Review article
REFERENCE   2  (bases 1 to 2029)
  AUTHORS   Tyagi,N., Qipshidze,N., Munjal,C., Vacek,J.C., Metreveli,N.,
            Givvimani,S. and Tyagi,S.C.
  TITLE     Tetrahydrocurcumin ameliorates homocysteinylated cytochrome-c
            mediated autophagy in hyperhomocysteinemia mice after cerebral
            ischemia
  JOURNAL   J Mol Neurosci 47 (1), 128-138 (2012)
   PUBMED   22212488
REFERENCE   3  (bases 1 to 2029)
  AUTHORS   Blom,H.J. and Smulders,Y.
  TITLE     Overview of homocysteine and folate metabolism. With special
            references to cardiovascular disease and neural tube defects
  JOURNAL   J Inherit Metab Dis 34 (1), 75-81 (2011)
   PUBMED   20814827
  REMARK    Review article
REFERENCE   4  (bases 1 to 2029)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   5  (bases 1 to 2029)
  AUTHORS   Fernandez-Sanchez,M.E., Gonatopoulos-Pournatzis,T., Preston,G.,
            Lawlor,M.A. and Cowling,V.H.
  TITLE     S-adenosyl homocysteine hydrolase is required for Myc-induced mRNA
            cap methylation, protein synthesis, and cell proliferation
  JOURNAL   Mol Cell Biol 29 (23), 6182-6191 (2009)
   PUBMED   19805518
  REMARK    GeneRIF: report that Myc promotes upregulation of S-adenosyl
            homocysteine hydrolase.
REFERENCE   6  (bases 1 to 2029)
  AUTHORS   Eloranta,T.O., Khomutov,A.R., Khomutov,R.M. and Hyvonen,T.
  TITLE     Aminooxy analogues of spermidine as inhibitors of spermine synthase
            and substrates of hepatic polyamine acetylating activity
  JOURNAL   J Biochem 108 (4), 593-598 (1990)
   PUBMED   2292587
REFERENCE   7  (bases 1 to 2029)
  AUTHORS   Gomi,T., Takata,Y. and Fujioka,M.
  TITLE     Rat liver S-adenosylhomocysteinase. Spectrophotometric study of
            coenzyme binding
  JOURNAL   Biochim Biophys Acta 994 (2), 172-179 (1989)
   PUBMED   2910349
REFERENCE   8  (bases 1 to 2029)
  AUTHORS   Ogawa,H., Gomi,T., Mueckler,M.M., Fujioka,M., Backlund,P.S. Jr.,
            Aksamit,R.R., Unson,C.G. and Cantoni,G.L.
  TITLE     Amino acid sequence of S-adenosyl-L-homocysteine hydrolase from rat
            liver as derived from the cDNA sequence
  JOURNAL   Proc Natl Acad Sci U S A 84 (3), 719-723 (1987)
   PUBMED   3027698
REFERENCE   9  (bases 1 to 2029)
  AUTHORS   Gomi,T., Ogawa,H. and Fujioka,M.
  TITLE     S-adenosylhomocysteinase from rat liver. Amino acid sequences of
            the peptides containing active site cysteine residues modified by
            treatment with 5'-p-fluorosulfonylbenzoyladenosine
  JOURNAL   J Biol Chem 261 (29), 13422-13425 (1986)
   PUBMED   3759971
REFERENCE   10 (bases 1 to 2029)
  AUTHORS   Patel,B.T. and Tudball,N.
  TITLE     Localization of S-adenosylhomocysteine hydrolase and adenosine
            deaminase immunoreactivities in rat brain
  JOURNAL   Brain Res 370 (2), 250-264 (1986)
   PUBMED   3518860
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Nov 26, 2020 this sequence version replaced NM_017201.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061841.1, SRR26643284.5022.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760400,
                                           SAMEA5760434 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-54                JAXUCZ010000003.1  164044509-164044562 c
            55-245              JAXUCZ010000003.1  164038301-164038491 c
            246-321             JAXUCZ010000003.1  164036767-164036842 c
            322-471             JAXUCZ010000003.1  164034998-164035147 c
            472-584             JAXUCZ010000003.1  164034275-164034387 c
            585-792             JAXUCZ010000003.1  164033674-164033881 c
            793-880             JAXUCZ010000003.1  164033507-164033594 c
            881-998             JAXUCZ010000003.1  164033296-164033413 c
            999-1193            JAXUCZ010000003.1  164031694-164031888 c
            1194-2029           JAXUCZ010000003.1  164029338-164030173 c
FEATURES             Location/Qualifiers
     source          1..2029
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q41"
     gene            1..2029
                     /gene="Ahcy"
                     /note="adenosylhomocysteinase"
                     /db_xref="GeneID:29443"
                     /db_xref="RGD:69260"
     exon            1..54
                     /gene="Ahcy"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..1325
                     /gene="Ahcy"
                     /EC_number="3.13.2.1"
                     /note="S-adenosylhomocysteine hydrolase; adoHcyase;
                     S-adenosyl-L-homocysteine hydrolase"
                     /codon_start=1
                     /product="adenosylhomocysteinase"
                     /protein_id="NP_058897.1"
                     /db_xref="GeneID:29443"
                     /db_xref="RGD:69260"
                     /translation="MADKLPYKVADIGLAAWGRKALDIAENEMPGLMRMREMYSASKP
                     LKGARIAGCLHMTVETAVLIETLVALGAEVRWSSCNIFSTQDHAAAAIAKAGIPVFAW
                     KGETDEEYLWCIEQTLHFKDGPLNMILDDGGDLTNLIHTKHPQLLSGIRGISEETTTG
                     VHNLYKMMANGILKVPAINVNDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVV
                     AGYGDVGKGCAQALRGFGARVIITEIDPINALQAAMEGYEVTTMDEACKEGNIFVTTT
                     GCVDIILGRHFEQMKDDAIVCNIGHFDVEIDVKWLNENAVEKVNIKPQVDRYLLKNGH
                     RIILLAEGRLVNLGCAMGHPSFVMSNSFTNQVMAQIELWTHPDKYPVGVHFLPKKLDE
                     AVAEAHLGKLNVKLTKLTEKQAQYLGMPINGPFKPDHYRY"
     exon            55..245
                     /gene="Ahcy"
                     /inference="alignment:Splign:2.1.0"
     exon            246..321
                     /gene="Ahcy"
                     /inference="alignment:Splign:2.1.0"
     exon            322..471
                     /gene="Ahcy"
                     /inference="alignment:Splign:2.1.0"
     exon            472..584
                     /gene="Ahcy"
                     /inference="alignment:Splign:2.1.0"
     exon            585..792
                     /gene="Ahcy"
                     /inference="alignment:Splign:2.1.0"
     exon            793..880
                     /gene="Ahcy"
                     /inference="alignment:Splign:2.1.0"
     exon            881..998
                     /gene="Ahcy"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1193
                     /gene="Ahcy"
                     /inference="alignment:Splign:2.1.0"
     exon            1194..2029
                     /gene="Ahcy"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tcactcctag cggaagcttc gccagcatgg ctgataaact gccctacaaa gtcgcggaca
       61 ttggactggc tgcctgggga cggaaggccc tggacatagc tgagaacgag atgccaggtt
      121 tgatgcgcat gcgggagatg tactcagcct ccaagccact gaagggcgct cgcattgctg
      181 gctgcctgca catgactgtg gagactgctg tcctcattga gactctcgtg gccctgggtg
      241 ctgaggtgcg gtggtccagc tgcaacatct tctccactca ggaccatgca gcggctgcca
      301 ttgccaaggc tggcattcca gtgtttgcct ggaagggaga gacggatgaa gagtacctgt
      361 ggtgcattga gcagacgttg cacttcaagg acggacccct caacatgatt ctggatgatg
      421 gcggtgacct tactaacctc atccacacca aacacccaca gcttctgtca ggcatccgag
      481 gtatctctga ggagaccaca actggcgtcc acaacctcta caagatgatg gccaatggga
      541 tactgaaggt gcctgccatc aacgtcaacg attctgtcac caagagcaag tttgacaacc
      601 tctatggctg ccgggagtcc ctcatagatg gcatcaaacg ggccacagat gtgatgattg
      661 cgggcaaggt ggcagtggta gcaggctatg gtgatgtggg caagggttgt gcccaggccc
      721 tgcggggttt cggggcccga gtcatcatca ccgagattga ccccatcaat gcactgcaag
      781 ctgccatgga gggctacgag gtaaccacca tggacgaggc ctgtaaggag ggcaacatct
      841 ttgtgaccac cacgggctgt gttgatatca tccttggtcg gcactttgaa cagatgaagg
      901 atgatgccat tgtctgtaac attggacact tcgacgtgga gattgatgtg aagtggctca
      961 atgagaacgc tgtggagaag gtgaacatca agccccaggt ggaccgctac ttgctaaaga
     1021 atgggcaccg catcatcttg ctggctgagg gccgtctggt caacctgggt tgtgccatgg
     1081 gccaccccag cttcgtgatg agcaactcct tcacaaacca ggtgatggca cagattgagc
     1141 tgtggaccca cccagacaaa taccccgtgg gggttcactt cctgcctaag aagctggatg
     1201 aggcagtggc tgaagcccac ctgggcaagc tgaacgtgaa gctgaccaag ctgactgaga
     1261 agcaggctca gtacctgggc atgcccatta acggcccctt caagcctgat cactaccgct
     1321 actgagagct gggactgccc ttcaccttcc agctgccatc cttgttccag gccctacctc
     1381 tcgttcccaa gagcaaatgt caccaacttt gcagttactt ctccggtgtt ctgctccctc
     1441 ccccggccct catccacact gtgactggtc tttctgtctt tggcttctgc tgtacccctc
     1501 atactgttcc ctatgtggca tagagaacag agaggtacct gggaggcatc cacaggggat
     1561 ctgagctctt ggaaggtctg aggctggatg ttgctggtgg tcacaagccc atgcacctta
     1621 ctatccaaac tctcgcttgg tctttagatc cgtgtgcttg gtttacagac caatggtttc
     1681 tcggcccagg acccaagaag gagctctacc atgggggaag gaaccactgg agtttgaagg
     1741 ctcctgagag cttggccttt ttactgttgg gctgtctctt aaacctccta atactgagtt
     1801 ggtacttttg gtccctattt cacaagggtt aggacagatt aaccaagaaa ggacaagtga
     1861 cagagactga aaggggctgg aaaaacaaat agggaaaggc ctgtcactac ggtataattg
     1921 atggttccta tcacaagcct ggatcacaaa cagattaatt tgttctatgt ttatatactg
     1981 tttagaatgt taacacagga aggtggataa aatacagttt ctagtgcct
//
