LOCUS       NM_031835               1946 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus alanine-glyoxylate aminotransferase 2 (Agxt2),
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_031835
VERSION     NM_031835.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1946)
  AUTHORS   Granot-Hershkovitz,E., Spitzer,B., Yang,Y., Tarraf,W., Yu,B.,
            Boerwinkle,E., Fornage,M., Mosley,T.H., DeCarli,C., Kristal,B.S.,
            Gonzalez,H.M. and Sofer,T.
  TITLE     Genetic loci of beta-aminoisobutyric acid are associated with
            aging-related mild cognitive impairment
  JOURNAL   Transl Psychiatry 13 (1), 140 (2023)
   PUBMED   37120436
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1946)
  AUTHORS   Wei,J., Zhang,J., Wei,J., Hu,M., Chen,X., Qin,X., Chen,J., Lei,F.
            and Qin,Y.
  TITLE     Identification of AGXT2, SHMT1, and ACO2 as important biomarkers of
            acute kidney injury by WGCNA
  JOURNAL   PLoS One 18 (2), e0281439 (2023)
   PUBMED   36735737
  REMARK    GeneRIF: Identification of AGXT2, SHMT1, and ACO2 as important
            biomarkers of acute kidney injury by WGCNA.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1946)
  AUTHORS   Yoshino,Y., Kumon,H., Mori,T., Yoshida,T., Tachibana,A.,
            Shimizu,H., Iga,J.I. and Ueno,S.I.
  TITLE     Effects of AGXT2 variants on blood pressure and blood sugar among
            750 older Japanese subjects recruited by the complete enumeration
            survey method
  JOURNAL   BMC Genomics 22 (1), 287 (2021)
   PUBMED   33879046
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1946)
  AUTHORS   Amir,M., Hassanein,S.I., Abdel Rahman,M.F. and Gad,M.Z.
  TITLE     AGXT2 and DDAH-1 genetic variants are highly correlated with serum
            ADMA and SDMA levels and with incidence of coronary artery disease
            in Egyptians
  JOURNAL   Mol Biol Rep 45 (6), 2411-2419 (2018)
   PUBMED   30284143
REFERENCE   5  (bases 1 to 1946)
  AUTHORS   Hu,X.L., Zhou,J.P., Kuang,D.B., Qi,H., Peng,L.M., Yang,T.L., Li,X.,
            Zhang,W., Zhou,H.H. and Chen,X.P.
  TITLE     Considerable impacts of AGXT2 V140I polymorphism on chronic heart
            failure in the Chinese population
  JOURNAL   Atherosclerosis 251, 255-262 (2016)
   PUBMED   27423328
REFERENCE   6  (bases 1 to 1946)
  AUTHORS   Lee,I.S., Muragaki,Y., Ideguchi,T., Hase,T., Tsuji,M., Ooshima,A.,
            Okuno,E. and Kido,R.
  TITLE     Molecular cloning and sequencing of a cDNA encoding
            alanine-glyoxylate aminotransferase 2 from rat kidney
  JOURNAL   J Biochem 117 (4), 856-862 (1995)
   PUBMED   7592550
REFERENCE   7  (bases 1 to 1946)
  AUTHORS   Ogawa,T., Kimoto,M. and Sasaoka,K.
  TITLE     Dimethylarginine:pyruvate aminotransferase in rats. Purification,
            properties, and identity with alanine:glyoxylate aminotransferase 2
  JOURNAL   J Biol Chem 265 (34), 20938-20945 (1990)
   PUBMED   2123486
REFERENCE   8  (bases 1 to 1946)
  AUTHORS   Ueno,S., Sano,A., Hineno,T., Kondoh,K., Mizuno,T., Morino,H. and
            Kakimoto,Y.
  TITLE     Further studies on D-3-aminoisobutyrate-pyruvate aminotransferase
  JOURNAL   Biochim Biophys Acta 1035 (2), 128-131 (1990)
   PUBMED   2393662
REFERENCE   9  (bases 1 to 1946)
  AUTHORS   Tamaki,N., Kaneko,M., Mizota,C., Kikugawa,M. and Fujimoto,S.
  TITLE     Purification, characterization and inhibition of
            D-3-aminoisobutyrate aminotransferase from the rat liver
  JOURNAL   Eur J Biochem 189 (1), 39-45 (1990)
   PUBMED   2158891
REFERENCE   10 (bases 1 to 1946)
  AUTHORS   Okuno,E., Minatogawa,Y. and Kido,R.
  TITLE     Co-purification of alanine-glyoxylate aminotransferase with
            2-aminobutyrate aminotransferase in rat kidney
  JOURNAL   Biochim Biophys Acta 715 (1), 97-104 (1982)
   PUBMED   6803844
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC081765.1.
            
            On Jun 10, 2007 this sequence version replaced NM_031835.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081765.1, AB002584.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1946
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q16"
     gene            1..1946
                     /gene="Agxt2"
                     /gene_synonym="AGT2"
                     /note="alanine-glyoxylate aminotransferase 2"
                     /db_xref="GeneID:83784"
                     /db_xref="RGD:621767"
     exon            1..122
                     /gene="Agxt2"
                     /gene_synonym="AGT2"
                     /inference="alignment:Splign:2.1.0"
     CDS             38..1576
                     /gene="Agxt2"
                     /gene_synonym="AGT2"
                     /EC_number="2.6.1.44"
                     /EC_number="2.6.1.40"
                     /EC_number="2.6.1.18"
                     /note="AGT 2; D-AIBAT; beta-ALAAT II;
                     (R)-3-amino-2-methylpropionate--pyruvate transaminase;
                     beta-alanine-pyruvate aminotransferase;
                     D-3-aminoisobutyrate-pyruvate aminotransferase;
                     D-beta-aminoisobutyrate-pyruvate aminotransferase"
                     /codon_start=1
                     /product="alanine--glyoxylate aminotransferase 2,
                     mitochondrial"
                     /protein_id="NP_114023.1"
                     /db_xref="GeneID:83784"
                     /db_xref="RGD:621767"
                     /translation="MSLAWRTLQKAFYLETSLRILQMRPSLSCASRIYVPKLTLHTKH
                     NMPPCDFSPEKYQSLAYNHVLEIHKQHLSPVNTAYFQKPLLLHQGHMEWLFDSEGNRY
                     LDFFSGIVTVGVGHCHPKVTAVAKKQMDRLWHTSSVFFHSPMHEYAERLSALLPEPLK
                     VIFLVNSGSEANDLAMVMARAYSNHTDIISFRGAYHGCSPYTLGLTNVGIYKMKVPST
                     IACQSTMCPDVFRGPWGGSHCRDSPVQTVRKCSCAPDGCQAKERYIEQFKDTLNTSVA
                     TSIAGFFAEPIQGVNGVVQYPKEFLKEAFALVRERGGVCIADEVQTGFGRLGSHFWGF
                     QTHDTMPDIVTMAKGIGNGFPMAAVVTTPEIASSLAKHLHHFSTFGGSPLACAIGSAV
                     LEVIEEENLQRNSQEVGTYMLLKFAKLRDEFDIVGDVRGKGLMVGIEMVQDKISRQPL
                     PKTEVNQIHEDCKDMGLLVGRGGNFSQTFRIAPPMRVTKLEVDFAFEVFRSALTQHME
                     RRAK"
     exon            123..208
                     /gene="Agxt2"
                     /gene_synonym="AGT2"
                     /inference="alignment:Splign:2.1.0"
     exon            209..393
                     /gene="Agxt2"
                     /gene_synonym="AGT2"
                     /inference="alignment:Splign:2.1.0"
     exon            394..517
                     /gene="Agxt2"
                     /gene_synonym="AGT2"
                     /inference="alignment:Splign:2.1.0"
     exon            518..612
                     /gene="Agxt2"
                     /gene_synonym="AGT2"
                     /inference="alignment:Splign:2.1.0"
     exon            613..706
                     /gene="Agxt2"
                     /gene_synonym="AGT2"
                     /inference="alignment:Splign:2.1.0"
     exon            707..800
                     /gene="Agxt2"
                     /gene_synonym="AGT2"
                     /inference="alignment:Splign:2.1.0"
     exon            801..901
                     /gene="Agxt2"
                     /gene_synonym="AGT2"
                     /inference="alignment:Splign:2.1.0"
     exon            902..994
                     /gene="Agxt2"
                     /gene_synonym="AGT2"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1127
                     /gene="Agxt2"
                     /gene_synonym="AGT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..1219
                     /gene="Agxt2"
                     /gene_synonym="AGT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..1369
                     /gene="Agxt2"
                     /gene_synonym="AGT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1370..1468
                     /gene="Agxt2"
                     /gene_synonym="AGT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1469..1918
                     /gene="Agxt2"
                     /gene_synonym="AGT2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctgcttcca ctggattttc ttcctgcctg ggaaaagatg tctctagcct ggagaacatt
       61 gcagaaagct ttctacctgg agacctctct gagaatcctc cagatgcgtc catccctgag
      121 ctgtgcttct cggatatatg tacccaagct cactcttcat acaaagcaca acatgccacc
      181 atgtgacttc tcacctgaga aataccagtc tctggcctac aaccatgtcc tggagattca
      241 taagcagcac ctttctcctg tgaatacagc ctatttccag aagcctttgc tgctccacca
      301 gggacacatg gaatggctct ttgattcgga aggaaacaga tacctggact tcttctctgg
      361 gattgtaact gttggtgttg gtcactgcca cccgaaggta actgctgtgg caaaaaagca
      421 gatggaccgc ctgtggcata caagttctgt cttcttccac tctccgatgc atgaatatgc
      481 agagaggctg tcagcactcc ttcctgagcc tcttaaggtc attttcttgg taaacagtgg
      541 atcagaagcc aatgacctgg ccatggtgat ggccagggca tactcgaacc acacagacat
      601 catttctttc agaggagcct atcatggatg tagtccctac acacttggtc tgacgaatgt
      661 aggaatttac aagatgaaag tccccagtac gatagcctgc caatcgacaa tgtgcccaga
      721 tgttttccgt gggccttggg gaggaagcca ctgtcgggat tctccggtgc aaacagtcag
      781 gaaatgcagc tgtgctccag atggctgcca agctaaagaa cggtacattg aacagttcaa
      841 agacacactg aacacttctg tggccacgtc aattgctgga ttttttgcag agccaattca
      901 aggtgtgaat ggtgttgtcc agtacccaaa ggagtttctg aaggaagcct ttgcactggt
      961 tcgagagagg ggaggtgtat gcattgcaga tgaagtgcag acaggctttg gaaggctggg
     1021 ctctcacttc tggggtttcc aaacacatga tacaatgcct gacattgtca ccatggctaa
     1081 agggattgga aatggcttcc ccatggcagc agttgtgacc actccagaaa ttgcgagctc
     1141 tttggctaaa cacttacatc acttcagcac atttggagga agtcccctgg cctgcgccat
     1201 tggatctgct gtgcttgagg tgattgaaga agaaaatctc cagagaaaca gtcaagaagt
     1261 tggcacctac atgctgctaa agtttgctaa gcttcgggat gaatttgaca tcgttgggga
     1321 tgtgcgaggc aaaggcctta tggtggggat agagatggtt caagacaaga taagccgcca
     1381 gcctcttcct aaaacagaag tcaatcaaat ccatgaggac tgcaaagaca tggggctcct
     1441 agtgggtaga ggtggtaatt tttctcagac tttccgcatt gcgcccccga tgcgtgtcac
     1501 aaagctggaa gtggattttg catttgaagt atttcgttct gccttaactc aacacatgga
     1561 gagaagagct aagtaagaag agccccaagc ctcaagaact tctcaactat gctcagagtt
     1621 ggattggaga gatgctgaaa ccacaagtat tagatagaaa aaaaccctgc agccctctga
     1681 agtaattgta aaagactcga tggactatct actggctaca tttgtcaact gagtccccat
     1741 tctcctgata attccatcct tcaggagaag tatctgtcac tggctcacag aataagtctt
     1801 agtttgtgta gattagtctg ggctaatgtt atttcccgtt gcattaactg gtttgtaaat
     1861 gaatacacag tatatgtgtc gccgatgagt cctgaagtaa atcctttccg tgacactaaa
     1921 aaaaaaaaaa aaaaaaaaaa aaaaaa
//
