LOCUS       NM_001007654            2179 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus angiotensin II receptor-associated protein
            (Agtrap), mRNA.
ACCESSION   NM_001007654 XM_216588
VERSION     NM_001007654.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2179)
  AUTHORS   Sotozawa,M., Kinguchi,S., Wakui,H., Azushima,K., Funakoshi,K.,
            Nakajima,W., Miyazaki,T., Takahashi,T. and Tamura,K.
  TITLE     Enhancement of angiotensin II type 1 receptor-associated protein in
            the paraventricular nucleus suppresses angiotensin II-dependent
            hypertension
  JOURNAL   Hypertens Res 47 (1), 67-77 (2024)
   PUBMED   37884662
  REMARK    GeneRIF: Enhancement of angiotensin II type 1 receptor-associated
            protein in the paraventricular nucleus suppresses angiotensin
            II-dependent hypertension.
REFERENCE   2  (bases 1 to 2179)
  AUTHORS   Huang,H., Zhou,J., Cui,Z., Wang,B. and Hu,Y.
  TITLE     Angiotensin II type 1 receptor-associated protein plays a role in
            regulating the local renin-angiotensin system in HSC-T6 cells
  JOURNAL   Mol Med Rep 12 (3), 3763-3768 (2015)
   PUBMED   26018598
  REMARK    GeneRIF: A single dose of angiotensin(17) at the same concentration
            as angiotensin II induced Agtrap gene expression.
REFERENCE   3  (bases 1 to 2179)
  AUTHORS   Flister,M.J., Tsaih,S.W., O'Meara,C.C., Endres,B., Hoffman,M.J.,
            Geurts,A.M., Dwinell,M.R., Lazar,J., Jacob,H.J. and Moreno,C.
  TITLE     Identifying multiple causative genes at a single GWAS locus
  JOURNAL   Genome Res 23 (12), 1996-2002 (2013)
   PUBMED   24006081
REFERENCE   4  (bases 1 to 2179)
  AUTHORS   Granado,M., Fernandez,N., Monge,L., Figueras,J.C.,
            Carreno-Tarragona,G., Amor,S. and Garcia-Villalon,A.L.
  TITLE     Effects of coronary ischemia-reperfusion in a rat model of early
            overnutrition. Role of angiotensin receptors
  JOURNAL   PLoS One 8 (2), e54984 (2013)
   PUBMED   23383303
  REMARK    GeneRIF: The expression of both angiotensin AGTRa and AGTR2
            receptors was increased in the myocardium of overfed rats, and
            ischemia-reperfusion increased the expression of both receptors in
            control rats but reduced it in overfed rats.
REFERENCE   5  (bases 1 to 2179)
  AUTHORS   Wenzel,K., Rajakumar,A., Haase,H., Geusens,N., Hubner,N.,
            Schulz,H., Brewer,J., Roberts,L., Hubel,C.A., Herse,F., Hering,L.,
            Qadri,F., Lindschau,C., Wallukat,G., Pijnenborg,R., Heidecke,H.,
            Riemekasten,G., Luft,F.C., Muller,D.N., Lamarca,B. and Dechend,R.
  TITLE     Angiotensin II type 1 receptor antibodies and increased angiotensin
            II sensitivity in pregnant rats
  JOURNAL   Hypertension 58 (1), 77-84 (2011)
   PUBMED   21576625
  REMARK    GeneRIF: AT(1)-AB induces Ang II sensitivity. Our mechanistic study
            supports the existence of an 'autoimmune-activating receptor' that
            could contribute to Ang II sensitivity and possible to
            preeclampsia.
REFERENCE   6  (bases 1 to 2179)
  AUTHORS   Gustavsson,M., Mallard,C., Vannucci,S.J., Wilson,M.A.,
            Johnston,M.V. and Hagberg,H.
  TITLE     Vascular response to hypoxic preconditioning in the immature brain
  JOURNAL   J Cereb Blood Flow Metab 27 (5), 928-938 (2007)
   PUBMED   17033689
REFERENCE   7  (bases 1 to 2179)
  AUTHORS   Tanaka,Y., Tamura,K., Koide,Y., Sakai,M., Tsurumi,Y., Noda,Y.,
            Umemura,M., Ishigami,T., Uchino,K., Kimura,K., Horiuchi,M. and
            Umemura,S.
  TITLE     The novel angiotensin II type 1 receptor (AT1R)-associated protein
            ATRAP downregulates AT1R and ameliorates cardiomyocyte hypertrophy
  JOURNAL   FEBS Lett 579 (7), 1579-1586 (2005)
   PUBMED   15757644
REFERENCE   8  (bases 1 to 2179)
  AUTHORS   Cui,T., Nakagami,H., Iwai,M., Takeda,Y., Shiuchi,T., Tamura,K.,
            Daviet,L. and Horiuchi,M.
  TITLE     ATRAP, novel AT1 receptor associated protein, enhances
            internalization of AT1 receptor and inhibits vascular smooth muscle
            cell growth
  JOURNAL   Biochem Biophys Res Commun 279 (3), 938-941 (2000)
   PUBMED   11162453
REFERENCE   9  (bases 1 to 2179)
  AUTHORS   Akishita,M., Yamada,H., Dzau,V.J. and Horiuchi,M.
  TITLE     Increased vasoconstrictor response of the mouse lacking angiotensin
            II type 2 receptor
  JOURNAL   Biochem Biophys Res Commun 261 (2), 345-349 (1999)
   PUBMED   10425188
REFERENCE   10 (bases 1 to 2179)
  AUTHORS   Daviet,L., Lehtonen,J.Y., Tamura,K., Griese,D.P., Horiuchi,M. and
            Dzau,V.J.
  TITLE     Cloning and characterization of ATRAP, a novel protein that
            interacts with the angiotensin II type 1 receptor
  JOURNAL   J Biol Chem 274 (24), 17058-17062 (1999)
   PUBMED   10358057
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC082019.1.
            
            On Nov 29, 2004 this sequence version replaced XM_216588.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC082019.1, DN933749.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132301, SAMN06621351
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2179
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..2179
                     /gene="Agtrap"
                     /note="angiotensin II receptor-associated protein"
                     /db_xref="GeneID:298646"
                     /db_xref="RGD:1359346"
     exon            1..68
                     /gene="Agtrap"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..524
                     /gene="Agtrap"
                     /note="AT1 receptor-associated protein; angiotensin II,
                     type I receptor-associated protein"
                     /codon_start=1
                     /product="type-1 angiotensin II receptor-associated
                     protein"
                     /protein_id="NP_001007655.1"
                     /db_xref="GeneID:298646"
                     /db_xref="RGD:1359346"
                     /translation="MELPAVNLKVILLVHWLLTTWGCLAFSGSYAWGNFTILALGVWA
                     VAQRDSVDAIGMFLGGLVATIFLDIIYISIFYSSVAVGDTGRFSAGMAIFSLLLKPFS
                     CCLVYHMHRERGGELPLRSDFFGPSQEHSAYQTIDSSDSPADPLASLENKGQAAPRGY
                     "
     exon            69..103
                     /gene="Agtrap"
                     /inference="alignment:Splign:2.1.0"
     exon            104..209
                     /gene="Agtrap"
                     /inference="alignment:Splign:2.1.0"
     exon            210..405
                     /gene="Agtrap"
                     /inference="alignment:Splign:2.1.0"
     exon            406..2172
                     /gene="Agtrap"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtccccgtgg ccgtcgctca ggtgccctcc gccgggtcgg gatggagctg cctgccgtga
       61 acttgaaggt tattctcctg gttcactggc tgttgacaac ctggggctgc ttggcgttct
      121 caggctccta tgcttggggc aacttcacta tcctggccct gggtgtgtgg gctgtggccc
      181 agcgggactc tgttgatgcc attggcatgt ttcttggtgg cttggttgcc accatcttcc
      241 tggacattat ctacattagc atcttctact caagcgttgc cgttggggac actggccgct
      301 tcagtgccgg catggccatc ttcagcttgc tgctgaagcc cttctcctgc tgcctcgtct
      361 accacatgca ccgggagcga gggggtgagc tcccgctccg ctcggatttc ttcggacctt
      421 ctcaggaaca tagtgcctac cagacaattg actcgtcaga ctcacctgca gacccccttg
      481 caagcctgga gaacaagggc caagctgccc cccgggggta ctgaagctgt ccctggccgt
      541 cctggggccc agcaggatgc ttgtcacctt ctttactgga cctacaatgg ggtatcctcc
      601 attccctgcc acagaggtgg cctgagtcat gtgccctcgg aggtcccagc tgagaagagc
      661 ccagtcctaa ttctccatgc tgcccctcca ttcaagacac ctgttaaccc ctgggctaga
      721 actgtggttg gtttcttccc ctcctcccca tcactataac acacaaccgc cgagctgtgc
      781 agagtgttca gggccatcca ggccttatgg gccaatgatc actgcctctc aggctacccc
      841 aaggtgaccc agcccttctg gaagctctgt gagcttgtgg tcctgctcag cctgttctgc
      901 acaggagcca agtccctgtg cctctcagtg cctcatgaca gtgcctgaga accccaggcc
      961 cagatgcagt aggtctgtct gcagaggagc cctgacatta aaatgcaggg cctctgggcc
     1021 tgcactaggt tccagccatg tttgtgctcc gagctgggac ccaccctgcc gtctgggtgt
     1081 gacttcgccc tagactcagt tgcaggtgga acatagtttc agccacccat tatatcagcc
     1141 aaatggggtg gcagaggaag tgctggtcgg tgtggcatgt agacagacat ctatcctctg
     1201 attctaagtg actaatttca ctgcctctga tcctgaacca tgaggcaggg catgggtggc
     1261 ttcctctagc ctctgcgttc tgaccacagt cgactgcctc ctgaggtgcc agcgctccca
     1321 ctcttactca ccggcagacg tctggggaca gatacttgaa gacttatggg gagccgcagg
     1381 ctgaggtgag agtcctgaaa gcactctctg cacacgagac aggccgggag gctgagtgac
     1441 agcatcattg gtggggtcac tgcgtccatc tgctgcgtca aacacaatcc catgcaatca
     1501 gcacctaacc cagacctggt tggcatccac actgagccca gtgtgagcag agtgaggagc
     1561 ggtagctgtg atttgtttag gctgagtgca gcacagtgta aacaagagct ggggcccaga
     1621 gactcagagg cttagaggct cagccgcagg taaaggagtc ttctactgag cgtcacgatg
     1681 tgtgtttggt ccttggaacc gacttgcgaa agttatcctc tgacctccac actctttgtc
     1741 atggtttgag gttttacaca cacatacaaa cacaccacaa acagataaat gtaaaaacaa
     1801 acccagaata ttaaaaacgt gcctggtggg tggttaatgc cagcacttgg gaggcagagg
     1861 caggtgaatc tccgagttaa ggccagcctg gcctacagag cgagttccag gacagctggg
     1921 gctgtttcat agctctggga cacgtgtcaa gttcaagact gcagaggcct gaggagaagg
     1981 gagcacgtgg cctgaggcaa agaagacaag aagcccaaga tgttttctcg tgtttctgga
     2041 agggttcttg tcggaaggaa ggcctggggg ctggggattt agctcagtgg tagagcgctt
     2101 acctaggaag cgcaaggccg tgggttcggt ccccagctcc gaaaaaaaag aaccaaaaaa
     2161 aaaaaaaaaa aaaaaaaaa
//
