LOCUS       NM_012494               2861 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Rattus norvegicus angiotensin II receptor, type 2 (Agtr2), mRNA.
ACCESSION   NM_012494 XM_006257432
VERSION     NM_012494.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2861)
  AUTHORS   Maknis,T.R., Fussi,M.F., Pariani,A.P., Huhn,V., Vena,R., Favre,C.,
            Molinas,S.M. and Larocca,M.C.
  TITLE     Activation of angiotensin II type 2 receptor leads to preservation
            of primary cilia in tubular cells during renal
            ischaemia-reperfusion injury
  JOURNAL   J Physiol 602 (19), 5083-5103 (2024)
   PUBMED   39146457
  REMARK    GeneRIF: Activation of angiotensin II type 2 receptor leads to
            preservation of primary cilia in tubular cells during renal
            ischaemia-reperfusion injury.
REFERENCE   2  (bases 1 to 2861)
  AUTHORS   Olschewski,D.N., Nazarzadeh,N., Lange,F., Koenig,A.M., Kulka,C.,
            Abraham,J.A., Blaschke,S.J., Merkel,R., Hoffmann,B., Fink,G.R.,
            Schroeter,M., Rueger,M.A. and Vay,S.U.
  TITLE     The angiotensin II receptors type 1 and 2 modulate astrocytes and
            their crosstalk with microglia and neurons in an in vitro model of
            ischemic stroke
  JOURNAL   BMC Neurosci 25 (1), 29 (2024)
   PUBMED   38926677
  REMARK    GeneRIF: The angiotensin II receptors type 1 and 2 modulate
            astrocytes and their crosstalk with microglia and neurons in an in
            vitro model of ischemic stroke.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2861)
  AUTHORS   Kulkarni,K., Patel,S., Ali,R. and Hussain,T.
  TITLE     Angiotensin II type 2 receptor activation preserves megalin in the
            kidney and prevents proteinuria in high salt diet fed rats
  JOURNAL   Sci Rep 13 (1), 4277 (2023)
   PUBMED   36922642
  REMARK    GeneRIF: Angiotensin II type 2 receptor activation preserves
            megalin in the kidney and prevents proteinuria in high salt diet
            fed rats.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2861)
  AUTHORS   Quan,Y., Liu,P., Zhang,L. and Guo,J.
  TITLE     The effect of AT1R-1166A/C and AT2R-1675A/G polymorphisms on
            susceptibility to preeclampsia: A systematic review and
            meta-analysis
  JOURNAL   Medicine (Baltimore) 101 (45), e31008 (2022)
   PUBMED   36397318
  REMARK    GeneRIF: The effect of AT1R-1166A/C and AT2R-1675A/G polymorphisms
            on susceptibility to preeclampsia: A systematic review and
            meta-analysis.
REFERENCE   5  (bases 1 to 2861)
  AUTHORS   Barsha,G., Walton,S.L., Kwok,E., Mirabito Colafella,K.M.,
            Pinar,A.A., Hilliard Krause,L.M., Gaspari,T.A., Widdop,R.E.,
            Samuel,C.S. and Denton,K.M.
  TITLE     Relaxin Attenuates Organ Fibrosis via an Angiotensin Type 2
            Receptor Mechanism in Aged Hypertensive Female Rats
  JOURNAL   Kidney360 2 (11), 1781-1792 (2021)
   PUBMED   35373008
  REMARK    GeneRIF: Relaxin Attenuates Organ Fibrosis via an Angiotensin Type
            2 Receptor Mechanism in Aged Hypertensive Female Rats.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2861)
  AUTHORS   Koike,G., Winer,E.S., Horiuchi,M., Brown,D.M., Szpirer,C.,
            Dzau,V.J. and Jacob,H.J.
  TITLE     Cloning, characterization, and genetic mapping of the rat type 2
            angiotensin II receptor gene
  JOURNAL   Hypertension 26 (6 Pt 1), 998-1002 (1995)
   PUBMED   7490161
REFERENCE   7  (bases 1 to 2861)
  AUTHORS   Ichiki,T., Labosky,P.A., Shiota,C., Okuyama,S., Imagawa,Y.,
            Fogo,A., Niimura,F., Ichikawa,I., Hogan,B.L. and Inagami,T.
  TITLE     Effects on blood pressure and exploratory behaviour of mice lacking
            angiotensin II type-2 receptor
  JOURNAL   Nature 377 (6551), 748-750 (1995)
   PUBMED   7477267
REFERENCE   8  (bases 1 to 2861)
  AUTHORS   Kobayashi,S., Ohnishi,J., Nibu,Y., Nishimatsu,S., Umemura,S.,
            Ishii,M., Murakami,K. and Miyazaki,H.
  TITLE     Cloning of the rat angiotensin II type 2 receptor gene and
            identification of its functional promoter region
  JOURNAL   Biochim Biophys Acta 1262 (2-3), 155-158 (1995)
   PUBMED   7599191
REFERENCE   9  (bases 1 to 2861)
  AUTHORS   Najarian,J.S.
  TITLE     Overview of in vivo xenotransplantation studies: prospects for the
            future
  JOURNAL   Transplant Proc 24 (2), 733-738 (1992)
   PUBMED   1566502
  REMARK    Review article
REFERENCE   10 (bases 1 to 2861)
  AUTHORS   Bose,K.S. and Sarma,R.H.
  TITLE     Delineation of the intimate details of the backbone conformation of
            pyridine nucleotide coenzymes in aqueous solution
  JOURNAL   Biochem Biophys Res Commun 66 (4), 1173-1179 (1975)
   PUBMED   2
  REMARK    Erratum:[Biochem Pharmacol. 1975 Aug 15;24(16):1517-21. doi:
            10.1016/0006-2952(75)90029-5.. PMID: 8]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            On or before Aug 29, 2022 this sequence version replaced
            XM_006257432.4, NM_012494.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EV762974.1, SRR26643429.59747.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-60                JAXUCZ010000021.1  116914320-116914379
            61-121              JAXUCZ010000021.1  116914537-116914597
            122-2861            JAXUCZ010000021.1  116915765-116918504
FEATURES             Location/Qualifiers
     source          1..2861
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq34"
     gene            1..2861
                     /gene="Agtr2"
                     /gene_synonym="AT2-R; AT2R; AT<sub>2</sub>R"
                     /note="angiotensin II receptor, type 2"
                     /db_xref="GeneID:24182"
                     /db_xref="RGD:2072"
     exon            1..60
                     /gene="Agtr2"
                     /gene_synonym="AT2-R; AT2R; AT<sub>2</sub>R"
                     /inference="alignment:Splign:2.1.0"
     exon            61..121
                     /gene="Agtr2"
                     /gene_synonym="AT2-R; AT2R; AT<sub>2</sub>R"
                     /inference="alignment:Splign:2.1.0"
     exon            122..2861
                     /gene="Agtr2"
                     /gene_synonym="AT2-R; AT2R; AT<sub>2</sub>R"
                     /inference="alignment:Splign:2.1.0"
     CDS             159..1250
                     /gene="Agtr2"
                     /gene_synonym="AT2-R; AT2R; AT<sub>2</sub>R"
                     /note="angiotensin receptor 2; angiotensin II type 2
                     receptor; AT2; AT2 receptor"
                     /codon_start=1
                     /product="type-2 angiotensin II receptor"
                     /protein_id="NP_036626.1"
                     /db_xref="GeneID:24182"
                     /db_xref="RGD:2072"
                     /translation="MKDNFSFAATSRNITSSLPFDNLNATGTNESAFNCSHKPADKHL
                     EAIPVLYYMIFVIGFAVNIVVVSLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWAT
                     YYSYRYDWLFGPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQA
                     SYVVPLVWCMACLSSLPTFYFRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNIL
                     GFIIPLIFIATCYFGIRKHLLKTNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLT
                     FLDALTWMGIINSCEVIAVIDLALPFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFR
                     VPITWLQGKRETMSCRKSSSLREMDTFVS"
ORIGIN      
        1 ccagagtctg gggatggagc gagcacagaa ttgaaagctt tcttcagcct gcattttaag
       61 gagtgcgtgt gggaagctca gtaagctgat ttatgataac tgctttaaac actggcaact
      121 aaaagagtgt aaggattggg agtctctgac agttcaatat gaaggacaac ttcagttttg
      181 ctgccaccag cagaaacatc accagcagtc ttccttttga taatctcaac gcaactggca
      241 ccaatgagtc cgcatttaac tgctcacaca aaccggcaga taagcatttg gaagcaattc
      301 ctgttctcta ctacatgatt tttgtgattg gttttgctgt taacattgtt gtggtctcac
      361 tgttttgttg tcaaaagggc cctaaaaagg tgtccagcat ttacatcttc aatctggctg
      421 tggctgactt actccttttg gcaacccttc ctctctgggc aacctattac tcttatagat
      481 atgactggct ctttggacct gtgatgtgca aagtgtttgg ttcttttctg accctgaaca
      541 tgtttgcaag catttttttt attacgtgca tgagtgttga taggtaccaa tcggttatct
      601 acccttttct gtctcagaga aggaatccct ggcaagcatc ttatgtagtt ccccttgttt
      661 ggtgtatggc ttgtctgtcc tcattgccaa cattttattt ccgagatgtc agaaccattg
      721 aatacttagg tgtgaatgct tgtattatgg ctttcccacc tgagaaatat gctcagtggt
      781 ctgctgggat tgccttaatg aaaaatattc ttggctttat cattccttta atattcatag
      841 caacgtgtta ctttggaatc agaaaacatc tgctgaagac caatagctat gggaagaaca
      901 gaattacccg tgaccaagtc ttgaagatgg cagctgctgt tgtgttggca ttcatcattt
      961 gctggcttcc cttccatgtt ctgaccttct tggatgctct gacctggatg ggtatcatta
     1021 atagctgtga agttatagca gtcattgacc tggcacttcc ttttgccatc ctcctgggat
     1081 tcaccaacag ctgtgttaat cccttcctgt attgtttcgt tggaaaccgc ttccaacaga
     1141 agctccgtag tgtgtttaga gttcccatta cttggctcca aggcaagaga gagactatgt
     1201 cttgccgaaa aagcagttct cttagagaaa tggacacctt tgtgtcttaa atctgttagt
     1261 gggatgcatg taatcagcct agcaatggtt tggaggccca cacaaatgat ctttaagtga
     1321 catcagtata atataattct ttgctttttc taatctttat ttactccccc cagaacagga
     1381 aataagtata attataaacc tttatactcc accagctttc agtgatagtg ccttcttttt
     1441 ctggtccgtt ggcaggagat tgtcatatgt gagctttatc tataatctag aagtatctgg
     1501 gggaattatc tcgacttata attaaaaaca aattatgagt gatgatttga tgtctcggat
     1561 ttctccctgg aaaatgctgg catttcttag tggagtttta tgtccatttt catctgatat
     1621 ttttttctct tgaacaaggg ccaatttgaa cttcttacac tttccaacca tatgatagag
     1681 catgagaggt gggcactaag gttagcatgc tatacccttc tatatatgcc atgggttggt
     1741 agtggcttat tcagtctcta aatatatagg ttctcctttt aaagaaatta taagttgtgt
     1801 tccttttcca tttcactcaa gtatagcttt ttacttacta tctaaaacca ctgagtagat
     1861 ctagaatgtg gtttaaatca cacttctcta ttagcttatc cttgaagtta tagagcgcac
     1921 gctatttagt aaaacagaac taccctgaaa aagtatttta ttaaccacaa aactgaatat
     1981 acacttggaa aacttttcat ccattttgac tattgtttca agttttctat tctcttctga
     2041 tgatttttga acacgacaac aaaacactgt attattagat gacataaagg tcacttttta
     2101 catttttaac cttttgaaca tggtgctttg atatattcta tggtgacttg agtttaatta
     2161 ttcatgcttt tgttctgggc tgcgtcccaa aatatctttt tgaccctgaa aaagagagga
     2221 ttctttaatt ctttagcttt ataataaact gcacactggc ataggaaaag gttatgtcag
     2281 aatggaagtt tgatgccttc ttgggagcaa acagacccag agaaacggca agtttggtgt
     2341 ccaacaagga acttgtcaga acaaaggccc cctggggagt attttgaatc tgcatttctg
     2401 ggcacagttc cagaatatat aagagtctgt ggaggtgatt taaatcaagc ccaggtccac
     2461 agagctcatt ctcaacacga gtacatctct tacattagag gaatataatc ccggaaactg
     2521 agtcacctaa agttcactca aacttcacaa taagtattaa ttcaaacgtt caaaatgcca
     2581 ttctcttact gccccatatt ataccaggtc gcctgagacc tttctggact gataatgacc
     2641 tctgaggtag atttaaagtt ttgggaactt aacatttctg tcagatttca ggcttttttg
     2701 gttgaagaat cctctcatac cccttccttg gaaaaccctg atttcatgta ttcatattat
     2761 gtgttactaa gatcaagtag ctaaatatat aatcagttat gattttgtgt tttaagtaat
     2821 tttacacaac atctcataaa aataaaatca ttattgggag a
//
