LOCUS       NM_031009               2183 bp    mRNA    linear   ROD 06-OCT-2024
DEFINITION  Rattus norvegicus angiotensin II receptor, type 1b (Agtr1b), mRNA.
ACCESSION   NM_031009
VERSION     NM_031009.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2183)
  AUTHORS   Hogg,J.P. 3rd, Campbell,N., Deer,E., Fitzgerald,S., Cornelius,D.,
            Hoang,N., Turner,T., Amaral,L., Lemon,J.P., Ibrahim,T. and
            LaMarca,B.
  TITLE     The role of T cell stimulated agonistic autoantibodies to the
            angiotensin II type I receptor (AT1-AA) in mediating multiorgan
            dysfunction in IL-17 induced hypertension during pregnancy
  JOURNAL   Am J Reprod Immunol 91 (4), e13843 (2024)
   PUBMED   38606700
  REMARK    GeneRIF: The role of T cell stimulated agonistic autoantibodies to
            the angiotensin II type I receptor (AT1-AA) in mediating multiorgan
            dysfunction in IL-17 induced hypertension during pregnancy.
REFERENCE   2  (bases 1 to 2183)
  AUTHORS   Gao,Z.Y., Jiang,Y.J., Wang,J., Li,C. and Zhang,D.L.
  TITLE     Inhibition of angiotensin II type 1 receptor reduces oxidative
            stress damage to the intestinal barrier in severe acute
            pancreatitis
  JOURNAL   Kaohsiung J Med Sci 39 (8), 824-833 (2023)
   PUBMED   37132556
  REMARK    GeneRIF: Inhibition of angiotensin II type 1 receptor reduces
            oxidative stress damage to the intestinal barrier in severe acute
            pancreatitis.
REFERENCE   3  (bases 1 to 2183)
  AUTHORS   Aldossary,H.S., Nieves,D.J., Kavanagh,D.M., Owen,D., Ray,C.J.,
            Kumar,P., Coney,A.M. and Holmes,A.P.
  TITLE     Analyzing Angiotensin II Receptor Type 1 Clustering in PC12 Cells
            in Response to Hypoxia Using Direct Stochastic Optical
            Reconstruction Microscopy (dSTORM)
  JOURNAL   Adv Exp Med Biol 1427, 175-184 (2023)
   PUBMED   37322348
  REMARK    GeneRIF: Analyzing Angiotensin II Receptor Type 1 Clustering in
            PC12 Cells in Response to Hypoxia Using Direct Stochastic Optical
            Reconstruction Microscopy (dSTORM).
REFERENCE   4  (bases 1 to 2183)
  AUTHORS   Garrido-Gil,P., Rodriguez-Perez,A.I., Fernandez-Rodriguez,P.,
            Lanciego,J.L. and Labandeira-Garcia,J.L.
  TITLE     Expression of angiotensinogen and receptors for angiotensin and
            prorenin in the rat and monkey striatal neurons and glial cells
  JOURNAL   Brain Struct Funct 222 (6), 2559-2571 (2017)
   PUBMED   28161727
  REMARK    GeneRIF: Major components of the renin angiotensin system are
            located in striatal projection neurons, and striatal astrocytes and
            microglial cells of rats.
REFERENCE   5  (bases 1 to 2183)
  AUTHORS   Li,Z., Cao,Y., Li,L., Liang,Y., Tian,X., Mo,N., Liu,Y., Li,M.,
            Chui,D. and Guo,X.
  TITLE     Prophylactic angiotensin type 1 receptor antagonism confers
            neuroprotection in an aged rat model of postoperative cognitive
            dysfunction
  JOURNAL   Biochem Biophys Res Commun 449 (1), 74-80 (2014)
   PUBMED   24814703
REFERENCE   6  (bases 1 to 2183)
  AUTHORS   Ye,M.Q. and Healy,D.P.
  TITLE     Characterization of an angiotensin type-1 receptor partial cDNA
            from rat kidney: evidence for a novel AT1B receptor subtype
  JOURNAL   Biochem Biophys Res Commun 185 (1), 204-210 (1992)
   PUBMED   1599457
REFERENCE   7  (bases 1 to 2183)
  AUTHORS   Sandberg,K., Ji,H., Clark,A.J., Shapira,H. and Catt,K.J.
  TITLE     Cloning and expression of a novel angiotensin II receptor subtype
  JOURNAL   J Biol Chem 267 (14), 9455-9458 (1992)
   PUBMED   1374402
REFERENCE   8  (bases 1 to 2183)
  AUTHORS   Elton,T.S., Stephan,C.C., Taylor,G.R., Kimball,M.G., Martin,M.M.,
            Durand,J.N. and Oparil,S.
  TITLE     Isolation of two distinct type I angiotensin II receptor genes
  JOURNAL   Biochem Biophys Res Commun 184 (2), 1067-1073 (1992)
   PUBMED   1575725
REFERENCE   9  (bases 1 to 2183)
  AUTHORS   Kakar,S.S., Sellers,J.C., Devor,D.C., Musgrove,L.C. and Neill,J.D.
  TITLE     Angiotensin II type-1 receptor subtype cDNAs: differential tissue
            expression and hormonal regulation
  JOURNAL   Biochem Biophys Res Commun 183 (3), 1090-1096 (1992)
   PUBMED   1567388
REFERENCE   10 (bases 1 to 2183)
  AUTHORS   Iwai,N. and Inagami,T.
  TITLE     Identification of two subtypes in the rat type I angiotensin II
            receptor
  JOURNAL   FEBS Lett 298 (2-3), 257-260 (1992)
   PUBMED   1544458
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB730850.1, JAXUCZ010000002.1 and M87003.1.
            
            On Nov 18, 2005 this sequence version replaced NM_031009.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M87003.1, SRR26360172.246148.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN17050746, SAMN17050747
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                CB730850.1         40-56
            18-94               JAXUCZ010000002.1  104849169-104849245 c
            95-136              CB730850.1         133-174
            137-1853            JAXUCZ010000002.1  104774333-104776049 c
            1854-2183           M87003.1           1827-2156
FEATURES             Location/Qualifiers
     source          1..2183
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q24"
     gene            1..2183
                     /gene="Agtr1b"
                     /gene_synonym="Agtr1; AT1; AT1B; AT3; AT<sub>1</sub>R"
                     /note="angiotensin II receptor, type 1b"
                     /db_xref="GeneID:81638"
                     /db_xref="RGD:2071"
     exon            1..117
                     /gene="Agtr1b"
                     /gene_synonym="Agtr1; AT1; AT1B; AT3; AT<sub>1</sub>R"
                     /inference="alignment:Splign:2.1.0"
     exon            118..2181
                     /gene="Agtr1b"
                     /gene_synonym="Agtr1; AT1; AT1B; AT3; AT<sub>1</sub>R"
                     /inference="alignment:Splign:2.1.0"
     CDS             166..1245
                     /gene="Agtr1b"
                     /gene_synonym="Agtr1; AT1; AT1B; AT3; AT<sub>1</sub>R"
                     /note="type-1B angiotensin II receptor; angiotensin II
                     type-1B receptor; angiotensin receptor 1b; angiotensin II
                     type-1 receptor; angiotensin II receptor, type-1;
                     Angiotensin II receptor, type 1 (AT1B); AT1 receptor B;
                     angiotensin II type-1 receptor B"
                     /codon_start=1
                     /product="type-1 angiotensin II receptor B"
                     /protein_id="NP_112271.2"
                     /db_xref="GeneID:81638"
                     /db_xref="RGD:2071"
                     /translation="MTLNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIF
                     GNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNHLCK
                     IASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLMAGLAS
                     LPAVIYRNVYFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFVFPFLIILTSYTLI
                     WKALKKAYKIQKNTPRNDDIFRIIMAIVLFFFFSWVPHQIFTFLDVLIQLGIIRDCEI
                     ADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPTAKSHAGLSTKM
                     STLSYRPSDNMSSSAKKSASFFEVE"
ORIGIN      
        1 aggcagcagg gagtgacaga gaccagacca gacacacaca gcctttccag cgccagcgct
       61 gtggatgggg agcggccacc aggcttgaaa gaagcccaga gctgggcact gcacacggtg
      121 cattttaaat agtgtcagag agcaattcac ctcgccaagg gagacatgac ccttaactcc
      181 tctactgaag atggaattaa aagaatccaa gatgactgcc ccaaggctgg caggcacaat
      241 tacatatttg tcatgatccc tactctctac agcatcatct ttgtggtggg aatatttgga
      301 aacagcttgg tggtgattgt catttacttt tacatgaagc taaagactgt ggccagtgtt
      361 tttcttctga atcttgccct ggctgattta tgctttttgt tgactttgcc actgtgggca
      421 gtctataccg ctatggaata ccgatggccc ttcggcaacc acctatgtaa gatcgcttct
      481 gccagcgtca gtttcaatct ctatgccagt gtgtttctgc tcacgtgtct cagcatcgat
      541 cgctacctgg ccattgtcca cccaatgaag tctcgcctcc gccgcacgat gctggtagcc
      601 aaagtcacct gcatcatcat ctggctaatg gctggcttgg ccagtttgcc agccgtcatc
      661 taccgaaacg tatatttcat cgagaacacc aatatcacag tttgcgcttt tcattatgaa
      721 tctcagaact caacactccc cattggactg ggtctaacaa agaacattct gggcttcgtg
      781 ttccctttcc ttatcattct caccagctat actcttattt ggaaagccct aaagaaggct
      841 tataaaattc agaagaacac gccaagaaat gatgacatct ttaggataat tatggcgatt
      901 gtgcttttct tcttcttttc ctgggttccc caccaaatat tcacttttct ggatgtgctc
      961 attcagctgg gcattatccg tgactgtgaa attgctgaca ttgtggacac cgctatgccc
     1021 atcaccatct gcatagctta ttttaacaat tgcctgaatc ctctgtttta tggctttctg
     1081 gggaaaaaat ttaaaaaata tttcctccag cttctgaaat acattccccc aacggccaag
     1141 tcacacgcag gcttgtcaac aaaaatgagc actctttcct accgcccttc agataacatg
     1201 agttcatctg ccaaaaagtc tgcatctttt tttgaagtgg agtgagaggg ttcaaagcct
     1261 gcaagtgaag tgatttcctg acagcagaag ccagaggacc atttgggcta agcagctcac
     1321 tcactaccga aggagtgttc aacctccagc aatcctttca gggttgaagc agagaaagtg
     1381 ctcagtgtac acattttcaa aagtgggaaa caaaagcttt tttccccttt aaaacaaatt
     1441 ggagcaaagc cactgttaac cgcctttttt tgttgactga ataactgctt taaggacaat
     1501 gtcagaaatt gagtggctgt atggatttgg gggttaggga ggaggtgtac tagcagaaac
     1561 gtaatgtctc cagtcccctc tcaattctgt tacttttgat ttccacttga aggtatttag
     1621 aagctattaa atctgtagac aatcaaaagg agatgggagg tcaagagttt ctaagggtcc
     1681 aggaagctac ccatctgttt agttactagt gactatgaca ccattgttcc tgacacaaca
     1741 cagttaagac ttgctagaca gtagtcatca agtttcaaaa tgctttgtga agttcagcca
     1801 gtgtcttaag aattcagagc catgtgccaa aacagtacca cagaacagct tgcctgaata
     1861 atgtcttact gtagttgcaa agccaaactg cttgtcaagc tgtgattctg tcccagatag
     1921 ttgtgtcttc ctagttggat cagtttaatt tcatatctaa gaaatgtata atttcatatc
     1981 taagaaatgt atatgaaatg tatatgaaat gtataatttc atatctaaga aatgttaagc
     2041 agatttatca taaagtatgt tttatggttc taaaaatgta tattttatat atgttatgta
     2101 tatctatatc tctaagctgt tgtttgattg aagttgtagc aaagttgtat ttatcttgaa
     2161 ataaaaattt atcataatat aaa
//
