LOCUS       NM_030985               2208 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Rattus norvegicus angiotensin II receptor, type 1a (Agtr1a), mRNA.
ACCESSION   NM_030985
VERSION     NM_030985.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2208)
  AUTHORS   Ghosh,K., Zhou,J.J., Shao,J.Y., Chen,S.R. and Pan,H.L.
  TITLE     DNA demethylation in the hypothalamus promotes transcription of
            Agtr1a and Slc12a2 and hypertension development
  JOURNAL   J Biol Chem 300 (2), 105597 (2024)
   PUBMED   38160798
  REMARK    GeneRIF: DNA demethylation in the hypothalamus promotes
            transcription of Agtr1a and Slc12a2 and hypertension development.
REFERENCE   2  (bases 1 to 2208)
  AUTHORS   Paes-Leme,B., Monteiro,L.D.R.N., Gholami,K., Hoe,S.Z.,
            Ferguson,A.V., Murphy,D., Antunes-Rodrigues,J., Rorato,R.,
            Reis,L.C. and Mecawi,A.S.
  TITLE     Fasting increases circulating angiotensin levels and brain Agtr1a
            expression in male rats
  JOURNAL   J Neuroendocrinol 35 (11), e13334 (2023)
   PUBMED   37667574
  REMARK    GeneRIF: Fasting increases circulating angiotensin levels and brain
            Agtr1a expression in male rats.
REFERENCE   3  (bases 1 to 2208)
  AUTHORS   Chen,X., Gao,R., Song,Y., Xu,T., Jin,L., Zhang,W., Chen,Z.,
            Wang,H., Wu,W., Zhang,S., Zhang,G., Zhang,N., Chang,L., Liu,H.,
            Li,H. and Wu,Y.
  TITLE     Astrocytic AT1R deficiency ameliorates Abeta-induced cognitive
            deficits and synaptotoxicity through beta-arrestin2 signaling
  JOURNAL   Prog Neurobiol 228, 102489 (2023)
   PUBMED   37355221
  REMARK    GeneRIF: Astrocytic AT1R deficiency ameliorates Abeta-induced
            cognitive deficits and synaptotoxicity through beta-arrestin2
            signaling.
REFERENCE   4  (bases 1 to 2208)
  AUTHORS   Wang,J., Li,D., Zhang,Y., Xing,D., Lei,Z. and Jiao,X.
  TITLE     Angiotensin II type 1a receptor knockout ameliorates high-fat
            diet-induced cardiac dysfunction by regulating glucose and lipid
            metabolism
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 55 (9), 1380-1392 (2023)
   PUBMED   37501512
  REMARK    GeneRIF: Angiotensin II type 1a receptor knockout ameliorates
            high-fat diet-induced cardiac dysfunction by regulating glucose and
            lipid metabolism.
REFERENCE   5  (bases 1 to 2208)
  AUTHORS   Lei,L., Zhang,F., Huang,J., Yang,X., Zhou,X., Yan,H., Chen,C.,
            Zheng,S., Si,L., Jose,P.A., Zeng,C. and Yang,J.
  TITLE     Selenium deficiency causes hypertension by increasing renal AT1
            receptor expression via GPx1/H2O2/NF-kappaB pathway
  JOURNAL   Free Radic Biol Med 200, 59-72 (2023)
   PUBMED   36868433
  REMARK    GeneRIF: Selenium deficiency causes hypertension by increasing
            renal AT1 receptor expression via GPx1/H2O2/NF-kappaB pathway.
REFERENCE   6  (bases 1 to 2208)
  AUTHORS   Mauzy,C.A., Hwang,O., Egloff,A.M., Wu,L.H. and Chung,F.Z.
  TITLE     Cloning, expression, and characterization of a gene encoding the
            human angiotensin II type 1A receptor
  JOURNAL   Biochem Biophys Res Commun 186 (1), 277-284 (1992)
   PUBMED   1378723
REFERENCE   7  (bases 1 to 2208)
  AUTHORS   Bergsma,D.J., Ellis,C., Kumar,C., Nuthulaganti,P., Kersten,H.,
            Elshourbagy,N., Griffin,E., Stadel,J.M. and Aiyar,N.
  TITLE     Cloning and characterization of a human angiotensin II type 1
            receptor
  JOURNAL   Biochem Biophys Res Commun 183 (3), 989-995 (1992)
   PUBMED   1567413
REFERENCE   8  (bases 1 to 2208)
  AUTHORS   Langford,K., Frenzel,K., Martin,B.M. and Bernstein,K.E.
  TITLE     The genomic organization of the rat AT1 angiotensin receptor
  JOURNAL   Biochem Biophys Res Commun 183 (3), 1025-1032 (1992)
   PUBMED   1533121
REFERENCE   9  (bases 1 to 2208)
  AUTHORS   Iwai,N. and Inagami,T.
  TITLE     Identification of two subtypes in the rat type I angiotensin II
            receptor
  JOURNAL   FEBS Lett 298 (2-3), 257-260 (1992)
   PUBMED   1544458
REFERENCE   10 (bases 1 to 2208)
  AUTHORS   Bose,K.S. and Sarma,R.H.
  TITLE     Delineation of the intimate details of the backbone conformation of
            pyridine nucleotide coenzymes in aqueous solution
  JOURNAL   Biochem Biophys Res Commun 66 (4), 1173-1179 (1975)
   PUBMED   2
  REMARK    Erratum:[Biochem Pharmacol. 1975 Aug 15;24(16):1517-21. doi:
            10.1016/0006-2952(75)90029-5.. PMID: 8]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC078810.1.
            
            On Apr 5, 2007 this sequence version replaced NM_030985.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078810.1, CK472048.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760494, SAMN16093042
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2208
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p12"
     gene            1..2208
                     /gene="Agtr1a"
                     /gene_synonym="Agtr1; AT1; AT1A; AT1R"
                     /note="angiotensin II receptor, type 1a"
                     /db_xref="GeneID:24180"
                     /db_xref="RGD:2070"
     exon            1..129
                     /gene="Agtr1a"
                     /gene_synonym="Agtr1; AT1; AT1A; AT1R"
                     /inference="alignment:Splign:2.1.0"
     exon            130..212
                     /gene="Agtr1a"
                     /gene_synonym="Agtr1; AT1; AT1A; AT1R"
                     /inference="alignment:Splign:2.1.0"
     exon            213..2185
                     /gene="Agtr1a"
                     /gene_synonym="Agtr1; AT1; AT1A; AT1R"
                     /inference="alignment:Splign:2.1.0"
     CDS             265..1344
                     /gene="Agtr1a"
                     /gene_synonym="Agtr1; AT1; AT1A; AT1R"
                     /note="type-1A angiotensin II receptor; vascular type-1
                     angiotensin II receptor; angiotensin II type-1A receptor;
                     angiotensin receptor 1a; AT1 receptor A; angiotensin II
                     type-1 receptor A"
                     /codon_start=1
                     /product="type-1 angiotensin II receptor A"
                     /protein_id="NP_112247.2"
                     /db_xref="GeneID:24180"
                     /db_xref="RGD:2070"
                     /translation="MALNSSAEDGIKRIQDDCPKAGRHSYIFVMIPTLYSIIFVVGIF
                     GNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNHLCK
                     IASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLMAGLAS
                     LPAVIHRNVYFIENTNITVCAFHYESRNSTLPIGLGLTKNILGFLFPFLIILTSYTLI
                     WKALKKAYEIQKNKPRNDDIFRIIMAIVLFFFFSWVPHQIFTFLDVLIQLGVIHDCKI
                     SDIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPKAKSHSSLSTKM
                     STLSYRPSDNMSSSAKKPASCFEVE"
ORIGIN      
        1 gggactggat gatgctgtcc cgctggagag gattcgtggc ttgagtcctg ttccacccga
       61 tcaccgatca ccggggtggc cgaggccggt accagcgctg cggctctctc agctctgcca
      121 cattccctga gttaacatat gagagattgg tataaaatgg ctggcatttt gtctggataa
      181 atcacacaac cctcccagaa agtgatcacc aggtcaagtg gatttcgaat agtgtctgag
      241 accaactcaa cccagaaaaa caaaatggcc cttaactctt ctgctgaaga tggtatcaaa
      301 agaatccaag atgactgccc caaggctggc aggcacagtt acatatttgt catgatccct
      361 accctctaca gcatcatctt tgtggtggga atatttggaa acagcttggt ggtgattgtc
      421 atttactttt acatgaagct gaagactgtg gccagcgtct ttcttctcaa tctcgccttg
      481 gctgacttat gctttttgct gactttgccc ctgtgggcag tctataccgc tatggagtac
      541 cgctggccct tcggcaatca cctatgtaag atcgcttcgg ccagcgtgag cttcaacctc
      601 tacgccagtg tgttccttct cacgtgtctc agcatcgacc gctacctggc catcgtccac
      661 ccaatgaagt ctcgccttcg ccgcacgatg ctggtggcca aagtcacctg catcatcatc
      721 tggctgatgg ctggcttggc cagtttgcca gctgtcatcc accgaaatgt atacttcatc
      781 gagaacacca atatcacagt gtgcgcgttt cattatgagt ctcggaattc gacgctcccc
      841 atagggctgg gccttaccaa gaatattctg ggcttcttgt tccctttcct tatcattctc
      901 accagctata cccttatttg gaaagctcta aagaaggctt atgaaattca aaagaacaaa
      961 ccaagaaacg atgacatctt taggataatt atggcgattg tgcttttctt cttcttttcc
     1021 tgggtccccc accaaatatt cactttcctg gatgtgctga ttcagctggg cgtcatccat
     1081 gactgtaaaa tttctgacat cgtggacact gccatgccca tcaccatctg catagcgtat
     1141 tttaacaact gcctgaaccc tctgttctac ggctttctgg ggaagaaatt taaaaagtat
     1201 ttcctccagc tcctgaaata tattccccca aaggccaagt cccactcaag cctgtctacg
     1261 aaaatgagca cgctttctta ccggccttcg gataacatga gctcatcggc caaaaagcct
     1321 gcgtcttgtt ttgaggtgga gtgacaggtt caaagcacac tggcaatgta atgccctgac
     1381 agaagccagg gcagcctctg actaaatggc ttacgaccaa aggaccattc accctgcctc
     1441 aggatctaag cagaaaatgc gctcatcaga ctgtagataa tgactaaaac tctgagagaa
     1501 gactttgaag gagtaaccaa gcaaagccgt cttgcattaa tagatgatgg ctagccaaag
     1561 gaagagtcag gagctggatg gattggtggg tctggaaaac agttcgctgg cagaaatgca
     1621 atctcatcag tctccctttg ctatgttcct tttgatttcc acacgtaggt atgtggccca
     1681 tgctaaatat ttaggcaaga aacaagagat ggaaatcaag gtcacttgtt ctgttcaact
     1741 cccaaagggc aaggaacctt tgttgtccct gtagtcatta gcagtggaga cccacttgtc
     1801 actgttacta cacctatcgt gcaaagattt gctaatctgt agttatcaag tttcaggact
     1861 cctttgtaaa attcagccag tgttttagaa acatgtactg tccccagaca atgctagcca
     1921 gtggtgtact tatgtagcag tgttacccaa gtccacacat caaagtcaca ctgctttaat
     1981 aacgtgacat actaggtaca tctgcgttat ttcgcatctg agaaatgtac acagtcagag
     2041 gtgaatacac tatattccat acagtctgcc ttgctctcta aaaatatata ttctccacat
     2101 acgtgaacat ctttatctct aaactgtcat ttgatgaaat tttggcaatg tatgtttacc
     2161 tctaaataaa gtaattttat tgtaaaaaaa aaaaaaaaaa aaaaaaaa
//
