LOCUS       NM_134432               1958 bp    mRNA    linear   ROD 17-SEP-2024
DEFINITION  Rattus norvegicus angiotensinogen (Agt), mRNA.
ACCESSION   NM_134432
VERSION     NM_134432.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1958)
  AUTHORS   Toth,D.D., Souder,C.L. 2nd, Patuel,S., English,C.D., Konig,I.,
            Ivantsova,E., Malphurs,W., Watkins,J., Anne Costa,K., Bowden,J.A.,
            Zubcevic,J. and Martyniuk,C.J.
  TITLE     Angiotensin II Alters Mitochondrial Membrane Potential and Lipid
            Metabolism in Rat Colonic Epithelial Cells
  JOURNAL   Biomolecules 14 (8), 974 (2024)
   PUBMED   39199363
  REMARK    GeneRIF: Angiotensin II Alters Mitochondrial Membrane Potential and
            Lipid Metabolism in Rat Colonic Epithelial Cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1958)
  AUTHORS   Zhang,W., Cai,S., Wu,F., Luo,Y., Xiao,H., Yu,D., Zhong,X., Tao,P.
            and Huang,S.
  TITLE     Combining experiments and bioinformatics to identify transforming
            growth factor-beta1 as a key regulator in angiotensin II-induced
            trophoblast senescence
  JOURNAL   Placenta 152, 31-38 (2024)
   PUBMED   38781757
  REMARK    GeneRIF: Combining experiments and bioinformatics to identify
            transforming growth factor-beta1 as a key regulator in angiotensin
            II-induced trophoblast senescence.
REFERENCE   3  (bases 1 to 1958)
  AUTHORS   Marunouchi,T., Onda,S., Kurasawa,M. and Tanonaka,K.
  TITLE     Angiotensin II Is Involved in MLKL Activation During the
            Development of Heart Failure Following Myocardial Infarction in
            Rats
  JOURNAL   Biol Pharm Bull 47 (4), 809-817 (2024)
   PUBMED   38583954
  REMARK    GeneRIF: Angiotensin II Is Involved in MLKL Activation During the
            Development of Heart Failure Following Myocardial Infarction in
            Rats.
REFERENCE   4  (bases 1 to 1958)
  AUTHORS   Paes-Leme,B., Monteiro,L.D.R.N., Gholami,K., Hoe,S.Z.,
            Ferguson,A.V., Murphy,D., Antunes-Rodrigues,J., Rorato,R.,
            Reis,L.C. and Mecawi,A.S.
  TITLE     Fasting increases circulating angiotensin levels and brain Agtr1a
            expression in male rats
  JOURNAL   J Neuroendocrinol 35 (11), e13334 (2023)
   PUBMED   37667574
  REMARK    GeneRIF: Fasting increases circulating angiotensin levels and brain
            Agtr1a expression in male rats.
REFERENCE   5  (bases 1 to 1958)
  AUTHORS   Sykora,M., Kratky,V., Kopkan,L., Tribulova,N. and Szeiffova
            Bacova,B.
  TITLE     Anti-Fibrotic Potential of Angiotensin (1-7) in Hemodynamically
            Overloaded Rat Heart
  JOURNAL   Int J Mol Sci 24 (4), 3490 (2023)
   PUBMED   36834901
  REMARK    GeneRIF: Anti-Fibrotic Potential of Angiotensin (1-7) in
            Hemodynamically Overloaded Rat Heart.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1958)
  AUTHORS   Jeunemaitre,X., Soubrier,F., Kotelevtsev,Y.V., Lifton,R.P.,
            Williams,C.S., Charru,A., Hunt,S.C., Hopkins,P.N., Williams,R.R.,
            Lalouel,J.M. et al.
  TITLE     Molecular basis of human hypertension: role of angiotensinogen
  JOURNAL   Cell 71 (1), 169-180 (1992)
   PUBMED   1394429
REFERENCE   7  (bases 1 to 1958)
  AUTHORS   Hermann,K., Rittweger,R. and Ring,J.
  TITLE     Urinary excretion of angiotensin I, II, arginine vasopressin and
            oxytocin in patients with anaphylactoid reactions
  JOURNAL   Clin Exp Allergy 22 (9), 845-853 (1992)
   PUBMED   1422942
REFERENCE   8  (bases 1 to 1958)
  AUTHORS   Mauzy,C.A., Hwang,O., Egloff,A.M., Wu,L.H. and Chung,F.Z.
  TITLE     Cloning, expression, and characterization of a gene encoding the
            human angiotensin II type 1A receptor
  JOURNAL   Biochem Biophys Res Commun 186 (1), 277-284 (1992)
   PUBMED   1378723
REFERENCE   9  (bases 1 to 1958)
  AUTHORS   Tucker,B.J., Mundy,C.A., Maciejewski,A.R., Printz,M.P.,
            Ziegler,M.G., Pelayo,J.C. and Blantz,R.C.
  TITLE     Changes in glomerular hemodynamic response to angiotensin II after
            subacute renal denervation in rats
  JOURNAL   J Clin Invest 78 (3), 680-688 (1986)
   PUBMED   3745432
REFERENCE   10 (bases 1 to 1958)
  AUTHORS   Ohkubo,H., Nakayama,K., Tanaka,T. and Nakanishi,S.
  TITLE     Tissue distribution of rat angiotensinogen mRNA and structural
            analysis of its heterogeneity
  JOURNAL   J Biol Chem 261 (1), 319-323 (1986)
   PUBMED   3753601
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC078741.1.
            
            On Aug 8, 2004 this sequence version replaced NM_134432.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078741.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1958
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="19"
                     /map="19q12"
     gene            1..1958
                     /gene="Agt"
                     /gene_synonym="Ang; AngII; ANRT; PAT"
                     /note="angiotensinogen"
                     /db_xref="GeneID:24179"
                     /db_xref="RGD:2069"
     exon            1..170
                     /gene="Agt"
                     /gene_synonym="Ang; AngII; ANRT; PAT"
                     /inference="alignment:Splign:2.1.0"
     exon            171..1029
                     /gene="Agt"
                     /gene_synonym="Ang; AngII; ANRT; PAT"
                     /inference="alignment:Splign:2.1.0"
     CDS             201..1634
                     /gene="Agt"
                     /gene_synonym="Ang; AngII; ANRT; PAT"
                     /note="angiotensin II; serpin A8; angiotensinogen (serpin
                     peptidase inhibitor, clade A, member 8)"
                     /codon_start=1
                     /product="angiotensinogen precursor"
                     /protein_id="NP_602308.1"
                     /db_xref="GeneID:24179"
                     /db_xref="RGD:2069"
                     /translation="MTPTGAGLKATIFCILTWVSLTAGDRVYIHPFHLLYYSKSTCAQ
                     LENPSVETLPEPTFEPVPIQAKTSPVDEKTLRDKLVLATEKLEAEDRQRAAQVAMIAN
                     FMGFRMYKMLSEARGVASGAVLSPPALFGTLVSFYLGSLDPTASQLQVLLGVPVKEGD
                     CTSRLDGHKVLTALQAVQGLLVTQGGSSSQTPLLQSTVVGLFTAPGLRLKQPFVESLG
                     PFTPAIFPRSLDLSTDPVLAAQKINRFVQAVTGWKMNLPLEGVSTDSTLFFNTYVHFQ
                     GKMRGFSQLTGLHEFWVDNSTSVSVPMLSGTGNFQHWSDAQNNFSVTRVPLGESVTLL
                     LIQPQCASDLDRVEVLVFQHDFLTWIKNPPPRAIRLTLPQLEIRGSYNLQDLLAQAKL
                     STLLGAEANLGKMGDTNPRVGEVLNSILLELQAGEEEQPTESAQQPGSPEVLDVTLSS
                     PFLFAIYERDSGALHFLGRVDNPQNVV"
     exon            1030..1297
                     /gene="Agt"
                     /gene_synonym="Ang; AngII; ANRT; PAT"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1442
                     /gene="Agt"
                     /gene_synonym="Ang; AngII; ANRT; PAT"
                     /inference="alignment:Splign:2.1.0"
     exon            1443..1934
                     /gene="Agt"
                     /gene_synonym="Ang; AngII; ANRT; PAT"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccttgctcca tcttggctaa gcctggattc ccatggtccc ccgacctggg tcctccccca
       61 gcctctgtac agagtagcct gggaatagat ccatcttcac cccctcgagt ataaataagg
      121 ctgcttggtt caccagggga tagctgtgct tgtctgggct ggagctaaag gacacacaga
      181 agcaagtcca cagatccgtg atgactccca cgggggcagg cctgaaggcc accatcttct
      241 gcatcctgac ctgggtcagc ctgacagctg gggaccgcgt atacatccac ccctttcatc
      301 tcctctacta cagcaagagc acctgcgccc agctggagaa ccccagtgtg gagacgctcc
      361 cagagccaac ctttgagcct gtgcccattc aggccaagac ctcccccgtg gatgagaaga
      421 ccctgcgaga taagctcgtg ctggccactg agaagctaga ggctgaggat cggcagcgag
      481 ctgcccaggt cgcgatgatt gccaacttca tgggtttccg catgtacaag atgctgagtg
      541 aggcaagagg tgtagccagt ggggccgtcc tctctccacc ggccctcttt ggcaccctgg
      601 tctctttcta ccttggatcg ttggatccca cggccagcca gttgcaggtg ctgctgggcg
      661 tccctgtgaa ggagggagac tgcacctccc ggctggacgg acataaggtc ctcactgccc
      721 tgcaggctgt tcagggcttg ctggtcaccc agggtggaag cagcagccag acacccctgc
      781 tacagtccac cgtggtgggc ctcttcactg ccccaggctt gcgcctaaaa cagccatttg
      841 ttgagagctt gggtcccttc acccccgcca tcttccctcg ctctctggac ttatccactg
      901 acccagttct tgctgcccag aaaatcaaca ggtttgtgca ggctgtgaca gggtggaaga
      961 tgaacttgcc actagagggg gtcagcacgg acagcaccct atttttcaac acctacgttc
     1021 acttccaagg gaagatgaga ggcttctccc agctgactgg gctccatgag ttctgggtgg
     1081 acaacagcac ctcagtgtct gtgcccatgc tctcgggcac tggcaacttc cagcactgga
     1141 gtgacgccca gaacaacttc tccgtgacac gcgtgcccct gggtgagagt gtcaccctgc
     1201 tgctgatcca gccccagtgc gcctcagatc tcgacagggt ggaggtcctc gtcttccagc
     1261 acgacttcct gacttggata aagaacccgc ctcctcgggc catccgtctg accctgccgc
     1321 agctggaaat tcggggatcc tacaacctgc aggacctgct ggctcaggcc aagctgtcta
     1381 cccttttggg tgctgaggca aatctgggca agatgggtga caccaacccc cgagtgggag
     1441 aggttctcaa cagcatcctc cttgaactcc aagcaggcga ggaggagcag cccacagagt
     1501 ctgcccagca gcctggctca cccgaggtgc tggacgtgac cctgagcagt ccgttcctgt
     1561 tcgccatcta cgagcgggac tcaggtgcgc tgcactttct gggcagagtg gataaccccc
     1621 aaaatgtggt gtgatgcctc ctgtgtagcc atggagacaa ggccagcgtc agagagctat
     1681 cctgggcaaa aatcagtgcc ttcacccctg gcttcccgtc actccttcca gcaaggcaga
     1741 ggccgtctcc ttggagatgg cgctaactga gaataaatga tgagcagcag cctcctgggg
     1801 tgtgggtttg tttggacact ggggtgagag ccaggagctg gcactctgta taggaggact
     1861 gccatcctgg aaaaaaaaaa tggaccaaac aactgtttgt gaaataaaaa aaaaaaaatt
     1921 ccctttttat ttgaaaaaaa aaaaaaaaaa aaaaaaaa
//
