LOCUS       NM_175754               7280 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus agrin (Agrn), mRNA.
ACCESSION   NM_175754
VERSION     NM_175754.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7280)
  AUTHORS   Noel,G., Tham,D.K.L., MacVicar,B.A. and Moukhles,H.
  TITLE     Agrin plays a major role in the coalescence of the aquaporin-4
            clusters induced by gamma-1-containing laminin
  JOURNAL   J Comp Neurol 528 (3), 407-418 (2020)
   PUBMED   31454080
  REMARK    GeneRIF: Agrin plays a major role in the coalescence of the
            aquaporin-4 clusters induced by gamma-1-containing laminin.
REFERENCE   2  (bases 1 to 7280)
  AUTHORS   Lv,B., Min,S., Xie,F., Yang,J. and Chen,J.
  TITLE     Alleviating Sepsis-Induced Neuromuscular Dysfunction Linked With
            Acetylcholine Receptors by Agrin
  JOURNAL   J Surg Res 241, 308-316 (2019)
   PUBMED   31055156
  REMARK    GeneRIF: Study in rat sepsis model demonstrates that agrin/MuSK
            pathway is associated with neuromuscular dysfunction and
            reexpression of gamma- and alpha7-nAChR caused by sepsis.
REFERENCE   3  (bases 1 to 7280)
  AUTHORS   Barallobre-Barreiro,J., Gupta,S.K., Zoccarato,A.,
            Kitazume-Taneike,R., Fava,M., Yin,X., Werner,T., Hirt,M.N.,
            Zampetaki,A., Viviano,A., Chong,M., Bern,M., Kourliouros,A.,
            Domenech,N., Willeit,P., Shah,A.M., Jahangiri,M., Schaefer,L.,
            Fischer,J.W., Iozzo,R.V., Viner,R., Thum,T., Heineke,J.,
            Kichler,A., Otsu,K. and Mayr,M.
  TITLE     Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin
            Activity in Human Atrial Fibrillation
  JOURNAL   Circulation 134 (11), 817-832 (2016)
   PUBMED   27559042
REFERENCE   4  (bases 1 to 7280)
  AUTHORS   Barallobre-Barreiro,J., Oklu,R., Lynch,M., Fava,M., Baig,F.,
            Yin,X., Barwari,T., Potier,D.N., Albadawi,H., Jahangiri,M.,
            Porter,K.E., Watkins,M.T., Misra,S., Stoughton,J. and Mayr,M.
  TITLE     Extracellular matrix remodelling in response to venous
            hypertension: proteomics of human varicose veins
  JOURNAL   Cardiovasc Res 110 (3), 419-430 (2016)
   PUBMED   27068509
REFERENCE   5  (bases 1 to 7280)
  AUTHORS   Erasso,D., Tender,G., Levitt,R.C. and Cui,J.G.
  TITLE     Agrin requires specific proteins to selectively activate
            gamma-aminobutyric acid neurons for pain suppression
  JOURNAL   Exp Neurol 261, 646-653 (2014)
   PUBMED   25151458
REFERENCE   6  (bases 1 to 7280)
  AUTHORS   Glass,D.J., Bowen,D.C., Stitt,T.N., Radziejewski,C., Bruno,J.,
            Ryan,T.E., Gies,D.R., Shah,S., Mattsson,K., Burden,S.J.,
            DiStefano,P.S., Valenzuela,D.M., DeChiara,T.M. and Yancopoulos,G.D.
  TITLE     Agrin acts via a MuSK receptor complex
  JOURNAL   Cell 85 (4), 513-523 (1996)
   PUBMED   8653787
REFERENCE   7  (bases 1 to 7280)
  AUTHORS   Noakes,P.G., Miner,J.H., Gautam,M., Cunningham,J.M., Sanes,J.R. and
            Merlie,J.P.
  TITLE     The renal glomerulus of mice lacking s-laminin/laminin beta 2:
            nephrosis despite molecular compensation by laminin beta 1
  JOURNAL   Nat Genet 10 (4), 400-406 (1995)
   PUBMED   7670489
REFERENCE   8  (bases 1 to 7280)
  AUTHORS   Gee,S.H., Montanaro,F., Lindenbaum,M.H. and Carbonetto,S.
  TITLE     Dystroglycan-alpha, a dystrophin-associated glycoprotein, is a
            functional agrin receptor
  JOURNAL   Cell 77 (5), 675-686 (1994)
   PUBMED   8205617
REFERENCE   9  (bases 1 to 7280)
  AUTHORS   Rupp,F., Ozcelik,T., Linial,M., Peterson,K., Francke,U. and
            Scheller,R.
  TITLE     Structure and chromosomal localization of the mammalian agrin gene
  JOURNAL   J Neurosci 12 (9), 3535-3544 (1992)
   PUBMED   1326608
REFERENCE   10 (bases 1 to 7280)
  AUTHORS   Rupp,F., Payan,D.G., Magill-Solc,C., Cowan,D.M. and Scheller,R.H.
  TITLE     Structure and expression of a rat agrin
  JOURNAL   Neuron 6 (5), 811-823 (1991)
   PUBMED   1851019
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            [WARNING] On Apr 23, 2024 this sequence was replaced by
            NM_175754.3.
            
            On Nov 27, 2020 this sequence version replaced NM_175754.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M64780.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760386,
                                           SAMEA5760393 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-349               JAXUCZ010000005.1  172052477-172052825 c
            350-397             JAXUCZ010000005.1  172051996-172052043 c
            398-613             JAXUCZ010000005.1  172046283-172046498 c
            614-838             JAXUCZ010000005.1  172045989-172046213 c
            839-1063            JAXUCZ010000005.1  172045673-172045897 c
            1064-1270           JAXUCZ010000005.1  172045329-172045535 c
            1271-1489           JAXUCZ010000005.1  172044124-172044342 c
            1490-1684           JAXUCZ010000005.1  172043857-172044051 c
            1685-1885           JAXUCZ010000005.1  172043578-172043778 c
            1886-2034           JAXUCZ010000005.1  172043347-172043495 c
            2035-2140           JAXUCZ010000005.1  172043156-172043261 c
            2141-2257           JAXUCZ010000005.1  172042034-172042150 c
            2258-2422           JAXUCZ010000005.1  172041792-172041956 c
            2423-2566           JAXUCZ010000005.1  172041505-172041648 c
            2567-2691           JAXUCZ010000005.1  172041289-172041413 c
            2692-2797           JAXUCZ010000005.1  172041110-172041215 c
            2798-3130           JAXUCZ010000005.1  172040700-172041032 c
            3131-3268           JAXUCZ010000005.1  172040458-172040595 c
            3269-3396           JAXUCZ010000005.1  172039909-172040036 c
            3397-3511           JAXUCZ010000005.1  172039679-172039793 c
            3512-3631           JAXUCZ010000005.1  172039477-172039596 c
            3632-3979           JAXUCZ010000005.1  172039017-172039364 c
            3980-4172           JAXUCZ010000005.1  172038738-172038930 c
            4173-4388           JAXUCZ010000005.1  172038368-172038583 c
            4389-4618           JAXUCZ010000005.1  172037769-172037998 c
            4619-4753           JAXUCZ010000005.1  172037547-172037681 c
            4754-4850           JAXUCZ010000005.1  172037282-172037378 c
            4851-5015           JAXUCZ010000005.1  172037033-172037197 c
            5016-5127           JAXUCZ010000005.1  172036759-172036870 c
            5128-5139           JAXUCZ010000005.1  172036535-172036546 c
            5140-5256           JAXUCZ010000005.1  172036208-172036324 c
            5257-5449           JAXUCZ010000005.1  172035869-172036061 c
            5450-5537           JAXUCZ010000005.1  172035698-172035785 c
            5538-5762           JAXUCZ010000005.1  172033574-172033798 c
            5763-5866           JAXUCZ010000005.1  172033192-172033295 c
            5867-7280           JAXUCZ010000005.1  172031528-172032941 c
FEATURES             Location/Qualifiers
     source          1..7280
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..7280
                     /gene="Agrn"
                     /gene_synonym="AGR"
                     /note="agrin"
                     /db_xref="GeneID:25592"
                     /db_xref="RGD:2067"
     exon            1..349
                     /gene="Agrn"
                     /gene_synonym="AGR"
                     /inference="alignment:Splign:2.1.0"
     CDS             202..6024
                     /gene="Agrn"
                     /gene_synonym="AGR"
                     /codon_start=1
                     /product="agrin"
                     /protein_id="NP_786930.2"
                     /db_xref="GeneID:25592"
                     /db_xref="RGD:2067"
                     /translation="MPPLPLEHRPRQEPGASMLVRYFMIPCNICLILLATSTLGFAVL
                     LFLSNYKPGIHFTPAPPTPPDVCRGMLCGFGAVCEPSVEDPGRASCVCKKNACPATVA
                     PVCGSDASTYSNECELQRAQCNQQRRIRLLRQGPCGSRDPCANVTCSFGSTCVPSADG
                     QTASCLCPTTCFGAPDGTVCGSDGVDYPSECQLLSHACASQEHIFKKFNGPCDPCQGS
                     MSDLNHICRVNPRTRHPEMLLRPENCPAQHTPICGDDGVTYENDCVMSRIGATRGLLL
                     QKVRSGQCQTRDQCPETCQFNSVCLSRRGRPHCSCDRVTCDGSYRPVCAQDGHTYNND
                     CWRQQAECRQQRAIPPKHQGPCDQTPSPCHGVQCAFGAVCTVKNGKAECECQRVCSGI
                     YDPVCGSDGVTYGSVCELESMACTLGREIQVARRGPCDPCGQCRFGSLCEVETGRCVC
                     PSECVESAQPVCGSDGHTYASECELHVHACTHQISLYVASAGHCQTCGEKVCTFGAVC
                     SAGQCVCPRCEHPPPGPVCGSDGVTYLSACELREAACQQQVQIEEAHAGPCEPAECGS
                     GGSGSGEDDECEQELCRQRGGIWDEDSEDGPCVCDFSCQSVPRSPVCGSDGVTYGTEC
                     DLKKARCESQQELYVAAQGACRGPTLAPLLPVAFPHCAQTPYGCCQDNFTAAQGVGLA
                     GCPSTCHCNPHGSYSGTCDPATGQCSCRPGVGGLRCDRCEPGFWNFRGIVTDGHSGCT
                     PCSCDPRGAVRDDCEQMTGLCSCRPGVAGPKCGQCPDGQVLGHLGCEADPMTPVTCVE
                     IHCEFGASCVEKAGFAQCICPTLTCPEANSTKVCGSDGVTYGNECQLKAIACRQRLDI
                     STQSLGPCQESVTPGASPTSASMTTPRHILSKTLPFPHNSLPLSPGSTTHDWPTPLPI
                     SPHTTVSIPRSTAWPVLTVPPTAAASDVTSLATSIFSESGSANGSGDEELSGDEEASG
                     GGSGGLEPPVGSIVVTHGPPIERASCYNSPLGCCSDGKTPSLDSEGSNCPATKAFQGV
                     LELEGVEGQELFYTPEMADPKSELFGETARSIESTLDDLFRNSDVKKDFWSVRLRELG
                     PGKLVRAIVDVHFDPTTAFQASDVGQALLRQIQVSRPWALAVRRPLQEHVRFLDFDWF
                     PTFFTGAATGTTAAMATARATTVSRLPASSVTPRVYPSHTSRPVGRTTAPPTTRRPPT
                     TATNMDRPRTPGHQQPSKSCDSQPCLHGGTCQDQDSGKGFTCSCTAGRGGSVCEKVQP
                     PSMPAFKGHSFLAFPTLRAYHTLRLALEFRALETEGLLLYNGNARGKDFLALALLDGR
                     VQFRFDTGSGPAVLTSLVPVEPGRWHRLELSRHWRQGTLSVDGETPVVGESPSGTDGL
                     NLDTNLYVGGIPEEQVAMVLDRTSVGVGLKGCIRMLDINNQQLELSDWQRAAVQSSGV
                     GECGDHPCLPNPCHGGALCQALEAGMFLCQCPPGRFGPTCADEKSPCQPNPCHGAAPC
                     RVLSSGGAKCECPLGRSGTFCQTVLETAGSRPFLADFNGFSYLELKGLHTFERDLGEK
                     MALEMVFLARGPSGLLLYNGQKTDGKGDFVSLALHNRHLEFCYDLGKGAAVIRSKEPI
                     ALGTWVRVFLERNGRKGALQVGDGPRVLGESPKSRKVPHTMLNLKEPLYIGGAPDFSK
                     LARGAAVSSGFNGVIQLVSLRGHQLLTQEHVLRAVDVSPFADHPCTQALGNPCLNGGS
                     CVPREATYECLCPGGFSGLHCEKGLVEKSVGDLETLAFDGRTYIEYLNAVIESEKALQ
                     SNHFELSLRTEATQGLVLWIGKAAERADYMALAIVDGHLQLSYDLGSQPVVLRSTVKV
                     NTNRWLRIRAHREHREGSLQVGNEAPVTGSSPLGATQLDTDGALWLGGLQKLPVGQAL
                     PKAYGTGFVGCLRDVVVGHRQLHLLEDAVTKPELRPCPTP"
     exon            350..397
                     /gene="Agrn"
                     /gene_synonym="AGR"
                     /inference="alignment:Splign:2.1.0"
     exon            398..613
                     /gene="Agrn"
                     /gene_synonym="AGR"
                     /inference="alignment:Splign:2.1.0"
     exon            614..838
                     /gene="Agrn"
                     /gene_synonym="AGR"
                     /inference="alignment:Splign:2.1.0"
     exon            839..1063
                     /gene="Agrn"
                     /gene_synonym="AGR"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1270
                     /gene="Agrn"
                     /gene_synonym="AGR"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1489
                     /gene="Agrn"
                     /gene_synonym="AGR"
                     /inference="alignment:Splign:2.1.0"
     exon            1490..1684
                     /gene="Agrn"
                     /gene_synonym="AGR"
                     /inference="alignment:Splign:2.1.0"
     exon            1685..1885
                     /gene="Agrn"
                     /gene_synonym="AGR"
                     /inference="alignment:Splign:2.1.0"
     exon            1886..2034
                     /gene="Agrn"
                     /gene_synonym="AGR"
                     /inference="alignment:Splign:2.1.0"
     exon            2035..2140
                     /gene="Agrn"
                     /gene_synonym="AGR"
                     /inference="alignment:Splign:2.1.0"
     exon            2141..2257
                     /gene="Agrn"
                     /gene_synonym="AGR"
                     /inference="alignment:Splign:2.1.0"
     exon            2258..2422
                     /gene="Agrn"
                     /gene_synonym="AGR"
                     /inference="alignment:Splign:2.1.0"
     exon            2423..2566
                     /gene="Agrn"
                     /gene_synonym="AGR"
                     /inference="alignment:Splign:2.1.0"
     exon            2567..2691
                     /gene="Agrn"
                     /gene_synonym="AGR"
                     /inference="alignment:Splign:2.1.0"
     exon            2692..2797
                     /gene="Agrn"
                     /gene_synonym="AGR"
                     /inference="alignment:Splign:2.1.0"
     exon            2798..3130
                     /gene="Agrn"
                     /gene_synonym="AGR"
                     /inference="alignment:Splign:2.1.0"
     exon            3131..3268
                     /gene="Agrn"
                     /gene_synonym="AGR"
                     /inference="alignment:Splign:2.1.0"
     exon            3269..3396
                     /gene="Agrn"
                     /gene_synonym="AGR"
                     /inference="alignment:Splign:2.1.0"
     exon            3397..3511
                     /gene="Agrn"
                     /gene_synonym="AGR"
                     /inference="alignment:Splign:2.1.0"
     exon            3512..3631
                     /gene="Agrn"
                     /gene_synonym="AGR"
                     /inference="alignment:Splign:2.1.0"
     exon            3632..3979
                     /gene="Agrn"
                     /gene_synonym="AGR"
                     /inference="alignment:Splign:2.1.0"
     exon            3980..4172
                     /gene="Agrn"
                     /gene_synonym="AGR"
                     /inference="alignment:Splign:2.1.0"
     exon            4173..4388
                     /gene="Agrn"
                     /gene_synonym="AGR"
                     /inference="alignment:Splign:2.1.0"
     exon            4389..4618
                     /gene="Agrn"
                     /gene_synonym="AGR"
                     /inference="alignment:Splign:2.1.0"
     exon            4619..4753
                     /gene="Agrn"
                     /gene_synonym="AGR"
                     /inference="alignment:Splign:2.1.0"
     exon            4754..4850
                     /gene="Agrn"
                     /gene_synonym="AGR"
                     /inference="alignment:Splign:2.1.0"
     exon            4851..5015
                     /gene="Agrn"
                     /gene_synonym="AGR"
                     /inference="alignment:Splign:2.1.0"
     exon            5016..5127
                     /gene="Agrn"
                     /gene_synonym="AGR"
                     /inference="alignment:Splign:2.1.0"
     exon            5128..5139
                     /gene="Agrn"
                     /gene_synonym="AGR"
                     /inference="alignment:Splign:2.1.0"
     exon            5140..5256
                     /gene="Agrn"
                     /gene_synonym="AGR"
                     /inference="alignment:Splign:2.1.0"
     exon            5257..5449
                     /gene="Agrn"
                     /gene_synonym="AGR"
                     /inference="alignment:Splign:2.1.0"
     exon            5450..5537
                     /gene="Agrn"
                     /gene_synonym="AGR"
                     /inference="alignment:Splign:2.1.0"
     exon            5538..5762
                     /gene="Agrn"
                     /gene_synonym="AGR"
                     /inference="alignment:Splign:2.1.0"
     exon            5763..5866
                     /gene="Agrn"
                     /gene_synonym="AGR"
                     /inference="alignment:Splign:2.1.0"
     exon            5867..7280
                     /gene="Agrn"
                     /gene_synonym="AGR"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgcttatctc ctaccatgaa cctggagggc tggggagagg acctggtgct cccctagcca
       61 taactggcta aactttgaga tcacagctgc atctgctgct ccagagcacc cagcatgggg
      121 ggagtagctc cgaagaggcc taagggcact ccataagaac tcccacacac acccaggaat
      181 tgggctcgag ctgtatgtat catgcctcct ctgccactgg aacacagacc caggcaggag
      241 cctggtgcct ccatgctggt tcgatacttc atgatcccct gcaacatctg cttgatcctg
      301 ttggccactt ccacattggg ctttgcggtt ctgcttttcc tcagcaacta caaacctgga
      361 atccacttca caccagcgcc tcctacgcct cctgatgtat gcaggggaat gttatgtggc
      421 tttggtgctg tgtgtgaacc tagtgttgag gatccaggcc gtgcctcctg tgtgtgcaag
      481 aagaatgctt gccctgctac ggtggctcct gtgtgtggct cagatgcctc cacctatagc
      541 aacgagtgcg agctgcagcg cgcgcagtgc aaccagcaac ggcgcatccg cctgcttcgc
      601 caagggccat gtgggtcccg ggacccctgt gccaacgtga cctgcagttt cggtagtacc
      661 tgtgtacctt cggctgacgg acagactgcc tcatgtctgt gtcctacaac ctgcttcggg
      721 gcccctgatg gcacagtgtg tggcagtgac ggtgttgact accctagtga atgccagctg
      781 cttagtcatg cctgtgccag ccaggagcac atcttcaaga agttcaatgg tccttgtgat
      841 ccctgccagg gcagcatgtc agacctgaac cacatttgcc gtgtgaaccc acgtacacgg
      901 cacccagaaa tgcttctgcg gcctgagaac tgccctgccc agcacacgcc tatctgtgga
      961 gatgatgggg tcacctatga aaacgactgt gtcatgagcc gtataggtgc aacccgtggc
     1021 ctgcttctcc agaaagtacg ctctggtcaa tgccaaactc gagaccagtg cccggagacc
     1081 tgccagttta actccgtatg cctgtcccgc cgtggccgtc cccactgttc ctgcgatcgt
     1141 gtcacctgtg atgggtctta caggcctgtg tgtgcccaag atgggcacac atacaacaat
     1201 gactgttggc gccaacaggc tgagtgtcga caacagcggg ccattcctcc caagcaccag
     1261 ggcccgtgtg accagacccc gtccccatgc catggagtgc aatgtgcatt tggggcagta
     1321 tgcacagtga agaacgggaa agccgagtgt gagtgccagc gggtgtgctc cggcatctac
     1381 gatcctgtgt gcggcagtga cggtgtcact tacggcagtg tgtgcgagct ggaatccatg
     1441 gcctgtaccc ttgggcggga aatccaagtg gcccgcagag gaccctgtga cccatgtggg
     1501 cagtgccgtt ttggatccct gtgcgaggtg gaaactggac gctgtgtgtg cccctctgag
     1561 tgtgtggagt cagcccagcc cgtatgcggt tctgatggac acacatacgc tagtgaatgt
     1621 gagctgcatg tccacgcctg tacgcaccag atcagcctat acgtggcctc agctggacac
     1681 tgccagacct gtggagaaaa agtttgtact tttggggctg tgtgctcagc tggacagtgt
     1741 gtatgtcccc gttgtgagca ccctccacct ggccctgtgt gtggcagtga tggtgtcacc
     1801 tacctcagtg cctgtgagct acgcgaagct gcctgtcagc agcaggtaca aattgaggag
     1861 gcccatgcag ggccatgtga gccggctgag tgtggctcag ggggctctgg ttctggggag
     1921 gacgacgagt gtgaacagga gctatgccgg cagcgtggtg gtatctggga cgaggactca
     1981 gaagatgggc catgtgtctg tgactttagc tgccagagtg tccctagaag cccagtgtgt
     2041 ggctcggatg gagtcaccta tggcaccgag tgtgatctga agaaggccag gtgcgaatca
     2101 cagcaagaac tgtacgttgc tgctcaggga gcctgccgtg gccctacctt ggctccactg
     2161 ctacctgtgg ccttcccaca ctgtgcccaa accccctatg gctgctgcca ggacaatttc
     2221 actgctgccc agggtgtggg cttggctggc tgtcccagca cctgccattg caacccccat
     2281 ggctcctaca gtggcacttg tgacccagcc acagggcagt gctcctgccg accaggtgta
     2341 ggaggcctca ggtgtgatcg ctgtgaacct ggcttctgga acttccgtgg catcgtcacc
     2401 gatggacata gtggttgcac tccctgcagc tgcgaccctc ggggtgccgt aagggatgac
     2461 tgtgaacaga tgactggatt gtgttcctgt aggcctggtg tggctggtcc caagtgtgga
     2521 cagtgtccag atggtcaagt cctgggccat ctaggctgtg aagcagatcc catgacacct
     2581 gtgacttgtg tggagataca ctgcgagttc ggggcctcct gcgtagagaa ggctggtttt
     2641 gcccaatgta tctgcccaac cctcacatgt ccagaggcta actctaccaa ggtctgcgga
     2701 tcagacggtg tgacatatgg caatgaatgc cagctgaagg ccattgcctg ccgccagcgt
     2761 ctggacatct ccactcagag tcttggtccc tgccaggaga gtgttactcc tggggcttcc
     2821 ccaacatctg catctatgac taccccaagg catatcctga gcaagacgct gccatttccc
     2881 cacaacagcc ttcctctgtc tcccggcagt actacccatg attggcccac cccattaccc
     2941 atatcacctc acaccacagt cagcatcccc agaagcaccg cgtggcctgt gctgaccgtg
     3001 ccccctacag cagcagcctc tgacgtaacc agtctcgcaa catcaatctt cagtgaatcc
     3061 ggcagcgcca atgggagtgg cgacgaggaa ctgagtggag atgaggaggc cagtgggggc
     3121 gggtctgggg gacttgagcc cccggtgggc agcattgtgg tgacccatgg gccacccatc
     3181 gagagggctt cctgctacaa ctcacctttg ggctgctgct cagatggcaa gacaccctca
     3241 ctggactccg aaggctccaa ctgtcctgct accaaggcat tccagggcgt gctggagctt
     3301 gagggggtcg agggacagga actgttctac acacctgaga tggctgaccc caagtcagag
     3361 ttgtttgggg agaccgcaag gagcattgaa agcacgctgg acgacctgtt ccggaattca
     3421 gacgtcaaga aggacttctg gagtgtccgc ctacgggaac tggggcctgg caagttggtc
     3481 cgcgccattg tggacgttca ctttgaccct accacagcct tccaggcatc agatgtgggt
     3541 caggccttgc tccgacagat ccaggtatct aggccatggg ccctggcagt gaggaggcct
     3601 ctgcaggaac atgtgcgatt cttagacttt gactggtttc ccactttctt tacgggagct
     3661 gcaacaggaa ctacagctgc tatggccaca gccagagcca ccactgtgag ccgactgccg
     3721 gcctcttccg tcaccccacg agtctacccc agtcacacca gccggcctgt tggcagaact
     3781 acagcaccac caaccactcg ccggccacca accactgcca ccaacatgga ccggcctcgg
     3841 accccaggcc atcaacagcc ctcaaagtcc tgtgattccc aaccttgcct ccatggaggt
     3901 acctgccagg accaggattc tggcaagggt ttcacctgca gctgtactgc aggcaggggt
     3961 ggctctgtct gtgagaaagt acaacccccc tccatgccag cttttaaggg ccactccttc
     4021 ttggccttcc ccaccctccg agcctaccac acactgcgcc tagcactgga attccgggct
     4081 ttggagacag agggactgct actctacaat ggcaatgcac gtggcaaaga tttcctggct
     4141 ctggctctgt tggatgggcg tgtgcagttc aggtttgaca caggctcagg gccagcagtg
     4201 ctaacgagct tagtgccagt ggaaccagga cggtggcacc gcctcgagtt gtcacggcat
     4261 tggcgtcagg gcacactttc tgtggatggc gagactcctg ttgtaggtga aagtcccagt
     4321 ggcaccgatg gcctcaactt ggacacgaac ctctatgtgg gtggtatccc agaagaacaa
     4381 gttgccatgg tgcttgatcg gacctctgtg ggcgttggcc tgaaaggatg cattcgtatg
     4441 ctggatatca acaatcagca gctggagctt agcgactggc agagggctgc ggttcaaagc
     4501 tctggtgtgg gagaatgtgg agaccatccg tgcttaccta acccctgcca tggtggggcc
     4561 ctatgccagg cactggaggc tggcatgttc ctctgtcagt gcccgcctgg ccgctttggc
     4621 ccaacttgtg cagatgaaaa gagcccctgc cagccgaacc cctgccatgg ggcagccccc
     4681 tgtcgtgtgc tttccagcgg tggggccaag tgcgagtgcc ccctgggacg cagtggtacc
     4741 ttctgtcaga cagtcctgga gactgctggc tcccggccct tcctggctga ctttaatggc
     4801 ttctcctacc tggaactgaa aggcttgcac accttcgaga gagacctagg ggagaagatg
     4861 gcgctggaga tggtgttctt ggctcgtggg cccagtggct tactcctcta caatgggcag
     4921 aagacagatg gcaaggggga ctttgtatcc ctggccctgc ataaccggca cctagagttc
     4981 tgctatgacc ttggcaaggg ggctgcagtc atcaggagca aagagcccat agccctggga
     5041 acctgggtca gggtattcct ggaacgaaat ggccgcaagg gtgcccttca agtgggtgat
     5101 ggtccccgtg tgctagggga atctccgaaa tcccgcaagg ttccgcacac catgctcaac
     5161 ctcaaggagc ctctctatat tgggggagct cctgacttca gcaagctggc caggggggct
     5221 gcagtgtcct ctggcttcaa tggtgtcatc cagctggtgt ctctaagagg ccatcaactg
     5281 ctgactcagg agcatgtgtt gcgggcagta gatgtctcac cttttgcaga ccacccttgt
     5341 acccaggcct tgggcaaccc ctgccttaat gggggctcgt gtgtcccgag ggaagccact
     5401 tatgaatgcc tgtgtcctgg gggcttctct gggctgcact gcgaaaaggg gctagttgag
     5461 aagtcagtgg gggacctaga aacactggcc tttgatgggc ggacctacat cgaatacctc
     5521 aatgctgtga ttgagagtga gaaggcactg cagagcaacc actttgaact gagcttacgc
     5581 actgaggcca ctcaggggct ggtgctgtgg attggcaagg ctgcagaacg tgcagattac
     5641 atggccctgg ccatcgtgga cgggcacctg caactgagct atgacctagg ttcccagcca
     5701 gttgtgctgc gctccactgt gaaggtcaac accaaccgct ggcttcgaat cagggctcac
     5761 agggagcaca gggaaggttc ccttcaggtg ggcaatgaag cccctgtgac tggatcttcc
     5821 ccattgggtg ccacgcaact ggacacagat ggagccctgt ggcttggagg cctgcagaag
     5881 cttcctgtgg ggcaggctct acccaaggcc tatggcacag gttttgtggg ctgtctgcgg
     5941 gacgtggtag tgggccatcg ccagttgcat ctgctggagg acgctgtcac caaaccagag
     6001 ctaagaccct gccccactcc ctgagctgcc accagagctg ccaccttccc tactgtaatt
     6061 attttctatt tttgtaaact tgttgcattt ttatatgatt tttttgactg cacgttggcc
     6121 agaaggactg ctggcctggc ctcctttccg tccgggcagc tgtgctgcag agacaaagtg
     6181 gtgctaaggg actcttaagt agaccgtagc acctagagcc ctgggctttg aaggcagcct
     6241 taggacacac tcctctgcct aaggtaccgt gcctcagccc cttgcactgt atgttcctac
     6301 ctgtccactt gtattggtcc tttgggtctc ctggcccatt gctaggccct gtttgtgtgt
     6361 tattaatgtg ttattggatg agaactgtat ccctgagcag gagggtgctg ttggggttga
     6421 gggggccctt cattaaacca agtaacattg ggtcctttgt aggttcccac ttaagctgct
     6481 ctcctgtgtg tgctaagggc cagcctcacc ccaagctagc ctggacccct agtgctccct
     6541 gtgacaatac tgtgatataa aaaacctgat aattggggca tcatcttact tcccaaaatg
     6601 tgtttgcctg tccctggagg ctgtaaacag aagccaggct ccatctaggt tgtcctggct
     6661 ggtcctcagt tggccttccc cacctactca gttaccctga acatggtcat cctttcccca
     6721 aaacatcagg ccacttagga atccctaaga gggagtgcgt cactacggga tgtggttgac
     6781 ctccattgct tacctgccta agcagccagc tacatctgtc tctcaaagat gtccagccag
     6841 actcctaact atattcttca accattgatt ttgtttgatt tctgatgtgg aagtgcggtc
     6901 attcctgttc taacgcacag caaactttaa ttggtctaac gtgagggcaa cccacagttg
     6961 gtccactgta acgatggtca tccttgtttg agtgacagtt actgccgggt gtccagccaa
     7021 gggcaggtac tagaatggca gagatgacta tagagccaaa aatgactgaa actgaagcaa
     7081 ctgtctgctc ctccatcccc tatctttaat gtccagcaca gtcatctcgg gagaaaaacc
     7141 agacaaatct gggatggggg cagtctgacc ttcttcctgc ttcggtgatc aaggctagag
     7201 ggaactgcat ggtatcttgt tactaactcc agtatgtgtc aatgtcaaat accatgaaat
     7261 aaagtctgaa aaccttaaaa
//
