LOCUS       NM_001399425            6354 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus 1-acylglycerol-3-phosphate O-acyltransferase 5
            (Agpat5), transcript variant 2, mRNA.
ACCESSION   NM_001399425 XM_017600149
VERSION     NM_001399425.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6354)
  AUTHORS   Nagamachi,A., Matsui,H., Asou,H., Ozaki,Y., Aki,D., Kanai,A.,
            Takubo,K., Suda,T., Nakamura,T., Wolff,L., Honda,H. and Inaba,T.
  TITLE     Haploinsufficiency of SAMD9L, an endosome fusion facilitator,
            causes myeloid malignancies in mice mimicking human diseases with
            monosomy 7
  JOURNAL   Cancer Cell 24 (3), 305-317 (2013)
   PUBMED   24029230
REFERENCE   2  (bases 1 to 6354)
  AUTHORS   Prasad,S.S., Garg,A. and Agarwal,A.K.
  TITLE     Enzymatic activities of the human AGPAT isoform 3 and isoform 5:
            localization of AGPAT5 to mitochondria
  JOURNAL   J Lipid Res 52 (3), 451-462 (2011)
   PUBMED   21173190
REFERENCE   3  (bases 1 to 6354)
  AUTHORS   Lu,B., Jiang,Y.J., Man,M.Q., Brown,B., Elias,P.M. and Feingold,K.R.
  TITLE     Expression and regulation of 1-acyl-sn-glycerol- 3-phosphate
            acyltransferases in the epidermis
  JOURNAL   J Lipid Res 46 (11), 2448-2457 (2005)
   PUBMED   16150824
  REMARK    GeneRIF: rat AGPAT 2 and 5 mRNAs increased in parallel with both an
            increase in enzyme activity and permeability barrier formation late
            in rat epidermal development
REFERENCE   4  (bases 1 to 6354)
  AUTHORS   Lu,B., Jiang,Y.J., Zhou,Y., Xu,F.Y., Hatch,G.M. and Choy,P.C.
  TITLE     Cloning and characterization of murine 1-acyl-sn-glycerol
            3-phosphate acyltransferases and their regulation by PPARalpha in
            murine heart
  JOURNAL   Biochem J 385 (Pt 2), 469-477 (2005)
   PUBMED   15367102
REFERENCE   5  (bases 1 to 6354)
  AUTHORS   Florea,L., Di Francesco,V., Miller,J., Turner,R., Yao,A.,
            Harris,M., Walenz,B., Mobarry,C., Merkulov,G.V., Charlab,R.,
            Dew,I., Deng,Z., Istrail,S., Li,P. and Sutton,G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000016.1.
            
            On Jan 7, 2022 this sequence version replaced XM_017600149.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR21887620.113654.1,
                                           SRR21887620.114265.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN12840106,
                                           SAMN12840107 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-486               JAXUCZ010000016.1  77687663-77688148   c
            487-556             JAXUCZ010000016.1  77669317-77669386   c
            557-672             JAXUCZ010000016.1  77660275-77660390   c
            673-762             JAXUCZ010000016.1  77657805-77657894   c
            763-853             JAXUCZ010000016.1  77652663-77652753   c
            854-1015            JAXUCZ010000016.1  77650671-77650832   c
            1016-1139           JAXUCZ010000016.1  77649218-77649341   c
            1140-6354           JAXUCZ010000016.1  77641887-77647101   c
FEATURES             Location/Qualifiers
     source          1..6354
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16q12.5"
     gene            1..6354
                     /gene="Agpat5"
                     /gene_synonym="RGD1306405"
                     /note="1-acylglycerol-3-phosphate O-acyltransferase 5"
                     /db_xref="GeneID:306582"
                     /db_xref="RGD:1306405"
     exon            1..486
                     /gene="Agpat5"
                     /gene_synonym="RGD1306405"
                     /inference="alignment:Splign:2.1.0"
     CDS             268..1365
                     /gene="Agpat5"
                     /gene_synonym="RGD1306405"
                     /EC_number="2.3.1.51"
                     /note="isoform 2 is encoded by transcript variant 2;
                     1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon;
                     1-acylglycerol-3-phosphate O-acyltransferase 5
                     (lysophosphatidic acid acyltransferase, epsilon)"
                     /codon_start=1
                     /product="1-acyl-sn-glycerol-3-phosphate acyltransferase
                     epsilon isoform 2"
                     /protein_id="NP_001386354.1"
                     /db_xref="GeneID:306582"
                     /db_xref="RGD:1306405"
                     /translation="MLLSLVLHTYSMRYLLPSVLLLGSAPTYMLAWTLWRVLSALLPA
                     RLYQRVDDRLYCVYQNMVLFFFENYTGVQILLYGDLPKNKENVIYLANHQSTVDWIVA
                     DMLAARQDALGHVRYVLKDGLKWLPLYGFYFAQHGGIYVKRSAKFNDKEMRSKLQSYV
                     NAGTPMYLVIFPEGTRYNATYTKLLSASQAFAAQRGLAVLKHVLTPRIKATHVAFDSM
                     KSHLDAIYDVTVVYEGNEKNSGKYSNPPSMTEFLCKQCPRLHIHFDRIDRKEVPEEQE
                     HMKKWLHERFEIKDKLLVEFYDSPDPERRNKFPGKRVHSRLSVNKTLPSVLILGSLTA
                     AMLMTESGRKLYMGTWLYGTLLGCLWFVIKA"
     exon            487..556
                     /gene="Agpat5"
                     /gene_synonym="RGD1306405"
                     /inference="alignment:Splign:2.1.0"
     exon            557..672
                     /gene="Agpat5"
                     /gene_synonym="RGD1306405"
                     /inference="alignment:Splign:2.1.0"
     exon            673..762
                     /gene="Agpat5"
                     /gene_synonym="RGD1306405"
                     /inference="alignment:Splign:2.1.0"
     exon            763..853
                     /gene="Agpat5"
                     /gene_synonym="RGD1306405"
                     /inference="alignment:Splign:2.1.0"
     exon            854..1015
                     /gene="Agpat5"
                     /gene_synonym="RGD1306405"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1139
                     /gene="Agpat5"
                     /gene_synonym="RGD1306405"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..6354
                     /gene="Agpat5"
                     /gene_synonym="RGD1306405"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gacaggcgcg ggtcgcgcgg agcaaaagga gcacccagag gcgagcgcgc ccggcaagcc
       61 gaggcgtgcc ctttccgagg cggcgagcag gggcggtcac agtccccgcc gggtcccggg
      121 ccccgcggcc catgcggggg gcggagccag ggcggagggc ggcggcgcgg ccggccctgc
      181 gcggtgattg gcgggcggcc ggcggtggct gaggtcctgg cggccgcgcg ggcaacgcag
      241 gagagtcgcg gctggcgagc tgagaggatg ctgctgtccc tggtgctcca cacgtactct
      301 atgcgctacc tgctcccgag cgtcctgttg ctgggctcgg cgcccaccta catgctggcc
      361 tggacgctgt ggcgggtgct gtccgcgctg ctgcccgccc gtctgtacca gcgcgtggac
      421 gaccggcttt actgcgtcta ccagaacatg gtgctcttct tcttcgagaa ctacaccggg
      481 gtccagatat tgctatatgg agatttgcca aaaaataagg aaaatgtaat atatttagca
      541 aatcatcaaa gcacagttga ctggattgtt gcagacatgc tggctgcccg acaggatgct
      601 cttggacatg tgcgctatgt cctgaaagac gggttaaagt ggcttccatt gtatgggttc
      661 tactttgctc agcacggagg aatttatgta aaacgaagtg ccaaatttaa tgataaagaa
      721 atgagaagca agcttcagag ctacgtgaac gcaggaacac caatgtatct tgtgattttc
      781 ccagagggaa caaggtataa tgcaacatat acaaaactcc tctcagccag ccaggcattt
      841 gctgctcagc ggggccttgc agtattaaaa cacgtgctga caccaagaat aaaggcaact
      901 catgttgctt ttgattctat gaagagtcat ttagatgcaa tttatgatgt cacagtggtt
      961 tacgaaggga atgagaaaaa ttcaggaaaa tattcaaatc caccatccat gactgagttt
     1021 ctctgcaaac agtgcccaag acttcatatt cactttgacc gcatagacag aaaagaagtt
     1081 ccagaggaac aagaacacat gaaaaagtgg cttcatgagc gctttgagat aaaagataag
     1141 ttgctcgtag aattctatga ttcaccagat ccagaaagaa ggaacaaatt tcccgggaaa
     1201 cgcgttcact ccagactgag tgtcaacaag actttaccgt cagtgttgat cctggggagc
     1261 ttgactgcgg ccatgctcat gacggagtct ggaaggaaac tgtacatggg cacctggttg
     1321 tatggaaccc tccttggctg cctgtggttt gtcattaaag cctaagcacg tggaggctgc
     1381 agtcaccgtc tcttaccgat ggccgcacat tgcatcacac tgtttcctga gttagatacg
     1441 gatgactgaa cactggatga agtggctgac cacagccgac atgcatctga cggggcagca
     1501 catggctttt cagctgccgg gcttgctgga cacatgggag ccgagtggag cttatgctgg
     1561 ggctcttctt tttttttttt ttttttttgg tatgttttca tgaatcagtg tctacgtgta
     1621 aagatgatcg gatgctgcct gtgattttga tggctgtatt ttaacattag tttgcagtgt
     1681 gtttcgctat attggttatc ttccatttga ctacttggca gctcagactc ttaatactaa
     1741 agtattttat attttcaagc tatgtgatac tgggtttttt gttaatatct gaaagtcaat
     1801 gaaagacact gtaacaatgc gctaagatgt tccaagaaaa aggtgagacg tattcatagc
     1861 ggaaaagatc tgtctagtgt atatttttat tatattgctc tatttagcta attttcttta
     1921 tatttgcaaa ataatgaaca cttctaatat ttattaaaat gtttaatttg cataccccct
     1981 attctgcaga ggataacgtg tcaagtgtca gaatagactg gcagctcagc tctgtctcct
     2041 ttggcagagc atttagtagc ccagcctccg agcgattctg ttagtgcctc ccagtacctg
     2101 tgccattaag tacttataaa tgtaaggggc tgttaccttc atgtcagatg gacgcccacg
     2161 gagctgtaag gtgagagaag cctgccagca tcctgtctgt cctagcacgt gccttctgcc
     2221 cggctccctt tgcttttggc actgcgtttg gtctggagtg tggacgccca tggttgttcg
     2281 ctgtctgttc cagccctgac tctcaggctt ggggtcctcc agtggtgctg ttcattgttg
     2341 ggatgcgggc agtgctgctg ggccgggggt gagcctcctt ggctactgca gaagtattgt
     2401 acatttgttt atggcaagaa ccatcaggat tggataaatt tgttatttct ctttgatttc
     2461 catggagcca cactattggt ccatgtcccc tgtgaacaga gctaccttcc aggaccaaat
     2521 cacactctaa agtgtgattt gcaatatttc tatgttgtaa tttaagcgta attgcctact
     2581 agtcattgaa ggtaacattt ctgcaaactt catacagatt tttgtcacaa aattactata
     2641 ccaatgatct agttaaaata gaccaattga atcataataa ataatttttt tttaaattga
     2701 gggaaaattt gcctcttgtt tttttaaaac cagagaatga gctatttcaa acatctgcga
     2761 aagagtcatg tgctgtcact tgttttctat gtgttagtat gtatattcat gtatagatat
     2821 gtatattcac atgtgaatac gtgaatatag cagcctaaaa acagacaagc ttgtgcatca
     2881 tgttactatg ctgatggtaa tggtttttac ctgcaagggg aggttgagag tggtttcatg
     2941 tctttgttaa atacattttt tcagcagttc tattagagct tactttgacc agatcaaact
     3001 aagtgcaagt tctgagactt tgaatatggc tgaggtctag agggacagtt cagcagttaa
     3061 gagcacatgc cactgttgca agggcttcag ttcccagcac ccacatggag gctcacagaa
     3121 gacgataatt ctagctccat ggagttggac acatcctcta gcctccgtgg gaatcttaca
     3181 ctcttacaca cacacacact ttctctctct ctctctctct ctctctctct ctctctctct
     3241 cacacacaca cacacacaca cacacacaat ctttaaatat catggatgtg ctgtatatta
     3301 cactttaaga gacagaacca ttggaattac atggactgta gccgattctt ttctaacagg
     3361 gcacagtggt ctgcatatga tctcttgaat attagcactg tgcttactct cttcacaagt
     3421 agcctatcaa atgtggtagc tggaaataca ttgtatcaga atctttgaaa aattaggagc
     3481 gtatcctaaa catgttaatt ttgacttgac attactattt tctgaaatta actgtctgtg
     3541 attccttcca catagtttat gattttattt gtgttcatct tgagttacag cttagggact
     3601 gcagtcgttt tcatttgtca gactgccgcc atcagtgtgc atgcttttat gctcttcaga
     3661 aagggcactg ggatgaaagt gagaaaacaa taaagtcctt ctctctcatg tctgtgttct
     3721 ctaacatttc acaactcaga ctcacccgct ttccagatca aaaggttagt gattagcccc
     3781 ggaaagctac aatatttttt aaatattgag caaagtttaa aaaaatacat tggaataccc
     3841 caaattgtga agcgatgcag tagtcagatt atctaagcta atttgcctac ttttgggatg
     3901 tgacacctgc cctcccaagg ctttccccaa ccctggaacc tttcaggttc acttaccaag
     3961 gctggacgtg aaagtgccag cctggccagt tcttagatgc ttcgtggctt ccatatttca
     4021 tttctacttt tttcacttag atcagtgtca gattttcttt aaaacttata tctatttttt
     4081 tctttgtcat attatatgct ttatcaatca aatgacctaa ctaggttagc tattaaatct
     4141 atatattgaa atctgccaaa atgtgggcat aaataaactg gctcctaatt gtgtaccaga
     4201 tctacatttg aaaggacaga aatgtctcac aagatggtaa ggtcaaatgt aaaacactaa
     4261 actttaacct catcaattgc ttttgaagtg ttgacattaa agactgagtg gttgtggaat
     4321 gttaacatat ccatgggcag gctagtgtct ccttttcttt ttgtcttaag actaaacatt
     4381 ggctgactta aaatattacc agttctattc cgtttgcatt atagacaaaa tacgtaacat
     4441 ttaagcattg gtgtgaaaat cagtactttc atgaaactat tatttggaat atccagatgc
     4501 tttaatatta tgtaggtaag gtatttgtgt gattgactga atttaaaatc ttttattcat
     4561 acatcatgga taatagctgg gagttggcga cacatgactg caatccaggc actcagaaaa
     4621 ctcaggagga gagctctaca ttccaagtca gcctggtcta cgttcaagtt tcagactatc
     4681 caggactctg taccaagact tcaccctgcc cacacaacaa aagaggttaa atagagaatc
     4741 acttggaatt cagttgcaac attttttgtt acgatttcat ttaatgggct ggagagatgg
     4801 gtcagcagct aggatcagag tttgctcttt cagaggatgg atttcatttc cagtacctgt
     4861 ggggcagcag taactgaagt aactgtaact tcagttccag ggtatccaac accttcacac
     4921 agacacacgc aggcaaaaga ccaacatgca taaaatttaa ataaataatt aaaattattt
     4981 ttaagttttt acttgacata tttttagttt gtgtatgctg aggtagatct gttgctcttg
     5041 acaaactgag taatacatgg agtttataag aggtcagaga tctcagtttc agataatgta
     5101 ttttggttgc tacccaaaca gagaagttcc ttggaagaac cacatcgcat agaaaactga
     5161 tatcagctca gatacccagt acgtgatcag acaggccagt gttttacctg gactagtgtt
     5221 ttgtcgtatc tgaataaata aataacagac attctacaat tttataagtc ctcatatgga
     5281 aaataaaata gggaagccat tgacataatc tgttacccga agtgatcaag aaattaaatt
     5341 ccaaagtaac caagaagtgc ttggttactg ctatttccta tgtagcttca gaataaattc
     5401 cgatagtgtt actgggttca ccggtgcttt ataatccgga acagagggaa aatacgaacc
     5461 tcaatttttt ttttttatga gaatctggtg acaaaaagtt gcattgtttt attaagtgtt
     5521 ttatgtgtat gtgtctggtt tgttgccaga agctacatta tttcagatgt gtgttttgtt
     5581 tgagacttgc cgagtgctca ctgtttacca gcctggttcg ccatccaacc ttggacaact
     5641 ttaaataaag tgtgccccgg gtttatcacc tgctacaatg taagccacag tacaggcgaa
     5701 ctaattcagg taaagcagca gatgcagagc atagaaagaa tgtagccagt gctgactcag
     5761 gttctgtctt catagatgat gttcaggtca gatgagggtt tggatacata cagtctagtg
     5821 atgggatgcc atccagccct ttcctgtttg acaaggagac aatggggtat ggacgtggat
     5881 agtcctggtt atggttccga ttgtaggttt tgcttaaaat tcagatcaag tgctgtggag
     5941 agatatgtct agagaaagaa catctccatt atatgtctca tggcctctca actgctgcat
     6001 agaagctgga ttttcagggc tgggggcagg gtctgagtac tctgtgggaa tgtctgaggg
     6061 gttcctccac actgtggtaa actttagact aagtactctg tgctgatgta accttcagga
     6121 ggattcatgt cagagcttcc ctttacttct gtagtcaaga gtgtattgaa ggaggaatgt
     6181 actgtgggaa ggtcggtgtg gtgactccat ggagtgtggg gtcctatatg taaggttgca
     6241 ctcggttcag ctctacttgt caaaaataat ttgttcattg ttttctgata tatactagag
     6301 ttcagaattg tcagaaatgt tcattattaa acatttttcc ttgttaacgt aaaa
//
