LOCUS       NM_133406               1853 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus 1-acylglycerol-3-phosphate O-acyltransferase 4
            (Agpat4), mRNA.
ACCESSION   NM_133406
VERSION     NM_133406.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1853)
  AUTHORS   Bradley,R.M., Marvyn,P.M., Aristizabal Henao,J.J., Mardian,E.B.,
            George,S., Aucoin,M.G., Stark,K.D. and Duncan,R.E.
  TITLE     Acylglycerophosphate acyltransferase 4 (AGPAT4) is a mitochondrial
            lysophosphatidic acid acyltransferase that regulates brain
            phosphatidylcholine, phosphatidylethanolamine, and
            phosphatidylinositol levels
  JOURNAL   Biochim Biophys Acta 1851 (12), 1566-1576 (2015)
   PUBMED   26417903
REFERENCE   2  (bases 1 to 1853)
  AUTHORS   Eto,M., Shindou,H. and Shimizu,T.
  TITLE     A novel lysophosphatidic acid acyltransferase enzyme (LPAAT4) with
            a possible role for incorporating docosahexaenoic acid into brain
            glycerophospholipids
  JOURNAL   Biochem Biophys Res Commun 443 (2), 718-724 (2014)
   PUBMED   24333445
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Nov 26, 2020 this sequence version replaced NM_133406.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB067572.1, BC086992.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN12840107,
                                           SAMN12840108 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-127               JAXUCZ010000001.1  51180845-51180971   c
            128-385             JAXUCZ010000001.1  51148166-51148423   c
            386-555             JAXUCZ010000001.1  51095917-51096086   c
            556-717             JAXUCZ010000001.1  51085051-51085212   c
            718-871             JAXUCZ010000001.1  51084640-51084793   c
            872-974             JAXUCZ010000001.1  51081586-51081688   c
            975-1050            JAXUCZ010000001.1  51079571-51079646   c
            1051-1249           JAXUCZ010000001.1  51078001-51078199   c
            1250-1853           JAXUCZ010000001.1  51075081-51075684   c
FEATURES             Location/Qualifiers
     source          1..1853
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q11"
     gene            1..1853
                     /gene="Agpat4"
                     /note="1-acylglycerol-3-phosphate O-acyltransferase 4"
                     /db_xref="GeneID:170919"
                     /db_xref="RGD:619916"
     exon            1..127
                     /gene="Agpat4"
                     /inference="alignment:Splign:2.1.0"
     exon            128..385
                     /gene="Agpat4"
                     /inference="alignment:Splign:2.1.0"
     CDS             208..1344
                     /gene="Agpat4"
                     /EC_number="2.3.1.51"
                     /note="1-AGPAT 4; 1-AGP acyltransferase 4;
                     lysophosphatidic acid acyltransferase delta;
                     1-acylglycerol-3-phosphate O-acyltransferase 1
                     (lysophosphatidic acid acyltransferase, delta);
                     LPAAT-delta; 1-acylglycerol-3-phosphate O-acyltransferase
                     4 (lysophosphatidic acid acyltransferase, delta)"
                     /codon_start=1
                     /product="1-acyl-sn-glycerol-3-phosphate acyltransferase
                     delta"
                     /protein_id="NP_596897.1"
                     /db_xref="GeneID:170919"
                     /db_xref="RGD:619916"
                     /translation="MDLIGLLKSQFLCHLVFCYVFIASGLIVNAIQLCTLVIWPINKQ
                     LFRKINARLCYCVSSQLVMLLEWWSGTECTIYTDPKASPHYGKENAIVVLNHKFEIDF
                     LCGWSLAERLGILGNSKVLAKKELAYVPIIGWMWYFVEMIFCTRKWEQDRQTVAKSLL
                     HLRDYPEKYLFLIHCEGTRFTEKKHQISMQVAQAKGLPSLKHHLLPRTKGFAITVKCL
                     RDVVPAVYDCTLNFRNNENPTLLGVLNGKKYHADCYVRRIPMEDIPEDEDKCSAWLHK
                     LYQEKDAFQEEYYRTGVFPETPWVPPRRPWSLVNWLFWASLLLYPFFQFLVSMVSSGS
                     SVTLASLVLIFCMASMGVRWMIGVTEIDKGSAYGNIDNKRKQTD"
     exon            386..555
                     /gene="Agpat4"
                     /inference="alignment:Splign:2.1.0"
     exon            556..717
                     /gene="Agpat4"
                     /inference="alignment:Splign:2.1.0"
     exon            718..871
                     /gene="Agpat4"
                     /inference="alignment:Splign:2.1.0"
     exon            872..974
                     /gene="Agpat4"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1050
                     /gene="Agpat4"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1249
                     /gene="Agpat4"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1853
                     /gene="Agpat4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcgcttttt ctttccagtg ttggctgact tacagcttct ctaaagtaga ggcagtttct
       61 gaaccctagg ttcctgcctc gcagttctgg ctagtgagca ccaatgcaaa gagctgcccg
      121 gagcgagacg gtttcctgag ccccggatct ttctcccttc tggaactatt ccgccatacg
      181 tacttgtctc ttgagaatcc ccgcatcatg gacctcatcg ggctgctgaa gtcccagttt
      241 ctgtgtcacc tggtcttctg ctacgtgttc atcgcctccg ggctcattgt caacgccatc
      301 cagctgtgca cgctggtcat ctggcccatc aacaagcagc tgttccgaaa gataaacgcc
      361 agactctgct actgcgtctc cagccagttg gtgatgcttc tggagtggtg gtcaggtacg
      421 gagtgtacca tctacaccga cccgaaggcc tccccccact acgggaagga aaacgccatc
      481 gtggttctca atcacaagtt tgagattgac tttctctgtg gctggagcct ggctgagcgc
      541 ctagggatcc tggggaactc caaagtcctg gccaagaaag aactggctta tgtccccatc
      601 attggctgga tgtggtactt tgtggaaatg atcttctgca cacgcaagtg ggagcaagat
      661 cggcagacgg ttgccaagag cctgctgcac ctccgggact acccagagaa gtatctgttt
      721 ctgatccact gtgagggcac acggttcaca gagaagaaac accaaatcag catgcaggta
      781 gcccaagcca aggggctgcc cagcctcaag catcacctgc tgccacgcac caagggcttt
      841 gctatcactg tgaagtgctt gcgagatgtt gtcccagccg tatatgactg tacactcaat
      901 ttcagaaaca atgaaaaccc aacactgctg ggagtcttaa atggaaagaa atatcacgct
      961 gactgctacg ttaggaggat ccccatggaa gacatccctg aggatgagga caagtgctca
     1021 gcctggctac acaagctcta ccaggagaag gatgcctttc aggaggaata ctacaggaca
     1081 ggggtcttcc cagagactcc ctgggttccc ccacggcggc cctggtctct ggtcaactgg
     1141 ttgttctggg cgtcgctgct gctctatcct ttcttccagt tccttgttag catggtcagc
     1201 agcggttcct cggtgacgct ggccagcttg gtcctcatct tctgcatggc ctccatggga
     1261 gttcgatgga tgattggtgt gacagaaatc gacaagggct ctgcctatgg caacatcgac
     1321 aacaaacgga aacaaactga ctgatgtgga aaatgtcacc tccaaaggga accgtggggg
     1381 acagttggcc tctgcttagc ctttatagca gggttcagtg atggagactg gagggccttg
     1441 ctgggacaaa cagaaaccac agcccctcca gtcatggagt ttgccttggc gctggatggg
     1501 aaaggaagat ggttttatac ctttcccctc ccccatcccc gtgtgaatta ctgggtttgg
     1561 ttacgtttct tttcagttgc acacgtgttt gtgtgtatgt gtgtgtgaga gagatggggg
     1621 tgaggagaat gagtgtgtgg ttgcgtgtgc acttgtgacc ctgtgacagt agggtctgtg
     1681 aggctgcagg gaagggcagg gctggggtgg aagagaaggt gtgtgtccct gtcatcccgt
     1741 ggtgctgcgt cttctctaac catcgatcgc tggagacgga gtgaagtgtt tgggtaagac
     1801 aactaaatta tgcctccaaa taagaaaaag aattaaagtg tttgtctggg tca
//
