LOCUS       NM_001107821            1427 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus 1-acylglycerol-3-phosphate O-acyltransferase 2
            (Agpat2), mRNA.
ACCESSION   NM_001107821 XM_001074707 XM_231089
VERSION     NM_001107821.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1427)
  AUTHORS   Agarwal,A.K., Sukumaran,S., Cortes,V.A., Tunison,K., Mizrachi,D.,
            Sankella,S., Gerard,R.D., Horton,J.D. and Garg,A.
  TITLE     Human 1-acylglycerol-3-phosphate O-acyltransferase isoforms 1 and
            2: biochemical characterization and inability to rescue hepatic
            steatosis in Agpat2(-/-) gene lipodystrophic mice
  JOURNAL   J Biol Chem 286 (43), 37676-37691 (2011)
   PUBMED   21873652
REFERENCE   2  (bases 1 to 1427)
  AUTHORS   McHugh,P.C., Rogers,G.R., Glubb,D.M., Joyce,P.R. and Kennedy,M.A.
  TITLE     Proteomic analysis of rat hippocampus exposed to the antidepressant
            paroxetine
  JOURNAL   J Psychopharmacol 24 (8), 1243-1251 (2010)
   PUBMED   19346281
REFERENCE   3  (bases 1 to 1427)
  AUTHORS   Zhao,Y., Chen,Y.Q., Li,S., Konrad,R.J. and Cao,G.
  TITLE     The microsomal cardiolipin remodeling enzyme acyl-CoA
            lysocardiolipin acyltransferase is an acyltransferase of multiple
            anionic lysophospholipids
  JOURNAL   J Lipid Res 50 (5), 945-956 (2009)
   PUBMED   19075029
REFERENCE   4  (bases 1 to 1427)
  AUTHORS   Cortes,V.A., Curtis,D.E., Sukumaran,S., Shao,X., Parameswara,V.,
            Rashid,S., Smith,A.R., Ren,J., Esser,V., Hammer,R.E., Agarwal,A.K.,
            Horton,J.D. and Garg,A.
  TITLE     Molecular mechanisms of hepatic steatosis and insulin resistance in
            the AGPAT2-deficient mouse model of congenital generalized
            lipodystrophy
  JOURNAL   Cell Metab 9 (2), 165-176 (2009)
   PUBMED   19187773
REFERENCE   5  (bases 1 to 1427)
  AUTHORS   Beigneux,A.P., Vergnes,L., Qiao,X., Quatela,S., Davis,R.,
            Watkins,S.M., Coleman,R.A., Walzem,R.L., Philips,M., Reue,K. and
            Young,S.G.
  TITLE     Agpat6--a novel lipid biosynthetic gene required for
            triacylglycerol production in mammary epithelium
  JOURNAL   J Lipid Res 47 (4), 734-744 (2006)
   PUBMED   16449762
REFERENCE   6  (bases 1 to 1427)
  AUTHORS   Haque,W., Garg,A. and Agarwal,A.K.
  TITLE     Enzymatic activity of naturally occurring
            1-acylglycerol-3-phosphate-O-acyltransferase 2 mutants associated
            with congenital generalized lipodystrophy
  JOURNAL   Biochem Biophys Res Commun 327 (2), 446-453 (2005)
   PUBMED   15629135
REFERENCE   7  (bases 1 to 1427)
  AUTHORS   Lu,B., Jiang,Y.J., Zhou,Y., Xu,F.Y., Hatch,G.M. and Choy,P.C.
  TITLE     Cloning and characterization of murine 1-acyl-sn-glycerol
            3-phosphate acyltransferases and their regulation by PPARalpha in
            murine heart
  JOURNAL   Biochem J 385 (Pt 2), 469-477 (2005)
   PUBMED   15367102
REFERENCE   8  (bases 1 to 1427)
  AUTHORS   Agarwal,A.K., Arioglu,E., De Almeida,S., Akkoc,N., Taylor,S.I.,
            Bowcock,A.M., Barnes,R.I. and Garg,A.
  TITLE     AGPAT2 is mutated in congenital generalized lipodystrophy linked to
            chromosome 9q34
  JOURNAL   Nat Genet 31 (1), 21-23 (2002)
   PUBMED   11967537
REFERENCE   9  (bases 1 to 1427)
  AUTHORS   Eberhardt,C., Gray,P.W. and Tjoelker,L.W.
  TITLE     Human lysophosphatidic acid acyltransferase. cDNA cloning,
            expression, and localization to chromosome 9q34.3
  JOURNAL   J Biol Chem 272 (32), 20299-20305 (1997)
   PUBMED   9242711
REFERENCE   10 (bases 1 to 1427)
  AUTHORS   West,J., Tompkins,C.K., Balantac,N., Nudelman,E., Meengs,B.,
            White,T., Bursten,S., Coleman,J., Kumar,A., Singer,J.W. and
            Leung,D.W.
  TITLE     Cloning and expression of two human lysophosphatidic acid
            acyltransferase cDNAs that enhance cytokine-induced signaling
            responses in cells
  JOURNAL   DNA Cell Biol 16 (6), 691-701 (1997)
   PUBMED   9212163
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On Nov 4, 2022 this sequence version replaced NM_001107821.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643294.12329.1,
                                           SRR26643298.14603.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760389,
                                           SAMEA5760434 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-269               JAXUCZ010000003.1  29825889-29826157   c
            270-403             JAXUCZ010000003.1  29819030-29819163   c
            404-579             JAXUCZ010000003.1  29818170-29818345   c
            580-675             JAXUCZ010000003.1  29817965-29818060   c
            676-748             JAXUCZ010000003.1  29816548-29816620   c
            749-1427            JAXUCZ010000003.1  29814924-29815602   c
FEATURES             Location/Qualifiers
     source          1..1427
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p13"
     gene            1..1427
                     /gene="Agpat2"
                     /note="1-acylglycerol-3-phosphate O-acyltransferase 2"
                     /db_xref="GeneID:311821"
                     /db_xref="RGD:1309229"
     exon            1..269
                     /gene="Agpat2"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..924
                     /gene="Agpat2"
                     /EC_number="2.3.1.51"
                     /note="1-acylglycerol-3-phosphate O-acyltransferase 2
                     (lysophosphatidic acid acyltransferase, beta)"
                     /codon_start=1
                     /product="1-acyl-sn-glycerol-3-phosphate acyltransferase
                     beta"
                     /protein_id="NP_001101291.1"
                     /db_xref="GeneID:311821"
                     /db_xref="RGD:1309229"
                     /translation="MDPWPWLTAALLLLLLLVQLNRTARFYVKVGLYCVLCLSFSAAA
                     SIVCLLRHGGRTVDNMSIISWFVRSFKYVYGLRFEVSGQKKLEVDGPCVIISNHQSIL
                     DMMGLMEILPKRCVQIAKRELMFTGPVGLIMYLGGVYFINRQQAKTAMSLMADLGDLM
                     VKENLKVWIYPEGTRNDNGDLLPFKKGAFYLAIQAQVPIIPVVYSSFSSFYNVKTKLF
                     TSGTIRVQVLDAVPTNGLTDADVTKLVDTCYQSMRATFLQISEIPQENSTIKESGVLP
                     AQ"
     exon            270..403
                     /gene="Agpat2"
                     /inference="alignment:Splign:2.1.0"
     exon            404..579
                     /gene="Agpat2"
                     /inference="alignment:Splign:2.1.0"
     exon            580..675
                     /gene="Agpat2"
                     /inference="alignment:Splign:2.1.0"
     exon            676..748
                     /gene="Agpat2"
                     /inference="alignment:Splign:2.1.0"
     exon            749..1427
                     /gene="Agpat2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcccggccc gccctctacc ctcggcgctc ctcaaaaggg gcgcgggcgg cggacagcgg
       61 cgccgtcggg gctggggtgc ggccgccatg gacccgtggc cgtggctgac ggcggcgctg
      121 ctgctgctgt tgctgcttgt gcagctgaac cgcacagcca ggttctacgt caaggtcggt
      181 ctctactgcg tgctctgcct gtccttctcc gccgcggcct cgatcgtctg cctgctgcgc
      241 cacggcggcc gcaccgtgga taacatgagc atcatcagct ggtttgttcg gtccttcaag
      301 tacgtgtatg gccttcgctt tgaggtcagc ggacagaaga aactggaggt ggacggtccc
      361 tgtgtcatca tttctaatca ccagagcatc ctagacatga tgggtctcat ggaaatactc
      421 cctaagcgct gtgtgcagat tgccaagcgt gagctaatgt tcacaggacc cgtgggcctc
      481 atcatgtacc tagggggtgt ctatttcatc aaccgccagc aagccaaaac tgccatgtcc
      541 ttgatggccg acctaggcga cctcatggtc aaggagaacc tcaaagtgtg gatttaccca
      601 gagggtacac gcaacgacaa tggagacctg ttgcccttta aaaaaggtgc cttctacttg
      661 gccatccagg cccaggtacc catcatccct gtggtgtact cctccttttc ctccttctac
      721 aatgttaaga cgaagctctt cacctcagga acgatcaggg tacaagtgct ggatgctgtc
      781 cctaccaatg gccttacgga tgctgatgtc accaaacttg tggacacttg ctaccagtcc
      841 atgagagcca cctttctaca gatttctgag attccccaag agaactctac cattaaggag
      901 tctggggtct tgccagccca gtagcccagg ctacaggacc aggggagctg ggggaagacc
      961 aatgggaagc agaggctgaa gagtggacag aaggccgcag cctcccactt accaagcatc
     1021 atcatagcct gctcccgtgc tggcctggct ctccctgggg cctggaatca ggaagcccct
     1081 tctggcatag gccttaaacc caggacccta tgtaatttcc catctcgagc ctgtgcctcc
     1141 agaatccagc aagagggctg acccacaaga ccacgaggca cctaggaatg ggcaacgcat
     1201 tacccaaggc ccaccccatc atgcaggaca aacattcagg aaccaggcag tggcctgtat
     1261 caggccatca tgaagaggag gaacttggtc ttccagtctc aaggaagccg gttcacatag
     1321 caccagaggg cagagcctgc cacccccacc gtctgacggc ctcagtcaca aatcactgct
     1381 gtactttggt tctttttttt ataaatgaac tcagaagtgc ctagaga
//
