LOCUS       NP_001101291             278 aa            linear   ROD 30-MAR-2024
DEFINITION  1-acyl-sn-glycerol-3-phosphate acyltransferase beta [Rattus
            norvegicus].
ACCESSION   NP_001101291 XP_001074707 XP_231089
VERSION     NP_001101291.1
DBSOURCE    REFSEQ: accession NM_001107821.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 278)
  AUTHORS   Agarwal,A.K., Sukumaran,S., Cortes,V.A., Tunison,K., Mizrachi,D.,
            Sankella,S., Gerard,R.D., Horton,J.D. and Garg,A.
  TITLE     Human 1-acylglycerol-3-phosphate O-acyltransferase isoforms 1 and
            2: biochemical characterization and inability to rescue hepatic
            steatosis in Agpat2(-/-) gene lipodystrophic mice
  JOURNAL   J Biol Chem 286 (43), 37676-37691 (2011)
   PUBMED   21873652
REFERENCE   2  (residues 1 to 278)
  AUTHORS   McHugh,P.C., Rogers,G.R., Glubb,D.M., Joyce,P.R. and Kennedy,M.A.
  TITLE     Proteomic analysis of rat hippocampus exposed to the antidepressant
            paroxetine
  JOURNAL   J Psychopharmacol 24 (8), 1243-1251 (2010)
   PUBMED   19346281
REFERENCE   3  (residues 1 to 278)
  AUTHORS   Zhao,Y., Chen,Y.Q., Li,S., Konrad,R.J. and Cao,G.
  TITLE     The microsomal cardiolipin remodeling enzyme acyl-CoA
            lysocardiolipin acyltransferase is an acyltransferase of multiple
            anionic lysophospholipids
  JOURNAL   J Lipid Res 50 (5), 945-956 (2009)
   PUBMED   19075029
REFERENCE   4  (residues 1 to 278)
  AUTHORS   Cortes,V.A., Curtis,D.E., Sukumaran,S., Shao,X., Parameswara,V.,
            Rashid,S., Smith,A.R., Ren,J., Esser,V., Hammer,R.E., Agarwal,A.K.,
            Horton,J.D. and Garg,A.
  TITLE     Molecular mechanisms of hepatic steatosis and insulin resistance in
            the AGPAT2-deficient mouse model of congenital generalized
            lipodystrophy
  JOURNAL   Cell Metab 9 (2), 165-176 (2009)
   PUBMED   19187773
REFERENCE   5  (residues 1 to 278)
  AUTHORS   Beigneux,A.P., Vergnes,L., Qiao,X., Quatela,S., Davis,R.,
            Watkins,S.M., Coleman,R.A., Walzem,R.L., Philips,M., Reue,K. and
            Young,S.G.
  TITLE     Agpat6--a novel lipid biosynthetic gene required for
            triacylglycerol production in mammary epithelium
  JOURNAL   J Lipid Res 47 (4), 734-744 (2006)
   PUBMED   16449762
REFERENCE   6  (residues 1 to 278)
  AUTHORS   Haque,W., Garg,A. and Agarwal,A.K.
  TITLE     Enzymatic activity of naturally occurring
            1-acylglycerol-3-phosphate-O-acyltransferase 2 mutants associated
            with congenital generalized lipodystrophy
  JOURNAL   Biochem Biophys Res Commun 327 (2), 446-453 (2005)
   PUBMED   15629135
REFERENCE   7  (residues 1 to 278)
  AUTHORS   Lu,B., Jiang,Y.J., Zhou,Y., Xu,F.Y., Hatch,G.M. and Choy,P.C.
  TITLE     Cloning and characterization of murine 1-acyl-sn-glycerol
            3-phosphate acyltransferases and their regulation by PPARalpha in
            murine heart
  JOURNAL   Biochem J 385 (Pt 2), 469-477 (2005)
   PUBMED   15367102
REFERENCE   8  (residues 1 to 278)
  AUTHORS   Agarwal,A.K., Arioglu,E., De Almeida,S., Akkoc,N., Taylor,S.I.,
            Bowcock,A.M., Barnes,R.I. and Garg,A.
  TITLE     AGPAT2 is mutated in congenital generalized lipodystrophy linked to
            chromosome 9q34
  JOURNAL   Nat Genet 31 (1), 21-23 (2002)
   PUBMED   11967537
REFERENCE   9  (residues 1 to 278)
  AUTHORS   Eberhardt,C., Gray,P.W. and Tjoelker,L.W.
  TITLE     Human lysophosphatidic acid acyltransferase. cDNA cloning,
            expression, and localization to chromosome 9q34.3
  JOURNAL   J Biol Chem 272 (32), 20299-20305 (1997)
   PUBMED   9242711
REFERENCE   10 (residues 1 to 278)
  AUTHORS   West,J., Tompkins,C.K., Balantac,N., Nudelman,E., Meengs,B.,
            White,T., Bursten,S., Coleman,J., Kumar,A., Singer,J.W. and
            Leung,D.W.
  TITLE     Cloning and expression of two human lysophosphatidic acid
            acyltransferase cDNAs that enhance cytokine-induced signaling
            responses in cells
  JOURNAL   DNA Cell Biol 16 (6), 691-701 (1997)
   PUBMED   9212163
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000003.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XP_231089.4, XP_001074707.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643294.12329.1,
                                           SRR26643298.14603.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760389,
                                           SAMEA5760434 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..278
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3p13"
     Protein         1..278
                     /product="1-acyl-sn-glycerol-3-phosphate acyltransferase
                     beta"
                     /EC_number="2.3.1.51"
                     /note="1-acylglycerol-3-phosphate O-acyltransferase 2
                     (lysophosphatidic acid acyltransferase, beta)"
                     /calculated_mol_wt=30970
     Region          62..261
                     /region_name="PlsC"
                     /note="1-acyl-sn-glycerol-3-phosphate acyltransferase
                     [Lipid transport and metabolism]; COG0204"
                     /db_xref="CDD:439974"
     CDS             1..278
                     /gene="Agpat2"
                     /coded_by="NM_001107821.3:88..924"
                     /db_xref="GeneID:311821"
                     /db_xref="RGD:1309229"
ORIGIN      
        1 mdpwpwltaa lllllllvql nrtarfyvkv glycvlclsf saaasivcll rhggrtvdnm
       61 siiswfvrsf kyvyglrfev sgqkklevdg pcviisnhqs ildmmglmei lpkrcvqiak
      121 relmftgpvg limylggvyf inrqqaktam slmadlgdlm vkenlkvwiy pegtrndngd
      181 llpfkkgafy laiqaqvpii pvvyssfssf ynvktklfts gtirvqvlda vptngltdad
      241 vtklvdtcyq smratflqis eipqenstik esgvlpaq
//
