LOCUS       NM_212458               2091 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus 1-acylglycerol-3-phosphate O-acyltransferase 1
            (Agpat1), mRNA.
ACCESSION   NM_212458
VERSION     NM_212458.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2091)
  AUTHORS   Agarwal AK, Sukumaran S, Cortes VA, Tunison K, Mizrachi D, Sankella
            S, Gerard RD, Horton JD and Garg A.
  TITLE     Human 1-acylglycerol-3-phosphate O-acyltransferase isoforms 1 and
            2: biochemical characterization and inability to rescue hepatic
            steatosis in Agpat2(-/-) gene lipodystrophic mice
  JOURNAL   J Biol Chem 286 (43), 37676-37691 (2011)
   PUBMED   21873652
REFERENCE   2  (bases 1 to 2091)
  AUTHORS   Ghosh D, Lippert D, Krokhin O, Cortens JP and Wilkins JA.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   3  (bases 1 to 2091)
  AUTHORS   Aguado B and Campbell RD.
  TITLE     Characterization of a human lysophosphatidic acid acyltransferase
            that is encoded by a gene located in the class III region of the
            human major histocompatibility complex
  JOURNAL   J Biol Chem 273 (7), 4096-4105 (1998)
   PUBMED   9461603
REFERENCE   4  (bases 1 to 2091)
  AUTHORS   Kume K and Shimizu T.
  TITLE     cDNA cloning and expression of murine
            1-acyl-sn-glycerol-3-phosphate acyltransferase
  JOURNAL   Biochem Biophys Res Commun 237 (3), 663-666 (1997)
   PUBMED   9299423
REFERENCE   5  (bases 1 to 2091)
  AUTHORS   West J, Tompkins CK, Balantac N, Nudelman E, Meengs B, White T,
            Bursten S, Coleman J, Kumar A, Singer JW and Leung DW.
  TITLE     Cloning and expression of two human lysophosphatidic acid
            acyltransferase cDNAs that enhance cytokine-induced signaling
            responses in cells
  JOURNAL   DNA Cell Biol 16 (6), 691-701 (1997)
   PUBMED   9212163
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX883044.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085852.1, SRR8487231.64469.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2091
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..2091
                     /gene="Agpat1"
                     /note="1-acylglycerol-3-phosphate O-acyltransferase 1"
                     /db_xref="GeneID:406165"
                     /db_xref="RGD:1303287"
     exon            1..252
                     /gene="Agpat1"
                     /inference="alignment:Splign:2.1.0"
     exon            253..452
                     /gene="Agpat1"
                     /inference="alignment:Splign:2.1.0"
     CDS             262..1116
                     /gene="Agpat1"
                     /EC_number="2.3.1.51"
                     /note="1-acylglycerol-3-phosphate O-acyltransferase 1
                     (lysophosphatidic acid acyltransferase, alpha)"
                     /codon_start=1
                     /product="1-acyl-sn-glycerol-3-phosphate acyltransferase
                     alpha"
                     /protein_id="NP_997623.1"
                     /db_xref="GeneID:406165"
                     /db_xref="RGD:1303287"
                     /translation="MELWPGAWTALLLLLLLLLSTLWFCSSSAKYFFKMAFYNGWILF
                     LAILAIPVCAVRGRNVENMKILRLLLLHVKYLYGIRVEVRGAQHFPPTQPYVVVSNHQ
                     SSLDLLGMMEVLPDRCVPIAKRELLWAGSAGLACWLAGVIFIDRKRTGDAISVMSEVA
                     QTLLTQDVRVWVFPEGTRNHNGSMLPFKRGAFHLAVQAQVPIVPIVMSSYQDFYCKKE
                     RRFTSGRCQVRVLPPVPTEGLTPDDVPALADRVRHSMLTIFREISTDGLGGGDCLKKP
                     GGAGEARL"
     exon            453..586
                     /gene="Agpat1"
                     /inference="alignment:Splign:2.1.0"
     exon            587..762
                     /gene="Agpat1"
                     /inference="alignment:Splign:2.1.0"
     exon            763..858
                     /gene="Agpat1"
                     /inference="alignment:Splign:2.1.0"
     exon            859..931
                     /gene="Agpat1"
                     /inference="alignment:Splign:2.1.0"
     exon            932..2091
                     /gene="Agpat1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtagccccg gccctcagag agccggcagg gagggaggga gggtgttggg ggtacggccc
       61 cccaccattc ctaccggtat gggcccagct tcccactccc accacccctc catcggccgg
      121 ggctaggaca tccccaaatc ctgtcgcccc cttggcaccg acaccgagac agagatacag
      181 ccagccgcca ccaccgctgc cgcagcctgg ctggggaagg ggcccgtccc ccaggctccc
      241 cgccccattg aggtgaccag aatggagctg tggcccgggg cctggacggc gctgctgctg
      301 ctgctcctcc tcctgctgtc caccctgtgg ttctgcagct ccagtgccaa gtatttcttc
      361 aagatggcct tctacaatgg ttggatcctc ttcctggcaa tactcgcgat ccctgtgtgc
      421 gccgttcgag gacgcaatgt cgagaacatg aagatcttgc gtctgctgct gctccacgtc
      481 aaatacttgt atgggatccg agtggaggtg cggggggctc agcacttccc tcccacacag
      541 ccctacgttg ttgtctccaa ccaccagagt tccctcgacc tgcttggaat gatggaggta
      601 ctgccagatc gctgtgtgcc cattgccaag cgtgaactat tatgggctgg ctctgccggg
      661 ctggcctgct ggctggcagg agtcatcttc attgaccgga aacgcacagg agacgctatc
      721 agtgtcatgt ccgaggtggc ccagaccctg ctcacccagg atgtgagagt ctgggttttt
      781 cctgaaggaa caagaaacca caatggctcc atgctgccct tcaaacgagg cgccttccac
      841 cttgcagtac aggcccaggt ccccatcgtc cccattgtca tgtcctccta tcaagacttc
      901 tactgcaaaa aggaacgccg cttcacctct gggcgatgtc aggtccgggt gctgccccca
      961 gtgcccacag aagggctcac accagatgat gtcccagctc tggcagacag agtccggcac
     1021 tccatgctca ccatcttccg ggagatctcc actgatggcc tgggtggtgg cgattgtcta
     1081 aagaagcctg ggggagcggg cgaggcccgg ctctgagctc cacccgtcct ccccttcttc
     1141 ctccccatac ctgacacagg gcctgaggca gggccaggcc cacttccctg gtccccactc
     1201 cctactctcc ttttggaatc ctcaacttct gaagtgaatg tcactccatg ttctgtccct
     1261 gccccaccca tggactctcc tgcgtgggtg cagtctccac tccaagccca cctgccatct
     1321 tgtcttgtgg gactattgcc taccctcatc tcaagtggct catgatacaa gggtgggaga
     1381 cattccatcc catcccttcc ctagtggtct ctttgtggcc ttctctccct ctccgcccta
     1441 cactggacaa tgaactcatc tgttctgtgg agcagtccac ccctcacccc aagtctgcag
     1501 actgactggg ctcacctgct actgaggact cccccgtcct gtggctggaa gctgaacctg
     1561 acactcctca ccggctcacc tggggactgc ctcagcactg tcaccctcca tctccatggg
     1621 gctgtcaccc tccgtggggc tggctcttgt cactcagagg tctctcgtcc ctgcccatgc
     1681 ccggggctga gcacactcca catgccaatg tctgtgtccc cgccacacca cacccctgcc
     1741 cccagtagtg gtcttcaggg ccctggccca caccatctaa ccaaattctg gagaggcagg
     1801 tgccagaagc tgtgctctct cctccctggg gccttaggga gaagaacctg actctggcaa
     1861 gagggagagc ggggcactta atttatttct ttctttgagg tacctccctc ccgggtcaat
     1921 tttcatttcc tcccagtggc gctggccccc ctgcctccca ctctagaccc attcctcaaa
     1981 cccaggaggt agactggggg aagaaggaac gggcgggatc cagttttgtg tggttggttt
     2041 ttattatctg gataacagca agcaactgga aataaagaga aagagagacg t
//
