LOCUS       NM_001271193            3150 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus argonaute RISC catalytic component 3 (Ago3),
            mRNA.
ACCESSION   NM_001271193 XM_001058231
VERSION     NM_001271193.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3150)
  AUTHORS   Park,M.S., Phan,H.D., Busch,F., Hinckley,S.H., Brackbill,J.A.,
            Wysocki,V.H. and Nakanishi,K.
  TITLE     Human Argonaute3 has slicer activity
  JOURNAL   Nucleic Acids Res 45 (20), 11867-11877 (2017)
   PUBMED   29040713
REFERENCE   2  (bases 1 to 3150)
  AUTHORS   Sun,S., Ma,J., Zhang,Q., Wang,Q., Zhou,L., Bai,F., Hu,H., Chang,P.,
            Yu,J. and Gao,B.
  TITLE     Argonaute proteins in cardiac tissue contribute to the heart injury
            during viral myocarditis
  JOURNAL   Cardiovasc Pathol 25 (2), 120-126 (2016)
   PUBMED   26764146
REFERENCE   3  (bases 1 to 3150)
  AUTHORS   Hu,Q., Tanasa,B., Trabucchi,M., Li,W., Zhang,J., Ohgi,K.A.,
            Rose,D.W., Glass,C.K. and Rosenfeld,M.G.
  TITLE     DICER- and AGO3-dependent generation of retinoic acid-induced DR2
            Alu RNAs regulates human stem cell proliferation
  JOURNAL   Nat Struct Mol Biol 19 (11), 1168-1175 (2012)
   PUBMED   23064648
REFERENCE   4  (bases 1 to 3150)
  AUTHORS   Gu,S., Jin,L., Huang,Y., Zhang,F. and Kay,M.A.
  TITLE     Slicing-independent RISC activation requires the argonaute PAZ
            domain
  JOURNAL   Curr Biol 22 (16), 1536-1542 (2012)
   PUBMED   22795694
REFERENCE   5  (bases 1 to 3150)
  AUTHORS   Modzelewski,A.J., Holmes,R.J., Hilz,S., Grimson,A. and Cohen,P.E.
  TITLE     AGO4 regulates entry into meiosis and influences silencing of sex
            chromosomes in the male mouse germline
  JOURNAL   Dev Cell 23 (2), 251-264 (2012)
   PUBMED   22863743
REFERENCE   6  (bases 1 to 3150)
  AUTHORS   Yoda,M., Kawamata,T., Paroo,Z., Ye,X., Iwasaki,S., Liu,Q. and
            Tomari,Y.
  TITLE     ATP-dependent human RISC assembly pathways
  JOURNAL   Nat Struct Mol Biol 17 (1), 17-23 (2010)
   PUBMED   19966796
REFERENCE   7  (bases 1 to 3150)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   8  (bases 1 to 3150)
  AUTHORS   Chi,S.W., Zang,J.B., Mele,A. and Darnell,R.B.
  TITLE     Argonaute HITS-CLIP decodes microRNA-mRNA interaction maps
  JOURNAL   Nature 460 (7254), 479-486 (2009)
   PUBMED   19536157
REFERENCE   9  (bases 1 to 3150)
  AUTHORS   Wu,L., Fan,J. and Belasco,J.G.
  TITLE     Importance of translation and nonnucleolytic ago proteins for
            on-target RNA interference
  JOURNAL   Curr Biol 18 (17), 1327-1332 (2008)
   PUBMED   18771919
REFERENCE   10 (bases 1 to 3150)
  AUTHORS   Meister,G., Landthaler,M., Patkaniowska,A., Dorsett,Y., Teng,G. and
            Tuschl,T.
  TITLE     Human Argonaute2 mediates RNA cleavage targeted by miRNAs and
            siRNAs
  JOURNAL   Mol Cell 15 (2), 185-197 (2004)
   PUBMED   15260970
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Sep 6, 2012 this sequence version replaced XM_001058231.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.2219688.1,
                                           SRR26360176.2406544.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-270               JAXUCZ010000005.1  143998468-143998737 c
            271-442             JAXUCZ010000005.1  143986344-143986515 c
            443-563             JAXUCZ010000005.1  143977859-143977979 c
            564-772             JAXUCZ010000005.1  143975791-143975999 c
            773-909             JAXUCZ010000005.1  143974762-143974898 c
            910-1044            JAXUCZ010000005.1  143953355-143953489 c
            1045-1132           JAXUCZ010000005.1  143948438-143948525 c
            1133-1280           JAXUCZ010000005.1  143948176-143948323 c
            1281-1400           JAXUCZ010000005.1  143946859-143946978 c
            1401-1523           JAXUCZ010000005.1  143945539-143945661 c
            1524-1657           JAXUCZ010000005.1  143944724-143944857 c
            1658-1842           JAXUCZ010000005.1  143942851-143943035 c
            1843-2002           JAXUCZ010000005.1  143936816-143936975 c
            2003-2093           JAXUCZ010000005.1  143935184-143935274 c
            2094-2288           JAXUCZ010000005.1  143932288-143932482 c
            2289-2423           JAXUCZ010000005.1  143931441-143931575 c
            2424-2525           JAXUCZ010000005.1  143929492-143929593 c
            2526-2725           JAXUCZ010000005.1  143927656-143927855 c
            2726-3150           JAXUCZ010000005.1  143926489-143926913 c
FEATURES             Location/Qualifiers
     source          1..3150
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..3150
                     /gene="Ago3"
                     /gene_synonym="Eif2c3"
                     /note="argonaute RISC catalytic component 3"
                     /db_xref="GeneID:313593"
                     /db_xref="RGD:1309163"
     exon            1..270
                     /gene="Ago3"
                     /gene_synonym="Eif2c3"
                     /inference="alignment:Splign:2.1.0"
     CDS             252..2834
                     /gene="Ago3"
                     /gene_synonym="Eif2c3"
                     /EC_number="3.1.26.n2"
                     /note="eukaryotic translation initiation factor 2C, 3;
                     argonaute 3, RISC catalytic component"
                     /codon_start=1
                     /product="protein argonaute-3"
                     /protein_id="NP_001258122.1"
                     /db_xref="GeneID:313593"
                     /db_xref="RGD:1309163"
                     /translation="MEIGSAGPIGAQPLLIVPRRPGYGTMGKPIKLLANCFQVEIPKI
                     DVYLYEVDIKPDKCPRRVNREVVDSMVQHFKVTIFGDRRPVYDGKRSLYTANPLPVAT
                     TGVDLDVTLPGEGGKDRPFKVSVKFVSRVSWHLLHEVLTGRTLPEPLELDKPISTNPV
                     HAVDVVLRHLPSMKYTPVGRSFFSAPEGYDHPLGGGREVWFGFHQSVRPAMWKMMLNI
                     DVSATAFYKAQPVIQFMCEVLDIHNIDEQPRPLTDSHRVKFTKEIKGLKVEVTHCGTM
                     RRKYRVCNVTRRPASHQTFPLQLENGQTVERTVAQYFREKYTLQLKYPHLPCLQVGQE
                     QKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIKATARSAPDRQEEISRLVRSANYETD
                     PFVQEFQFKVRDEMAHVTGRVLPAPMLQYGGRNRTVATPSHGVWDMRGKQFHTGVEIK
                     MWAIACFATQRQCREEILKGFTDQLRKISKDAGMPIQGQPCFCKYAQGADSVEPMFRH
                     LKNTYSGLQLIIVILPGKTPVYAEVKRVGDTLLGMATQCVQVKNVIKTSPQTLSNLCL
                     KINVKLGGINNILVPHQRPSVFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDAHPS
                     RYCATVRVQRPRQEIIQDLASMVRELLIQFYKSTRFKPTRIIFYRDGVSEGQFRQVLY
                     YELLAIREACISLEKDYQPGITYIVVQKRHHTRLFCADRTERVGRSGNIPAGTTVDTD
                     ITHPYEFDFYLCSHAGIQGTSRPSHYHVLWDDNCFTADELQLLTYQLCHTYVRCTRSV
                     SIPAPAYYAHLVAFRARYHLVDKEHDSAEGSHVSGQSNGRDPQALAKAVQIHQDTLRT
                     MYFA"
     exon            271..442
                     /gene="Ago3"
                     /gene_synonym="Eif2c3"
                     /inference="alignment:Splign:2.1.0"
     exon            443..563
                     /gene="Ago3"
                     /gene_synonym="Eif2c3"
                     /inference="alignment:Splign:2.1.0"
     exon            564..772
                     /gene="Ago3"
                     /gene_synonym="Eif2c3"
                     /inference="alignment:Splign:2.1.0"
     exon            773..909
                     /gene="Ago3"
                     /gene_synonym="Eif2c3"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1044
                     /gene="Ago3"
                     /gene_synonym="Eif2c3"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1132
                     /gene="Ago3"
                     /gene_synonym="Eif2c3"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1280
                     /gene="Ago3"
                     /gene_synonym="Eif2c3"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..1400
                     /gene="Ago3"
                     /gene_synonym="Eif2c3"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..1523
                     /gene="Ago3"
                     /gene_synonym="Eif2c3"
                     /inference="alignment:Splign:2.1.0"
     exon            1524..1657
                     /gene="Ago3"
                     /gene_synonym="Eif2c3"
                     /inference="alignment:Splign:2.1.0"
     exon            1658..1842
                     /gene="Ago3"
                     /gene_synonym="Eif2c3"
                     /inference="alignment:Splign:2.1.0"
     exon            1843..2002
                     /gene="Ago3"
                     /gene_synonym="Eif2c3"
                     /inference="alignment:Splign:2.1.0"
     exon            2003..2093
                     /gene="Ago3"
                     /gene_synonym="Eif2c3"
                     /inference="alignment:Splign:2.1.0"
     exon            2094..2288
                     /gene="Ago3"
                     /gene_synonym="Eif2c3"
                     /inference="alignment:Splign:2.1.0"
     exon            2289..2423
                     /gene="Ago3"
                     /gene_synonym="Eif2c3"
                     /inference="alignment:Splign:2.1.0"
     exon            2424..2525
                     /gene="Ago3"
                     /gene_synonym="Eif2c3"
                     /inference="alignment:Splign:2.1.0"
     exon            2526..2725
                     /gene="Ago3"
                     /gene_synonym="Eif2c3"
                     /inference="alignment:Splign:2.1.0"
     exon            2726..3150
                     /gene="Ago3"
                     /gene_synonym="Eif2c3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gacccgggag agcgaaaagc ggcggcggcg gggcggctgg agggtcccgg aggtgcgcgc
       61 gtcagcagct gtaggcgacg caagttccgg acccggcttc agcgtcctca cctcaggact
      121 gtcgccgctc ttaccttgct gctgactgtc tccggacagt gcctcttctg cctggagctt
      181 tcagagggcg tccgctcctc acctctgtgg tggcaccttt ctcttgtgaa gcactcccca
      241 cagctccatg aatggaaatc ggctccgcag gacccattgg ggcccagccc ctactcatag
      301 tgcccagaag acctgggtat ggcactatgg gcaaacccat taaactgttg gctaactgtt
      361 ttcaagttga aatcccaaag atcgatgtct acctctatga ggtcgacatc aaacccgaca
      421 agtgtcctcg aagagtgaac agagaagtag ttgactcaat ggttcagcat tttaaagtga
      481 ctatatttgg agaccgtaga ccagtttatg atggaaaaag aagcctttac acagccaatc
      541 cacttcctgt ggcaactact ggggtagatt tagatgttac tttacctggg gaaggtggaa
      601 aagatcgccc tttcaaggtg tcagtgaagt ttgtgtccag agtcagttgg cacctactac
      661 atgaagttct gactggtcgg actttgcctg agccactgga attagacaag ccaatcagca
      721 ctaacccggt ccatgccgtt gatgtggtgc tccgacatct gccctctatg aaatatacgc
      781 ctgtggggcg ctcctttttc tcagctccag aaggatacga ccaccctctt ggagggggca
      841 gggaagtatg gtttggattc catcaatctg ttcggcctgc catgtggaaa atgatgctca
      901 atattgatgt ttctgccact gccttttaca aagcacagcc tgtcattcag ttcatgtgtg
      961 aagttcttga cattcacaac atcgatgagc aacccagacc cctgaccgat tctcatcggg
     1021 taaaattcac taaggagata aaaggtctga aggttgaagt gactcattgt ggaacaatga
     1081 gacggaaata ccgtgtctgt aatgtaacaa gaaggcctgc cagccaccaa acatttcctt
     1141 tacagctaga aaatggccaa actgtggaga gaactgtagc tcagtatttc cgagaaaagt
     1201 acacacttca gctgaagtac ccacaccttc cctgtctgca agtggggcag gagcagaagc
     1261 atacatacct gccactagaa gtctgtaata ttgtggctgg acagaggtgt atcaagaaac
     1321 taacagacaa tcagacttct actatgatta aggcaacagc aagatctgca ccagatagac
     1381 aagaggaaat tagcagattg gtaagaagtg caaattatga aacagatcca tttgttcagg
     1441 agtttcagtt taaagtgcgg gatgagatgg cccatgtgac cggtcgagta ctgccagcac
     1501 ctatgctcca gtatggagga cggaaccgga cagtagcaac accaagccac ggagtatggg
     1561 acatgagagg aaaacagttc cacacaggag ttgaaatcaa aatgtgggct atcgcttgct
     1621 ttgccacaca gaggcagtgc agagaagaaa tactgaaagg attcacagac cagcttcgga
     1681 agatctccaa ggatgcaggg atgcccatcc agggtcagcc atgtttctgc aaatacgcac
     1741 agggggcaga cagcgtggag cccatgttcc ggcatctcaa gaatacctac tcaggactgc
     1801 agctcattat cgtcatcctg cctgggaaga cgccggtata tgcggaggtg aagcgtgtag
     1861 gagacacact tttgggtatg gccacacagt gtgtgcaagt caagaatgta ataaaaacat
     1921 ctcctcaaac tctttcaaac ttgtgcctaa agatcaatgt taaacttgga ggaatcaata
     1981 atattcttgt acctcatcaa agaccttctg tgttccagca accagtgatc ttcctgggcg
     2041 cagatgtcac acacccgcct gctggtgacg ggaagaagcc ttccattgct gctgttgtag
     2101 gcagtatgga tgcccatcca agcagatact gtgccacagt gagagttcag agaccccgac
     2161 aggaaatcat ccaggacttg gcctccatgg tccgggaact gctcatccaa ttttacaagt
     2221 caacccgatt caaacctact cggatcatct tttatcggga tggtgtttcc gaaggacagt
     2281 ttagacaggt attatattat gagctcctgg caattcgaga agcctgtatc agtttggaaa
     2341 aagactatca acctggaata acctacattg tcgttcagaa gagacatcat acgcgattgt
     2401 tctgtgctga tagaacagaa agggtgggaa gaagcggcaa catcccagct ggaaccacag
     2461 tggatacaga catcactcac ccgtatgaat tcgactttta tctctgcagc catgctggaa
     2521 tacagggaac cagccgtcct tctcactatc acgttctgtg ggatgacaac tgcttcactg
     2581 cggatgaact gcagctgctg acctaccagc tctgccacac ctacgtgcgc tgtaccaggt
     2641 ccgtgtcgat ccctgcacca gcgtactatg ctcacctggt ggcgttcaga gccaggtacc
     2701 atctggtgga caaggagcat gacagtgctg aaggaagcca tgtgtcagga cagagcaatg
     2761 gacgagatcc acaagctctt gccaaggctg tccagattca ccaagatacc ttacgcacaa
     2821 tgtacttcgc ttagcaagtc caagtgatct ccgagaggaa gagctggagc tcgtatgttt
     2881 ccagtggact cagttcactg gggaggcctc cagccgcaca gaagccaata ctatgtaggg
     2941 gtctggacct tacgttgatc cgaggaaaaa tgtttactct gtcaaagaac acagcactgt
     3001 tgtataccag ggagccagcc cgctgctttt ttgcagtgtc ctgtagaaga agcatcacgg
     3061 ttgttcgttc tcacttctta cagtctaacc ccattaatac ctttacctca agttgcttag
     3121 cggcacaacc gtctctgcaa aaaaagtaaa
//
