LOCUS       NM_001048185            1312 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus agmatinase (Agmat), mRNA; nuclear gene for
            mitochondrial product.
ACCESSION   NM_001048185 XM_001072765 XM_216570
VERSION     NM_001048185.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1312)
  AUTHORS   Yan,S., Xu,C., Yang,M., Zhang,H., Cheng,Y., Xue,Z., He,Z., Wang,T.,
            Bai,S., Wang,G., Wu,J., Tong,Z. and Cai,X.
  TITLE     The expression of agmatinase manipulates the affective state of
            rats subjected to chronic restraint stress
  JOURNAL   Neuropharmacology 229, 109476 (2023)
   PUBMED   36849038
  REMARK    GeneRIF: The expression of agmatinase manipulates the affective
            state of rats subjected to chronic restraint stress.
REFERENCE   2  (bases 1 to 1312)
  AUTHORS   Madai,V.I., Poller,W.C., Peters,D., Berger,J., Paliege,K.,
            Bernard,R., Veh,R.W. and Laube,G.
  TITLE     Synaptic localisation of agmatinase in rat cerebral cortex revealed
            by virtual pre-embedding
  JOURNAL   Amino Acids 43 (3), 1399-1403 (2012)
   PUBMED   22160263
  REMARK    GeneRIF: pre- and postsynaptic expression of agmatinase in rats
            supports a proposed role in the modulation of the neurotransmitter
            agmatin.
REFERENCE   3  (bases 1 to 1312)
  AUTHORS   Bernstein,H.G., Derst,C., Stich,C., Pruss,H., Peters,D., Krauss,M.,
            Bogerts,B., Veh,R.W. and Laube,G.
  TITLE     The agmatine-degrading enzyme agmatinase: a key to agmatine
            signaling in rat and human brain?
  JOURNAL   Amino Acids 40 (2), 453-465 (2011)
   PUBMED   20563878
  REMARK    GeneRIF: Agmatinase activity was predominantly detected in neurons
            of rat and human brain.
REFERENCE   4  (bases 1 to 1312)
  AUTHORS   Uribe,E., Salas,M., Enriquez,S., Orellana,M.S. and Carvajal,N.
  TITLE     Cloning and functional expression of a rodent brain cDNA encoding a
            novel protein with agmatinase activity, but not belonging to the
            arginase family
  JOURNAL   Arch Biochem Biophys 461 (1), 146-150 (2007)
   PUBMED   17291445
  REMARK    GeneRIF: Agmatinase activity is adscribed to a novel protein with
            an active site that promiscuously catalyzes a reaction other than
            the one it evolved to catalyze.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC105628.1.
            
            On or before Sep 17, 2006 this sequence version replaced
            XM_216570.3, XM_001072765.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC105628.1, BC091231.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1312
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1312
                     /gene="Agmat"
                     /note="agmatinase"
                     /db_xref="GeneID:298607"
                     /db_xref="RGD:1308424"
     exon            1..289
                     /gene="Agmat"
                     /inference="alignment:Splign:2.1.0"
     CDS             15..1076
                     /gene="Agmat"
                     /EC_number="3.5.3.1"
                     /EC_number="3.5.3.7"
                     /EC_number="3.5.3.17"
                     /note="agmatinase, mitochondrial; AUH; agmatine
                     ureohydrolase (agmatinase); arginase, mitochondrial;
                     guanidinobutyrase, mitochondrial; guanidinopropionase,
                     mitochondrial; guanidino acid hydrolase, mitochondrial"
                     /codon_start=1
                     /product="guanidino acid hydrolase, mitochondrial
                     precursor"
                     /protein_id="NP_001041650.1"
                     /db_xref="GeneID:298607"
                     /db_xref="RGD:1308424"
                     /translation="MLQLLKSSWVRSAGSGVVTWRASAGLFCPGTRQASDTSDTLHHP
                     SPSSESQVQPVRVCSMMHLPLQSSPEGLDAAFVGVPLDTGTSNRPGARFGPRRIREES
                     LMLGTVNPSTGALPFQSLRVADLGNVNVNLYNLQDSCRLIREAYQNILATGCIPLTLG
                     GDHTITYPILQAVAKEHGPVGLVHVGAHSNTSDKPLEDKVYHRTPFRRSVDEGLLDSK
                     RVVQIGIRGSSRTLDPYRYSRSQGFRVVLAEDCWMKSLVPLMAEIRQQMGGVPLYISF
                     AIDALDPAYAPGTGTPEIAGLTPSQALEIIRGCQGLNVVGCDLVEVSPPYDLSGNTAL
                     LAANLLFEMLCALPKVTTV"
     exon            290..492
                     /gene="Agmat"
                     /inference="alignment:Splign:2.1.0"
     exon            493..541
                     /gene="Agmat"
                     /inference="alignment:Splign:2.1.0"
     exon            542..737
                     /gene="Agmat"
                     /inference="alignment:Splign:2.1.0"
     exon            738..917
                     /gene="Agmat"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1002
                     /gene="Agmat"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1270
                     /gene="Agmat"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctcaatagg cggcatgctg cagctgctga agtccagctg ggtccggagt gcggggtctg
       61 gggtggtcac gtggcgtgcc tctgcggggc tcttctgtcc tgggacccgc caggcttcag
      121 atacctcaga taccctacat cacccgtccc ctagctctga gtcacaggta cagccggtac
      181 gcgtctgttc catgatgcac ttgcccctgc agtcctcccc cgaggggctg gatgctgctt
      241 tcgtcggtgt gcctctggat accggaactt ccaaccggcc cggggcaaga tttggacccc
      301 gtcgcatccg ggaggagtca ctgatgctgg ggactgtcaa tcccagcacg ggagccctcc
      361 ccttccagtc cctcagggtt gcagacctag gcaatgtgaa cgtcaatctc tacaaccttc
      421 aggacagctg ccggctaatc cgagaggcct atcagaacat cctagcaact ggctgcattc
      481 ctctgacctt gggtggagac cataccatca catatcccat actgcaagcc gtggcaaaag
      541 agcatggccc tgtgggttta gtgcatgtgg gtgcccacag caacacctcg gacaaacctc
      601 tggaggacaa ggtctaccat cggacacctt tccgccgaag tgtggatgag ggactgctgg
      661 acagcaagcg agtggtacag ataggtatcc ggggctcctc caggaccctg gatccctaca
      721 gatacagtcg gagccagggc ttccgtgtgg tcctggctga agactgttgg atgaagtcac
      781 tggtccccct gatggcagag atcaggcagc agatgggggg tgtgcctctt tacatcagct
      841 ttgccataga tgccttggat cctgcctatg ccccagggac agggacacca gaaattgctg
      901 ggctcacccc tagtcaggct ctggagatca tccggggctg tcaaggcctg aatgtggtgg
      961 gctgtgacct tgtggaagtt tccccgccgt atgatctctc tggaaacaca gccctcctcg
     1021 cggctaacct actgtttgag atgctgtgtg ctctccccaa ggtgacaact gtctgagtca
     1081 gtgttcctga agttgaaaca gactgggtca tgatgaagcc tcaaggccct gtgaacgaac
     1141 tgtggctagg atcaaagaac ccctcctgtg aggtgtcacc acaaacaagg gcaattcaga
     1201 gcattacccc gaacagctcg aacagctcgt gtctctttcc ttcctaacat taaaacattt
     1261 atttaatttt aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aa
//
