LOCUS       NM_001127497            2228 bp    mRNA    linear   ROD 17-JUL-2023
DEFINITION  Rattus norvegicus acylglycerol kinase (Agk), mRNA; nuclear gene for
            mitochondrial product.
ACCESSION   NM_001127497 XM_001070395 XM_578248
VERSION     NM_001127497.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2228)
  AUTHORS   Kang Y, Stroud DA, Baker MJ, De Souza DP, Frazier AE, Liem M, Tull
            D, Mathivanan S, McConville MJ, Thorburn DR, Ryan MT and
            Stojanovski D.
  TITLE     Sengers Syndrome-Associated Mitochondrial Acylglycerol Kinase Is a
            Subunit of the Human TIM22 Protein Import Complex
  JOURNAL   Mol Cell 67 (3), 457-470 (2017)
   PUBMED   28712726
REFERENCE   2  (bases 1 to 2228)
  AUTHORS   Vukotic M, Nolte H, Konig T, Saita S, Ananjew M, Kruger M, Tatsuta
            T and Langer T.
  TITLE     Acylglycerol Kinase Mutated in Sengers Syndrome Is a Subunit of the
            TIM22 Protein Translocase in Mitochondria
  JOURNAL   Mol Cell 67 (3), 471-483 (2017)
   PUBMED   28712724
REFERENCE   3  (bases 1 to 2228)
  AUTHORS   Abu El-Asrar AM, Mohammad G, Nawaz MI, Siddiquei MM, Kangave D and
            Opdenakker G.
  TITLE     Expression of lysophosphatidic acid, autotaxin and acylglycerol
            kinase as biomarkers in diabetic retinopathy
  JOURNAL   Acta Diabetol 50 (3), 363-371 (2013)
   PUBMED   22864860
  REMARK    GeneRIF: Our findings suggest that ATX-AGK-LPA signaling axis might
            be an important player in the development and progression of
            diabetic retinopathy.
REFERENCE   4  (bases 1 to 2228)
  AUTHORS   Mortensen M, Ferguson DJ, Edelmann M, Kessler B, Morten KJ, Komatsu
            M and Simon AK.
  TITLE     Loss of autophagy in erythroid cells leads to defective removal of
            mitochondria and severe anemia in vivo
  JOURNAL   Proc Natl Acad Sci U S A 107 (2), 832-837 (2010)
   PUBMED   20080761
REFERENCE   5  (bases 1 to 2228)
  AUTHORS   Epand RM, Shulga YV, Timmons HC, Perri AL, Belani JD, Perinpanathan
            K, Johnson-McIntire LB, Bajjalieh S, Dicu AO, Elias C, Rychnovsky
            SD and Topham MK.
  TITLE     Substrate chirality and specificity of diacylglycerol kinases and
            the multisubstrate lipid kinase
  JOURNAL   Biochemistry 46 (49), 14225-14231 (2007)
   PUBMED   18004883
REFERENCE   6  (bases 1 to 2228)
  AUTHORS   Van Overloop H, Gijsbers S and Van Veldhoven PP.
  TITLE     Further characterization of mammalian ceramide kinase: substrate
            delivery and (stereo)specificity, tissue distribution, and
            subcellular localization studies
  JOURNAL   J Lipid Res 47 (2), 268-283 (2006)
   PUBMED   16269826
REFERENCE   7  (bases 1 to 2228)
  AUTHORS   Bektas M, Payne SG, Liu H, Goparaju S, Milstien S and Spiegel S.
  TITLE     A novel acylglycerol kinase that produces lysophosphatidic acid
            modulates cross talk with EGFR in prostate cancer cells
  JOURNAL   J Cell Biol 169 (5), 801-811 (2005)
   PUBMED   15939762
REFERENCE   8  (bases 1 to 2228)
  AUTHORS   Waggoner DW, Johnson LB, Mann PC, Morris V, Guastella J and
            Bajjalieh SM.
  TITLE     MuLK, a eukaryotic multi-substrate lipid kinase
  JOURNAL   J Biol Chem 279 (37), 38228-38235 (2004)
   PUBMED   15252046
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473959.1.
            
            On or before May 22, 2008 this sequence version replaced
            XM_001070395.1, XM_578248.2.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132265,
                              SAMD00132268 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2228
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q23"
     gene            1..2228
                     /gene="Agk"
                     /gene_synonym="RGD1562046"
                     /note="acylglycerol kinase"
                     /db_xref="GeneID:502749"
                     /db_xref="RGD:1562046"
     exon            1..49
                     /gene="Agk"
                     /gene_synonym="RGD1562046"
                     /inference="alignment:Splign:2.1.0"
     exon            50..156
                     /gene="Agk"
                     /gene_synonym="RGD1562046"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..1321
                     /gene="Agk"
                     /gene_synonym="RGD1562046"
                     /codon_start=1
                     /product="acylglycerol kinase, mitochondrial"
                     /protein_id="NP_001120969.1"
                     /db_xref="GeneID:502749"
                     /db_xref="RGD:1562046"
                     /translation="MTTFFKTLRNHWKKTTAGLCLLTWGGHWLYGKHCDNLLRRAACQ
                     EAQVFGNQLIPPNAQVKKATVFLNPAACKGKARTLFEKNAAPILHLSGMDVTVVKTDY
                     EGQAKKLLELMETTDVIIVAGGDGTLQEVVTGVLRRTDEATFSKIPIGFIPLGQTSSL
                     SHTLFAESGNKVQHVTDAALAIVKGETVPLDVLQIKGEKEQPVYAMTGLRWGSFRDAG
                     VKVSKYWYLGPLKTKAAHFFSTLQEWPQTHQASISYTGPTERPPIGPEDAAPRPSLYR
                     RILRRLASFWAQPQDAFSPEVSPEVWKDVQLSTIELSITTRNTQLDLTSKEDFMNICI
                     EPDTVSKGDFIIIGSKKVRDPGLRAAGTECLHASRCTLSLPEGTEGSFSIDSEEYEAM
                     PVEVKLLPRKLQFFCDPRKREQMLQSTSQ"
     exon            157..196
                     /gene="Agk"
                     /gene_synonym="RGD1562046"
                     /inference="alignment:Splign:2.1.0"
     exon            197..276
                     /gene="Agk"
                     /gene_synonym="RGD1562046"
                     /inference="alignment:Splign:2.1.0"
     exon            277..352
                     /gene="Agk"
                     /gene_synonym="RGD1562046"
                     /inference="alignment:Splign:2.1.0"
     exon            353..445
                     /gene="Agk"
                     /gene_synonym="RGD1562046"
                     /inference="alignment:Splign:2.1.0"
     exon            446..478
                     /gene="Agk"
                     /gene_synonym="RGD1562046"
                     /inference="alignment:Splign:2.1.0"
     exon            479..573
                     /gene="Agk"
                     /gene_synonym="RGD1562046"
                     /inference="alignment:Splign:2.1.0"
     exon            574..643
                     /gene="Agk"
                     /gene_synonym="RGD1562046"
                     /inference="alignment:Splign:2.1.0"
     exon            644..723
                     /gene="Agk"
                     /gene_synonym="RGD1562046"
                     /inference="alignment:Splign:2.1.0"
     exon            724..781
                     /gene="Agk"
                     /gene_synonym="RGD1562046"
                     /inference="alignment:Splign:2.1.0"
     exon            782..929
                     /gene="Agk"
                     /gene_synonym="RGD1562046"
                     /inference="alignment:Splign:2.1.0"
     exon            930..1027
                     /gene="Agk"
                     /gene_synonym="RGD1562046"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1098
                     /gene="Agk"
                     /gene_synonym="RGD1562046"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1183
                     /gene="Agk"
                     /gene_synonym="RGD1562046"
                     /inference="alignment:Splign:2.1.0"
     exon            1184..2228
                     /gene="Agk"
                     /gene_synonym="RGD1562046"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tttttgtgag agcacacagg aaaggccgga cgctgagcgg cgggcagcgg agaagatgac
       61 cacattcttt aaaacacttc gaaatcattg gaagaaaact acagctggcc tctgcttgct
      121 gacatgggga ggtcactggc tctatggaaa gcactgtgat aacctgctaa gaagagcagc
      181 ttgtcaagaa gctcaggtgt ttggcaacca gctcattcct cccaatgcac aagtgaagaa
      241 agccaccgtc tttctcaatc ctgcagcttg caaaggcaaa gccagaactc tatttgaaaa
      301 aaatgctgcc ccaattttac acctgtctgg catggatgtg actgtcgtca agacagatta
      361 tgagggacaa gccaagaagc tcttggagtt gatggaaacg accgatgtga tcattgttgc
      421 tggaggagat ggcaccctgc aggaggttgt tactggagta cttagaagaa cagatgaggc
      481 taccttcagt aagattccaa ttggatttat cccgctggga cagaccagta gtttgagtca
      541 caccctcttt gctgaaagtg gaaacaaagt ccaacatgtc acagatgccg cactggccat
      601 tgtgaaaggg gagactgttc cacttgacgt cttgcagatc aagggtgaaa aagaacagcc
      661 tgtctatgcc atgaccggcc tccggtgggg atccttcaga gatgctggcg tcaaagttag
      721 caagtactgg tatcttggtc ctctaaaaac caaagcagcc cactttttca gcactcttca
      781 ggagtggcct cagacccatc aggcctccat ctcttacacg ggccctacag agagacctcc
      841 cattgggcct gaagatgctg ctccccggcc ttctctgtac aggagaatat tacgtaggct
      901 tgcctcattc tgggcacagc cacaggatgc cttctcccca gaggtgagcc ctgaggtctg
      961 gaaagatgta caactgtcca ccattgaact gtccatcaca acccgaaaca cccaacttga
     1021 cctgacgagc aaagaggact ttatgaacat ttgcattgag cctgacactg tcagcaaagg
     1081 agatttcata atcataggca gtaagaaggt gagagaccct ggtctgcgag cagccggcac
     1141 cgagtgtctc cacgccagcc gctgcactct gtctcttcct gagggaactg agggctcctt
     1201 cagcatcgac agcgaggagt atgaagccat gcctgtggag gtcaaactcc tgcccagaaa
     1261 acttcagttc ttctgtgatc caaggaagag agagcaaatg ctgcagagca catcccagtg
     1321 agcctcagcc ttgcgggggc gttcctaggc tgccctgcgg cagcactgcg gggcgttccc
     1381 aggctgctct tcaagccacc agtgggacca taagggaatg tgtgtgcttc tggcccagtg
     1441 tcacaggatc ccaaaggaat tttcatggca agtaccccca acccgtttgc ttcctagagc
     1501 acataccctg tcacccaacc tgtggtcagt actctgttaa cccctgcttt ccttacgttg
     1561 aggcagttga cccctcctac acagtggttg tctcaggctg cttcaaggac attcttgccc
     1621 tcactgagtt ggaaagggct ggagttttgt gattgcccca cagtggagag tagaatctgt
     1681 agactaagct cctgtttcag ttctcagacc gtcctggggc ctccggggaa gcagctgctg
     1741 tctctgggtg tctctccctc tttctgggct ctctcatggg tgctgctctt ttgtgagctc
     1801 tctgccttgg ttggttggtc tcatctggaa agcaaatgtg aggttgttcc ctcttcagcc
     1861 ttggcaaacg tattgtaaaa cgccatttaa aaacaaacta gtgcttcctc attgtttgtg
     1921 tgcatgtgta caactgaggc tcatgttgaa aactaactga cctggggccc accccccaaa
     1981 ctttgtacct caacctggca ggaggccagc gttgctcatt ttaaaagact gcttcccagg
     2041 tgaatcaacc ataccgggag aaagtgtttt aaatctactt cataaactta tatgtattat
     2101 atatatattt ttaaaaatca cgtttgtgtt gacgtctgtt gtttccatga gaggttaaac
     2161 acttatcagt gtgcttacta gtgttgtgta aatattgttt aagaataaaa gactttcatc
     2221 attctttt
//
