LOCUS       NM_053336               1443 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Rattus norvegicus advanced glycosylation end product-specific
            receptor (Ager), mRNA.
ACCESSION   NM_053336
VERSION     NM_053336.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1443)
  AUTHORS   Carr,K.D., Weiner,S.P., Vasquez,C. and Schmidt,A.M.
  TITLE     Involvement of the Receptor for Advanced Glycation End Products
            (RAGE) in high fat-high sugar diet-induced anhedonia in rats
  JOURNAL   Physiol Behav 271, 114337 (2023)
   PUBMED   37625475
  REMARK    GeneRIF: Involvement of the Receptor for Advanced Glycation End
            Products (RAGE) in high fat-high sugar diet-induced anhedonia in
            rats.
REFERENCE   2  (bases 1 to 1443)
  AUTHORS   El-Din,M.I.G., George,M.Y. and Youssef,F.S.
  TITLE     Chemical characterization of the polyphenolic rich fraction of
            Thunbergia erecta and its therapeutic potential against doxorubicin
            and cyclophosphamide-induced cognitive impairment in rats
  JOURNAL   J Ethnopharmacol 307, 116213 (2023)
   PUBMED   36708885
REFERENCE   3  (bases 1 to 1443)
  AUTHORS   Zhang,L., Luo,L., Xue,L., Ran,D., Yang,F., Tang,Q. and Jiang,W.
  TITLE     RAGE signaling pathway is involved in CUS-induced depression-like
            behaviors by regulating the expression of NR2A and NR2B in rat
            hippocampus DG
  JOURNAL   Exp Neurol 361, 114299 (2023)
   PUBMED   36521778
  REMARK    GeneRIF: RAGE signaling pathway is involved in CUS-induced
            depression-like behaviors by regulating the expression of NR2A and
            NR2B in rat hippocampus DG.
REFERENCE   4  (bases 1 to 1443)
  AUTHORS   Li,Y., Qin,M., Zhong,W., Liu,C., Deng,G., Yang,M., Li,J., Ye,H.,
            Shi,H., Wu,C., Lin,H., Chen,Y., Huang,S., Zhou,C., Lv,Z. and Gao,L.
  TITLE     RAGE promotes dysregulation of iron and lipid metabolism in
            alcoholic liver disease
  JOURNAL   Redox Biol 59, 102559 (2023)
   PUBMED   36502724
REFERENCE   5  (bases 1 to 1443)
  AUTHORS   Taghadosi,Z., Zarifkar,A., Razban,V. and Aligholi,H.
  TITLE     The effect of chronic stress and its preconditioning on spatial
            memory as well as hippocampal LRP1 and RAGE expression in a
            streptozotocin-induced rat model of Alzheimer's disease
  JOURNAL   Metab Brain Dis 37 (8), 2699-2710 (2022)
   PUBMED   35930096
  REMARK    GeneRIF: The effect of chronic stress and its preconditioning on
            spatial memory as well as hippocampal LRP1 and RAGE expression in a
            streptozotocin-induced rat model of Alzheimer's disease.
REFERENCE   6  (bases 1 to 1443)
  AUTHORS   Fehrenbach,H., Kasper,M., Tschernig,T., Shearman,M.S., Schuh,D. and
            Muller,M.
  TITLE     Receptor for advanced glycation endproducts (RAGE) exhibits highly
            differential cellular and subcellular localisation in rat and human
            lung
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 44 (7), 1147-1157 (1998)
   PUBMED   9846897
REFERENCE   7  (bases 1 to 1443)
  AUTHORS   Lander,H.M., Tauras,J.M., Ogiste,J.S., Hori,O., Moss,R.A. and
            Schmidt,A.M.
  TITLE     Activation of the receptor for advanced glycation end products
            triggers a p21(ras)-dependent mitogen-activated protein kinase
            pathway regulated by oxidant stress
  JOURNAL   J Biol Chem 272 (28), 17810-17814 (1997)
   PUBMED   9211935
REFERENCE   8  (bases 1 to 1443)
  AUTHORS   Renard,C., Chappey,O., Wautier,M.P., Nagashima,M., Lundh,E.,
            Morser,J., Zhao,L., Schmidt,A.M., Scherrmann,J.M. and Wautier,J.L.
  TITLE     Recombinant advanced glycation end product receptor
            pharmacokinetics in normal and diabetic rats
  JOURNAL   Mol Pharmacol 52 (1), 54-62 (1997)
   PUBMED   9224812
REFERENCE   9  (bases 1 to 1443)
  AUTHORS   Yan,S.D., Chen,X., Fu,J., Chen,M., Zhu,H., Roher,A., Slattery,T.,
            Zhao,L., Nagashima,M., Morser,J., Migheli,A., Nawroth,P., Stern,D.
            and Schmidt,A.M.
  TITLE     RAGE and amyloid-beta peptide neurotoxicity in Alzheimer's disease
  JOURNAL   Nature 382 (6593), 685-691 (1996)
   PUBMED   8751438
REFERENCE   10 (bases 1 to 1443)
  AUTHORS   Hori,O., Brett,J., Slattery,T., Cao,R., Zhang,J., Chen,J.X.,
            Nagashima,M., Lundh,E.R., Vijay,S., Nitecki,D. et al.
  TITLE     The receptor for advanced glycation end products (RAGE) is a
            cellular binding site for amphoterin. Mediation of neurite
            outgrowth and co-expression of rage and amphoterin in the
            developing nervous system
  JOURNAL   J Biol Chem 270 (43), 25752-25761 (1995)
   PUBMED   7592757
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BX883044.1, BC084697.1 and CR475487.1.
            
            On Sep 23, 2009 this sequence version replaced NM_053336.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L33413.1, BC084697.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676784, SAMN16676785
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                BX883044.1         210640-210657
            19-1222             BC084697.1         1-1204
            1223-1230           CR475487.1         196-203             c
            1231-1443           BC084697.1         1213-1425
FEATURES             Location/Qualifiers
     source          1..1443
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..1443
                     /gene="Ager"
                     /gene_synonym="RAGE"
                     /note="advanced glycosylation end product-specific
                     receptor"
                     /db_xref="GeneID:81722"
                     /db_xref="RGD:69258"
     exon            1..105
                     /gene="Ager"
                     /gene_synonym="RAGE"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..1262
                     /gene="Ager"
                     /gene_synonym="RAGE"
                     /note="receptor for advanced glycosylation end products"
                     /codon_start=1
                     /product="advanced glycosylation end product-specific
                     receptor precursor"
                     /protein_id="NP_445788.2"
                     /db_xref="GeneID:81722"
                     /db_xref="RGD:69258"
                     /translation="MPTGTVARAWVLVLALWGAVAGGQNITARIGEPLMLSCKGAPKK
                     PTQKLEWKLNTGRTEAWKVLSPQGDPWDSVARILPNGSLLLPAIGIVDEGTFRCRATN
                     RLGKEVKSNYRVRVYQIPGKPEIVNPASELTANVPNKVGTCVSEGSYPAGTLSWHLDG
                     KPLIPDGKGTVVKEETRRHPETGLFTLRSELTVTPAQGGTTPTYSCSFSLGLPRHRPL
                     NTAPIQPRVREPLPPEGIQLLVEPEGGTVAPGGTVTLTCAISAQPPPQIHWIKDGTPL
                     PLAPSPVLLLPEVGHEDEGIYSCVATHPSHGPQESPPVNIRVTETGDEGQAAGSVDGS
                     GLGTLALALGILGGLGIAALLIGAILWRKRQPRLEERKAPESQEDEEERAELNQSEEA
                     EMPENGAGGP"
     exon            106..212
                     /gene="Ager"
                     /gene_synonym="RAGE"
                     /inference="alignment:Splign:2.1.0"
     exon            213..405
                     /gene="Ager"
                     /gene_synonym="RAGE"
                     /inference="alignment:Splign:2.1.0"
     exon            406..470
                     /gene="Ager"
                     /gene_synonym="RAGE"
                     /inference="alignment:Splign:2.1.0"
     exon            471..558
                     /gene="Ager"
                     /gene_synonym="RAGE"
                     /inference="alignment:Splign:2.1.0"
     exon            559..738
                     /gene="Ager"
                     /gene_synonym="RAGE"
                     /inference="alignment:Splign:2.1.0"
     exon            739..869
                     /gene="Ager"
                     /gene_synonym="RAGE"
                     /inference="alignment:Splign:2.1.0"
     exon            870..1011
                     /gene="Ager"
                     /gene_synonym="RAGE"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1038
                     /gene="Ager"
                     /gene_synonym="RAGE"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1165
                     /gene="Ager"
                     /gene_synonym="RAGE"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1420
                     /gene="Ager"
                     /gene_synonym="RAGE"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agccacagta ggaagtgggg cagacagaac caggagcctg ggaaggaagc accatgccaa
       61 cggggacagt agctagagcc tgggtactgg ttcttgctct gtggggagcc gtagctggtg
      121 gtcagaacat cacagcccgg atcggagagc cacttatgct gagctgtaag ggggccccta
      181 agaagccaac ccagaagcta gaatggaaac tgaacacagg aaggactgaa gcttggaagg
      241 tcctctctcc ccagggagac ccctgggaca gtgtggctcg aatcctcccc aatggttcac
      301 tcctccttcc agctatcgga attgtcgatg aggggacttt ccggtgtcgg gcaactaaca
      361 ggcttgggaa ggaggtcaag tccaactacc gagtccgagt ctaccagatt cctgggaagc
      421 cggaaattgt gaatcctgcc tctgaactca cagccaatgt ccctaataag gtggggacgt
      481 gtgtgtctga ggggagctac cctgcaggga cccttagctg gcacttggat gggaaacctc
      541 tgattcctga tggcaaaggg acagttgtga aggaggagac caggaggcac cctgagacgg
      601 gactcttcac gcttcggtca gagctcacag tgaccccagc ccaaggaggg accactccta
      661 cctattcctg cagcttcagc ctgggccttc ctcggcacag acccctgaac acagccccca
      721 tccagccccg agtcagggag cccctgcctc cagagggcat tcagctgttg gttgagcctg
      781 aaggtggaac agtcgctcct ggtgggaccg tgaccctgac ctgtgccatc tctgcccagc
      841 ctccccctca aatccactgg ataaaagatg gcacacccct gccccttgcc cccagccctg
      901 tgctgctcct ccctgaggta gggcatgagg atgagggcat ctacagctgc gtggccaccc
      961 accctagcca tggacctcag gaaagccctc ctgtcaacat cagggtcaca gaaaccggtg
     1021 atgaaggaca agctgcaggc tctgtggatg ggtctgggct gggaacgcta gccctggcct
     1081 tagggatcct gggaggcctg ggaatagccg ctctgctcat tggggccatc ctgtggcgaa
     1141 aacgacaacc cagactcgag gagaggaagg ccccagaaag ccaggaggac gaggaggaac
     1201 gtgcagagct gaatcagtca gaggaagcgg aaatgccaga gaatggtgca gggggacctt
     1261 aagagcgccc aggcaaaccc tgtctccttc agcttccgac ctcagctgtg ctggctccag
     1321 acgagctccc ccactctacg atcccaattc aacctcgagc cactttcttc tccaaccaga
     1381 gcccacatga tccatgctga gtaaacacct gacacatgtt aaaaaaaaaa aaaaaaaaaa
     1441 aaa
//
