LOCUS       NM_001126372            3307 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Rattus norvegicus AGBL carboxypeptidase 5 (Agbl5), mRNA.
ACCESSION   NM_001126372 XM_001064958 XM_001065011 XM_001065062 XM_001065119
            XM_001065177 XR_006450
VERSION     NM_001126372.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3307)
  AUTHORS   Xia,P., Ye,B., Wang,S., Zhu,X., Du,Y., Xiong,Z., Tian,Y. and Fan,Z.
  TITLE     Glutamylation of the DNA sensor cGAS regulates its binding and
            synthase activity in antiviral immunity
  JOURNAL   Nat Immunol 17 (4), 369-378 (2016)
   PUBMED   26829768
  REMARK    Erratum:[Nat Immunol. 2016 Apr;17(4):469. doi:
            10.1038/ni0416-469e.. PMID: 27002845]
REFERENCE   2  (bases 1 to 3307)
  AUTHORS   Tort,O., Tanco,S., Rocha,C., Bieche,I., Seixas,C., Bosc,C.,
            Andrieux,A., Moutin,M.J., Aviles,F.X., Lorenzo,J. and Janke,C.
  TITLE     The cytosolic carboxypeptidases CCP2 and CCP3 catalyze
            posttranslational removal of acidic amino acids
  JOURNAL   Mol Biol Cell 25 (19), 3017-3027 (2014)
   PUBMED   25103237
REFERENCE   3  (bases 1 to 3307)
  AUTHORS   Rodriguez de la Vega Otazo,M., Lorenzo,J., Tort,O., Aviles,F.X. and
            Bautista,J.M.
  TITLE     Functional segregation and emerging role of cilia-related cytosolic
            carboxypeptidases (CCPs)
  JOURNAL   FASEB J 27 (2), 424-431 (2013)
   PUBMED   23085998
REFERENCE   4  (bases 1 to 3307)
  AUTHORS   Rogowski,K., van Dijk,J., Magiera,M.M., Bosc,C., Deloulme,J.C.,
            Bosson,A., Peris,L., Gold,N.D., Lacroix,B., Bosch Grau,M., Bec,N.,
            Larroque,C., Desagher,S., Holzer,M., Andrieux,A., Moutin,M.J. and
            Janke,C.
  TITLE     A family of protein-deglutamylating enzymes associated with
            neurodegeneration
  JOURNAL   Cell 143 (4), 564-578 (2010)
   PUBMED   21074048
REFERENCE   5  (bases 1 to 3307)
  AUTHORS   Kimura,Y., Kurabe,N., Ikegami,K., Tsutsumi,K., Konishi,Y.,
            Kaplan,O.I., Kunitomo,H., Iino,Y., Blacque,O.E. and Setou,M.
  TITLE     Identification of tubulin deglutamylase among Caenorhabditis
            elegans and mammalian cytosolic carboxypeptidases (CCPs)
  JOURNAL   J Biol Chem 285 (30), 22936-22941 (2010)
   PUBMED   20519502
REFERENCE   6  (bases 1 to 3307)
  AUTHORS   Kalinina,E., Biswas,R., Berezniuk,I., Hermoso,A., Aviles,F.X. and
            Fricker,L.D.
  TITLE     A novel subfamily of mouse cytosolic carboxypeptidases
  JOURNAL   FASEB J 21 (3), 836-850 (2007)
   PUBMED   17244818
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC166490.1.
            
            On or before May 8, 2008 this sequence version replaced
            XR_006450.1, XM_001065062.1, XM_001065177.1, XM_001064958.1,
            XM_001065119.1, XM_001065011.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166490.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3307
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q14"
     gene            1..3307
                     /gene="Agbl5"
                     /note="AGBL carboxypeptidase 5"
                     /db_xref="GeneID:362710"
                     /db_xref="RGD:1598311"
     exon            1..524
                     /gene="Agbl5"
                     /inference="alignment:Splign:2.1.0"
     exon            525..785
                     /gene="Agbl5"
                     /inference="alignment:Splign:2.1.0"
     CDS             571..3069
                     /gene="Agbl5"
                     /EC_number="3.4.17.24"
                     /note="ATP/GTP binding protein-like 5; protein
                     deglutamylase CCP5"
                     /codon_start=1
                     /product="cytosolic carboxypeptidase-like protein 5"
                     /protein_id="NP_001119844.1"
                     /db_xref="GeneID:362710"
                     /db_xref="RGD:1598311"
                     /translation="MELRCGGLLFSSRFDSGNLAHVEKVETVPSDGEGVGGAATAPTS
                     GSASSPDYEFNVWTRPDCAETEYENGNRSWFYFSVRGGTPGKLIKINIMNMNKQSKLY
                     SQGMAPFVRTLPSRPRWERIRERPTFEMTETQFVLSFVHRFVEGRGATTFFAFCYPFS
                     YSDCQDLLSQLDQRFPENYSAHSSPLDSIYYHRELLCYSLDGLRVDLLTITSCHGLRD
                     DREPRLEQLFPDVGTPRPFRFTGKRIFFLSSRVHPGETPSSFVFNGFLDFILRPDDPR
                     AQTLRRLFVFKLIPMLNPDGVVRGHYRTDSRGVNLNRQYLKPDAVLHPAIYGAKAVLL
                     YHHVHSRLNSKNPSNQQPSSLHLPPEVPLSDLEKANNLHNELHLGQSPDGENHDRWTE
                     TEPTEEKTDPVWIMPQPIPELEEPAPDAIPPKESGVAYYVDLHGHASKRGCFMYGNSF
                     SDESTQVENMLYPKLISLNSAHFDFQGCNFSEKNMYARDRRDGQSKEGSGRVAIYKAS
                     GIIHSYTLECNYNTGRSVNSIPAACHDNGRASPPPPPTFPSRYTVELFEQVGRALAIA
                     ALDMAECNPWPRIVLSEHSSLTNLRAWMLKHVRNSRGLTSTANVGLNKKRGSRTPPKS
                     NNGLPVSCSENALSRARSFSTGTSTGGSSSQQNSPQMKNSPSFPFHGSRPAGLPGLGS
                     STQKVSHRVLGPVREPRCPDRRRRQQQQQQQQQQQQQQQQQPLNQRSTTSSLAPSPTL
                     ASASPTSSRNMGSCLLPNSLSLSGSSCPFSSSGDKPEAVMVIGKSLLGAGARIPCIRT
                     RLQTCQRRVSARRGPGFPRLGPGWAGAHRRLAEG"
     exon            786..957
                     /gene="Agbl5"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1121
                     /gene="Agbl5"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1299
                     /gene="Agbl5"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..1478
                     /gene="Agbl5"
                     /inference="alignment:Splign:2.1.0"
     exon            1479..1938
                     /gene="Agbl5"
                     /inference="alignment:Splign:2.1.0"
     exon            1939..2108
                     /gene="Agbl5"
                     /inference="alignment:Splign:2.1.0"
     exon            2109..2244
                     /gene="Agbl5"
                     /inference="alignment:Splign:2.1.0"
     exon            2245..2447
                     /gene="Agbl5"
                     /inference="alignment:Splign:2.1.0"
     exon            2448..2659
                     /gene="Agbl5"
                     /inference="alignment:Splign:2.1.0"
     exon            2660..2860
                     /gene="Agbl5"
                     /inference="alignment:Splign:2.1.0"
     exon            2861..2973
                     /gene="Agbl5"
                     /inference="alignment:Splign:2.1.0"
     exon            2974..3020
                     /gene="Agbl5"
                     /inference="alignment:Splign:2.1.0"
     exon            3021..3283
                     /gene="Agbl5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccgggtgga gggcccgggt gccggggccc gaggtgccgc ctcgctagcg ggaaagggag
       61 cgggagcagc ggcccggaga gaggtgaggg gctctgtgtg gactgcggcc ccgccggcag
      121 gccccgcccc cttctctcag ccgctccgcg ggagcccccg tcgaatgcca ccccgccccc
      181 ccggcctgcg gcggcccgcc aaccccgcct ctggctgact acctcggctc ctgtggcctc
      241 acctctgacc cctaggacca gccttcccgt cctccagtat atctgtctcg acccctccca
      301 cgcctccaaa ccccaccctg ccccggaccc gccaggcagt gcgagggtcc tcgggaatcg
      361 aggagctgcc tgctgcttcc aagcgggact ctactggccc agccttccta ggggtgctta
      421 ggacgcccgt tacccacacc ttcgagggta gcttttgcac gggctcgtgt ctacagggcg
      481 ggaggatgga aacagaccct aattggaact gaggttcagg gcagctctca gggcctgtgt
      541 ggggcaagag gatgctttcc cagcctcacc atggagctgc gctgtggggg attgctgttc
      601 agttctcgct ttgattcagg gaacctagcc catgtggaaa aggtggagac tgtgcctagt
      661 gatggggaag gcgtaggagg ggcggcaaca gcccccacta gtggttctgc ttcttcccct
      721 gactacgagt tcaacgtatg gacgcgccca gactgtgctg aaacagaata tgagaatggg
      781 aacaggtcat ggttctactt cagtgtccgg ggaggaactc caggaaagct tatcaagatc
      841 aatattatga acatgaacaa gcagagcaaa ctatattctc agggcatggc cccctttgtg
      901 cgcacattgc cttcccggcc acgctgggaa cgcattagag agcggcccac ctttgagatg
      961 acagagacac agtttgtgct atcctttgtt caccgtttcg tagagggccg aggagccacc
     1021 accttcttcg ccttctgcta ccccttctcc tacagtgact gccaggattt gctaagtcag
     1081 ctagaccagc gctttccaga gaattactct gcccatagca gtcctctgga tagcatttat
     1141 taccaccgag agcttctctg ctattctctg gatggacttc gggtagatct actaacaatc
     1201 acctcctgcc atgggcttcg agatgatcgg gagccccgtc tagagcagct atttcctgat
     1261 gttggcactc cccgaccatt ccgtttcaca ggcaaaagga tattcttctt aagcagtagg
     1321 gttcaccctg gagagactcc atctagcttt gtcttcaatg gctttctgga cttcatcctt
     1381 cgacctgatg acccccgggc ccaaactctc cgtcgactct ttgtttttaa attgattccc
     1441 atgttaaacc ctgatggtgt ggtccggggc cactaccgca cagactcccg tggagtgaac
     1501 ctgaaccgtc agtacttgaa gcccgatgct gtcctgcacc cagccatcta tggcgctaag
     1561 gccgtgctgc tttatcatca cgtgcactcg cgcctcaact ccaagaatcc ctcgaaccag
     1621 cagcccagca gccttcatct tcctcctgaa gttcctcttt ctgacctcga gaaagctaat
     1681 aatctccaca atgaattgca ccttgggcag tcacctgatg gggaaaacca tgacaggtgg
     1741 actgagacag agccgacaga agaaaagact gacccggtgt ggattatgcc acaaccgatt
     1801 cctgaacttg aggagccagc ccctgacgcc atccccccaa aagagagtgg tgttgcttac
     1861 tatgtggact tgcatggaca tgcttccaaa aggggctgct ttatgtatgg aaacagcttt
     1921 agtgatgaga gcacacaggt ggaaaacatg ctatatccaa agctcatctc cttgaattca
     1981 gcccactttg acttccaggg ctgcaatttc tctgaaaaga acatgtatgc ccgggaccgt
     2041 agggacggcc agtccaagga gggaagtggc cgtgttgcaa tctacaaagc ctcagggata
     2101 atccacagct acacacttga atgcaactac aacactggac gctcagtcaa cagcatccct
     2161 gctgcctgcc atgacaatgg gcgcgccagc ccccctcccc ctccgacttt cccctccaga
     2221 tacactgtgg aactgtttga gcaggtggga cgagctctgg ccatcgcagc actggacatg
     2281 gcggagtgta acccatggcc ccgaatcgtg ctgtcggaac acagcagcct caccaacctg
     2341 cgggcctgga tgctgaagca cgtgcgcaat agccgaggcc tgaccagcac tgcaaacgtg
     2401 ggcctgaaca agaagcgagg atcgcggact cctcccaaga gtaacaatgg attgcctgtt
     2461 tcctgttctg aaaatgcctt gagccgggct cgaagtttta gcactggtac aagtactggt
     2521 ggtagcagca gccaacaaaa ttctccacag atgaagaact ctcccagctt cccttttcat
     2581 ggcagtcggc ctgcagggct gccaggcctg ggctctagca cccaaaaggt cagccatcgg
     2641 gtgctgggcc ctgtcagaga gccccgatgc ccagacagaa ggcggcggca gcagcagcag
     2701 cagcagcagc agcagcagca gcagcagcag cagcagcagc cactgaacca acgctctaca
     2761 acaagcagcc tagccccatc cccaactctg gctagtgcta gcccaacctc ctcccgaaac
     2821 atgggctcct gcctcctgcc caattcactc agcttatcag ggagcagctg cccattctcg
     2881 tcttcagggg acaagccaga ggctgtcatg gtgattggga aaagcctact aggggctggt
     2941 gctcggatcc cctgcattag gactcgtttg cagacctgcc agaggagagt ttccgccagg
     3001 aggggtcccg gattccccag gctaggccca ggttgggccg gagctcaccg ccgactcgca
     3061 gagggatgag aggctcaagc cccacatccc ccatccccca gaccagagag agcagtgagc
     3121 tggagccggg accccgctct gctacaccag ggtgagcacc ggagtccagt ccttcatccc
     3181 acccctcatt tctactatcc ttcaccccca tttcagcatt caggataatg gtctcacttt
     3241 cttactgatc ccaaagacta aatgcacttt tattaagaat ctaaaaaaaa aaaaaaaaaa
     3301 aaaaaaa
//
