LOCUS       NM_001031641            1215 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus aspartylglucosaminidase (Aga), mRNA.
ACCESSION   NM_001031641 XM_214403
VERSION     NM_001031641.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1215)
  AUTHORS   Danyukova,T., Ariunbat,K., Thelen,M., Brocke-Ahmadinejad,N.,
            Mole,S.E. and Storch,S.
  TITLE     Loss of CLN7 results in depletion of soluble lysosomal proteins and
            impaired mTOR reactivation
  JOURNAL   Hum Mol Genet 27 (10), 1711-1722 (2018)
   PUBMED   29514215
REFERENCE   2  (bases 1 to 1215)
  AUTHORS   Thaysen-Andersen,M., Venkatakrishnan,V., Loke,I., Laurini,C.,
            Diestel,S., Parker,B.L. and Packer,N.H.
  TITLE     Human neutrophils secrete bioactive paucimannosidic proteins from
            azurophilic granules into pathogen-infected sputum
  JOURNAL   J Biol Chem 290 (14), 8789-8802 (2015)
   PUBMED   25645918
REFERENCE   3  (bases 1 to 1215)
  AUTHORS   Peltola,M., Tikkanen,R., Peltonen,L. and Jalanko,A.
  TITLE     Ser72Pro active-site disease mutation in human lysosomal
            aspartylglucosaminidase: abnormal intracellular processing and
            evidence for extracellular activation
  JOURNAL   Hum Mol Genet 5 (6), 737-743 (1996)
   PUBMED   8776587
REFERENCE   4  (bases 1 to 1215)
  AUTHORS   Tenhunen,K., Laan,M., Manninen,T., Palotie,A., Peltonen,L. and
            Jalanko,A.
  TITLE     Molecular cloning, chromosomal assignment, and expression of the
            mouse aspartylglucosaminidase gene
  JOURNAL   Genomics 30 (2), 244-250 (1995)
   PUBMED   8586423
REFERENCE   5  (bases 1 to 1215)
  AUTHORS   Butor,C., Griffiths,G., Aronson,N.N. Jr. and Varki,A.
  TITLE     Co-localization of hydrolytic enzymes with widely disparate pH
            optima: implications for the regulation of lysosomal pH
  JOURNAL   J Cell Sci 108 (Pt 6), 2213-2219 (1995)
   PUBMED   7673341
REFERENCE   6  (bases 1 to 1215)
  AUTHORS   Rip,J.W., Coulter-Mackie,M.B., Rupar,C.A. and Gordon,B.A.
  TITLE     Purification and structure of human liver aspartylglucosaminidase
  JOURNAL   Biochem J 288 (Pt 3) (Pt 3), 1005-1010 (1992)
   PUBMED   1281977
REFERENCE   7  (bases 1 to 1215)
  AUTHORS   Tollersrud,O.K. and Aronson,N.N. Jr.
  TITLE     Comparison of liver glycosylasparaginases from six vertebrates
  JOURNAL   Biochem J 282 (Pt 3) (Pt 3), 891-897 (1992)
   PUBMED   1554372
REFERENCE   8  (bases 1 to 1215)
  AUTHORS   Fisher,K.J. and Aronson,N.N. Jr.
  TITLE     Characterization of the mutation responsible for
            aspartylglucosaminuria in three Finnish patients. Amino acid
            substitution Cys163----Ser abolishes the activity of lysosomal
            glycosylasparaginase and its conversion into subunits
  JOURNAL   J Biol Chem 266 (18), 12105-12113 (1991)
   PUBMED   1904874
REFERENCE   9  (bases 1 to 1215)
  AUTHORS   Ikonen,E., Baumann,M., Gron,K., Syvanen,A.C., Enomaa,N., Halila,R.,
            Aula,P. and Peltonen,L.
  TITLE     Aspartylglucosaminuria: cDNA encoding human aspartylglucosaminidase
            and the missense mutation causing the disease
  JOURNAL   EMBO J 10 (1), 51-58 (1991)
   PUBMED   1703489
REFERENCE   10 (bases 1 to 1215)
  AUTHORS   Tollersrud,O.K. and Aronson,N.N. Jr.
  TITLE     Purification and characterization of rat liver glycosylasparaginase
  JOURNAL   Biochem J 260 (1), 101-108 (1989)
   PUBMED   2775174
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC098718.1.
            
            On Aug 12, 2005 this sequence version replaced XM_214403.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC098718.1, CF109696.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1215
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="16"
                     /map="16p11"
     gene            1..1215
                     /gene="Aga"
                     /note="aspartylglucosaminidase"
                     /db_xref="GeneID:290923"
                     /db_xref="RGD:1309646"
     exon            1..134
                     /gene="Aga"
                     /inference="alignment:Splign:2.1.0"
     CDS             8..1045
                     /gene="Aga"
                     /EC_number="3.5.1.26"
                     /note="n(4)-(Beta-N-acetylglucosaminyl)-L-asparaginase;
                     glycosylasparaginase;
                     N4-(N-acetyl-beta-glucosaminyl)-L-asparagine amidase"
                     /codon_start=1
                     /product="N(4)-(Beta-N-acetylglucosaminyl)-L-asparaginase
                     precursor"
                     /protein_id="NP_001026811.1"
                     /db_xref="GeneID:290923"
                     /db_xref="RGD:1309646"
                     /translation="MARKWNLPFLLLPLVLGIPLVRGSNPLPLVVNTWPFKNATEAAW
                     WTLVSGGSALDAVEKGCAMCEKEQCGGTVGFGGSPDEVGETTLDAMIMDGTAMDVGAV
                     GGLRRIKNAIGVARKVLEHTTHTLLVGDSATKFAVSMGFTSEDLSTNTSRALHSDWLS
                     RNCQPNYWRNVIPDPSKYCGPYKPPDFLEQNNRAHKEVDIHSHDTIGMVVIHKTGHTA
                     AGTSTNGLKFKIPGRVGDSPIPGAGAYADDMAGAAAATGDGDTLLRFLPSYQAVEYMR
                     GGDDPARACQKVISRIQKYYPKFFGAVICANVTGSYGAACNRLPTFTQFSFMVYNSLH
                     NQAIEEKVDCM"
     exon            135..288
                     /gene="Aga"
                     /inference="alignment:Splign:2.1.0"
     exon            289..401
                     /gene="Aga"
                     /inference="alignment:Splign:2.1.0"
     exon            402..514
                     /gene="Aga"
                     /inference="alignment:Splign:2.1.0"
     exon            515..626
                     /gene="Aga"
                     /inference="alignment:Splign:2.1.0"
     exon            627..702
                     /gene="Aga"
                     /inference="alignment:Splign:2.1.0"
     exon            703..810
                     /gene="Aga"
                     /inference="alignment:Splign:2.1.0"
     exon            811..944
                     /gene="Aga"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1182
                     /gene="Aga"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctctgctatg gcgcggaagt ggaatctccc ttttcttctc ctgccgctcg ttctgggtat
       61 acccctggtg cggggctcca accctctacc cctggtcgtc aacacttggc cttttaagaa
      121 tgccaccgaa gcagcgtggt ggacattagt gtctggaggt tctgccctgg atgcggtgga
      181 gaagggctgt gctatgtgtg aaaaggagca atgtggtggt actgtaggct ttggaggaag
      241 tcctgatgaa gttggggaaa ccaccctgga tgccatgatc atggatggca ctgctatgga
      301 tgtgggagca gtgggaggcc ttagaagaat taaaaatgct attggagtgg ctcggaaagt
      361 cttggagcat accacgcaca cgcttttagt gggggactca gccaccaagt ttgctgtaag
      421 tatggggttt accagtgagg acttatctac caatacctca agagctcttc attcagattg
      481 gctttctcga aactgccagc caaattattg gagaaacgtt ataccagatc cttcaaaata
      541 ctgtggaccc tacaaaccac ctgatttctt agagcagaat aaccgtgccc acaaagaagt
      601 ggatatccac agtcatgata ctattggcat ggttgtaatc cataagacgg gacatactgc
      661 tgctggcaca tctacaaatg gtttaaaatt caaaatacct ggtcgtgtag gagactcacc
      721 aatccctgga gctggagcct atgctgatga catggctgga gcagctgcgg ccactggaga
      781 tggtgacaca ctcctgagat ttctgccaag ctaccaagct gtagaatata tgagaggagg
      841 agatgatcca gccagagctt gccaaaaagt gatttcaaga attcagaaat attatccaaa
      901 attctttgga gctgttatat gtgccaatgt gacaggaagt tatggtgctg cttgcaacag
      961 acttccaaca tttactcaat ttagtttcat ggtttataac tctctacaca atcaggcgat
     1021 tgaagaaaaa gtagactgca tgtaatctct cttgtctgtc aacatatgta tttaaagagg
     1081 aaagacgtga cggcgggaag gttgctcact gacatggagt gatcctcaat tatttcaagt
     1141 tcttgtgtaa attaagtgca aaaataaata tgctgtagtg ttaaaaaaaa aaaaaaaaaa
     1201 aaaaaaaaaa aaaaa
//
